scholarly journals DISTRIBUTION OF CORONARY ARTERY CALCIUM SCORE BASED ON AGE AND GENDER IN HEALTHY POPULATION

2021 ◽  
Vol 20 (1) ◽  
pp. 1-8
Author(s):  
Andreas Hartanto Santoso ◽  
Caesar Rio Julyanto Putra ◽  
Josephine Rasidi ◽  
Hoo Felicia Davina Hadi Gunawan ◽  
Joshua Henrina Sundjaja ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Age Groups ◽  
Calcium Score ◽  
The Elderly ◽  
Healthy Population ◽  
Elderly Male ◽  
Age And Gender ◽  
Asymptomatic Patients ◽  
And Gender ◽  
Asymptomatic Individuals

Introduction: Coronary Artery Calcification (CAC) score may give information in cardiovascular risk stratification asymptomatic individuals. Profiles and distribution of CAC scores are still scarce in Indonesia. This study aimed to evaluate the distribution of CAC based on age and gender in asymptomatic patients. Methods: Subjects were asymptomatic Asian above 40 years-old undergoing cardiovascular check-up, including Computed Tomography (CT) CAC at Siloam Heart Institute, from April 2018 to August 2019. Data were obtained retrospectively and analyzed statistically with IBM SPSS version 22. Results: A total of 1640 patients were enrolled, with males slightly more than half. The mean age was 55,6 ± 9,6 years, with age group of 50-59 years as the majority (35,9%). Almost half of the subjects had zero CAC score. Around two-thirds of females, particularly below 50 years old, had zero CAC scores. CAC scores >400 were more prevalent in males across all age groups. The majority of healthy males had a CAC score between 0-99. There was a positive correlation between age and CAC scores in both genders. Females with CAC score >400 were found mostly after 70 years old, ten years older than males. CAC score >1000 was more prevalent in older males compared to females. Conclusion: The distribution of CAC score is remarkably affected by age and gender. Zero CAC score is found predominant in our subjects. CAC scores of ≥400 are common in males across all age groups. CAC score >1000 is more exclusively found in the elderly male

P5309Age and gender distributions of coronary artery calcium in the Dutch adult population: preliminary results of the ImaLife study

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
C Xia ◽  
M Rook ◽  
G J Pelgrim ◽  
J N Van Bolhuis ◽  
P M A Van Ooijen ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Reference Values ◽  
Coronary Artery Calcium ◽  
Adult Population ◽  
Age Groups ◽  
Population Based ◽  
Imaging Biomarkers ◽  
Dutch Population ◽  
Age And Gender ◽  
And Gender

Abstract Background Coronary artery calcium (CAC) scoring is a promising tool for cardiovascular risk classification. Population-based reference values are important for the clinical interpretation of CAC scores. Purpose To establish standards of CAC distributions by age and gender in an unselected Dutch population, which can be used to determine reference values. Methods ImaLife (Imaging in Lifelines) is a computed tomography (CT) based substudy of the Lifelines cohort, with a primary aim to establish reference values of imaging biomarkers for early stages of coronary artery disease in adults (above 45 years old). In total, 12,000 participants will be enrolled from an unselected adult population in the northern Netherlands for CAC scoring with third generation dual-source CT. CAC is quantified with dedicated commercial software using the Agatston method. Results Included so far were 3,702 participants (57.5% females, mean age 54 years, range 45–82 years). CAC was present in 39.2% of participants, with a higher prevalence of CAC in men (55.3%) than in women (27.3%). CAC scores increased with increasing age in both genders. The percentiles of CAC scores by age and gender groups are summarized in the table. Agatston CAC score percentiles by age and gender Percentiles Women – Age, years Men – Age, years 45–49 50–54 55–59 60–64 65∼ 45–49 50–54 55–59 60–64 65∼ N 505 634 719 260 10 355 473 543 185 18 25th 0 0 0 0 0 0 0 0 1 75 50th 0 0 0 0 4 0 1 6 22 556 75th 0 0 6 33 386 6 21 72 129 751 90th 4 26 77 120 1037 49 154 242 500 1803 Conclusion This preliminary result presents CAC distribution by age and gender in a middle-aged unselected Dutch population. Compared with the Heinz Nixdorf Recall study, CAC scores in our cohort for both genders were lower in the 5-year age groups between 45 and 64 years. Based on the overall data, expected within 2 years, reference values of CAC for the Dutch population can be established.

