scholarly journals PEMURNIAN CATECHIN DARI GAMBIR KOTO PANJANG, PESISIR SELATAN

2015 ◽  
Vol 5 (1) ◽  
pp. 40
Author(s):  
Norman Ferdinal
Keyword(s):  
Molecular Structure ◽  
Melting Point ◽  
Organic Solvent ◽  
Ethyl Acetate ◽  
1H Nmr ◽  
13C Nmr ◽  
Cold Water ◽  
Hot Water ◽  
Added Value ◽  
Bargaining Position

Vol 5 No 1ABSTRACT The research about catechin purification from gambier was purposed to find its solubility properties in various solvent such as in cold water, hot water, hexane, ethyl acetate, and methanol. By knowing its solubility properties, the easiest way to purify the catechin could be gotten which is yielding about 7.33%. Further, the molecular structure has been gotten by determining its melting point and using spectrophotometric measurements such as UV, IR, 1H NMR, 13C NMR. Based on those measurements, d-cathecin structure with a melting point of 175 - 177 ºC was founded. The expected benefit from this research is it could be benefiting the development of gambier purification industry in order to enhancing added value of West Sumatera’s commodities. It would make Western Sumatera gaining stronger bargaining position due to the capability on selling not only on the crude form to abroad. The result of this research has indicated that catechin purification can be performed using an organic solvent and water.  Keywords: Purification, catechin, gambier

scholarly journals ISOLASI KUMARIN DARI KULIT BUAH LIMAU SUNDAI (Citrus nobilis Lour)

2017 ◽  
Vol 18 (02) ◽  
pp. 137-145
Author(s):  
Melindra Mulia
Keyword(s):  
Melting Point ◽  
Ir Spectra ◽  
Ethyl Acetate ◽  
1H Nmr ◽  
Column Chromatography ◽  
13C Nmr ◽  
Ethyl Acetate Extract ◽  
2D Nmr ◽  
White Needle ◽  
Pure White

Coumarin has been isolated and characteritated from rind of  Citrus nobilis Lour by maseration methode with methanol. After fractionation by n-hexane and ethyl acetate, collected the phase ethyl acetate which positive of coumarin. From ethyl acetate extract coumarin have been isolated by column chromatography. The isolation results was obtain 2,159 g of pure white needle-shape crystalline with the melting point of 126,2-127,60C. Structure of the isolated coumarine was elucidated by spectroscopic methodes, UV-Vis,13C-NMR, 1H-NMR, 2D-NMR (DEPT/HSQC, COSY, NOESY, HMBC) and IR spectra. Based on the spectra data the isolated coumarine is marmin.

scholarly journals Quinazolin-4(3H)-ones and 5,6-Dihydropyrimidin-4(3H)-ones from β-Aminoamides and Orthoesters

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2925 ◽  
Author(s):  
Joshua Gavin ◽  
Joel Annor-Gyamfi ◽  
Richard Bunce
Keyword(s):  
Acetic Acid ◽  
Melting Point ◽  
1H Nmr ◽  
13C Nmr ◽  
Pressure Tube ◽  
Absolute Ethanol ◽  
Basic Nitrogen ◽  
One Step ◽  
Ft Ir

Quinazolin-4(3H)-ones have been prepared in one step from 2-aminobenzamides and orthoesters in the presence of acetic acid. Simple 2-aminobenzamides were easily converted to the heterocycles by refluxing in absolute ethanol with 1.5 equivalents of the orthoester and 2 equivalents of acetic acid for 12–24 h. Ring-substituted and hindered 2-aminobenzamides as well as cases incorporating an additional basic nitrogen required pressure tube conditions with 3 equivalents each of the orthoester and acetic acid in ethanol at 110 °C for 12–72 h. The reaction was tolerant towards functionality on the benzamide and a range of structures was accessible. Workup involved removal of the solvent under vacuum and either recrystallization from ethanol or trituration with ether-pentane. Several 5,6-dihydropyrimidin-4(3H)-ones were also prepared from 3-amino-2,2-dimethylpropionamide. All products were characterized by melting point, FT-IR, 1H-NMR, 13C-NMR, and HRMS.

scholarly journals ANTIOXIDANT ACTIVITY OF 2,6,4’-TRIHYDROXY-4-METHOXY BENZOPHENONE FROM ETHYL ACETATE EXTRACT OF LEAVES OF MAHKOTA DEWA (Phaleria macrocarpa (Scheff.) Boerl.)

