Characteristics of Chinese Families in Which Children and Both Parents Are Diagnosed with Malignant Tumors: A Retrospective Study

Background: Soft tissue sarcomas are a rare and heterogeneous group of malignant tumors of mesenchymal origin that comprise less than 1 percent of all adult malignancies. Although they occur anywhere in the body, they involve most commonly in extremities, trunk, retroperitoneum and head and neck. The aim of the study was to analyze clinical and histopathological features of various soft tissue sarcomas.Methods: This was a retrospective study, conducted in tertiary cancer centre in Odisha during the period 2015 to 2018. We collected clinical parameters like age, sex, site of swelling, any associated pain and biopsy reports and these variables were correlated with final histopathology reports.Results: A total of 107 patients were included in the study, with male to female ratio of 2:1(71 and 36) and average age of 43.45 years. All of them presented with a swelling. The lower extremities were the most common sites i.e. 44.62%. Pleomorphic sarcoma was the most frequent histologic variety comprising 43% and less frequent variety were angiosarcoma, and myxoid sarcoma.Conclusions: Soft tissue sarcoma are predominant in males and middle aged population are frequently affected. Most common affected site is lower extremity and pleomorphic sarcoma is the prominent histologic type.

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Retrospective Study of Mammary Lesions in Bitches - Uberlândia, MG, Brazil

Acta Scientiae Veterinariae ◽

10.22456/1679-9216.80788 ◽

2017 ◽

Vol 45 (1) ◽

pp. 8

Author(s):

Mariana Batista Andrade ◽

Ednaldo Carvalho Guimarães ◽

Arlinda Flores Coleto ◽

Nicolle Pereira Soares ◽

Alessandra Aparecida Medeiros-Ronchi

Keyword(s):

Retrospective Study ◽

Tumor Size ◽

Hormone Receptors ◽

Malignant Tumors ◽

Histological Grade ◽

Mammary Tumors ◽

Mammary Glands ◽

Malignant Neoplasms ◽

The Mean ◽

Inguinal Glands

Background: Mammary tumors are a type of neoplasia that are most commonly found in female dogs and are mostly malignant. The aim of this study, performed in the Laboratory of Veterinary Pathology of the Federal University of Uberlândia (LVP-FUU) from 2004 to 2014, was to determine the prevalence of mammary tumors in bitches and to verify the relationship between the epidemiological factors (age and breed) and clinicopathological aspects (ulceration, tumor size, and malignancy) in the occurrence of tumors.Materials, Methods & Results: A retrospective study was carried out using histopathological information retrieved from the LPV-UFU database. We collected the information on age and breed of female dogs, as well as about the location, macroscopic aspects, and histological diagnosis of mammary lesions. Only female dogs were considered for this study; a total of 911 histopathological protocols (with only one diagnosis) were analyzed along with 36 protocols that presented more than one diagnosis of mammary tumor. The age of animals ranged from one to 20 years, and the mean age was 9.99 years. The most affected breeds of dogs were: Cross breed (39.56% - 288/728) and Poodle (20.19% - 147/728). The inguinal glands were most affected by the malignant tumors (P < 0.05). A prevalence of tumors bigger than 5 cm in diameter (T3) was observed in the elderly animals (P = 0.0154) and in the inguinal mammary glands (P = 0.044). Simple carcinoma was the most frequent histological type.Discussion: Research shows that more than 40% of the tumors in bitches are located in the mammary glands, emphasizing the importance of this type of neoplasia in female dogs. Mammary tumors develop more frequently in the middle-aged and elderly bitches, with the highest occurrence being in the age range of 8 and 10 years, corroborating our observation in the present study that the mean age of bitches was 9.99 years. In this survey, a higher incidence was observed in mongrel bitches compared to that in the Poodle breed. Some authors affirm that there is no racial predisposition for the occurrence of this pathology; however, a compilation of data suggests a predisposition of at least 10 breeds, with the involvement of an as yet unidentified genetic component. Of these, six breeds (Poodle, Cocker Spaniel, Pointer, Maltese, Yorkshire Terrier, and Dachshund) were found to be predisposed to mammary tumors in this study. The percentage (49.23%) of malignant tumors found in the inguinal glands is consistent with the findings reported in literature, and might be associated with a greater amount of parenchyma, abundance of hormone receptors in these glands, and vascularization provided by the caudal superficial epigastric artery and vulvar branches of external pudendal artery. Tumor size is considered to be a prognostic factor and tumors ≤ 3 cm in diameter (T1) have a better prognosis. Consequently, the prevalence of tumors ≥ 5 cm in diameter (T3) in elderly animals is probably related to malignancy of the lesions, because tumors usually progress to a worse histological grade with time. The higher occurrence of T3 in inguinal glands might be related to the abundance of parenchyma and/or hormonal receptors in them. As in the present study, data from literature refer to the superiority of malignant histological types, with prevalence varying between 68 and 91%. When prolonged, the time between the onset of tumor and clinical evaluation may be a determinant in the progression from benign to malignant tumors. Among the malignant neoplasms, simple carcinoma was observed to be prevalent, followed by mixed tumors with carcinoma, in agreement with the results of several studies. It is concluded that mammary tumors are more prevalent in older mongrel dogs and Poodle. Attention should be paid to inguinal mammary tumors, because these are mainly malignant.

