scholarly journals Hepatobiliary phenotype of individuals with chronic intestinal disorders

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jessica Voss ◽  
Carolin V. Schneider ◽  
Moritz Kleinjans ◽  
Tony Bruns ◽  
Christian Trautwein ◽  
...  
Keyword(s):  
Functional Relationship ◽  
Liver Enzymes ◽  
Liver Function Tests ◽  
Population Based ◽  
Intestinal Surgery ◽  
Elevated Liver Enzymes ◽  
Clinical Consequences ◽  
History Of ◽  
Hepatobiliary Diseases ◽  
The Impact

AbstractDespite the known functional relationship between the gut and the liver, the clinical consequences of this circuit remain unclear. We assessed the hepatobiliary phenotype of cohorts with celiac disease (CeD), Crohn´s disease (CD) and ulcerative colitis (UC). Baseline liver function tests and the frequency of hepatobiliary diseases were analyzed in 2377 CeD, 1738 CD, 3684 UC subjects and 488,941 controls from the population-based UK Biobank cohort. In this cohort study associations were adjusted for age, sex, BMI, diabetes, and alcohol consumption. Compared to controls, cohorts with CeD, but not CD/UC displayed higher AST/ALT values. Subjects with CD/UC but not CeD had increased GGT levels. Elevated ALP and cholelithiasis were significantly more common in all intestinal disorders. Non-alcoholic steatohepatitis and hepatocellular carcinoma (HCC) were enriched in CeD and CD (NASH: taOR = 4.9 [2.2–11.0] in CeD, aOR = 4.2 [1.7–10.3] in CD, HCC: aOR = 4.8 [1.8–13.0] in CeD, aOR = 5.9 [2.2–16.1] in CD), while cholangitis was more common in the CD/UC cohorts (aOR = 11.7 [9.1–15.0] in UC, aOR = 3.5 [1.8–6.8] in CD). Chronic hepatitis, autoimmune hepatitis (AIH) and cirrhosis were more prevalent in all intestinal disorders. In UC/CD, a history of intestinal surgery was associated with elevated liver enzymes and increased occurrence of gallstones (UC: aOR = 2.9 [2.1–4.1], CD: 1.7 [1.2–2.3]). Our data demonstrate that different intestinal disorders predispose to distinct hepatobiliary phenotypes. An increased occurrence of liver cirrhosis, NASH, AIH and HCC and the impact of surgery warrant further exploration.

scholarly journals The Impact of Preeclampsia on Work-Related Psychosocial Aspects and Need for Recovery

2021 ◽  
Vol 6 (3) ◽  
pp. 1-7
Author(s):  
Muijsers HEC ◽  
Keyword(s):  
Cognitive Deficits ◽  
Liver Enzymes ◽  
Memory Function ◽  
Need For Recovery ◽  
Subjective Cognitive Impairment ◽  
Work Related ◽  
Elevated Liver Enzymes ◽  
History Of ◽  
The Impact ◽  
Syndrome Report

Women with a history of preeclampsia and/or Hemolysis Elevated Liver enzymes Low Platelets (HELLP) syndrome report impaired cognitive functioning, such as concentration problems and decreased memory function. The presence of subjective cognitive impairment, depressive symptoms and cognitive deficits may affect working abilities.

scholarly journals S19 The impact of clotting abnormalities on the natural history of idiopathic pulmonary fibrosis: an extended follow up of a population based cohort

Thorax ◽  
2016 ◽  
Vol 71 (Suppl 3) ◽  
pp. A13.1-A13
Author(s):  
V Navaratnam ◽  
AW Fogarty ◽  
T McKeever ◽  
N Thompson ◽  
G Jenkins ◽  
...  
Keyword(s):  
Natural History ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Population Based ◽  
History Of ◽  
The Impact

scholarly journals Long-term mortality due to infection associated with elevated liver enzymes: a population-based cohort study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tak Kyu Oh ◽  
Eun Sun Jang ◽  
In-Ae Song
Keyword(s):  
Cohort Study ◽  
Liver Enzymes ◽  
Adult Population ◽  
Population Based ◽  
Study Data ◽  
Point Increase ◽  
Elevated Liver Enzymes ◽  
Glutamyl Transpeptidase ◽  
Long Term Mortality

