scholarly journals PROFIL PENGGUNAAN ANTIBIOTIK PASIEN HAEC PASCA OPERASI DI RSUD DR. SOETOMO TAHUN 2015-2018

2018 ◽  
Vol 18 (2) ◽  
pp. 76-79
Author(s):  
Erfano Muhammad Falah

Abstract. HAEC (Hirschsprung-associated Enterocolitis) is one of serious and life-threatening complication of patient with HD (Hirschsprung’s Disease). The etiology of HAEC is still unknown until now, however, the existence of gram-negative bacterial especially C. Dificille has been linked to occurrence of patient with HAEC. HAEC frequently found at patient with HD post-operative surgery. The treatment for HD patient post-operative with HAEC are rectal irrigation, fluid therapy, and antibiotics. Because of the wide variety of sign and symptoms in HAEC post operative patient, under treatment has always been an issue that can leads to higher mortality in HAEC patient. Data of antibiotics application for HAEC post-operative patient in Dr. Soetomo General Hospital have not been collected. Because of the issue, writer is interested to effectuate case study about the used of antibiotics for HAEC patient post operative in  Dr. Soetomo General Hospital at period 2015-2018.Methods : This is a descriptive observational research that analyze through collecting data from medical record by retrospective. This research is using Total Sampling technique from 38 patients that going through HD operative surgery at Dr. Soetomo General Hospital from 2015 to 2018. From 38 patients that going through operative surgery, five patient experience HAEC as complication post HD operative surgery.Results : Five patient with HAEC with HD post-operative are successfully healed and dismissed from hospital. In four out of five patients Metronidazole was selected as the main antibiotic used (80%). Gentamicin was used in three patients using Metronidazole as the main antibiotic (60%). Ampicillin was used in 2 patients using Metronidazole as the main antibiotic (40%). There was only one patient who used metronidazole as a single antibiotic therapy. Ceftriaxone was used in one patient with Metronidazole as the main antibiotic and was used as a single antibiotic therapy in another patient with sepsis complication and diagnosed with HD at the aged below one week. Keywords : HAEC ; HD ; Hirschsprung-associated Enterocolitis ; Hirschsprung’s Disease ; Antibiotics ; Post-Operative  Abstrak. HAEC (Hirschsprung-associated Enterocolitis) merupakan suatu komplikasi yang serius dan dapat mengancam kehidupan pada pasien HD (Hirschsprung’s Disease). Etiologi dari HAEC masih belum dapat dipastikan sampai sekarang, namun adanya infeksi bakteri C. Dificille berkaitan erat dengan terjadinya HAEC. HAEC adalah salah satu komplikasi yang sering dijumpai pada pasien pasca operasi HD. Penanganan HAEC pasca operasi terdiri dari irigasi rektal, terapi cairan, dan antibiotik. Tanda dan gejala yang diperlihatkan pasien HAEC sangatlah bervariatif sehingga sering menyebabkan penanganan dibawah standar prosedur. Data mengenai penanganan dan terapi antibiotika pada pasien HAEC pasca operasi di RSUD Dr. Soetomo Surabaya belum diketahui, oleh karena itu penulis melakukan penelitian mengenai pemilihan antibiotika pada penanganan pasien HAEC pasca operasi HD di RSUD Dr. Soetomo Surabaya pada tahun 2015-2018.Metode : Penelitian dengan jenis observasional deskriptif yang menggunakan data rekam medis untuk melihat data pasien secara retrospektif. Penelitian menggunakan teknik Total Sampling pada 38 pasien yang menjalani operasi HD di RSUD Dr. Soetomo pada tahun 2015-2018. Pada 38 pasien yang menjalani operasi HD, terdapat 5 pasien mengalami komplikasi HAEC pasca operasi HDHasil : Didapatkan hasil lima pasien dengan HAEC pasca operasi HD sembuh dan keluar rumah sakit (100%). Pada empat dari lima pasien Metronidazol dipilih sebagai penggunaan antibiotik utama (80%). Gentamicin digunakan pada tiga pasien yang menggunakan Metronidazol sebagai antibiotik utama (60%). Ampicillin digunakan pada 2 pasien yang menggunakan Metronidazol sebagai antibiotik utama (40%). Hanya terdapat satu pasien yang menggunakan Metronidazol sebagai terapi antibiotik tunggal. Ceftriaxone digunakan pada salah satu pasien dengan Metronidazol sebagai antibiotik utama dan digunakan juga sebagai terapi antibiotik tunggal pada satu pasien lainnya yang mengalami HD dengan komplikasi sepsis pada usia dibawah satu minggu. Kata kunci : HAEC ;  HD ; Hirschsprung-associated Enterocolitis ; Hirschsprung’s Disease ; Antibiotik ; Pasca Operasi 

