scholarly journals Impact of Vitamin D Supplementation in a Heart Failure Population

2021 ◽  
Vol 28 (4) ◽  
pp. 350-356
Author(s):  
Márcia Cravo ◽  
Nuno Pereira ◽  
Ana Vigário ◽  
Tânia Ferreira ◽  
Rita Rego ◽  
...  
Keyword(s):  
Heart Failure ◽  
Vitamin D ◽  
Nyha Class ◽  
Vitamin D Supplementation ◽  
Walking Distance ◽  
Single Center Study ◽  
Study Population ◽  
Baseline Characteristics ◽  
The Impact ◽  
Score Index

Introduction: Vitamin D (VD) deficiency is a major comorbidity, frequently associated to heart failure (HF). VD supplementation effects in these patients remain unknown. Therefore, this study aims to evaluate the impact of VD deficiency treatment or therapy correction in HF patients´ cohort. Material and Methods: Observational retrospective single-center study enrolling patients admitted to a HF clinic with VD deficiency. VD was prescribed to these patients with reassessment of its levels 12 months later. Study population was divided in: [VD (+) group: corrected VD deficiency] and [VD (-): maintained VD deficiency]. Variables were analysed in both groups. Results and Conclusion: Eighty-seven patients were included with no difference of baseline characteristics between the groups. Poor compliance was reported in 40% of VD (-) patients. After treatment, there were no statistically difference in variables analysed between the two groups: NYHA class I, NT-proBNP, HF hospitalizations in the previous year, Duke Activity Score Index score and 6-minute Walking Distance. VD (+) group had a statistically significant decrease of NT-proBNP level over time (1740 ± 2761 pg/mL to 851 ± 1436 pg/mL, p = 0.001). Statistically, both groups had a significant reduction of the number of HF hospitalizations, between baseline and 12 months later (1.02 ± 0.67 to 0.29 ± 0.82, p< 0.001 and 1.03 ± 1.04 to 0.40 ± 0.81, p = 0.001, for VD (+) and VD (-), respectively). Therefore, the correction of VD deficiency did not have impact in the variables analysed. The improvements reported within both groups may reflect the impact of the HF clinic optimized care.

scholarly journals Vitamin D Deficiency Contributes to the Reduction and Impaired Function of NaïveCD45RA+Regulatory T Cell in Chronic Heart Failure

2015 ◽  
Vol 2015 ◽  
pp. 1-18 ◽  
Author(s):  
Yan-hui Ma ◽  
Yun-lan Zhou ◽  
Chao-yan Yue ◽  
Guang-hui Zhang ◽  
Lin Deng ◽  
...  
Keyword(s):  
Heart Failure ◽  
Vitamin D ◽  
T Cell ◽  
Chronic Heart Failure ◽  
Cardiovascular Health ◽  
Cell Function ◽  
Foxp3 Expression ◽  
Vitamin D Supplementation ◽  
The Impact

The effect of vitamin D pertinent to cardiovascular health on the heart itself is considered to shift toward an anti-inflammatory response in chronic heart failure (CHF); however, its underlying mechanism is not completely understood. In this study, we demonstrated that plasma 25(OH)D level, negatively associated with NT-ProBNP, correlated with the decreased Treg in CHF compared to the patients with other cardiovascular diseases and healthy and older donors. Naïve Treg cell (CD4+CD45RA+Foxp3loT) subset, rather than whole Treg cells, contributes to the reduction of Treg in CHF. 1,25(OH)2D treatment maintained partial expression of CD45RA on CD4+T cell afterαCD3/CD28 monoclonal antibodies activation and ameliorated the impaired CD4+CD45RA+T cell function from CHF patients through upregulating Foxp3 expression and IL-10 secretionin vitro. Low level of vitamin D receptor (VDR) was detected in CD4+CD45RA+T cell of CHF than control, while 1,25(OH)2D treatment increased the VDR expression to exert its immunosuppression on T cell. The results of this study might provide tangible evidence to our knowledge of the impact of vitamin D supplementation on naïve Tregs, which may offer new means of preventing and treating CHF.