AbstractWe aimed to investigate whether elevated liver enzymes in the adult population were associated with mortality due to infection. As a population-based cohort study, data from the National Health Insurance Service Health Screening Cohort were used. Adult individuals (aged ≥ 40 years) who underwent standardized medical examination between 2002 and 2003 were included, and infectious mortality was defined as mortality due to infection between 2004 and 2015. Aspartate transaminase (AST), alanine aminotransferase (ALT), γ-glutamyl transpeptidase (γ-GTP), AST/ALT ratio, and dynamic AST/ALT ratio (dAAR) were included in multivariable Cox modeling. A total of 512,746 individuals were included in this study. Infectious mortality occurred in 2444 individuals (0.5%). In the multivariable model, moderate and severe elevation in AST was associated with 1.94-fold [hazard ratio (HR):1.94, 95% confidence interval (CI) 1.71–2.19; P < 0.001] and 3.93-fold (HR: 3.93, 95% CI 3.05–5.07; P < 0.001) higher infectious mortality respectively, compared with the normal AST group. Similar results were observed for moderate and severe elevation in ALT and mild, moderate, and severe elevation in γ-GTP. Additionally, a 1-point increase in the AST/ALT ratio and dAAR was associated with higher infection mortality. Elevated liver enzymes (AST, ALT, AST/ALT ratio, γ-GTP, and dAAR) were associated with increased infectious mortality.

scholarly journals A Case of Massive Hepatic Infarction in a Patient with HELLP Syndrome

2019 ◽  
Vol 09 (01) ◽  
pp. e84-e87
Author(s):  
Jessica Morgan ◽  
Micaela Della Torre ◽  
Anna Whelan ◽  
Sophia Rodriguez ◽  
Laura DiGiovanni
Keyword(s):  
Liver Enzymes ◽  
Epigastric Pain ◽  
Early Recognition ◽  
Rare Complication ◽  
Liver Function Tests ◽  
True Incidence ◽  
Hepatic Infarction ◽  
Elevated Liver Enzymes ◽  
Blood Pressures ◽  
The Right

Background Hepatic infarction is an exceedingly rare complication of hemolysis, elevated liver enzymes, and low platelets syndrome. Few cases have been described in the medical literature and the true incidence remains unknown. It can lead to fulminant liver failure, liver transplant, or death if not promptly addressed. Case Report A 22-year-old primigravida presented with right upper quadrant and epigastric pain at 28 weeks' gestation. She had severely elevated blood pressures requiring intravenous antihypertensives as well as proteinuria, thrombocytopenia, and mild transaminitis. Within 6 hours of admission, her rapidly rising liver function tests (LFTs) necessitated urgent delivery by primary cesarean section. Her liver enzymes continued to rapidly worsen postoperatively and immediate postpartum computed tomography of the abdomen and pelvis revealed massive hepatic infarction, 11 × 10 × 15 cm, of the right lobe of the liver. Her transaminases peaked at alanine transferase of 2,863 IU/L and aspartate transferase of 2,732 IU/L. She received supportive multidisciplinary intensive care, and LFTs returned to normal by postoperative day 20. Conclusion Hepatic infarction is an extraordinarily rare complication of pre-eclampsia. Early recognition and prompt multidisciplinary management are vital to prevent catastrophic bleeding, hepatic failure, and death.

scholarly journals The Impact of Family History of Allergy on Risk of Food Allergy: A Population-Based Study of Infants

2013 ◽  
Vol 10 (11) ◽  
pp. 5364-5377 ◽  
Author(s):  
Jennifer Koplin ◽  
Katrina Allen ◽  
Lyle Gurrin ◽  
Rachel Peters ◽  
Adrian Lowe ◽  
...  
Keyword(s):  
Food Allergy ◽  
Family History ◽  
Population Based ◽  
Population Based Study ◽  
History Of ◽  
The Impact

scholarly journals Hepatitis por citomegalovirus: Presentación de dos casos

2013 ◽  
Vol 6 (2) ◽  
Author(s):  
Carlos Tori ◽  
Raúl Leon Barua ◽  
Carlos Roe
Keyword(s):  
Blood Test ◽  
Liver Enzymes ◽  
The Other ◽  
General Malaise ◽  
Igg Antibodies ◽  
Premature Babies ◽  
Normal Individuals ◽  
Elevated Liver Enzymes ◽  
History Of ◽  
Low Prevalence