2020 ◽  
Vol 44 (3) ◽  
pp. 150-153
Author(s):  
Richard A. Meena ◽  
Melissa N. Warren ◽  
Thomas E. Reeve ◽  
Olamide Alabi

Aortocaval fistula (ACF) is a rare and life-threatening complication associated with rupture of an abdominal aortic aneurysm (rAAA). Early detection and management of ACF’s during surgical repair of rAAAs is recommended to reduce the risk of future aneurysm-related complications, including mortality. There is a paucity of current literature on the natural history of ACFs postendovascular exclusion. We present a case study describing the detection of a persistent ACF by duplex ultrasonography (DU) postendovascular aortic repair (EVAR).


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Vera Plekhova ◽  
Ellen De Paepe ◽  
Katrien Van Renterghem ◽  
Myriam Van Winckel ◽  
Lieselot Y. Hemeryck ◽  
...  

AbstractHirschsprung's disease (HD) is a congenital structural abnormality of the colon seen in approximately 1 to 5000 live births. Despite surgical correction shortly after presentation, up to 60% of patients will express long-term gastrointestinal complaints, including potentially life-threatening Hirschsprung-associated enterocolitis (HAEC). In this study fecal samples from postoperative HD patients (n = 38) and their healthy siblings (n = 21) were analysed using high-resolution liquid chromatography—mass spectrometry aiming to further unravel the nature of the chronic gastrointestinal disturbances. Furthermore, within the patient group, we compared the faecal metabolome between patients with and without a history of HAEC as well as those diagnosed with short or long aganglionic segment. Targeted analysis identified several individual metabolites characteristic for all HD patients as well as those with a history of HAEC and long segment HD. Moreover, multivariate models based on untargeted data established statistically significant (p < 0.05) differences in comprehensive faecal metabolome in the patients’ cohort as a whole and in patients with a history of HAEC. Pathway analysis revealed the most impact on amino sugar, lysine, sialic acid, hyaluronan and heparan sulphate metabolism in HD, as well as impaired tyrosine metabolism in HAEC group. Those changes imply disruption of intestinal mucosal barrier due to glycosaminoglycan breakdown and dysbiosis as major metabolic changes in patients’ group and should be further explored for potential diagnostic or treatment targets.


Author(s):  
Iskandar Rahardjo Budianto ◽  
Agus Firmansyah ◽  
Yefta Moenadjat ◽  
Ahmad Aulia Jusuf ◽  
Vivian Soetikno

BACKGROUND Hirschsprung-associated enterocolitis (HAEC) is a life-threatening complication of Hirschsprung’s disease. Studies using animal models on the pathogenesis of HAEC are limited. Thus, this study aimed to establish a rat model of HAEC using topical application of 0.1% benzalkonium chloride (BAC) in the sigmoid colon. METHODS 55 male Sprague Dawley rats aged 10−12 weeks old were separated into 11 groups. The control group (n = 5) was euthanized on day-7, and the other 10 groups (n = 5 in each group) treated with 0.1% BAC in the sigmoid colon for 15 min to induce Hirschsprung’s disease were euthanized on day-7, -10, -12, -14, -17, -19, -21, -23, -25, and -28. The sigmoid colon was excised, fixed in formalin, and sectioned for histological examinations with hematoxylin and eosin staining. The degree of HAEC was compared within all groups. RESULTS Rats that were sacrificed on day-7 to -12 showed the 1st degree or early HAEC, which was most likely caused by BAC application. The 2nd degree of HAEC occurred in rats that were sacrificed on day-14 that showed a macrophage infiltration in the sigmoid colon, thus fulfilled the initial criteria for HAEC (p = 0.0025 versus control). The degree of enterocolitis increased with time, and the highest degree was found in rats that were sacrificed on day-28 (p<0.001 versus control). CONCLUSIONS Topical application of 0.1% BAC for 15 min was successfully produced HAEC model in rats, which was occurred on day-14 after the application. This model provides a useful resource for further research on the pathogenesis of HAEC.