scholarly journals Combined Effect of Walking and Vitamin D Intake on Patients with Heart Failure

2021 ◽  
pp. 55-59
Author(s):  
Muhammad Usama Javed ◽  
Tanzeel ur Rehman Mustafa ◽  
Sharoz Mukhtar Shah ◽  
Iza Babar ◽  
Fatima Maham Iqtidar ◽  
...  
Keyword(s):  
Heart Failure ◽  
Vitamin D ◽  
Nyha Class ◽  
Vitamin D Supplementation ◽  
P Value ◽  
Heart Failure Therapy ◽  
Walk Distance ◽  
Patients With Heart Failure ◽  
Minute Walk Distance ◽  
Minute Walk

Objective: Patients with heart failure may benefit from vitamin D treatment, according to new research (Congestive Heart Failure). Methods: In our current nonrandomized clinical research, 43 individuals with dilated cardiomyopathy who did not exhibit substantial gains in physical functioning with optimum heart failure therapy were included. Twelve weeks of weekly vitamin D supplements (200,000 IU) were added to the heart failure therapy to help improve the patient's condition. On the other hand, researchers looked at how it affected the 6-minute walk distance and pro-BNP levels. To analyses the data, we utilized SPSS version 19. Accordingly, we utilized random samples t-tests to assess the substantial role of vitamin D supplementation on pre-intervention vitamin D level, 6-minute walk distance, and pro-BNP level, respectively. Significance was defined as an alpha value less than 0.01. Results: Individuals in NYHA class II (66%) were the majority, while those in NYHA classes I, III and IV were represented by 18%, 8% and 5%, accordingly. Following 14 weeks of vitamin D treatment, the group's mean vitamin D level was increased from 17.596.57ng/ml at baseline to 32.974.65ng/ml (p0.0006). Pre-intervention mean distance travelled was 806382ft, however after the intervention it rose to 945392ft (p-value 0.07). While before the intervention, the mean per-BNP level of research participant was 1025-636, and after intervention, it had enhanced to 160-80--a statistically significant improvement (p=0.005). Conclusion: According to a decline in blood pro-BNP characterized by an increase in six-minute walk distance, vitamin D administration decreases the intensity of heart failure.

scholarly journals Vitamin D and Blood Parameters

Biomolecules ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1017
Author(s):  
Thomas Müller ◽  
Lutz Lohse ◽  
Andreas Blodau ◽  
Katja Frommholz
Keyword(s):  
Vitamin D ◽  
Mean Corpuscular Volume ◽  
Plasma Concentrations ◽  
Blood Parameters ◽  
Vitamin D Supplementation ◽  
Mean Corpuscular Hemoglobin ◽  
Corpuscular Volume ◽  
Corpuscular Haemoglobin ◽  
Mean Corpuscular Haemoglobin ◽  
The Impact

Background: Vitamin D has a steroid- and an anabolic-resembling chemical structure. Vitamin D is essential for many processes in the human body after hydroxylation. Aims of the Study: To investigate the impact of 25-hydroxy-vitamin D plasma concentrations on the blood parameters number of erythrocytes, hematocrit, mean corpuscular hemoglobin and mean corpuscular volume. Methods: Serial assessments were done in 290 patients with multiple sclerosis and repeated after a mean interval of 245 days. A recommendation for vitamin D supplementation was given in case of a concentration lower than 20 ng/mL combined with a prescription of a formulation containing vitamin D but not vitamin K. Results: There was a fall of vitamin D in 119 subjects and a rise in 164, while no change appeared in 7 participants. When vitamin D values went down between both assessments moments, the computed increase of mean corpuscular haemoglobin was significantly lower compared with the rise of mean corpuscular haemoglobin associated with a vitamin D elevation. When vitamin D declined, the computed fall of mean corpuscular volume fall was significantly lower compared with the decrease of mean corpuscular volume, when vitamin D rose. Positive correlations were found between differences of vitamin D and mean corpuscular haemoglobin, respectively mean corpuscular volume. Inverse relations appeared between disparities of vitamin D and erythrocytes, respectively haematocrit. Conclusions: The elevation of vitamin D plasma levels provides enhanced preconditions for a better tissue oxygenation on a cellular level.