Two cases of hepatitis by cytomegalovirus are described, one in a child and the other in a young adult, presenting with a history of fever, general malaise, hepatomegaly and no jaundice. Their blood test showed atypical lymphocytes, normal bilirubin, elevated liver enzymes, and IgG antibodies against cytomegalovirus. Their course was un was unremarkable except for asthenia which persisted in spite of clinical and laboratory improvement. This course was unremarkable except for asthenia which persisted in spite of clinical and laboratory improvement. This presentation is done because of the low prevalence or infrequent diagnosis of anicteric hepatitis due to cytomegalovirus in normal individuals. Most of the literature refers to congenital cases, premature babies, or patients with debilitating or immunocompromising diseases.

ETHNOGENESIS AND ETHNOGRAPHIC HISTORY OF THE UZBEK PEOPLE

2019 ◽  
Vol 18 (2) ◽  
pp. 17-23
Author(s):  
Nurullo Tursunov ◽  
Keyword(s):  
Material Culture ◽  
Population Based ◽  
Historical Events ◽  
Political Processes ◽  
Cultural Processes ◽  
History Of ◽  
Ethnographic History ◽  
The Impact

The article aims to study the ethnographic status of the studied region, the impact of historical events on ethno-cultural processes, the role of socio-political processes in the material culture of the region's population based on historical and ethnographic materials

scholarly journals The Risk Factors and the Impact of Hernia Development on Technique Survival in Peritoneal Dialysis Patients: A Population-Based Cohort Study

2015 ◽  
Vol 35 (3) ◽  
pp. 351-359 ◽  
Author(s):  
Shang-Feng Yang ◽  
Chia-Jen Liu ◽  
Wu-Chang Yang ◽  
Chao-Fu Chang ◽  
Chih-Yu Yang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Peritoneal Dialysis ◽  
Protective Factor ◽  
Female Gender ◽  
Population Based ◽  
Chronic Obstructive ◽  
Research Database ◽  
Hernia Formation ◽  
History Of ◽  
The Impact

ObjectivesThere is a lack of consensus on the risk factors for hernia formation, and the impact on peritoneal dialysis (PD) survival has seldom been studied.MethodsThis was a population-based study and all collected data were retrieved from the National Health Insurance Research Database of Taiwan. Patients who commenced PD between January 1998 and December 2006 were screened for inclusion. Multiple logistic regression and Cox proportional hazards models were applied to estimate the predictors for hernia formation and determine the predictors of PD withdrawal.ResultsA total of 6,928 PD patients were enrolled and followed until December 2009, with 631 hernia events and 391 hernioplasties being registered in 530 patients (7.7%). The incidence rate was 0.04 hernias/patient/year. Longer PD duration (per 1 month increase, hazard ratio (HR) 1.019) and history of mitral valve prolapse (MVP) (HR 1.584) were independent risk factors for hernia formation during PD, and female gender (HR 0.617) was a protective factor. On the other hand, there were 4,468 PD withdrawals, with cumulative incidence rates of 41% at 1 year, 66% at 3 years, and 82% at 5 years. Independent determinants for cumulative PD withdrawal included hernia formation during PD (HR 1.154), age (per 1 year increase, HR 1.014), larger dialysate volume (per 1 liter increase, HR 0.496), female gender (HR 0.763), heart failure (HR 1.092), hypertension (HR 1.207), myocardial infarction (HR 1.292), chronic obstructive pulmonary disease (COPD) (HR 1.227), cerebrovascular accident (CVA) (HR 1.364), and history of MVP (HR 0.712)ConclusionsProlonged PD duration was a risk factor for hernia formation, and female gender was protective. Hernia formation during PD therapy may increase the risk of PD withdrawal.

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