2019 ◽  
Vol 7 (20) ◽  
pp. 3488-3492
Author(s):  
Anggreiny Anggi ◽  
Dadik Wahyudi Wijaya ◽  
Oke Rina Ramayani

AIM: To evaluate the risk factors of CAUTI in ICU patients at Haji Adam Malik General Hospital and Universitas Sumatera Utara Hospital, Medan, Indonesia. METHODS: This hospital-based observational research was an observational analytic research with a cross-sectional study. This research was conducted at Haji Adam Malik General Hospital Medan, Universitas Sumatera Utara Hospital, and Department of Microbiology Medical Faculty of Medicine Universitas Sumatera Utara, on July to August 2018 until the number of samples was fulfilled. The samples were adults aged ≥18 years, admitted to an ICU between July until August 2018 with an indwelling urinary catheter during their admission, admitted in ICU with different complaints and presentations and developed clinical evidence of infection that did not originate from patient’s original admitting diagnosis, in accordance which corresponded to the inclusion criteria by using consecutive sampling technique were included in the study. Patients who were shifted out of the ICU within 48 h of admission were excluded from the study. These critical patients were referred for monitoring, observation, and management from different departments, e.g., medic, general surgery, neurosurgery, gynaecology/obstetrics, and accident/emergency departments. RESULTS: From this research, it was found that fifty-four patients with catheter were screened for UTI infection. Of those, 24 patients (44.4%) were confirmed to have UTI by urine culture. Pseudomonas aeroginosa (16.7%) and Enterococcus faecalis (12.5%) were the most common pathogens. Patients aged > 50 years old (P < 0.03) and catheter use > 6 days (P < 0.03) were both significantly associated with increased risk of developing UTI. CONCLUSION: There are eleven uropathogens identified in this study: Pseudomonas aeruginosa, Enterococcus faecalis, Escherichia coli, Klebsiella pneumonia, MRSA, Salmonella enteric, Acinetobacter baumanii, Acinetobacter lwoffi, Acinetobacter haemoliticus, Burkholderia cepacia, and Staphylococcus sciur.  


Author(s):  
C. BAESTAENS ◽  
S. HELLEMANS

A sportive man in his 50's from Philadelphia with a brutal syncope from Lyme carditis In the case of a syncope at a young age in a patient with no medical history - especially if he or she comes from endemic regions - Lyme disease should be excluded through serological testing. Lyme carditis is a potentially life-threatening complication after infection with the bacterium Borrelia burgdorferi. This is shown in the discussed case of a 51-year-old sportive man who registered for a consultation after a brutal syncope. Under antibiotic therapy, the severe conduction disturbances progressively cleared up and a permanent pacemaker could be avoided.


2018 ◽  
Vol 2 (1) ◽  
Author(s):  
Akhmad Khoyrun Najakh ◽  
Dwiwiyati Astogini ◽  
Sri Martini

The purpose of this study was to analyze the influence of attitudes on the intention to choose Islamic banks, to analyze the effect of subjective norm on the intention to choose Islamic banks. to analyze the effect of the control behavior of the intention to choose the Islamic banks, to analyze the moderating influence of religiosity on the relationship attitudes, subjective norms and behavioral control of the intention to choose the Islamic banks . The method used is a survey with a sampling technique used purposive sampling with a sample size of this study was 100 respondents . Further analysis tools used in this study is multiple regression analysis using SPSS 16.0 software . Based on this study it can be concluded that the attitude does not affect to the intention of choose Bank BRISyariah. Subjective norm positive effect on intention choose Bank BRISyariah. Control behavior does not affect to the intention choose Bank BRISyariah. Relationship between Attitudes, Subjective Norms and Behavior Control with the intention to select Bank BRISyariah not moderated by religiosity.Based on these conclusions can be said that the Bank BRISyariah should improve understanding related to the subjective norm in order to increase the number of customers who use the services of Islamic Banking . Further research is recommended in order to follow up and develop this research to further explore the independent and dependent variables continued before and after behavioral intention or intention to perform a specific action .


1997 ◽  
Vol 36 (4) ◽  
pp. 631
Author(s):  
Sue Yun Yu ◽  
Gye Yeon Lim ◽  
Ji Yeong Yun ◽  
Seong Tae Hahn ◽  
Hak Hee Kim ◽  
...  

JMS SKIMS ◽  
2019 ◽  
Vol 21 (2) ◽  
pp. 117-119
Author(s):  
Munir Ahmad Wani ◽  
Mubarak Ahmad Shan ◽  
Syed Muzamil Andrabi ◽  
Ajaz Ahmad Malik

Gallstone ileus is an uncommon and often life-threatening complication of cholelithiasis. In this case report, we discuss a difficult diagnostic case of gallstone ileus presenting as small gut obstruction with ischemia. A 56-year-old female presented with abdominal pain and vomiting. A CT scan was performed and showed an evolving bowel obstruction with features of gut ischemia with pneumobilia although no frank hyper density suggestive of a gallstone was noted. The patient underwent emergency surgery and a 60 mm obstructing calculus was removed from the patient's jejunum, with a formal tube cholecystostomy. JMS 2018: 21 (2):117-119


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