Aggressive granular cell tumor of the neurohypophysis with optic tract edema and invasion into third ventricle

Background: Granular cell tumors (GCTs) of the neurohypophysis are parasellar tumors arising from pituicytes in the neurohypophysis and are generally considered benign slow-growing tumors. We present a case of sellar GCT with aggressive features. Case Description: A 70-year-old female presented with progressive vision impairment found to have bitemporal visual field defects. Subsequent magnetic resonance imaging (MRI) revealed a 2.9 cm × 2.5 cm × 2.5 cm parasellar mass with extension into the third ventricle and causing optic tract edema (OTE). Right frontotemporal orbital craniotomy was performed and the tumor was partially removed to decompress optic nerves. Pathology identified the tumor as granular tumor of the sellar region. The patient’s vision improved minimally after the surgery. Follow-up MRI after 3 months and 11 months showed stable left OTE. Conclusion: GCTs were thought to be benign tumors with slow growth, but they could potentially possess aggressive features and invade into surrounding structures as described in this case. OTE can be a rare MRI finding of GCTs. Only one case of GCT-related OTE has been reported in literature to our best knowledge.

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Intractable Trigeminal Neuralgia Secondary to Osteoma of the Clivus: A Case Report and Literature Review

Journal of Neurosciences in Rural Practice ◽

10.1055/s-0041-1742118 ◽

2022 ◽

Author(s):

Ebtesam Abdulla ◽

Krishna Das ◽

Joseph Ravindra ◽

Tejal Shah ◽

Sara George

Keyword(s):

Trigeminal Neuralgia ◽

Pressure Effect ◽

Benign Tumors ◽

Radiographic Images ◽

Patient Reported ◽

Magnetic Resonance Imaging Mri ◽

The Right ◽

Slow Growing ◽

Serial Observation

AbstractSkull base osteomas (SBOs) are benign tumors that are frequently detected on radiographic images by coincidence. They are known for being slow-growing tumors and rarely symptomatic. The therapeutic approach for SBOs can differ substantially. Depending on the symptoms, size, and location of the tumor, this can range from serial observation to vigorous surgical extirpation. Clival osteoma is extremely rare. We report a case of clival osteoma, causing intractable trigeminal neuralgia due to the pressure effect on the trigeminal nerve at Meckel's cave. We also provide a review of pertinent literature. A 37-year-old woman presented with intractable trigeminal neuralgia. Cranial magnetic resonance imaging (MRI) demonstrated a large, lobulated, extra-axial lesion involving the right cerebellopontine angle and epicentering the clivus. Pathologically, the specimen was proven to be osteoma. The patient reported complete symptom resolution over a 4-year follow-up period. To the best of the authors' knowledge, this is the first clinical case of intractable trigeminal neuralgia due to clival osteoma.

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Giant Parotid Pleomorphic Adenoma with Atypical Histological Presentation and Long-Term Recurrence-Free Follow-Up after Surgery: A Case Report and Review of the Literature

Case Reports in Dentistry ◽

10.1155/2020/8828775 ◽

2020 ◽

Vol 2020 ◽

pp. 1-18

Author(s):

Mohammed AlKindi ◽

Sundar Ramalingam ◽

Lujain Abdulmajeed Hakeem ◽

Manal A. AlSheddi

Keyword(s):

