scholarly journals Pulmonary rehabilitation and tuberculosis: a new approach for an old disease

Pneumologia ◽  
2019 ◽  
Vol 68 (3) ◽  
pp. 107-113
Author(s):  
Beatrice Mahler ◽  
Alina Croitoru
Keyword(s):  
Quality Of Life ◽  
Muscle Weakness ◽  
Pulmonary Rehabilitation ◽  
Functional Independence ◽  
Daily Activities ◽  
New Approach ◽  
Antituberculous Treatment ◽  
Long Time ◽  
The Impact

Abstract Tuberculosis (TB) is still a leading cause of morbidity and mortality worldwide. The impact on patient’s life is significant, leading to physical, mental and social deconditioning, not only in active TB but also in post TB sequela. Although with specific antituberculous treatment sputum negativity can be achieved, TB extrapulmonary symptoms such as cachexia, muscle weakness and depression may persist for a long time. The pulmonary rehabilitation (PR) may be a useful tool in this patient’s therapy in active and also in sequela phase. The benefits of PR are: reducing symptomatology, improving the degree of functional independence and quality of life, and increasing the ability to perform daily activities. This article discusses the components of a PR programme in active TB and TB sequela, and the results obtained by studies so far.

scholarly journals The quality of life perception by gender and place of residence during assessment of thrombocytopenia impact on patients’ daily activities using TSIDAV vignette

2017 ◽  
Vol 127 (1) ◽  
pp. 24-27
Author(s):  
Monika Szkultecka-Dębek ◽  
Mariola Drozd ◽  
Marta Bem
Keyword(s):  
Quality Of Life ◽  
Western Europe ◽  
Human Life ◽  
Daily Activities ◽  
Place Of Residence ◽  
Disease Symptoms ◽  
Long Time ◽  
The Impact ◽  
Very High

Abstract Introduction. The term “quality of life” has been present in the literature for a long time now. It was created in the middle of the last century in Western Europe and from the societal perspective the term initially defined the level of material life, gradually being expanded to other aspects of human life, like happiness, education, broadly defined individual freedom and health. Aim. To analyze differences by gender and place of residence in perception of quality of life based on data from the assessment of thrombocytopenia impact on daily activities using TSIDAV vignette among Polish patients. Material and methods. We assessed the impact of thrombocytopenia symptoms on patients’ daily activities using TSIDAV vignette. We wanted to understand the reason for different perception of symptoms and why visible symptoms are perceived as worse by women in comparison to men. We analyzed the groups by age and place of residence. Results. Within 48 collected questionnaires, 31 were provided by women and 17 by men. As many as 29% of men declared the biggest impact on daily activities due to petechiae and easy bruising. The same symptoms were assessed as having significant impact on daily activities by 68% and 65% of women respectively. The results in relation to the two symptoms were similar in terms of impact: both men and women assessed it as high impact, however in general, a lower proportion of men identified this as an issue. As many as 53% of the pre-menopausal women declared the thrombocytopenia impact on daily activities as very high. Similar results were observed in the male group. Those before retirement age assessed disease symptoms as very high in comparison to the group of older patients. No significant differences in relation to place of residence were observed. During literature research we found that depending on patients’ gender, the perception of the impact of disease on patients quality of life may often differ. Conclusions. We found out that the perception of disease symptoms impact on quality of life is different by women and men. That may be the result of different factors such as the influence of social roles determined for each sex. At the same time, the perception of the impact of thrombocytopenia symptoms on daily activity almost does not depend on age or place of residence of neither women nor men.

scholarly journals Improved gastrointestinal profile with diroximel fumarate is associated with a positive impact on quality of life compared with dimethyl fumarate: results from the randomized, double-blind, phase III EVOLVE-MS-2 study

2021 ◽  
Vol 14 ◽  
pp. 175628642199399 ◽  
Author(s):  
Annette Wundes ◽  
Sibyl Wray ◽  
Ralf Gold ◽  
Barry A. Singer ◽  
Elzbieta Jasinska ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Medication Use ◽  
Dimethyl Fumarate ◽  
Daily Activities ◽  
Phase Iii ◽  
Symptomatic Medication ◽  
Gi Symptoms ◽  
Symptom Intensity ◽  
The Impact