2011 ◽  
Vol 11 (2) ◽  
pp. 180-185 ◽  
Author(s):  
Susilawati Susilawati ◽  
Sabirin Matsjeh ◽  
Harno Dwi Pranowo ◽  
Chairil Anwar
Keyword(s):  
Antioxidant Activity ◽  
Ethyl Acetate ◽  
1H Nmr ◽  
Column Chromatography ◽  
13C Nmr ◽  
Ethyl Acetate Extract ◽  
Chemical Constituent ◽  
Traditional Medicines ◽  
Phaleria Macrocarpa ◽  
Spherical Crystal

Mahkota dewa plant (Phaleria macrocarpa (Scheff.) Boerl.) which is included into family of Thymelaeaceae is one of Indonesia's traditional medicines. Chemical constituent has been isolated from ethyl acetate extract of leaves of mahkota dewa. Sample was extracted with methanol, concentrated then extracted by n-hexane, chloroform and ethyl acetate. The ethyl acetate extract was separated and fractionated by column chromatography. The first fraction was purified by TLC preparative and recrystalization. Compound was isolated as red-brown spherical crystal in 8 mg (m.p. 129-131 °C). Its spot gave dark fluoroscence at TLC plate (UV366) with Rf of 0.3 at TLC chromatogram with eluent of n-hexane : ethyl acetate (7:3); 0.6 with n-hexane : ethyl acetate (1:1); 0.9 with -hexane : ethyl acetate (4:6). This compound was dissolved in methanol. Compound was identified by UV, IR, 1H NMR, 13C NMR and NMR 2 dimension (HMQC, COSY, HMBC and DEPT-135) spectroscopic as 2,6,4'-trihydroxy-4-methoxybenzophenon. This compound as well as the ethyl acetate extract showed antioxidant activity on DPPH with IC50 was 10.57 and 101.06 μg/mL, respectively. This compound showed strong antioxidant activity on DPPH, almost to the standard antioxidant activity of quercetin (IC50 of 2.93 μg/mL)

scholarly journals SYNTHESIS N-PHENYLAMINEDITHIOCARBAMATE AS CHELATING AGENT IN SOLVENT EXTRACTION

2014 ◽  
Vol 2 (3) ◽  
Author(s):  
Soja Siti Fatimah ◽  
Vera Musfiroh ◽  
Zackiyah Zackiyah ◽  
Husein H. Bahti ◽  
Iwan Hastiawan ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Solvent Extraction ◽  
1H Nmr ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Carbon Disulphide ◽  
Chelating Agent ◽  
Dithiocarbamate Derivatives

Dithiocarbamate derivatives is a versatile ligand that contain two atoms of sulfur as a strong electrondonor. It combines with metals. N-phenylaminedithiocarbamate has synthesized and applied in solvent exctration. Synthesis carried out with addition carbon disulphide to N-phenylamine and concentrated pottasium hydroxyde in metanol. The result was characterized by spectroscopy 1H-NMR, 13C-NMR, FTIR, Elemental Analysis, that showed molecular structure was significant. Applied N-Phenylaminedithiocarbamate in solvent extraction showed precent of result Cu(II), Co(II), Cr(III) and Ni (II) were 90.45% - 99.99% at pH 4-9.

scholarly journals Phytochemical constituents of the flowers of Sarcococca coriacea of Nepalese origin

1970 ◽  
Vol 21 ◽  
pp. 1-7 ◽  
Author(s):  
N. P. Rai ◽  
B. B. Adhikari ◽  
Arjun Paudel ◽  
K. Masuda ◽  
R. D. Mckelvey ◽  
...  
Keyword(s):  
Melting Point ◽  
Spectral Data ◽  
Oleanolic Acid ◽  
1H Nmr ◽  
13C Nmr ◽  
Chemical Society ◽  
Chromatographic Technique ◽  
Sugar Alcohol ◽  
Steroidal Glycosides ◽  
Phytochemical Constituents

From the flowers of Sarcococca coriacea, a triterpenoic acid, oleanolic acid, a pentahydric sugar alcohol, xylitol along with the mixture of steroidal glycosides, stigmasterol-3-O-β-D-glucopyranoside and β-sitosterol-3-O-β-D-glucopyranoside have been isolated by chromatographic technique. Their structures were established on the basis of IR, 1H-NMR, 13C-NMR, spectral data as well as melting point and Co-TLC comparison with the authentic samples. DOI: 10.3126/jncs.v21i0.214Journal of Nepal Chemical Society Vol.21 2006 p.1-7

scholarly journals Triterpenoids from the Stem Bark of Crataeva nurvala

1970 ◽  
Vol 7 (1) ◽  
pp. 71-74 ◽  
Author(s):  
Md Enamul Haque ◽  
Md Nahidul Islam ◽  
Dipankar Das Gupta ◽  
Mahbub Hossain ◽  
Hossain Uddin Shekhar ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Key Words ◽  
Silica Gel ◽  
1H Nmr ◽  
13C Nmr ◽  
Ethyl Acetate Extract ◽  
Stem Bark ◽  
First Report ◽  
Spectroscopic Analyses ◽  
Phytochemical Investigation