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Mcl-1 Expression Is Up-Regulated in Malignancies of the Parotid Gland

Disease Markers ◽

10.1155/2011/810218 ◽

2011 ◽

Vol 30 (5) ◽

pp. 229-233 ◽

Cited By ~ 2

Author(s):

Gregor Heiduschka ◽

Boban M. Erovic ◽

Johannes Pammer ◽

Ulana Kotowski ◽

Alexandra Kaider ◽

...

Keyword(s):

Overall Survival ◽

Retrospective Study ◽

Statistical Analysis ◽

Parotid Gland ◽

Poor Prognosis ◽

Malignant Tumors ◽

Gland Tumor ◽

Parotid Gland Tumor ◽

Apoptotic Protein ◽

Pleomorphic Adenomas

The anti-apoptotic protein Mcl-1 is highly expressed in various types of malignant tumors. Overexpression is reported to correlate with poor prognosis and disease progression. We report the expression levels of Mcl-1 in tumor samples of the parotid gland. A retrospective study containing 108 patients was performed. A tissue microarray of six malignancies of the parotid gland and pleomorphic adenoma as control was constructed. Parotid gland tumor samples were immunohistochemically stained for Mcl-1 and expression intensities were assessed. Statistical analysis included correlation to patients' clinical data and comparison of malignancies to the adenoma.All malignancies had significantly higher expression of Mcl-1 than the pleomorphic adenomas. The intensity, however, had no significant correlation to overall survival.Our immunohistochemical findings indicate that parotid gland malignancies produce high levels of Mcl-1 protein. Therefore, Mcl-1 might serve as a predictive co-marker in tumors of the parotid gland.

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A 10-year retrospective study of malignant tumors in the oral and maxillofacial regions.

Journal of Japanese Society of Oral Oncology ◽

10.5843/jsot.14.37 ◽

2002 ◽

Vol 14 (2) ◽

pp. 37-43

Author(s):

Ryoko Ukon ◽

Yoshio Yamashita ◽

Masaaki Goto ◽

Koichiro Ihara ◽

Takeshi Katsuki

Keyword(s):

Retrospective Study ◽

Malignant Tumors ◽

Oral And Maxillofacial Regions

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Epidemiological and Clinicopathological Analysis of 92 Odontogenic Tumors: A 5-year Retrospective Study

The Journal of Contemporary Dental Practice ◽

10.5005/jp-journals-10024-2175 ◽

2017 ◽

Vol 18 (11) ◽

pp. 1056-1060 ◽

Cited By ~ 2

Author(s):

Ipsita Sharma ◽

Geetanjali Bawa ◽

Syed Vaseemuddin ◽

Amit Joseph ◽

Jimmy K Sangtani

Keyword(s):

Retrospective Study ◽

Benign Tumor ◽

Malignant Tumors ◽

Oral Pathology ◽

Odontogenic Tumors ◽

Odontogenic Myxoma ◽

Common Benign Tumor ◽

Clinicopathological Analysis ◽

Odontogenic Epithelium ◽

Odontogenic Fibroma

ABSTRACT Introduction Odontogenic tumors (OTs) are a heterogeneous group of lesions that are derived from odontogenic apparatus comprised of odontogenic epithelium, ectomesenchyme, and/or mesenchymal elements. The OTs show marked geographical variation. This study was conducted to analyze the epidemiology and clinicopathological presentation of OTs based on age, sex, and site. Materials and methods This study was conducted in Department of Oral Pathology and Microbiology. Records were reviewed retrospectively for all the lesions of oral cavity from January 2010 to December 2015. A total of 92 lesions were found to be OTs and were classified into benign and malignant tumors. They were further subdivided into three subtypes based on the types of odontogenic tissues involved. These were epithelial OTs (EOTs), mixed OTs (MIXOTs), and mesenchymal OTs (MOTs). Results Of 92 OTs, 84 were benign (males 48, females 36) and 8 were malignant (male 2, females 6). The most common benign tumor was ameloblastoma (AME) (20), followed by keratocystic OT (KCOT) (17), calcifying EOT (CEOT) (14), compound odontome (OD-Cd) (12), complex odontome (OD-Cx) (10), odontogenic fibroma (OF) (5), odontogenic myxoma (OM) (4), and cementoblastoma (CB) (2). The most common malignant tumor was primary intraosseous squamous cell carcinoma (PIOSCC) (3) followed by fibrosarcoma (FS) (3) and ameloblastic carcinoma (AC). Conclusion Author concluded that there was geographic and demographic variation in distribution of OTs, which may be attributed to socioeconomic and genetic factors. Clinical significance Literature showing prevalence of OTs in India is negligible. By this article, we have analyzed the frequency of various OTs according to sex, age, and site. A comprehensive record of OTs should be started so that pathologists and surgeons would be able to acquire the information about the tumor for reference in the future. How to cite this article Sharma I, Venkatesh D, Bawa G, Vaseemuddin S, Joseph A, Sangtani JK. Epidemiological and Clinicopathological Analysis of 92 Odontogenic Tumors: A 5-year Retrospective Study. J Contemp Dent Pract 2017;18(11):1056-1060.

