Neonatal morbidity and mortality associated with maternal haemolysis, elevated liver enzymes and low platelets syndrome the impact of neutropenia

1998 ◽  
Vol 157 (5) ◽  
pp. 439-439 ◽  
Author(s):  
M. Schwab ◽  
E. Kuhls
Keyword(s):  
Liver Enzymes ◽  
Neonatal Morbidity ◽  
Morbidity And Mortality ◽  
Elevated Liver Enzymes ◽  
The Impact

scholarly journals Babesiosis in Pregnancy: An Imitator of HELLP Syndrome

2019 ◽  
Vol 09 (02) ◽  
pp. e147-e152 ◽  
Author(s):  
Raminder Khangura ◽  
Nayo Williams ◽  
Shontreal Cooper ◽  
Anne- Marie Prabulos
Keyword(s):  
Hellp Syndrome ◽  
Clinical Presentation ◽  
Liver Enzymes ◽  
Neonatal Morbidity ◽  
Pregnancy Complication ◽  
Morbidity And Mortality ◽  
Fetal Outcomes ◽  
Laboratory Findings ◽  
Elevated Liver Enzymes ◽  
In Pregnancy

AbstractHELLP syndrome (hemolysis, elevated liver enzymes, and low platelets) is a serious pregnancy complication that can cause significant maternal and neonatal morbidity and mortality. There are several conditions that may occur in pregnancy that may imitate the laboratory findings and clinical presentation of HELLP syndrome. Babesiosis is a parasitic imitator of HELLP syndrome that can be spread by the tick, transfusions, or congenitally. Recognition and treatment of this condition is important to optimize maternal and fetal outcomes.

scholarly journals The Impact of Preeclampsia on Work-Related Psychosocial Aspects and Need for Recovery

2021 ◽  
Vol 6 (3) ◽  
pp. 1-7
Author(s):  
Muijsers HEC ◽  
Keyword(s):  
Cognitive Deficits ◽  
Liver Enzymes ◽  
Memory Function ◽  
Need For Recovery ◽  
Subjective Cognitive Impairment ◽  
Work Related ◽  
Elevated Liver Enzymes ◽  
History Of ◽  
The Impact ◽  
Syndrome Report

Women with a history of preeclampsia and/or Hemolysis Elevated Liver enzymes Low Platelets (HELLP) syndrome report impaired cognitive functioning, such as concentration problems and decreased memory function. The presence of subjective cognitive impairment, depressive symptoms and cognitive deficits may affect working abilities.

scholarly journals Prevalence of Hemolysis, Elevated Liver Enzymes, Low Platelet Count Syndrome in Pregnant Women in a Tertiary Care Hospital

2020 ◽  
Vol 58 (226) ◽  
Author(s):  
Sarita Sitaula ◽  
Tara Manandhar ◽  
Baburam Dixit Thapa ◽  
Ramesh Shrestha ◽  
Dinesh Dharel
Keyword(s):  
Platelet Count ◽  
Confidence Interval ◽  
Liver Enzymes ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Morbidity And Mortality ◽  
Care Hospital ◽  
Perinatal Morbidity ◽  
Elevated Liver Enzymes ◽  
Low Platelet Count

Introduction: Hemolysis, Elevated Liver Enzymes, Low Platelet count syndrome refers to biological syndrome occurring in pre-eclamptic and eclamptic women. There is a higher rate of maternal and perinatal morbidity and mortality due to the syndrome. So, the objective of the study is to find the prevalence and maternal- perinatal outcome in the syndrome. Methods: A descriptive cross-sectional study was done in a tertiary care hospital from 1st April 2017 to 30th March 2018 after obtaining ethical clearance from the Institutional Review Committee. The inclusion criteria were patients giving consent for participation and those who delivered in our hospital. Patient with the syndrome who delivered outside and referred in the postpartum period was excluded because details of the neonate may not be available. The Statistical Package for Social Sciences version 21 was used for the analysis of the data. Point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data. Results: Out of 11974 deliveries, the prevalence of Hemolysis, Elevated Liver Enzymes, Low Platelet count syndrome was 83 (0.69%) at 95% Confidence Interval (59.06-78.94). Maternal complications were seen in 19 (22.9%) and common complications being acute renal failure 9 (47.37%) followed by postpartum hemorrhage 4 (21.05%). Nearly 27 (33%) of patients required maternal ICU stay and there was one maternal mortality. Conclusions: Hemolysis, Elevated Liver Enzymes, Low Platelet count syndrome is one of the major causes of maternal and perinatal morbidity and mortality. Hence early recognition and prompt management may improve maternal and fetal outcomes.

scholarly journals COVID-19 and HELLP: Overlapping Clinical Pictures in Two Gravid Patients

2020 ◽  
Vol 10 (02) ◽  
pp. e179-e182 ◽  
Author(s):  
Itamar Futterman ◽  
Miriam Toaff ◽  
Liel Navi ◽  
Camille A. Clare
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Liver Enzymes ◽  
Clinical Findings ◽  
Peripheral Smear ◽  
Fetal Demise ◽  
Emergency Cesarean ◽  
Elevated Liver Enzymes ◽  
Novel Coronavirus ◽  
Clinical Pictures ◽  
The Impact

