scholarly journals The Impact of Preeclampsia on Work-Related Psychosocial Aspects and Need for Recovery

2021 ◽  
Vol 6 (3) ◽  
pp. 1-7
Author(s):  
Muijsers HEC ◽  
Keyword(s):  
Cognitive Deficits ◽  
Liver Enzymes ◽  
Memory Function ◽  
Need For Recovery ◽  
Subjective Cognitive Impairment ◽  
Work Related ◽  
Elevated Liver Enzymes ◽  
History Of ◽  
The Impact ◽  
Syndrome Report

Women with a history of preeclampsia and/or Hemolysis Elevated Liver enzymes Low Platelets (HELLP) syndrome report impaired cognitive functioning, such as concentration problems and decreased memory function. The presence of subjective cognitive impairment, depressive symptoms and cognitive deficits may affect working abilities.

scholarly journals Hepatobiliary phenotype of individuals with chronic intestinal disorders

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jessica Voss ◽  
Carolin V. Schneider ◽  
Moritz Kleinjans ◽  
Tony Bruns ◽  
Christian Trautwein ◽  
...  
Keyword(s):  
Functional Relationship ◽  
Liver Enzymes ◽  
Liver Function Tests ◽  
Population Based ◽  
Intestinal Surgery ◽  
Elevated Liver Enzymes ◽  
Clinical Consequences ◽  
History Of ◽  
Hepatobiliary Diseases ◽  
The Impact

AbstractDespite the known functional relationship between the gut and the liver, the clinical consequences of this circuit remain unclear. We assessed the hepatobiliary phenotype of cohorts with celiac disease (CeD), Crohn´s disease (CD) and ulcerative colitis (UC). Baseline liver function tests and the frequency of hepatobiliary diseases were analyzed in 2377 CeD, 1738 CD, 3684 UC subjects and 488,941 controls from the population-based UK Biobank cohort. In this cohort study associations were adjusted for age, sex, BMI, diabetes, and alcohol consumption. Compared to controls, cohorts with CeD, but not CD/UC displayed higher AST/ALT values. Subjects with CD/UC but not CeD had increased GGT levels. Elevated ALP and cholelithiasis were significantly more common in all intestinal disorders. Non-alcoholic steatohepatitis and hepatocellular carcinoma (HCC) were enriched in CeD and CD (NASH: taOR = 4.9 [2.2–11.0] in CeD, aOR = 4.2 [1.7–10.3] in CD, HCC: aOR = 4.8 [1.8–13.0] in CeD, aOR = 5.9 [2.2–16.1] in CD), while cholangitis was more common in the CD/UC cohorts (aOR = 11.7 [9.1–15.0] in UC, aOR = 3.5 [1.8–6.8] in CD). Chronic hepatitis, autoimmune hepatitis (AIH) and cirrhosis were more prevalent in all intestinal disorders. In UC/CD, a history of intestinal surgery was associated with elevated liver enzymes and increased occurrence of gallstones (UC: aOR = 2.9 [2.1–4.1], CD: 1.7 [1.2–2.3]). Our data demonstrate that different intestinal disorders predispose to distinct hepatobiliary phenotypes. An increased occurrence of liver cirrhosis, NASH, AIH and HCC and the impact of surgery warrant further exploration.

scholarly journals Hepatitis por citomegalovirus: Presentación de dos casos

2013 ◽  
Vol 6 (2) ◽  
Author(s):  
Carlos Tori ◽  
Raúl Leon Barua ◽  
Carlos Roe
Keyword(s):  
Blood Test ◽  
Liver Enzymes ◽  
The Other ◽  
General Malaise ◽  
Igg Antibodies ◽  
Premature Babies ◽  
Normal Individuals ◽  
Elevated Liver Enzymes ◽  
History Of ◽  
Low Prevalence

Two cases of hepatitis by cytomegalovirus are described, one in a child and the other in a young adult, presenting with a history of fever, general malaise, hepatomegaly and no jaundice. Their blood test showed atypical lymphocytes, normal bilirubin, elevated liver enzymes, and IgG antibodies against cytomegalovirus. Their course was un was unremarkable except for asthenia which persisted in spite of clinical and laboratory improvement. This course was unremarkable except for asthenia which persisted in spite of clinical and laboratory improvement. This presentation is done because of the low prevalence or infrequent diagnosis of anicteric hepatitis due to cytomegalovirus in normal individuals. Most of the literature refers to congenital cases, premature babies, or patients with debilitating or immunocompromising diseases.

