Synthesis, characterisation, and antioxidant study of Cr(III)-rutin complex

AbstractThe article describes the synthesis and characterisation of the Cr(III)-rutin complex along with an estimate of its antioxidant activity. The complex was characterised using elemental analysis, UV-VIS, IR, conductance data, thermal, and gravimetric analyses. In the UV-VIS study, a bathochromic shift of approximately 98 nm indicates the formation of a rutin complex by more than one chelating site. The FT-IR spectra clearly show the formation of the Cr—O bond between rutin and Cr(III) at 494 cm−1, while the thermal study shows the presence of eight coordinated water molecules in the complex. The gravimetric analysis quantitatively proves the presence of four chloride ions. From these data, the formula of the Cr(III)-rutin complex was deduced as [Cr2(C27H28O16)(H2O)8]Cl4. Moreover, the antioxidant study of the complex was evaluated by using 2,2′-diphenyl-1-picrylhydrazyl (DPPH) free-radical, ferric-reducing, and phosphomolybdenum assays, which show that the complex has a higher antioxidant activity than rutin.

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Microwave-Assisted Synthesis, Characterization, Antimicrobial and Antioxidant Activity of Some New Isatin Derivatives

Journal of Chemistry ◽

10.1155/2013/192039 ◽

2013 ◽

Vol 2013 ◽

pp. 1-7 ◽

Cited By ~ 16

Author(s):

G. Kiran ◽

T. Maneshwar ◽

Y. Rajeshwar ◽

M. Sarangapani

Keyword(s):

Antioxidant Activity ◽

Free Radical ◽

Radical Scavenging ◽

Microwave Assisted Synthesis ◽

Stable Free Radical ◽

Ft Ir ◽

Antimicrobial And Antioxidant Activity ◽

New Compounds ◽

Isatin Derivatives

A series of β-Isatin aldehyde-N,N′-thiocarbohydrazone derivatives were synthesized and assayed for theirin vitroantimicrobial and antioxidant activity. The new compounds were characterized based on spectral (FT-IR, NMR, MS) analyses. All the test compounds possessed a broad spectrum of activity having MIC values rangeing from 12.5 to 400 μg/ml against the tested microorganisms. Among the compounds3e,3jand3nshow highest significant antimicrobial activity. The free radical scavenging effects of the test compounds against stable free radical DPPH (α,α-diphenyl-β-picryl hydrazyl) and H2O2were measured spectrophotometrically. Compounds3j,3n,3l, and3e, respectively, had the most effective antioxidant activity against DPPH and H2O2scavenging activity.

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Synthesis and Characterisation of Co(II) Cu(II) Zn(III) and La(II) Complexes of Standard Antidiabetic Drugs

Material Science Research India ◽

10.13005/msri/110107 ◽

2014 ◽

Vol 11 (1) ◽

pp. 51-61

Author(s):

Mohammad Tawkir

Keyword(s):

Elemental Analysis ◽

Analysis Data ◽

Esr Spectra ◽

Molar Conductance ◽

Elemental Analysis Data ◽

Water Molecules ◽

Geometrical Structures ◽

Conductance Data ◽

Ft Ir ◽

Hydrated Complexes

Metal complxes of Glimeperide drugs were prepared and characterized based on elemental analysis, FT-IR, Molar conductance and thermal analysis (TGA and DTG) technique. From elemental analysis data, the complexes were proposed to have general formulae (GLM)2Co2H2O, (GLM)2Cu, (GLM)2Zn,and (GLM)2La2H2O. The molar conductance data reveal that all the metal complexes are non-electrolytic, IR spectra shows that GLM are coordinated to metal ions in a neutral bidentate manner from the ESR spectra and XRD-spectra. It is found that the geometrical structures of these complexes are tetrahedral Cu(II) ,Zn(II) and octrahedral Co(II), La(II). The thermal behavior of these complexesstudied using thermogravimetric analysis (TGA and DTG) techniques. The results obtained shows that the hydrated complexes lose water molecules of hydration followed immediately by decomposition of the anions and ligand molecules in the successive unseparate steps.

