Age-associated changes in vascular health and its relation with erythropoietin

Objectives: Vascular stiffness due to ageing assessed by alteration in mean arterial blood pressure, brachial-ankle and carotid-femoral pulse wave velocity (b-f PWV/c-f PWV) and brachial and ankle arterial stiffness index (ASI). The present study aimed to determine the influence of ageing on vascular health and its relation to oxygen sensing protein that is, erythropoietin (EPO), in both genders (men and women). Materials and Methods: Randomly selected 204 healthy participants involving men and women between 20 and 95 years among the general population of city. The total sample size was split into six groups from Group I to VI, each containing 17 men participants and 17 women participants. We determined PWV [brachial-ankle and carotid-femoral (PWV)] and ASI (brachial ASI and ankle ASI) by using periscope and estimated serum erythropoietin (Epo) by ELISA method and implemented a one-way ANOVA post hoc test for statistical analysis by using SPSS software version 23. Results: Decreased serum EPO with increased vascular parameters such as mean arterial pressure (MAP), PWV and ASI observed in Group 5 and 6 of both genders. Conclusion: We conclude that ageing influences PWV, ASI, MAP and EPO in men and women participants.

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Cardiovascular response to physical exercise and the risk of Internet addiction in 15–16-year-old adolescents

Journal of Behavioral Addictions ◽

10.1556/2006.2021.00021 ◽

2021 ◽

Author(s):

Liliya V. Poskotinova ◽

Olga V. Krivonogova ◽

Oleg S. Zaborsky

Keyword(s):

Heart Rate ◽

Physical Exercise ◽

Internet Addiction ◽

Cardiovascular Response ◽

Total Sample ◽

Significant Group ◽

Arterial Blood ◽

Group I ◽

Health Related ◽

Group Ii

AbstractBackground and aimSubjective symptoms of Internet addiction (IA), such as interpersonal and health-related problems (IH-RP), do not correlate with objective physiological parameters. This study aimed to investigate the cardiovascular reactivity after physical exercise in 15–16-year-old adolescents showing different severities of symptoms of health-related problems due to Internet overuse.MethodsThis study included 20 healthy adolescents (boys, 15–16 years) with different risks of IA (by the Chen internet addiction scale [CIAS]). The physical exercise test was to perform a standing broad jump three times. The arterial blood pressures and heart rates were recorded before, immediately after, and at 4 minutes of rest after exercise.Results and discussionThe total sample of adolescents was divided into two groups, that is, those with IH-RP scores of 12 or less (Group I, n = 12) and those scoring more than 12 points (Group II, n = 8). The diastolic blood pressure significantly increased after exercise in group II, whereas it remained stable in group I. The heart rate in group I tended to increase, but the changes were not statistically significant. Group II adolescents showed significant increases in heart rate, and at rest, this parameter was significantly higher than the baseline value.ConclusionsAdolescents with a risk of IA and severe symptoms of interpersonal and health-related problems had increased sympathetic activity during and after speed-strength physical exercise compared to those without the aforementioned symptoms.

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Oxygen Fraction Adjustment According to Body Surface Area during Extracorporeal Circulation

The Heart Surgery Forum ◽

10.1532/hsf.1325 ◽

2015 ◽

Vol 18 (3) ◽

pp. 098

Author(s):

Cem Arıtürk ◽

Serpil Ustalar Özgen ◽

Behiç Danışan ◽

Hasan Karabulut ◽

Fevzi Toraman

Keyword(s):

Body Temperature ◽

Surface Area ◽

Body Surface Area ◽

Body Surface ◽

Extracorporeal Circulation ◽

Group Iii ◽

Oxygen Fraction ◽

Arterial Blood ◽

Group I ◽

Group Ii

Background: The inspiratory oxygen fraction (FiO2) is usually set between 60% and 100% during conventional extracorporeal circulation (ECC). However, this strategy causes partial oxygen pressure (PaO2) to reach hyperoxemic levels (>180 mmHg). During anesthetic management of cardiothoracic surgery it is important to keep PaO2 levels between 80-180 mmHg. The aim of this study was to assess whether adjusting FiO2 levels in accordance with body temperature and body surface area (BSA) during ECC is an effective method for maintaining normoxemic PaO2 during cardiac surgery.Methods: After approval from the Ethics Committee of the University of Acıbadem, informed consent was given from 60 patients. FiO2 adjustment strategies applied to the patients in the groups were as follows: FiO2 levels were set as 0.21 × BSA during hypothermia and 0.21 × BSA + 10 during rewarming in Group I; 0.18 × BSA during hypothermia and 0.18 × BSA + 15 during rewarming in Group II; and 0.18 × BSA during hypothermia and variable with body temperature during rewarming in Group III. Arterial blood gas values and hemodynamic parameters were recorded before ECC (T1); at the 10th minute of cross clamp (T2); when the esophageal temperature (OT) reached 34°C (T3); when OT reached 36°C (T4); and just before the cessation of ECC (T5).Results: Mean PaO2 was significantly higher in Group I than in Group II at T2 and T3 (P = .0001 and P = .0001, respectively); in Group I than in Group III at T1 (P = .02); and in Group II than in Group III at T2, T3, and T4 (P = .0001 for all). Conclusion: Adjustment of FiO2 according to BSA rather than keeping it at a constant level is more appropriate for keeping PaO2 between safe level limits. However, since oxygen consumption of cells vary with body temperature, it would be appropriate to set FiO2 levels in concordance with the body temperature in the rewarming period.