scholarly journals Poverty, old age and gender in nineteenth-century England: the case of Hertfordshire

2005 ◽  
Vol 20 (3) ◽  
pp. 351-384 ◽  
Author(s):  
NIGEL GOOSE
Keyword(s):  
Nineteenth Century ◽  
Family Support ◽  
Elderly Women ◽  
The Elderly ◽  
Elderly Male ◽  
Age And Gender ◽  
Local Sources ◽  
Short And Long Term ◽  
And Gender

This article examines the relative incidence of poverty among the elderly in nineteenth-century Hertfordshire with special reference to gender. Both national and local sources are employed to highlight the particular difficulties experienced by the elderly, male poor under the New Poor Law, and the short and long term problems they faced as a result of seasonal unemployment and an overstocked labour market. For elderly women, the extent to which their poverty was relieved by employment in cottage industry, almshouse accommodation, the continuing receipt of out-relief and a higher incidence of family support are examined to provide an assessment of the manner in which poverty was gendered in the nineteenth century.

scholarly journals Absence of age and gender effects on the pharmacokinetics of a single 500-milligram oral dose of levofloxacin in healthy subjects.

1997 ◽  
Vol 41 (7) ◽  
pp. 1562-1565 ◽  
Author(s):  
S C Chien ◽  
A T Chow ◽  
J Natarajan ◽  
R R Williams ◽  
F A Wong ◽  
...  
Keyword(s):  
Renal Function ◽  
Healthy Subjects ◽  
Age Groups ◽  
The Elderly ◽  
Gender Effects ◽  
Pharmacokinetic Parameters ◽  
Age And Gender ◽  
Male And Female ◽  
Young Males ◽  
And Gender

The influence of age and gender on the pharmacokinetics of levofloxacin in healthy subjects receiving a single oral 500-mg dose of levofloxacin was investigated in this parallel design study. Six young males (aged 18 to 40 years), six elderly males (aged > or = 65 years), six young females (aged 18 to 40 years), and six elderly females (aged > or = 65 years) were enrolled and completed the study. The study reveals that the bioavailability (rate and extent) of levofloxacin was not affected by either age or gender. In both age (young and elderly) and gender (male and female) groups of subjects, peak concentrations in plasma were reached at approximately 1.5 h after dosing; renal clearance of levofloxacin accounted for approximately 77% of total body clearance, and approximately 76% of the administered dose was recovered unchanged in urine over the 36 h of collection. The apparent differences in the calculated pharmacokinetic parameters for levofloxacin between the age groups (young versus elderly) and between the gender groups (males versus females) could be explained by differences in renal function among the subjects. A single dose of 500 mg of levofloxacin administered orally to both young and old, male and female healthy subjects was found to be safe and well tolerated. As the differences in levofloxacin kinetics between the young and the elderly or the males and the females are limited and are mainly related to the renal function of the subjects, dose adjustment based on age or gender alone is not necessary.

scholarly journals Asymptomatic people with SARS-CoV-2 as unseen carriers of COVID-19: A systematic review and meta-analysis

2020 ◽  
Author(s):  
Gopiram Syangtan ◽  
Shrijana Bista ◽  
Prabin Dawadi ◽  
Binod Rayamajhee ◽  
Lok Bahadur Shrestha ◽  
...  
Keyword(s):  
English Language ◽  
Meta Analysis ◽  
Age Groups ◽  
Published Data ◽  
Pooled Data ◽  
Asymptomatic Patients ◽  
Pooled Prevalence ◽  
Study Population ◽  
And Gender ◽  
Asymptomatic Individuals