Pleomorphic Adenoma ◽

Surgical Management ◽

Early Stage ◽

English Literature ◽

Benign Tumors ◽

Adjuvant Radiation ◽

Extracapsular Dissection ◽

Slow Growing

Salivary gland tumors (SGT) comprise 3% of all head and neck tumors, are mostly benign, and arise frequently in the parotid gland. Pleomorphic adenoma (PA) is the commonest SGT, representing 60-70% of all benign parotid tumors. Clinically, parotid PA presents as irregular, lobulated, asymptomatic, slow-growing preauricular mass, involving both superficial and deep lobes, and could grow to gigantic proportions. Histologically, PA has epithelial and mesenchymal elements in chondromyxoid matrix and is managed surgically. Based on a review of 43 cases reported in English literature since 1995, giant parotid PA is reported as large as 35 cm (diameter) and 7.3 kg (resected weight). Although rare, 10 cases of malignant transformation were reported in the review. Surgical management included extracapsular dissection (ECD), superficial parotidectomy, and total parotidectomy for benign tumors, and adjuvant radiation or chemotherapy for malignant tumors. We further present the case of a 36-year-old healthy male with slow-growing and asymptomatic giant parotid PA, of 4-year duration. The patient presented with firm, lobulated preauricular swelling, provisionally diagnosed as PA based on radiographic and cytological findings. The tumor was resected through ECD, and the patient had uneventful postoperative recovery and a 7-year recurrence-free follow-up period. Histological examination revealed epimyoepithelial proliferation punctuated by chondromyxoid areas, with extensive squamous metaplasia and keratin cysts. To the best of knowledge from indexed literature, giant parotid PA is rarely reported in Saudi Arabia. In addition to its rarity, this case is reported for its benign nature despite atypical histological presentation, successful surgical management without complications, and long-term recurrence-free follow-up. Based on this report, clinicians must be aware of atypical histological presentations associated with PA and plan suitable surgical management and follow-up to avoid morbidity. Nevertheless, attempts must be made to diagnose and manage these lesions at an early stage and before they reach gigantic proportions.

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Benign Granular Cell Tumors of the Larynx: A Review of 36 Cases with Clinicopathologic Data

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348947508400304 ◽

1975 ◽

Vol 84 (3) ◽

pp. 308-314 ◽

Cited By ~ 47

Author(s):

John Compagno ◽

Vincent J. Hyams ◽

Pierre Ste-Marie

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Vocal Cord ◽

Granular Cell Tumor ◽

Squamous Epithelium ◽

Granular Cell ◽

Cell Tumor ◽

Clinical Impression ◽

True Vocal Cord

The clinical, microscopic, and gross features of 36 cases of benign granular cell tumor arising in the larynx are reviewed and studied. This infrequent lesion, when in the larynx, is found most commonly on the true vocal cord in adults in their third, fourth, and fifth decades; there is no obvious sex predilection. Slowly increasing hoarseness was the primary complaint in our cases. Clinically, the tumors are considered benign. The most common clinical impression was a vocal cord papilloma. The microscopic pattern of the granular cell tumors is uniform and bland, but there may be a marked pseudoepitheliomatous hyperplasia of the overlying squamous epithelium, often stimulating squamous cell carcinoma. Follow-up information is discussed, as is the origin and histogenesis of this lesion.

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Cervicomedullary Ganglioglioma in a Child – A Case Report

Prague Medical Report ◽

10.14712/23362936.2018.12 ◽

2018 ◽

Vol 119 (2-3) ◽

pp. 122-127

Author(s):

Eshagh Bahrami ◽

Morteza Taheri ◽

Feyzollah Ebrahimniya

Keyword(s):