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Identifikasi Senyawa Kimia Aktif Antioksidan Dari Ekstrak Etil Asetat Buah Andaliman (Zanthoxylum acanthopodium DC)

Talenta Conference Series Tropical Medicine (TM) ◽

10.32734/tm.v1i3.283 ◽

2018 ◽

Vol 1 (3) ◽

pp. 162-166

Author(s):

Wiwi Winarti ◽

Partomuan Simanjuntak ◽

Muhammad Fahmi Syahidin

Keyword(s):

Antioxidant Activity ◽

Fourier Transform ◽

Free Radical ◽

Vitamin C ◽

Ethyl Acetate ◽

Positive Control ◽

Fruit Extract ◽

Stomach Pain ◽

Infra Red ◽

Ft Ir

Buah andaliman, (Zanthoxylum acanthopodium DC),banyak dikonsumsi oleh masyarakat sebagai bumbu makanan dan obat tradisional seperti obat sakit perut, tonikum, dan anti mikroba. Penelitian ini bertujuan untuk mengidentifikasi senyawa yang berkhasiat sebagai antioksidan dari ekstrak buah andaliman. Ekstraksi dilakukan secara maserasi kinetik menggunakan pelarut n-heksan, dan etil asetat. Ekstrak kental yang diperoleh kemudian diuji aktivitas antioksidan dengan metode peredaman radikal bebas menggunakan DPPH. Sebagai kontrol positif digunakan vitamin C. Selanjutnya dilakukan pemurnian dengan kromatografi kolom sampai diperoleh isolat EA.X.6.1 yang mempunyai aktivitas antioksidan tertinggi. Hasil uji aktivitas antioksidan dengan metode peredaman radikal bebas DPPH (1,1-difenil-2-pikrilhidrazil) menunjukkan bahwa ekstrak etil asetat buah andaliman mempunyai aktivitas antioksidan dengan nilai IC50 sebesar 66,91 bpj, dan isolat EA.X.6.1 yang memiliki aktivitas antioksidan tertinggi dengan nilai IC50 sebesar 135,58 bpj. Berdasarkan hasil analisis dengan spektrofotometri UV-Vis, spektrofotometri Fourier Transform Infra Red (FT- IR) dan Kromatografi Gas-Spektrometri Massa (KG-SM) diduga senyawa aktif antioksidan yang terdapat dalam ekstrak etil asetat buah andaliman adalah 2-metoksi-4-vinilfenol. Andaliman fruit, (Zanthoxylum acanthopodium DC), is widely consumed by people as a food spice and traditional medicine to treat stomach pain, tonic, and as anti-microbial drugs. This study aimed to identify compounds that wereefficacious as antioxidants of andaliman fruit extract. The extraction was performed by kinetic maceration method using n-hexane and ethyl acetate. Then, the crude was tested for its antioxidant activity by free radical DPPH scavenging method. Vitamin C was used as a positive control. Furthermore, the extract was purified by column chromatography to obtain isolate EA.X.6.1 which has the highest antioxidant activity. The results of evaluation on antioxidant activity by free radical DPPH (1,1-difenil-2-pikrilhidrazil)scavenging method showed that ethyl acetate andaliman fruit extract revelaed antioxidant activity with IC50value of 66,91 bpj and isolate EA.X.6.1 which showed the highest antioxidant activity with IC50value of 135,58 bpj. Based on analysis using UV-Vis spectrophotometer, spectrophotometer Fourier Transform Infra Red (FT- IR) and Gas Chromatography- Mass Spectrophotometry (GC-MS), it was considered that antioxidant chemical active compound in ethyl acetate andaliman fruit extract was 2-methoxy-4-vinylphenol

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In-Situ Copper(II) Complexes of Some Quinolone Drug Ligands Were Discussed for Their Molecular Structures: Synthesis in Binary Solvent

Journal of Computational and Theoretical Nanoscience ◽

10.1166/jctn.2017.6363 ◽

2017 ◽

Vol 14 (1) ◽

pp. 561-576 ◽

Cited By ~ 1

Author(s):

Samy M El-Megharbel ◽

M. A Hussien ◽

Moamen S Refat

Keyword(s):