Two triterpenoids, phragmalin triacetate (1) and lupeol (2) were isolated from an ethyl acetate extract of the stem bark of Crataeva nurvala (Capparidaceae) by repeated chromatography over silica gel. The structures of these compounds were determined by spectroscopic analyses (UV, IR, 1H NMR, 13C NMR and EIMS). This is the first report of the systematic phytochemical investigation and the presence of these compounds 1 and 2 from this plant. Key words: Crataeva, Capparidaceae, Phragmalin triacetate and Lupeol.  DOI = 10.3329/dujps.v7i1.1221 Dhaka Univ. J. Pharm. Sci. 7(1): 71-74, 2008 (June)

scholarly journals ISOLASI SIKLOKOMUNOL DARI DAUN SUKUN Artocarpus altilis (PARKINSON) FOSBERG SERTA AKTIVITASNYA SEBAGAI ANTIKANKER

2014 ◽  
Vol 16 (2) ◽  
pp. 82-86 ◽  
Author(s):  
Chandra Risdian ◽  
Tjandrawati Mozef ◽  
Puspa D.N Lotulung
Keyword(s):  
Liver Cirrhosis ◽  
Ethyl Acetate ◽  
Silica Gel ◽  
1H Nmr ◽  
13C Nmr ◽  
Anticancer Agent ◽  
Ethyl Acetate Extract ◽  
Gradient Elution ◽  
Artocarpus Altilis ◽  
Mcf 7

Daun sukun (Artocarpus altilis) sudah lama dijadikan sebagai obat tradisional untuk mengatasi berbagai penyakit seperti liver cirrhosis, hipertensi, dan diabetes. Ekstrak etil asetat dari daun sukun juga berpotensi menghambat pertumbuhan sel kanker. Beberapa senyawa yang telah diketahui sebagai agen antikanker di dalam ekstrak etil asetat daun sukun adalah golongan geranil flavonoid. Akan tetapi, senyawa pyranoflavoid belum dilaporkan dapat ditemukan pada daun sukun. Untuk itu, penelitian ini bertujuan untuk mengisolasi senyawa pyranoflavonoid dari ekstrak etil asetat daun sukun dan menguji aktivitasnya sebagai antikanker. Daun sukun diekstraksi dengan etanol 70% kemudian dilakukan partisi dengan petroleum eter dan etil asetat. Ekstrak etil asetat yang diperoleh difraksinasi dengan kromatografi kolom silica gel dengan gradient elusi heksan-etil asetat sehingga diperoleh senyawa kristal berwarna kuning, AA3. Senyawa AA3 kemudian diidentifikasi dengan spektrofotometer UV-Vis, LC-MS, 1H-NMR dan 13C-NMR dan diperoleh hasil bahwa senyawa AA3 tersebut adalah siklokomunol yang merupakan golongan pyranoflavonoid. Uji antikanker siklokomunol dengan MCF-7 dan T47D menunjukkan adanya aktivitas antikanker dengan nilai IC50 masing-masing adalah 75.46 µM dan 36.20 µM selama 48 jam.Kata kunci:Artocarpus altilis, siklokomunol, antikanker, MCF-7, T47D. Leaves of breadfruit Artocarpus altilis (Parkinson) Fosberg has long been used as traditional medicine to overcome a variety of diseases such as liver cirrhosis, hypertension, and diabetes. Ethyl acetate extract of the leaves of breadfruit also potentially inhibit the growth of cancer cells. Several compounds have been known as an anticancer agent in the ethyl acetate extract of leaves of breadfruit is belong to geranyl flavonoid group. However, the compound belong to pyranoflavoid group has not been reported can be found on the leaves of breadfruit. Therefore, this study aims to isolate the pyranoflavonoid compound from ethyl acetate extract of leaves of breadfruit and tested as an anticancer agent. Breadfruit leaves were extracted with 70% ethanol and then made a partition with petroleum ether and ethyl acetate. Ethyl acetate extract obtained was fractionated by silica gel column chromatography with gradient elution of hexane-ethyl acetate to obtain a yellow crystalline compound, AA3. AA3 compound was identified by UV-Vis spectrophotometer, LC-MS, 1H-NMR and 13C-NMR and obtained results that AA3 compound is siklokomunol which is belong to pyranoflavonoid group. Anticancer test of siklokomunol with MCF-7 and T47D showed anticancer activity with IC50 values of each are 75.46 µM and 36.20 µM, respectively, for 48 hours.Keywords: Artocarpus altilis, siklokomunol, anticancer, MCF-7, T47D.