Brain abscess due to Listeria monocytogenes after HELLP syndrome in a patient with antiphospholipid syndrome

Lupus ◽  
2016 ◽  
Vol 26 (9) ◽  
pp. 1002-1004 ◽  
Author(s):  
A Fervienza ◽  
M Bodro ◽  
P Castro ◽  
S Hernández ◽  
I Teixidó ◽  
...  
Keyword(s):  
Listeria Monocytogenes ◽  
Brain Abscess ◽  
Antiphospholipid Syndrome ◽  
Hellp Syndrome ◽  
Unusual Case ◽  
Liver Enzymes ◽  
Neurological Dysfunction ◽  
Mri Scan ◽  
Elevated Liver Enzymes ◽  
History Of

Objective To illustrate an unusual case of Listeria cerebral abscess. Material and methods A 32-year-old pregnant woman with thrombotic antiphospholipid syndrome (APS) received corticotherapy for two weeks due to hemolysis, elevated liver enzymes, low platelet (HELLP) syndrome. After delivery she presented with neurological symptoms and fever. Results The MRI scan confirmed the presence of a brain abscess, and Listeria monocytogenes was isolated in blood cultures. After eight weeks of antibiotic treatment, the patient presented no sequelae. Conclusion L. monocytogenes should be included in the differential diagnosis of patients with fever and neurological dysfunction, especially in those with a recent history of corticotherapy.

scholarly journals Postpartum Pseudoaneurysm After Cesarean Delivery

2018 ◽  
Vol 35 (2) ◽  
pp. 136-140 ◽  
Author(s):  
Dora DiGiacinto ◽  
Jennifer E. Bagley ◽  
Bradford Gildon ◽  
Gina Cantrell
Keyword(s):  
Cesarean Delivery ◽  
Uterine Artery ◽  
Liver Enzymes ◽  
Vascular Lesion ◽  
Artery Pseudoaneurysm ◽  
Elevated Liver Enzymes ◽  
Life Threatening ◽  
History Of ◽  
Low Platelet Count ◽  
Uterine Artery Pseudoaneurysm

Uterine artery pseudoaneurysm is an uncommon vascular lesion that can be life threatening. A ruptured uterine artery pseudoaneurysm can cause acute massive hemorrhaging, creating a true emergency for the postpartum patient. The etiology is more commonly seen with traumatic procedures such as cesarean delivery or curettage. This case report is of a patient with a history of HELLP (hemolysis, elevated liver enzymes, low platelet count) syndrome who presented with heavy bleeding after a cesarean delivery. Sonography was primarily used to diagnose the uterine artery pseudoaneurysm. Because of the massive hemorrhaging in this case, a hysterectomy was performed.

scholarly journals Nonalcoholic Fatty Liver Disease in Patients Investigated for Elevated Liver Enzymes

2003 ◽  
Vol 17 (1) ◽  
pp. 38-42 ◽  
Author(s):  
Krikor Kichian ◽  
Ross Mclean ◽  
Leah M Gramlich ◽  
Robert J Bailey ◽  
Vincent G Bain
Keyword(s):  
Liver Disease ◽  
Liver Biopsy ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Nonalcoholic Steatohepatitis ◽  
Fatty Liver Disease ◽  
Liver Enzymes ◽  
Nonalcoholic Fatty Liver ◽  
Elevated Liver Enzymes ◽  
History Of