Magnetic Moments ◽

Esr Spectra ◽

Molecular Structures ◽

Water Molecules ◽

Binary Solvent ◽

Carboxylate Groups ◽

Conductance Data ◽

Spin Resonance ◽

Ft Ir

A series of copper solid complexes with different generation of quinolone drugs of the type [Cu(L)n(Cl)x(H2O)y]·zH2O ((1) L: nalidixic acid (Nal), n = 2, x = 2, y = 2, z = 9; (2) L: oxolonic acid (Oxo), n = 2, x = 2, y = 2, z = 2; (3) L: pipemidic acid (Pip), n = 2, x = 2, y = 2, z = 4; (4) L: lomefloxacin (Lom), n = 2, x = 2, y = 2, z = 2; (5) L: pefloxacin mesylate (Pef), n = 2, x = 2, y = 2, z 2; (6) L: levofloxacin (Lev), n = 2, x = 2, y = 2, z = 2) were synthesized and identified using micro-analytical, FT-IR spectroscopy, conductance data, effective magnetic moments, electronic UV-vis spectra, electron-spin-resonance (ESR) spectra. Except levofloxacin that behaves as bi-dentate fashion through oxygen atoms of pyridone and carboxylate groups, the other quinolone drug chelates acts as uni-dentate via nitrogen atom of pyridone/piperazyl moiety. Electronic spectroscopic tools are in agreement with an octahedral geometrical structure. Thermal degradation analyses TG-DTG in nitrogen gas environmental are discussed the number and location of water molecules. The thermal decomposition process is completely in 3–5 steps, that the first step is responsible to loss of uncoordinated water molecules. The stabilities of Cu(II) complex 1–5 were studied dependent on activations of energy E*, entropy ΔS*, enthalpy ΔH* and Gibbs free energy ΔG* that have been estimated using Coats-Redfern and Horowitz-Metzeger non-isothermal methods. Molecular docking was used to predict the binding between some quinolone drugs with the receptor of breast cancer mutant 3hb5-oxidoreductase.

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Synthesis and Characterization of Some New Thermal Stable Polymers - Polymerization of N-[4-N´ -(Benzylamino-carbonyl)phenyl]maleimide

E-Journal of Chemistry ◽

10.1155/2007/857326 ◽

2007 ◽

Vol 4 (2) ◽

pp. 222-231 ◽

Cited By ~ 1

Author(s):

B. L. Hiran ◽

Jyoti Chadhary ◽

S. N. Paliwal ◽

Suresh Meena ◽

P. R. Chaudhary

Keyword(s):

Free Radical ◽

Thermo Gravimetric Analysis ◽

Radical Copolymerization ◽

Synthesis And Characterization ◽

Gravimetric Analysis ◽

Thermo Gravimetric ◽

H Nmr ◽

Free Radical Initiator ◽

Ft Ir

This article describes the synthesis and characterization of homopolymer (H-BCPM) of N-[4-N'-(benzylamino-carbonyl) phenyl] maleimide (N-BACPMI) and copolymer (C-BCPM) of N-BACPMI withn-butyl acrylate (BA). The new monomer was synthesized fromp-aminobenzoic acid, maleic anhydride and benzylamine. The homopolymerization of N-BACPMI is initiated by free radical using AIBN in THF solvent at 65°C. Radical copolymerization of N-BACPMI with BA, initiated by AIBN, was performed in THF solvent using equimolar amount. Effect of the different free radical initiator AIBN, BPO and solventsp-Dioxane, THF, DMF and DMSO was studied. Homopolymer and Copolymer were characterized by intrinsic viscosity, solubility test, FT-IR,1H-NMR spectral analysis and elemental analysis. Thermal behaviour was studied by Thermo gravimetric analysis.

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Synthesis, crystal structure, infrared spectrum, and thermal properties of [Ni(1,10-phenanthroline)3](fumarate)·9H2O complex with hydrogen bonded supramolecular layers involving fumarate anions

Acta Chimica Slovaca ◽

10.2478/acs-2019-0009 ◽

2019 ◽

Vol 12 (1) ◽

pp. 56-62

Author(s):

Anna Uhrinová ◽

Juraj Černák

Keyword(s):