Background: Diroximel fumarate (DRF) is a novel oral fumarate approved for relapsing forms of multiple sclerosis (MS). DRF demonstrated significantly improved gastrointestinal (GI) tolerability versus dimethyl fumarate (DMF) with fewer days of Individual Gastrointestinal Symptom and Impact Scale (IGISIS) scores ⩾2, GI adverse events (AEs), and treatment discontinuations due to GI AEs. Our aim was to evaluate the impact of GI tolerability events on quality of life (QoL) for patients with relapsing–remitting MS who received DRF or DMF in EVOLVE-MS-2. Methods: A post hoc analysis was conducted in patients who were enrolled in the randomized, blinded, 5-week, EVOLVE-MS-2 [ClinicalTrials.gov identifier: NCT03093324] study of DRF versus DMF. Patients completed daily IGISIS and Global GISIS (GGISIS) eDiary questionnaires to assess GI symptom intensity and interference with daily activities and work. Results: In total, 504 patients (DRF, n = 253; DMF, n = 251) received study drug and 502 (DRF, n = 253; DMF, n = 249) completed at least one post-baseline questionnaire. With DRF, GI symptoms were less likely to interfere ‘quite a bit’ or ‘extremely’ with regular daily activities [IGISIS: DRF, 9.5% (24/253) versus DMF, 28.9% (72/249)] or work productivity [GGISIS: DRF, 6.1% (10/165) versus DMF, 11.3% (18/159)]. DRF-treated patients had fewer days with ⩾1 h of missed work (DRF, 43 days, n = 20 versus DMF, 88 days, n = 26). DMF-treated patients reported highest GI symptom severity and missed work at week 2–3 shortly after completing the titration period, which coincided with the majority of GI-related treatment discontinuations [58.3% (7/12)]. GI tolerability AEs [DRF, 34.8% (88/253); DMF, 48.2% (121/251)], concomitant symptomatic medication use [DRF, 19.3% (17/88) versus DMF, 30.6% (37/121)], and GI-related discontinuations (DRF, 0.8% versus DMF, 4.8%) were lower with DRF versus DMF. Conclusions: The improved GI tolerability with DRF translated into clinically meaningful benefits to QoL, as patients experienced less impact on daily life and work and required less concomitant symptomatic medication use. Trial registration: [ClinicalTrials.gov identifier: NCT03093324]

scholarly journals Relationship between dental fluorosis and quality of life: a population based study

2005 ◽  
Vol 19 (2) ◽  
pp. 150-155 ◽  
Author(s):  
Edgard Michel-Crosato ◽  
Maria Gabriela Haye Biazevic ◽  
Edgard Crosato
Keyword(s):  
Quality Of Life ◽  
Water Supply ◽  
Dental Fluorosis ◽  
Female Gender ◽  
Population Based ◽  
Daily Activities ◽  
Cross Sectional ◽  
Significance Level ◽  
The Impact

The aim of this study was to verify the prevalence of dental fluorosis in schoolchildren aged 6 to 15 and its possible association with the impacts on their daily activities. This study is observational, cross-sectional and analytical. A total of 513 schoolchildren from the city of Pinheiro Preto, SC, took part in this study. The children were examined by three calibrated dentists, after obtaining a kappa > 0.80. To assess the prevalence of fluorosis, clinical examinations were performed according to the methodology set forth by the 4th edition of the WHO. To assess the impact of fluorosis on their daily activities, a modified OIDP (Oral Impacts on Daily Performance) was adopted. The statistical analysis used was the Chi-squared test with a 5% significance level. Of the total number of children examined, 262 (51.1%) were of the female gender and 251 (48.9%) were of the male gender. In regard to the prevalence of fluorosis, 94 (18.3%) of the children presented this condition, while 419 children (81.7%) presented a normal condition. In regard to the severity of fluorosis, few children presented severe alterations. No association was found between dental fluorosis and gender (p = 0.646), between fluorosis and socioeconomic status (p = 0.848) or between fluorosis and access to public water supply system (p = 0.198). The activities that most affected children's daily performance were: oral hygiene (40.9%) and food intake or enjoying food (40.4%). None of the daily activities could be associated with the occurrence of dental fluorosis. The prevalence of dental fluorosis was consonant with the standards found for locations with optimum fluoride content in the water supply. The questionable and very slight levels of fluorosis were the most frequently found, without influence in the quality of life of the schoolchildren participating in the study.

scholarly journals Comparison of the Effect of Custom Insole With CAD-CAM and Conventional Insole on FAOS Questionnaire Subscales in Patients With Plantar Fasciitis