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Malignant Tumors of the Nose and Paranasal Sinuses: A Retrospective Review of 291 Cases

Ear Nose & Throat Journal ◽

10.1177/014556130108000417 ◽

2001 ◽

Vol 80 (4) ◽

pp. 272-277 ◽

Cited By ~ 22

Author(s):

David Goldenberg ◽

Avishai Golz ◽

Milo Fradis ◽

Dan Martu ◽

Aviram Netzer ◽

...

Keyword(s):

Retrospective Study ◽

General Population ◽

Paranasal Sinuses ◽

Retrospective Review ◽

Malignant Tumors ◽

Malignant Neoplasms ◽

Nose And Paranasal Sinuses ◽

Romanian Population

Malignant neoplasms of the nose and paranasal sinuses are not common among the general population. We present a retrospective study of 291 cases of malignant tumors of the nose and paranasal sinuses that were diagnosed in a northern Romanian population over a period of 35 years. We review the etiology, diagnosis, prognosis, and treatment of these tumors.

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Is Revision Surgery Necessary for Patients With High Risk of Recurrence After Parotidectomy? A Multicenter Retrospective Study

Annals of Otology Rhinology & Laryngology ◽

10.1177/00034894211045269 ◽

2021 ◽

pp. 000348942110452

Author(s):

Médarine Roch ◽

Olivier Mauvais ◽

Sebastien Vergez ◽

Esteban Brenet ◽

Pierre Lindas ◽

...

Keyword(s):

Retrospective Study ◽

High Risk ◽

Revision Surgery ◽

Malignant Tumors ◽

Positive Lymph Node ◽

Low Grade ◽

Close Margin ◽

Complete Excision ◽

Systematic Revision ◽

Tumor Residue

Objectives: Close margin is a frequent situation after parotidectomy. The need for systematic prophylactic revision surgery is a question that arises regularly for malignant tumors, as it exposes to a high risk of facial palsy, while oncological benefits are unclear. Study Design: retrospective study. Setting: Multicentric. Subjects and Methods: We included all patients operated for systematic revision surgery in case of close margins after parotidectomy for a malignant tumor and analyzed the rate of tumor residue and its risk factors. Results: A tumor residue was identified in 43.5% of 23 cases, but none in case of initial complete excision with supra-millimetric margins. Invaded lymph nodes were identified in 6 cases, but none in case of low-grade tumors. Conclusions: Systematic revision seems mandatory in case of infra-millimetric margins and high-grade tumors or positive lymph node; further studies are needed to confirm whether it can be spared for T1-T2/N0 low-grade tumors, with close margins but complete initial excision.

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Insulinoma: A retrospective study analyzing the differences between benign and malignant tumors

Pancreatology ◽

10.1016/j.pan.2018.01.009 ◽

2018 ◽

Vol 18 (3) ◽

pp. 298-303 ◽

Cited By ~ 8

Author(s):

A.B. Câmara-de-Souza ◽

M.T.K. Toyoshima ◽

M.L. Giannella ◽

D.S. Freire ◽

C.P. Camacho ◽

...

Keyword(s):

Retrospective Study ◽

Malignant Tumors

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Retrospective Evaluation of Lingual Tumors in 42 Dogs: 1999–2005

Journal of the American Animal Hospital Association ◽

10.5326/0440308 ◽

2008 ◽

Vol 44 (6) ◽

pp. 308-319 ◽

Cited By ~ 19

Author(s):

Jason A. Syrcle ◽

Jennifer J. Bonczynski ◽

Sebastien Monette ◽

Philip J. Bergman

Keyword(s):

Prognostic Factors ◽

Retrospective Study ◽

Benign Tumor ◽

Malignant Tumors ◽

Benign Tumors ◽

Tumor Type ◽

Retrospective Evaluation ◽

Short Term ◽

Drinking Habits

In this retrospective study of 42 cases of lingual tumors in dogs, 27 (64%) were malignant, and 15 (36%) were benign. Median survival time for dogs with benign tumors was >1607 days, compared to 286 days for malignant tumors. Prognostic factors significantly associated with increased survival included complete histological margins (P=0.036), smaller tumor size (P=0.003), and benign tumor type (P=0.011). Smaller tumors were more likely to be completely resected (P=0.008) and were less likely to recur (P=0.001). Partial or subtotal glossectomies were performed in 13 cases. Short-term morbidity associated with glossectomy included ptyalism and dehiscence. Long-term morbidity included minor changes in eating and drinking habits.

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