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DAILY VARIABILITY OF ARTERIAL STIFFNESS INDEX IN RELATION TO TARGET ORGAN DAMAGE AND SEVERITY OF ARTERIAL HYPERTENSION

Journal of Hypertension ◽

10.1097/01.hjh.0000539491.80964.81 ◽

2018 ◽

Vol 36 (Supplement 1) ◽

pp. e179

Author(s):

A. Merezhanova ◽

E. Tarlovskaya ◽

K. Mazalov ◽

M. Mazalova ◽

N. Kamardina ◽

...

Keyword(s):

Arterial Stiffness ◽

Arterial Hypertension ◽

Target Organ Damage ◽

Organ Damage ◽

Target Organ ◽

Stiffness Index ◽

Daily Variability ◽

Arterial Stiffness Index

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Utility of the Mini-Cog for Detection of Cognitive Impairment in Primary Care: Data from Two Spanish Studies

International Journal of Alzheimer s Disease ◽

10.1155/2013/285462 ◽

2013 ◽

Vol 2013 ◽

pp. 1-7 ◽

Cited By ~ 5

Author(s):

Cristóbal Carnero-Pardo ◽

Isabel Cruz-Orduña ◽

Beatriz Espejo-Martínez ◽

Carolina Martos-Aparicio ◽

Samuel López-Alcalde ◽

...

Keyword(s):

Primary Care ◽

Cognitive Impairment ◽

Characteristic Curve ◽

Total Sample ◽

Phase Iii ◽

Kappa Index ◽

Two Phase ◽

Clock Drawing Test ◽

Pooled Data ◽

Post Hoc

Objectives. To study the utility of the Mini-Cog test for detection of patients with cognitive impairment (CI) in primary care (PC).Methods. We pooled data from two phase III studies conducted in Spain. Patients with complaints or suspicion of CI were consecutively recruited by PC physicians. The cognitive diagnosis was performed by an expert neurologist, after formal neuropsychological evaluation. The Mini-Cog score was calculatedpost hoc, and its diagnostic utility was evaluated and compared with the utility of the Mini-Mental State (MMS), the Clock Drawing Test (CDT), and the sum of the MMS and the CDT (MMS+CDT) using the area under the receiver operating characteristic curve (AUC). The best cut points were obtained on the basis of diagnostic accuracy (DA) and kappa index.Results. A total sample of 307 subjects (176 CI) was analyzed. The Mini-Cog displayed an AUC (±SE) of0.78±0.02, which was significantly inferior to the AUC of the CDT (0.84±0.02), the MMS (0.84±0.02), and theMMS+CDT(0.86±0.02). The best cut point of the Mini-Cog was 1/2 (sensitivity 0.60, specificity 0.90, DA 0.73, and kappa index0.48±0.05).Conclusions. The utility of the Mini-Cog for detection of CI in PC was very modest, clearly inferior to the MMS or the CDT. These results do not permit recommendation of the Mini-Cog in PC.

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Ambulatory arterial stiffness index predicts stroke in a general population

Journal of Hypertension ◽

10.1097/01.hjh.0000249703.57478.78 ◽

2006 ◽

Vol 24 (11) ◽

pp. 2247-2253 ◽

Cited By ~ 114

Author(s):

Tine W Hansen ◽

Jan A Staessen ◽

Christian Torp-Pedersen ◽

Susanne Rasmussen ◽

Yan Li ◽

...

Keyword(s):

General Population ◽

Arterial Stiffness ◽

Stiffness Index ◽

Arterial Stiffness Index

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Effect of unilateral resistance training on arterial compliance in elderly men

Applied Physiology Nutrition and Metabolism ◽

10.1139/h07-048 ◽

2007 ◽

Vol 32 (4) ◽

pp. 670-676 ◽

Cited By ~ 9

Author(s):

Fleur Poelkens ◽

Mark Rakobowchuk ◽

Kirsten A. Burgomaster ◽

Maria T.E. Hopman ◽

Stuart M. Phillips ◽

...

Keyword(s):

Blood Pressure ◽

Resistance Training ◽

Arterial Compliance ◽

Stiffness Index ◽

Elderly Men ◽

Arterial Diameter ◽

Healthy Elderly ◽

Arterial Blood ◽

The Impact ◽

Peak Blood

An increase in age coincides with a decrease in arterial compliance, which is related to a higher risk for cardiovascular accidents. Evidence regarding the effects of resistance training on arterial compliance is conflicting. Currently, little information is available about the effect of resistance training on arterial compliance in elderly men. We assessed the impact of 10 weeks of unilateral arm and leg resistance training on carotid, brachial, and femoral arterial compliance in 12 healthy elderly men (mean age ± SD, 71 ± 7 y). Arterial compliance was evaluated before, after 4 weeks, and after 10 weeks of unilateral resistance training by simultaneously measuring arterial diameter and blood pressure in each artery. There were no significant differences in arterial compliance or stiffness index in any of the arteries examined after 10 weeks of training. However, after 10 weeks of resistance training, resting heart rate decreased from 76 ± 4 beats/min to 61 ± 3 beats/min (p < 0.05), plasma glucose decreased from 6.0 ± 0.9 to 5.1 ± 0.9 mmol/L (mean ± SE) (p < 0.05), and carotid artery peak blood flow increased from 1831 mL/min to 2245 mL/min (p < 0.05). There were no significant changes in resting arterial blood pressure. Unilateral resistance training for 10 weeks does not alter peripheral and central arterial compliance elderly men.

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