2020 ◽  
Vol 21 (2) ◽  
pp. 256-271
Author(s):  
Sara Shojaie ◽  
◽  
Mahmood Bahramizade ◽  
Monireh Ahamadi Bani ◽  
Mohsen Movahedi Yeganeh ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Plantar Fasciitis ◽  
Daily Activities ◽  
Foot And Ankle ◽  
Custom Made ◽  
Significant Difference ◽  
Cad Cam ◽  
Pain Symptoms ◽  
The Impact

Objective: One of the significant causes of foot pain is plantar fasciitis. The use of medical insoles is a conventional treatment for this condition. The purpose of this study was to compare the effect of the customized insole with the CAD-CAM and conventional insole on pain, symptoms, daily activity, exercise and recreational activity, and quality of life in patients with PF. Materials & Methods: This quasi-experimental study was performed on 14 patients with plantar fasciitis (five women and nine men) with the mean age of 40 years. Fourteen patients have been diagnosed with orthopedic pain after being diagnosed with plantar fasciitis according to inclusion criteria. Diagnosis of the complication of plantar fasciitis by orthopedic physician, Patients with flexible flat foot. No neurological disorders or any foot pathology such as diabetes and osteoarthritis. Patients were randomly assigned into two groups of 7 using customized insole with CAD-CAM and conventional (prefabricated) insole. From the outset it was found to be one of two types of insole to be studied: first the patient was given a CNC insole, and the other 13 patients received the same insole and divided into two groups. The instrument of this study was the FAOS questionnaire (foot and ankle outcomes) which measures the five variables of pain, symptoms, daily activities, sports and recreational activities, and quality of life. Both groups completed the questionnaire before using the insole and again after six weeks. Compressive scan of both groups was accomplished using EMED foot pressure system. The custom-made insole was designed using Rhino Cross software and then shaved using EVA foam blocks with 50% shore using a CNC machine. In the conventional insoles group, patients received conventional polyurethane insoles based on the length measurements of the single leg. Patients completed the questionnaire again after six weeks. Data were analyzed by SPSS software v. 22. After checking the normality of the data by Shapiro-Wilk test, non-parametric Mann-Whitney and Wilcoxon tests were used to analyze the data. Results: In the pre-intervention phase, there was no significant difference in pain, symptoms, daily activities, recreational-sports activities, and quality of life in the two groups, and the two groups were homogeneous. After six weeks, there was a significant difference between the two groups in the FAOS questionnaire (P<0.05). There was no significant difference between the two groups in pain score, symptoms, daily activities, recreational-sport activities, and quality of life (P <0.05). Conclusion: According to the results of this study, both customized insoles with CAD-CAM and conventional insoles are effective in improving FAOS questionnaire subscales. There was no significant difference in the impact between the two types of insoles in foot and ankle.

Sensory dysfunction and quality of life after great auricular nerve sacrifice during parotidectomy: our experience

2015 ◽  
Vol 129 (11) ◽  
pp. 1121-1127 ◽  
Author(s):  
J Galli ◽  
M Pandolfini ◽  
M Rigante ◽  
L Schinaia ◽  
M L Guidi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Neck Region ◽  
Inverse Correlation ◽  
Daily Activities ◽  
Sensory Dysfunction ◽  
Great Auricular Nerve ◽  
Item Quality ◽  
The Impact ◽  
Moderate Inverse Correlation

AbstractObjective:This study aimed to investigate the impact on patients' quality of life of great auricular nerve sacrifice during parotidectomy.Methods:A retrospective review was conducted of 191 consecutive patients who underwent parotidectomy with great auricular nerve sacrifice between 2006 and 2011. Residual sensory dysfunction and its impact on quality of life was analysed using an eight-item quality of life survey.Results:In all, 139 out of 191 patients (72.8 per cent) experienced one or more abnormal sensations in the ear or neck region after surgery. There was a moderate inverse correlation between the number of abnormal sensations and time elapsed since surgery. Moreover, the degree of discomfort correlated significantly with the frequency of symptom occurrence (p< 0.001), duration of the abnormal sensation (p< 0.001) and size of the affected area (p< 0.001).Conclusion:Sacrifice of the great auricular nerve has only a small impact on patient quality of life; their daily activities are not significantly affected.