Crystal Structure ◽

Fumaric Acid ◽

Ionic Crystal ◽

Thermal Study ◽

Water Molecules ◽

Chemical Analyses ◽

X Ray ◽

Ft Ir ◽

Ft Ir Spectroscopy ◽

Hydrogen Bonded

Abstract From the aqueous-ethanolic system Ni(OH)2—H2fum—phen (H2fum = fumaric acid, phen = 1,10-phenanthroline), novel complex [Ni(phen)3](fum)·9H2O (1) was isolated and characterized by chemical analyses and FT-IR spectroscopy. Results of single crystal X-ray structure analysis have shown that the ionic crystal structure of 1 is built of [Ni(phen)3]2+ complex cations, fumarate dianions and nine crystallographically independent water molecules of crystallization. The Ni(II) atom exhibits hexa-coordination by three phen ligands with mean Ni-N bond length of 2.090 Å. Water molecules form hydrophilic supramolecular layers with fumarate dianions via extended network of O—H···O type hydrogen bonds with O···O distances from the range of 2.676(2)—2. 916(2) Å; hydrophobic complex cations are embedded between these layers. Thermal study of 1 has shown that endothermic dehydration in the temperature range of 95—195 °C takes at least two steps of the process. Graphical Abstract Crystal structure of [Ni(phen)3]fum·9H2O (phen = 1,10-phenanthroline; H2fum = fumaric acid) which is built of supramolecular layers formed by hydrogen bonded water solvate molecules and fum dianions and between the supramolecular layers embedded [Ni(phen)3]2+ complex cations is described here.

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Synthesis, Fluorescence Properties of 2-Acetyl-2'-Chloroacetanilide with Rare Earth Nitrates Complexes

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.219-220.574 ◽

2011 ◽

Vol 219-220 ◽

pp. 574-577

Author(s):

Xi Shi Tai ◽

Lin Tong Wang

Keyword(s):

Rare Earth ◽

Rare Earth Ions ◽

Fluorescence Properties ◽

Water Molecules ◽

Single Crystal Diffraction ◽

X Ray ◽

Rare Earth Nitrates ◽

Ft Ir ◽

Coordinated Water ◽

The Eu

The reaction of 2-acetyl-2'-chloroacetanilide (L) with rare earth nitrates in CH3CH2OH followed by recrystallization in CH3CH2OH gave rise to colorless block crystals materials. The complexes and ligand were analyzed by FAB, elemental analysis(C, H, N), FT-IR spectra, TG-DTA, molar conductivity and X-ray single crystal diffraction. The fluorescence properties of ligand and the Eu (Ⅲ) complex also have been investigated. The results of crystal structure and spectral data show that the rare earth ions coordinated with oxygen and nitrogen atoms of the ligand, the nitrate and coordinated water molecules. The Eu (Ⅲ) complex material shows characteristic red emissions.

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Charge density in NiCl2.4H2O at 295 and 30 K

Acta Crystallographica Section B Structural Science ◽

10.1107/s0108768199005741 ◽

1999 ◽

Vol 55 (6) ◽

pp. 830-840 ◽

Cited By ~ 6

Author(s):

H. Ptasiewicz-Bak ◽

I. Olovsson ◽

G. J. McIntyre

Keyword(s):

Lone Pair ◽

Chloride Ions ◽

Water Molecules ◽

Nickel Ion ◽

X Ray ◽

Charge Densities ◽

Crystalline Environment ◽

Coordinated Water ◽

The Individual ◽

Two Peaks

The charge distribution has been determined by multipole refinements against single-crystal X-ray diffraction data. In the refinements a comparison was made between the densities based on H-atom parameters from X-ray and neutron data, respectively. X-ray study: λ(Mo Kα) = 0.71073 Å, F(000) = 408; at 30 K: R(F) = 0.015 for 6686 reflections; at 295 K: R(F) = 0.022 for 4630 reflections. The nickel ion is octahedrally surrounded by four water molecules and two chloride ions, forming a locally neutral Ni(H2O)4Cl2 complex. Two of the water molecules are coordinated to nickel approximately in one of the tetrahedral (`lone-pair') directions; the other two are trigonally coordinated. At 30 K one H atom in one of the trigonally coordinated water molecules is disordered, with equal occupation of two different positions. Owing to the polarizing influence of the nickel ion there are two peaks in the lone-pair plane of the water molecules when these are tetrahedrally coordinated; for those trigonally coordinated there is just one peak. The individual (`partial') charge densities, calculated from the deformation functions of only nickel or the separate water molecules, have also been calculated to study the effects of superposition of the individual densities. In the individual density of nickel an excess is observed in the diagonal directions and a deficiency in the ligand directions. However, owing to the influence of the whole crystalline environment, the maxima around nickel are not found in the planes defined by nickel and the six ligands.

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