Abstract Background The impact of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) on pregnancies is currently under investigation. There is a significant overlap between the clinical findings in novel coronavirus disease 2019 (COVID-19) and hemolysis, elevated liver enzymes, and low platelets syndrome (HELLP). Cases Patients presented at 22 and 29 weeks of gestation with suspected COVID-19 pneumonia. While the patient at 22 weeks of gestation subsequently had an intrauterine fetal demise, the patient at 29 weeks of gestation delivered via an emergency cesarean delivery for nonreassuring fetal status. Both patients also developed transaminitis, thrombocytopenia, and disseminated intravascular coagulation with a proof of hemolysis on peripheral smear. Conclusion Clinicians are encouraged to consider both of these diagnoses when caring for pregnant women during the COVID-19 pandemic to assure that both maternal and fetal concerns are addressed and treated appropriately.

scholarly journals Prevalence of HCV-Helicobacter pylori co-infection and its effects on liver function enzymes of patients in Lahore, Pakistan

2019 ◽  
Vol 01 (03) ◽  
pp. 09-14
Author(s):  
Sohaib Bin Wahid ◽  
Muhammad Waqar ◽  
Zobaria Rehman ◽  
Muhammad Wasim ◽  
Muhammad Idrees
Keyword(s):  
Helicobacter Pylori ◽  
Liver Function ◽  
Blood Count ◽  
Liver Enzymes ◽  
Complete Blood Count ◽  
Liver Function Tests ◽  
Morbidity And Mortality ◽  
Function Tests ◽  
H Pylori ◽  
The Impact

Helicobacter pylori and HCV are the most prevalent pathogens worldwide associated with high rates of morbidity and mortality. This study aimed to determine the prevalence of H. pylori in HCV infected patients and compares changes in liver function tests (LFTs) of both HCV mono-infected and HCV/H. pylori co-infected patients. Eighty-seven participants participated in this study who were first screened for HCV using GeneXpert technology followed by H. pylori antigen stool test. A complete blood count (CBC) analysis and LFTs were performed to determine the impact of HCV and H. pylori on liver enzymes. Our findings suggested that 45% of patients had HCV mono-infection, whereas 55% were co-infected with both HCV and H. pylori. Furthermore, we also observed that ALT, AST, and ALP levels were significantly elevated in HCV/H. pylori co-infected patients as compared to HCV mono-infected patients. To the best of our knowledge, this is the first study to report the prevalence of H. pylori in HCV infected subjects of Lahori population

scholarly journals SÍNDROME HELLP: A CONDUTA OBSTÉTRICA E SUAS CONTROVÉRSIAS

2018 ◽  
Vol 5 (3) ◽  
pp. 75-78
Author(s):  
Flávia da Silva Oliveira ◽  
Fábio Roberto Ruiz de Moraes
Keyword(s):  
Conservative Treatment ◽  
Perinatal Mortality ◽  
Hellp Syndrome ◽  
Liver Enzymes ◽  
Signs And Symptoms ◽  
Clinical Entity ◽  
Morbidity And Mortality ◽  
General Malaise ◽  
Elevated Liver Enzymes ◽  
Mortalidade Materna

RESUMO A síndrome HELLP pode ocorrer na pré-eclâmpsia (PE) ou na eclampsia e se caracteriza pelo conjunto de sinais e sintomas associados à hemólise microangiopática, elevação de enzimas hepáticas e plaquetopenia, podendo afetar 0,6% das gestações e 4-12% das pacientes com PE grave. Responsável por elevados índices de mortalidade materna e perinatal, a paciente pode apresentar-se com mal estar geral, epigastralgia, dor em hipocôndrio direito, náuseas ou vômitos, cefaléia, escotomas, associados a quadro hipertensivo e proteinúria. A conduta obstétrica na Síndrome HELLP ainda apresenta controvérsias na literatura, principalmente quando estamos diante de gestações em estágio inicial. Existem condutas favoráveis ao tratamento conservador no intuito de estabilizar a progressão da doença e reduzir a morbidade e mortalidade da mãe e do feto. Outras que postergam a interrupção da gestação por período de 48 horas nos menores de 34 semanas. E ainda temos condutas obstétricas que adotam a interrupção de emergência, independente da idade gestacional.   Palavras-chave: Síndrome HELLP, Pré-eclâmpsia grave, Eclâmpsia, gestação de alto risco. ABSTRACT HELLP syndrome is a clinical entity that can occur in pre-eclampsia or eclampsia and is characterized by presenting a set of signs and symptoms associated with mircroangiopathic hemolysis, raised elevated liver enzymes and thrombocytopenia, which may affect 0.6% of pregnancies and 4-12% of patients with severe PE. Responsible for high rates of maternal and perinatal mortality, the patient may present with general malaise, epigastralgia, right hypochondrium pain, nausea or vomiting, headache, scotomas, associated with hypertension and proteinuria. The obstetric behavior in HELLP syndrome is still controversial in the literature, especially when we are in the early stages of pregnancy. It was observed that some authors favor conservative treatment in order to stabilize the progression of the disease and reduce morbidity and mortality of the mother and the fetus. However, other authors take the course of postponing gestation of less than 34 weeks per 48-hour period. And we still have obstetric behaviors that adopt the emergency interruption, regardless of gestational.

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