Abstract Background The asymptomatic patients with SARS-CoV-2 can act as an unseen carrier for magnifying the transmission of COVID-19. Aims This study was designed to appraise the burden of asymptomatic individuals and estimate their occurrence among different age groups and gender by reviewing the existing published data on asymptomatic people with COVID-19. Methods Three electronic databases: PubMed, Embase and Web of Science (WoS) were used to search studies as per the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) and the search was limited to English language. The study population of this review includes asymptomatic individuals infected by COVID-19. All original articles which have reported cases of the COVID-19 patients with no symptoms until 31 April 2020 were included in the study. Random effects model was applied to analyze pooled data on the prevalence of symptomless cases among total COVID-19 infected patients and also on different age groups and gender. Results In the meta-analysis of 16 studies, comprising 2,788 COVID-19 infected patients, the pooled prevalence of asymptomatic cases was 48.2% (95% CI, 30%-67%). Among the asymptomatic patients, 55.5% (95% CI, 43.6%-66.8%) were female and 49.6% (95% CI, 20.5%-79.1%) were children. Conclusion About half of the COVID-19 infected patients were asymptomatic cases. Children and females were more apparent to be asymptomatic patient of COVID-19 and could act as unseen carrier of SARS-CoV-2. Symptom based screening only, might fail to identify all SARS-CoV-2 infections escalating the threat of global spread of SARS-CoV-2. Therefore, mass surveillance system tracking asymptomatic cases is a pressing need of public health, paying special attention to female and young children, which could aid in prevention and containment of this unprecedented pandemic.

Age and Gender Distributions of Pedestrian Accidents across the Life-Span

1994 ◽  
Vol 79 (3_suppl) ◽  
pp. 1680-1682 ◽  
Author(s):  
Johannes Kingma
Keyword(s):  
Life Span ◽  
Motor Vehicle ◽  
Age Groups ◽  
The Elderly ◽  
Mortality Rates ◽  
Motor Vehicles ◽  
Emergency Unit ◽  
Age And Gender ◽  
Pedestrian Accidents ◽  
And Gender

Causes of pedestrian accidents ( N = 534) were investigated for patients treated for injuries at the emergency unit of a hospital. Accidents in collisions with motor vehicles were the main cause (87.8%). Young children (0–9 years old) and the elderly (above 60 years of age) are the most vulnerable in terms of mortality rates observed in these age groups. Preponderance of males in pedestrian accidents was observed in the accident categories of collisions with motor vehicle and bicycle, whereas a slight preponderance of females was found in collisions with other traffic. The predominant age groups were located in the range from 0 through 19 years.

Abstract 15193: The Impact of Age and Gender on Door to Balloon Time in Patients with ST Elevation Myocardial Infarction

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Sakura Nagumo
Keyword(s):  
Female Gender ◽  
The Elderly ◽  
Young Female ◽  
Elderly Male ◽  
Age And Gender ◽  
Timi Flow Grade ◽  
Female Patients ◽  
Elderly Female ◽  
And Gender ◽  
The Impact

Introduction: Shortening door-to-balloon (D2B) time is important to improve outcomes in patients suffering ST elevated acute myocardial infarction (STEMI). Age and gender are associated with poor outcomes in previous reports, however the impact of differences in age and gender on D2B time is still unclear. Objective: To determine the association of age and gender with D2B time in patients suffering STEMI. Methods: The Yokohama cardiovascular workshop registry is a prospective multicenter cohort in an urban area of Japan. 1261 consecutive STEMI patients during May 2010 to May 2013 were enrolled for the present analysis. Patients were divided into four groups according to age (>75years old) and gender; elderly female (n=146), young female (n=125), elderly male (n=206) and young male (n=783). Results: D2B time was longer in female gender (93.2 vs. 85.5 min, p<0.01) and in the elderly (92.3 vs. 85.1, p<0.001). Among the four groups described above, D2B time was the longest in elderly female patients and followed by young female patients (p=0.002). Elderly female patients also had the lowest proportion of Killip class I, the longest time interval from hospital arrival to achieve TIMI flow grade 2/3, the worst final TIMI flow grade and the highest in-hospital mortality. The percentage of patients in achieving D2B time <90min was the lowest in elderly male (p<0.001, odds ratio 0.54) followed by elderly female (p=0.009, odds ratio 0.61). Conclusions: Both female gender and higher age were associated with longer D2B time in patients with STEMI. Further effort should be made to shorten the D2B time, especially in the elderly and women, for the improvement of clinical outcomes.

