Effect of LSD-25 in the Rat on Operant Approach to a Visual or Auditory Conditioned Stimulus
Keyword(s):
Albino rats ( N = 200) required progressively more time per trial to perform a previously learned response to obtain food reward than saline and untreated controls following administration of increasing doses of LSD-25 (100, 200, 400 μg/kg). Ss conditioned to respond to a light stimulus showed more response decrement than animals cued by an auditory stimulus for increasing LSD-25 levels. Within each stimulus modality, a greater response decrement was observed following administration of LSD-25 for the higher intensity stimulus value for all but one treatment group. Results were discussed in relation to reports of sensitization and sensory blockage actions for LSD-25.