scholarly journals Multiple giant cell formation – A consequence of type II pyrethroid intoxication

2018 ◽  
Vol 11 (2) ◽  
pp. 178-179
Author(s):  
Brijender Bhushan ◽  
Prabhu Narain Saxena

Abstract Pesticides are the main remedy for pest eradication, but their use has been found to be harmful also to various non-target organisms. In this study, giant cell formation was observed in hepatocytes of experimental albino rats following two type II pyrethroid pesticdes, Cypermethrin and Beta-cyfluthrin. Histopathological examination was done for this purpose and the results revealed the formation of giant cells and polyploidy condition following intoxication of these experimental compounds with Beta-cyfluthrin, with an edge over, and Cypermethrin, probably due to structural differences.

PEDIATRICS ◽  
1958 ◽  
Vol 21 (3) ◽  
pp. 436-442
Author(s):  
C. Lenore Simpson ◽  
Donald Pinkel

A fatal case of measles complicating leukemia in an infant is reported. Giant-cell pneumonia and a few giant cells in lymph nodes were seen as in previously reported cases. In addition, necroses in liver, lymph nodes, thymus, pancreas and kidney associated with giant-cell formation and inclusion bodies were observed.


1976 ◽  
Vol 22 (3) ◽  
pp. 431-434 ◽  
Author(s):  
K. G. Johnson ◽  
I. J. Mcdonald

Growth of Neisseria perflava, Neisseria cinerea, and Neisseria sicca strain Kirkland in media supplemented with sucrose (0.5 to 5.0% w/v) resulted in the formation of giant cells. Response to sucrose was specific in that a variety of other carbohydrates did not mediate giant cell formation. Giant cells appeared only under growth conditions and did not lyse upon transfer to medium lacking sucrose or upon resuspension in hypotonic media. Reversion of giant to normal cells occurred when giant cells were used as inocula and allowed to multiply in media lacking sucrose.


2015 ◽  
Vol 41 (5) ◽  
pp. e212-e222 ◽  
Author(s):  
Mike Barbeck ◽  
Samuel Udeabor ◽  
Jonas Lorenz ◽  
Markus Schlee ◽  
Marzellus Grosse Holthaus ◽  
...  

The present preclinical and clinical study assessed the inflammatory response to a high-temperature–treated xenogeneic material (Bego-Oss) and the effects of this material on the occurrence of multinucleated giant cells, implantation bed vascularization, and regenerative potential. After evaluation of the material characteristics via scanning electron microscopy, subcutaneous implantation in CD-1 mice was used to assess the inflammatory response to the material for up to 60 days. The clinical aspects of this study involved the use of human bone specimens 6 months after sinus augmentation. Established histologic and histomorphometric analysis methods were applied. After implantation, the material was well integrated into both species without any adverse reactions. Material-induced multinucleated giant cells were observed in both species and were associated with enhanced vascularization. These results revealed the high heat treatment led to an increase in the inflammatory tissue response to the biomaterial, and a combined increase in multinucleated giant cell formation. Further clarification of the differentiation of the multinucleated giant cells toward so-called osteoclast-like cells or foreign-body giant cells is needed to relate these cells to the physicochemical composition of the material.


1958 ◽  
Vol 32 (3) ◽  
pp. 135-144 ◽  
Author(s):  
C. S. Cole ◽  
H. W. Howard

Giant cell formation was studied in the roots of potatoes grown in a soil infested with Heterodera rostochiensis.Some indication of giant cell formation was found in roots fixed 14 days after planting of sprouted tubers in the infested soil.Giant cells may be formed by the cells of the cortex, the endodermis, the pericycle and the parenchyma cells of the central vascular strand.The first giant cells appear to be formed in the cortex and pericycle.Giant cells in the cortex are only found near the head of an eelworm.Giant cell formation by the parenchyma cells of the central vascular strand leads to no cambium and hence no secondary xylem being produced in those sectors of the root where they occur.The occurrence of sectors of the root in which there is no secondary xylem gives the central vascular strand an irregular appearance.Some giant cells may be multinucleate. They all have granular cytoplasm.