scholarly journals Adherence to early pulmonary rehabilitation after COPD exacerbation and risk of hospital readmission: a secondary analysis of the COPD-EXA-REHAB study

2020 ◽  
Vol 7 (1) ◽  
pp. e000582
Author(s):  
Jakob Kjærgaard ◽  
Carsten Bogh Juhl ◽  
Peter Lange ◽  
Torgny Wilcke
Keyword(s):  
Quality Of Life ◽  
Hospital Admission ◽  
Physical Performance ◽  
Pulmonary Rehabilitation ◽  
Walk Test ◽  
Exacerbation Of Copd ◽  
The Impact ◽  
Test Result

BackgroundEarly pulmonary rehabilitation after exacerbation of chronic obstructive pulmonary disease (COPD) has previously been shown to reduce the risk of hospital admission and improve physical performance and quality of life. However, the impact of attendance at early rehabilitation programmes has not been established.ObjectivesTo evaluate the impact of increasing attendance to pulmonary rehabilitation on the risk of hospital admission, physical performance and quality of life in patients attending an early rehabilitation programme after an exacerbation of COPD.MethodsThis study was a secondary exploratory analysis of the randomised controlled trial COPD-EXA-REHAB study, involving patients hospitalised with an exacerbation of COPD. The COPD-EXA-REHAB study compared early pulmonary rehabilitation, starting within 2 weeks after an exacerbation, with standard treatment, that is, the same programme starting 2 months later. The present analysis included only the 70 patients allocated to early pulmonary rehabilitation.ResultsAt 1-year follow-up, we found an association between the number of sessions attended and a reduction in hospital admissions (incidence rate ratio 0.93 (95% CI 0.88 to 0.99), p=0.02), corresponding to a 7% reduction for each session attended. Similarly, at 2-month follow-up, physical performance was positively associated with sessions attended: the mean Incremental Shuttle Walk Test result improved by 8 m with each session (95% CI 2.54 to 13.56, p=0.005) and the Endurance Shuttle Walk Test result by 44 s (95% CI 18.41 to 68.95, p=0.001). Quality of life, assessed using the COPD Assessment Test, was not significantly associated with the number of attended sessions, with the average score increasing by 0.15 points with each session (95% CI −0.35 to 0.65, p=0.55).ConclusionIncreased attendance at early pulmonary rehabilitation after exacerbation of COPD was associated with reduced risk of hospital admission and improved physical performance.

scholarly journals Testosterone Deficiency and Testosterone Treatment in Older Men

Gerontology ◽  
2016 ◽  
Vol 63 (2) ◽  
pp. 144-156 ◽  
Author(s):  
Farid Saad ◽  
Gabriele Röhrig ◽  
Stephan von Haehling ◽  
Abdulmaged Traish
Keyword(s):  
Quality Of Life ◽  
Physical Function ◽  
Older Men ◽  
Functional Independence ◽  
Older Individuals ◽  
Testosterone Deficiency ◽  
Mineral Density ◽  
Testosterone Treatment ◽  
The Impact

Frailty is a clinical condition related to changes in metabolism, to sarcopenia, and to decline in muscle mass and strength, bone mineral density, and physical function with aging. The pathophysiology of frailty is multifactorial and associated with comorbidities. Testosterone is implicated in regulating metabolic functions, maintenance of muscle and bone, and inhibition of adipogenesis. In older individuals, reduced testosterone is thought to contribute to an altered state of metabolism, loss of muscle and bone, and increased fat, leading to sarcopenia, sarcopenic obesity, and frailty. While no direct relationship between testosterone deficiency (commonly known as hypogonadism) and frailty has been established (due to the multifactorial nature of frailty), clinical evidence suggests that testosterone deficiency is associated with increased sarcopenia and obesity. Testosterone treatment in frail older men with limited mobility and with testosterone deficiency improved insulin resistance, glucose metabolism, and body composition. These changes contribute to better physical function and improved quality of life. Because frailty increases disability, comorbidities, and the risk of hospitalization, institutionalization, and mortality in older men, it is warranted to explore the potential usefulness of testosterone treatment in frail men with hypogonadism in order to attenuate the progression of sarcopenia and frailty. In this paper, we will discuss the impact of testosterone deficiency on frailty and the potential role of testosterone treatment in ameliorating and reducing the progression of frailty. Such an approach may reduce disability and the risk of hospitalization and increase functional independence and quality of life.

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