Nonalcoholic fatty liver disease (NAFLD) is a common diagnosis among patients referred to gastroenterology and hepatology clinics for the evaluation of elevated liver enzymes. The diagnosis of NAFLD is supported by blood work to exclude other liver diseases, and by ultrasound evidence of fat in the liver in patients without a significant history of alcohol intake. The gold standard, however, is a liver biopsy to show the typical histological features of NAFLD, which are almost identical to those of alcohol-induced liver damage and can range from mild steatosis to cirrhosis. A variety of retrospective series have linked NAFLD to obesity, diabetes, hyperlipidemia, total parenteral nutrition, jejunoileal bypass surgery and certain medications. A subset of patients with NAFLD that had an initial presentation of elevated liver enzymes was studied. Two hundred and two patients were reviewed, of whom 49 met the inclusion criteria including a liver biopsy. Patients were excluded if insufficient data were available, if the patients had a significant history of ethanol intake or if they had other coexisting liver disease. These patients were seen between 1996 and 2000 in gastroenterology and hepatology clinics in two community hospitals and one regional liver transplant centre in Edmonton, Alberta. NAFLD was associated with a spectrum of changes in the liver ranging from mild steatosis to more significant steatosis with inflammation and fibrosis. Cases of NAFLD with steatosis and mixed inflammatory infiltration but lacking ballooning degeneration or fibrosis were prevalent in young (20 to 40 years of age) patients with no other significant medical history except for obesity. NAFLD with biopsies showing significant fibrosis and ballooning cell degeneration was associated with obesity, diabetes and older age. It was concluded that, in this predominantly outpatient setting, age over 40 years and diabetes at any age are risk factors for both nonalcoholic steatohepatitis and nonalcoholic steatohepatitis with cirrhosis. It is therefore recommended that patients with raised liver enzymes and suspected NAFLD be targeted for liver biopsy in their evaluation.

scholarly journals COVID-19 and HELLP: Overlapping Clinical Pictures in Two Gravid Patients

2020 ◽  
Vol 10 (02) ◽  
pp. e179-e182 ◽  
Author(s):  
Itamar Futterman ◽  
Miriam Toaff ◽  
Liel Navi ◽  
Camille A. Clare
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Liver Enzymes ◽  
Clinical Findings ◽  
Peripheral Smear ◽  
Fetal Demise ◽  
Emergency Cesarean ◽  
Elevated Liver Enzymes ◽  
Novel Coronavirus ◽  
Clinical Pictures ◽  
The Impact

Abstract Background The impact of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) on pregnancies is currently under investigation. There is a significant overlap between the clinical findings in novel coronavirus disease 2019 (COVID-19) and hemolysis, elevated liver enzymes, and low platelets syndrome (HELLP). Cases Patients presented at 22 and 29 weeks of gestation with suspected COVID-19 pneumonia. While the patient at 22 weeks of gestation subsequently had an intrauterine fetal demise, the patient at 29 weeks of gestation delivered via an emergency cesarean delivery for nonreassuring fetal status. Both patients also developed transaminitis, thrombocytopenia, and disseminated intravascular coagulation with a proof of hemolysis on peripheral smear. Conclusion Clinicians are encouraged to consider both of these diagnoses when caring for pregnant women during the COVID-19 pandemic to assure that both maternal and fetal concerns are addressed and treated appropriately.

scholarly journals A Disease-Modifying Approach for Advanced Hidradenitis Suppurativa (Regimen with Metformin, Liraglutide, Dapsone, and Finasteride): A Case Report

2017 ◽  
Vol 9 (2) ◽  
pp. 70-78 ◽  
Author(s):  
Birgit N. Khandalavala
Keyword(s):  
Hidradenitis Suppurativa ◽  
Liver Enzymes ◽  
Ethinyl Estradiol ◽  
Residual Disease ◽  
Antibiotic Use ◽  
Initial Weight Loss ◽  
The Past ◽  
Elevated Liver Enzymes ◽  
History Of ◽  
Abdominal Lesions

Hidradenitis suppurativa (HS) is a challenging skin disease with limited therapeutic options. Obesity and metabolic syndrome are being increasingly implicated and associated with younger ages and greater metabolic severity. A 19-year-old female with an 8-year history of progressively debilitating cicatricial HS disease presented with obesity, profound anemia, leukocytosis, increased platelet count, hypoalbuminemia, and elevated liver enzymes. A combination of metformin, liraglutide, levonorgestrel-ethinyl estradiol, dapsone, and finasteride was initiated. Acute antibiotic use for recurrences and flares could be slowly discontinued. Over the course of 3 years on this regimen, the liver enzymes normalized in 1 year, followed in2 years by complete resolution of the majority of the hematological and metabolic abnormalities. The sedimentation rate reduced from over 120 to 34 mm/h. She required 1 surgical intervention for perianal disease after 9 months on the regimen. Flares greatly diminished in intensity and duration, with none in the past 6 months. Right axillary lesions have completely healed with residual disease greatly reduced. Chiefly abdominal lesions are persistent. She was able to complete high school from home, start a job, and resume a normal life. Initial weight loss of 40 pounds was not maintained. The current regimen is being well tolerated and continued.

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