scholarly journals Vitamin D status and its determinants in Pre Diabetic pregnant mothers attending tertiary care centre in Tamilnadu, India

2020 ◽  
Vol 11 (1) ◽  
pp. 617-622
Author(s):  
Kavitha Durairaj ◽  
Muthulakshmi M ◽  
Venkataraman P ◽  
Murali R ◽  
Rukumani J ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Infection Type ◽  
Tertiary Care ◽  
Challenge Test ◽  
Vitamin D Supplementation ◽  
Ultraviolet B ◽  
Oral Glucose ◽  
College Hospital ◽  
The Impact

Vitamin D is a vital nutrient factor in the healthiness of the mother and infant. Vitamin D is mainly amalgamated in the skin following exposure to ultraviolet B radiation. Insufficiency of vitamin D in Pregnancy had been related to various sicknesses, such as respiratory infection, type 1 diabetes mellitus, high risk of childhood wheezing. The aim of this study was to investigate the impact of Vitamin D supplementation on the incidence of pregestational diabetes in pregnant women referred to antenatal clinics in SRM Medical College hospital, Tamilnadu, India. 200 pregnant women were recruited, and oral glucose challenge test (OGCT), serum calcium and 25(OH) D were determined. Participants were in the age group of 18 to 35 years, with a mean age of 26.29. Among the participants, 59% were multiparous. The present study showed that a high prevalence of vitamin D deficiency (61.5%) and insufficiency (34%) in pregnant women before supplementation with a mean of 16.84. Vitamin D supplementation during the early weeks of pregnancy might help in the improvement of maternal and child health.

scholarly journals Assessment of vitamin D among Sudanese Patients with Hypothyroidism

2021 ◽  
Vol 1 (2) ◽  
pp. 057-061
Author(s):  
Hasna Osman Fadalla Mohamed ◽  
Omer Fadol Edris ◽  
Gad Allah Modawe ◽  
Suhair Abdelrahman Ahmed
Keyword(s):  
Vitamin D ◽  
Autoimmune Diseases ◽  
Vitamin D Deficiency ◽  
Vitamin D Supplementation ◽  
Control Hospital ◽  
Study Population ◽  
Thyroid Profile ◽  
Methods Analytical ◽  
The Relationship

Background: Vitamin D deficiency is a worldwide health issue and its role as an immune modulator has recently been emphasized. Evidence increasingly indicates the important role of vitamin D in reducing the incidence of autoimmune diseases. However, at this time the search for its role in autoimmune diseases and thyroid is not critical. Objectives: The study aimed to assess the relationship between vitamin D deficiency in Sudanese patients with hypothyroidism. Methods: Analytical case control hospital based study, conducted in Fadil Hospital and Police Hospital, Khartoum city, Khartoum state. The study carried out from March 2018 to September 2018. A total of 100 subjects were enrolled in the study. Vitamin D deficiency was set at levels below 20 ng / ml. Thyroid hormones (TSH, T3 and T4) were assessed in all participants using auto analyzer TOSOH AIA 313,while vitamin D was estimated using ELIZA. The data were analyzed using SPSS version (21). Results: The study included 76(76%) females and 24(24%) males, no significance differences between thyroid profile among study population.75 (75%) deficiency of vitamin D and 25(25%) normal vitamin D. vitamin D deficiency was significantly lower in female than male with( p =0.001). Conclusion: The results indicated that patients with hypothyroidism suffer from vitamin D deficiency significantly associated with the degree and severity of hypothyroidism. This encourages the desirability of vitamin D supplementation and recommends the detection of vitamin D deficiency for all hypothyroidism patients.

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