Flow Rates of Resting Whole and Stimulated Parotid Saliva in Relation to Age and Gender

1994 ◽  
Vol 73 (8) ◽  
pp. 1416-1420 ◽  
Author(s):  
R.S. Percival ◽  
SJ Challacombe ◽  
P.D. Marsh
Keyword(s):  
Age Groups ◽  
The Elderly ◽  
Elderly Subjects ◽  
Parotid Saliva ◽  
Age And Gender ◽  
Flow Rates ◽  
Whole Saliva ◽  
And Gender ◽  
Saliva Flow ◽  
Unstimulated Whole Saliva

Dry mouth is a common feature in the elderly, but it is not clear what proportion of incidences are related to functional disturbances and whether age per se and gender play a role. The aim of this study was to determine the effects of age and gender on salivary flow rates. The effect of age on unstimulated (resting) whole and stimulated parotid saliva flow rates was determined in 116 unmedicated, healthy individuals. The subjects were divided into four age groups: 20-39 years (group A), 40-59 years (group B), 60-79 years (group C), and 80 years and over (group D). A significant decrease in the secretion rates of unstimulated whole saliva in relation to age was observed in the study population (p < 0.001). However, the flow rates of stimulated parotid saliva were not significantly different in the four age groups. Females had significantly lower mean flow rates than males for both unstimulated (resting) whole saliva (p < 0.005) and stimulated parotid saliva (p < 0.05). In the study as a whole, significant negative correlations were found between either the DMF index (decayed, missing, and filled teeth) or the DMFS index (decayed, missing, and filled tooth surfaces) and the flow rates of unstimulated whole saliva (p < 0.02), but no relationship to stimulated parotid saliva flow rates was apparent. The results suggest that elderly subjects have no impairment in their ability to respond to sialogogues but that resting saliva rates are significantly lower than in younger individuals and may contribute to the increase in oral mucosal diseases seen in the elderly.

scholarly journals Global dynamics of SARS-CoV-2 clades and their relation to COVID-19 epidemiology

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Samira M. Hamed ◽  
Walid F. Elkhatib ◽  
Ahmed S. Khairalla ◽  
Ayman M. Noreddin
Keyword(s):  
Severe Disease ◽  
Age Groups ◽  
Statistical Evidence ◽  
Global Dynamics ◽  
Age And Gender ◽  
Genomic Variations ◽  
Mild Disease ◽  
Asymptomatic Patients ◽  
Metadata Analysis ◽  
And Gender

AbstractExpansion of COVID-19 worldwide increases interest in unraveling genomic variations of novel SARS-CoV-2 virus. Metadata of 408,493 SARS-CoV-2 genomes submitted to GISAID database were analyzed with respect to genomic clades and their geographic, age, and gender distributions. Of the currently known SARS-CoV-2 clades, clade GR was the most prevalent worldwide followed by GV then GH. Chronological analysis revealed expansion in SARS-CoV-2 clades carrying D614G mutations with the predominance of the newest clade, GV, in the last three months. D614G clades prevail in countries with more COVID-19 cases. Of them, the clades GH and GR were more frequently recovered from severe or deceased COVID-19 cases. In contrast, G and GV clades showed a significantly higher prevalence among asymptomatic patients or those with mild disease. Metadata analysis showed higher (p < 0.05) prevalence of severe/deceased cases among males than females and predominance of GR clade in female patients. Furthermore, severe disease/death was more prevalent (p < 0.05) in elderly than in adults/children. Higher prevalence of the GV clade in children compared to other age groups was also evident. These findings uniquely provide a statistical evidence on the adaptation-driven evolution of SARS-CoV-2 leading to altered infectivity, virulence, and mortality.

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