scholarly journals SINTESIS DAN UJI TOKSISITAS SENYAWA ANALOG KURKUMIN 3,5 BIS((E)-METOKSI BENZILIDEN)-1-(2-ETIL ASETAT)-PIPERIDIN-4-ON

2018 ◽  
Vol 9 (1) ◽  
pp. 159-163
Author(s):  
Siti Aisyah ◽  
Adel Zamri ◽  
Hilwan Yuda Teruna
Keyword(s):  
Melting Point ◽  
Secondary Metabolites ◽  
Ethyl Acetate ◽  
1H Nmr ◽  
Toxicity Test ◽  
Biological Activities ◽  
Target Molecule ◽  
Curcumin Analogs ◽  
Phenolic Group ◽  
Ft Ir

Curcumin analogs are secondary metabolites and belong to the phenolic group. These compounds have biological activities, such as anti-inflammatory, anticancer and antioxidant. This studies has successfully synthesized 3,5-bis ((E)-metoxy benzylidene) -1-(- 2-ethyl acetate) piperidine 4-one analog compound from 4-piperidone with 4-methoxy benzaldehyde by using reflux method. Compounds obtained in the form of yellow solids with yield 83.01%. The melting point was measured, identified by TLC then elucidated with UV-Vis, FT-IR, LC-MS, 1H NMR obtained results showed that the curcumin compound had a structure in accordance with the target molecule. The toxicity test using the BSLT method showed that the two compounds had LC50 values = 1.061μg / mL.

scholarly journals Structure Modification of Quinine on C-9 Hydroxyl Group via Esterification Reaction

2020 ◽  
Vol 9 (1) ◽  
pp. 32-39
Author(s):  
Teni Ernawati ◽  
◽  
Minarti Minarti ◽  
Puspa Dewi Narrij Lotulung ◽  
◽  
...  
Keyword(s):  
Drug Discovery ◽  
Melting Point ◽  
1H Nmr ◽  
13C Nmr ◽  
Efficient Method ◽  
Hydroxyl Group ◽  
Esterification Reaction ◽  
Structure Modification ◽  
Carbonyl Chloride

Concept the role played by modified quinine in the asymmetric hydroxyl group inspired studies of modified quinine as chiral organic that lead to drug discovery development. A simple and efficient method for C-9 alkylation and arylation of quinine derivatives was reported. Series quinine derivatives were synthesized through the esterification of the hydroxyl group of quinine. The reaction with various alkyl and aryl carbonyl chloride resulted in the series of ester quinine derivatives. The structure of quinine derivatives was characterized by IR, melting point, UV, 1H NMR, 13C NMR, LCMS.

Study on Chemical Compositions of Manihot Esculenta Crantz(M. utilissima Pohl)Stalks

2011 ◽  
Vol 236-238 ◽  
pp. 394-398 ◽  
Author(s):  
Cong Jin Chen ◽  
Yue Li ◽  
Qiu Ming Su ◽  
Li Juan Qu ◽  
Dong Chen
Keyword(s):  
Organic Solvent ◽  
Manihot Esculenta ◽  
Cold Water ◽  
Sodium Hydroxide Solution ◽  
Hot Water ◽  
Water Extraction ◽  
Hydroxyl Group ◽  
Chemical Compositions ◽  
Acid Soluble Lignin ◽  
Soluble Lignin

The chemical compositions of Manihot esculenta crantz(M. utilissima Pohl)stalks were investigated, the contents of phenolic hydroxyl group and UV spectra of lignin were determined by ultraviolet-visible spectrophotometer. The result showed that the chemical compositions of Manihot esculenta crantz(M. utilissima Pohl)stalks were as follows: ashes 4.97%, cold water extraction 12.04%, hot water extraction 12.57%, 1% sodium hydroxide solution extraction 34.16%, benzene-alcohol solution extraction 4.20%, nitric acid-alcohol cellulose 35.86%, holo-cellulose 72.62%, pentosan 19.20%, acid-soluble lignin 2.51%, acid-insoluble lignin 26.10%, organic solvent-soluble lignin 1.07%, pectin content is 0.02%; it can be used as a non-wood renewable source of natural products.Phenolic hydroxyl content of organic solvent-soluble lignin and acid-insoluble lignin are 1.245 mmol·g-1 and 0.261mmol·g-1 respectively; the maximum absorption wavelength of organic solvent-soluble lignin and acid-soluble lignin in the UV region is near to 205 nm and 280 nm, but shifts to long wavelength or short wavelength with the nature of the different solvents.

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