1999 ◽  
Vol 2 (4) ◽  
pp. 353-359 ◽  
Author(s):  
George Koukoulis ◽  
Giorgina Mieli-Vergani ◽  
Bernard Portmann

The mechanism of liver giant cell formation is not clarified. Some authors consider the giant cells regenerative, others, degenerative. Paraffin sections of 10 archival cases of idiopathic neonatal hepatitis (INH), 8 of extrahepatic biliary atresia (EHBA), and 5 normal liver samples were immunostained with two well-characterized cell proliferation markers: anti-PCNA monoclonal antibody (MAb) (clone PC-10) and MAb MIB-1, which detects Ki-67, a nuclear proliferation-related antigen. In addition, polyclonal antibody to carcinoembryonic antigen (CEA) was used to identify remnants of canalicular, therefore hepatocytic, membranes in giant cells. Quantitative analysis of immunostaining was done by estimating PCNA and Ki-67 indices separately in giant cells and in nongiant hepatocytes. In normal samples, mean PCNA and Ki-67 indices were 1.22% and 0.74%, respectively. In the cases of INH and EHBA, only a small minority of giant cells showed PCNA or Ki-67 staining limited to occasional peripherally located nuclei. PCNA and Ki-67 indices were significantly higher in the non–giant cell compartment. CEA staining was seen only in rare giant cells as centrally located canalicular remnants bordered by polarized nuclei, suggesting that they had been formed from rosettes through dissolution of cell membranes. Other giant cells shared CEA-labeled canalicular membranes with mononuclear hepatocytes in rosettes. These findings indicate that the giant cells in INH and EHBA are not regenerative cells, they are not formed by amitotic division of nuclei in syncytia, and that fusion of rosette-forming hepatocytes is a possible mechanism of their formation.


2011 ◽  
Vol 6 (5) ◽  
pp. 675-684 ◽  
Author(s):  
Rostyslav Horbay ◽  
Rostyslav Stoika

AbstractThe study of giant cells in populations of different tumor cells and evaluation of their role in cancer development is an expanding field. The formation of giant cells has been shown to be followed by mitotic catastrophe, apoptosis, necrosis, and other types of cell elimination. Reports also demonstrate that giant cells can escape cell death and give rise to new cancer cells. However, it is not known if the programmed cell death is involved in this type of cell cycle disorders. Here we describe principal events that are observed during giant cell formation. We also consider the role of giant cells in cancer development, taking into account both published work and our own recent data in this field.


Author(s):  
Samar Khan

This review is intended to provide insight into the current state of understanding regarding the molecular and cellular mechanisms underlying the formation and function of various types of multinucleated giant cells. Present article mainly focus on various factors such as e.g. GCP/F, GM-CSF, Meltrin, MIP-1 that contribute to giant cell formation and function. This review focuses on recent efforts to develop a better understanding of the molecular and cellular biology of multinucleated giant cell formation and function.


1970 ◽  
Vol 48 (2) ◽  
pp. 271-276 ◽  
Author(s):  
Ronald E. Paulson ◽  
John M. Webster

Light and electron microscope studies show the changes which occur during transformation of small thin-walled plant cells into greatly enlarged "giant cells," which act as nutrient sources for the developing nematodes. Proliferation of cytoplasm and organelles, lobing of nuclei, and development of irregularly thickened cell walls suggested an increased metabolic activity in these cells. Giant cells appear to be most actively synthesizing materials, including a crystalline form of storage protein, during the later stages of nematode development. Numerous spiny vesicles were present and thought to be associated with the production of storage protein. Shortly after maturation of the female nematode, there was a breakdown of giant cell structure, characterized by a loss of membrane clarity and eventual disappearance of organelles.


Sign in / Sign up

Export Citation Format

Share Document