Spinal Cord ◽

Cervical Spinal Cord ◽

Frozen Section ◽

Young Patients ◽

Neurological Status ◽

Upper Cervical ◽

Magnetic Resonance Imaging Mri ◽

Slow Growing ◽

Section Report

Ganglioglioma is a benign slow-growing neoplasm that most frequently occurs at the supratentorial region. Nevertheless, there are occasional reports of ganglioglioma occurring in the brainstem and spinal cord. Here we report a rare case of the craniocervical ganglioglioma. A 3.5-year-old male, presented with severe progressive quadriparesis, gait disturbance, and sphincter deficit. Physical examination demonstrated the quadriparesis, associated with positive Hoffman, Babinski, and clonus signs, and increased respond of deep tendon reflexes. Magnetic resonance imaging (MRI) demonstrated an ill-defined mass within medulla and upper cervical spinal cord, which was hypo to iso signal on T1, heterogeneous iso to hypersignal on T2 and demonstrated marked bright enhancement on T1 with gadolinium (Gad) injection. On surgery, the mass had a soft texture, ill-defined border, and grey to brown appearance. According to the frozen section report, and due to the absence of the tumour-neural parenchymal interference, only decompression of the tumour and expansile duraplasty were performed. The histopathology revealed ganglioglioma. On last follow-up 14 months after surgery, the patient was asymptomatic and neurological status was improved. The craniocervical MRI demonstrated the tumour that did not grow. Although it is rare, the ganglioglioma should be in the differentiated diagnoses of tumours with compatible clinical and radiologic features even in the unusual locations, especially in the pediatric and young patients. Safety surgical resection should be considered in these patients, whenever possible. In the case of partial resection, that is common in the tumours located within functionally critical structures, long close follow-up rather than radiation therapy is required.

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A Rare Case of a Metastatic Malignant Abrikossoff Tumor

Case Reports in Oncology ◽

10.1159/000520385 ◽

2021 ◽

pp. 1868-1875

Author(s):

Mohamed Tayeb Salaouatchi ◽

Sandra De Breucker ◽

Héloise Rouvière ◽

Véronique Lesage ◽

Laureen Jeanne Armande Rocq ◽

...

Keyword(s):

Granular Cell Tumor ◽

Soft Tissues ◽

Granular Cell ◽

Cell Tumor ◽

Benign Tumors ◽

Large Size ◽

Positron Emission ◽

History Of ◽

Malignant Granular Cell Tumor ◽

Malignant And Benign Tumors

Abrikossoff tumor, also called granular cell tumor (GCT), is a neoplasm of the soft tissues which is most commonly a solitary, painless, and benign tumor. However, 2% of Abrikossoff tumors can be malignant. We report here the case of a 75-year-old male who presented a local recurrence of Abrikossoff tumor of the left thigh. The anatomopathological analysis concluded to a malignant GCT, and the F-18 fluorodeoxyglucose positron emission tomography showed multiple lesions in the lymph nodes and bones. The potential conversion to malignancy should alert practitioners because of the extremely poor prognosis. The diagnosis of malignant granular cell tumor should be based on a bundle of clinical and histological features and not solely on histologic features because of the challenging distinction between malignant and benign tumors due to the lack of well-defined criteria for the diagnosis of malignancy. Large size and recurrence are the most important clinical features predicting malignant behavior. Patients with a history of Abrikossoff tumor should be followed closely to monitor recurrence and malignant transformation. The apparent originality of our observation – which could lie in the evolution of a GCT tumor, initially considered as benign, to a malignant form – has to be challenged regarding the issue of classifying some cases according to the classical “benign” and “malignant” dichotomy.

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Granular cell tumor of the common hepatic duct presenting as cholangiocarcinoma and acute acalculous cholecystitis

Acta chirurgica iugoslavica ◽

10.2298/aci0804099b ◽

2008 ◽

Vol 55 (4) ◽

pp. 99-101 ◽

Cited By ~ 8

Author(s):

D. Bilanovic ◽

I. Boricic ◽

D. Zdravkovic ◽

T. Randjelovic ◽

N. Stanisavljevic ◽

...

Keyword(s):

Granular Cell Tumor ◽

Hepatic Duct ◽

Acalculous Cholecystitis ◽

Granular Cell ◽

Biliary Tree ◽

Cell Tumor ◽

Common Hepatic Duct ◽

Benign Tumors ◽

Acute Acalculous Cholecystitis ◽

Extrahepatic Biliary Tree

Granular cell tumors (GCT) are rare benign tumors. Less than 1% of GCTs involve the extrahepatic biliary tree. Most researches favor a Schwann cell origin. Patient, caucasion, female, 31 year old presented with 4 month history of painless jaundice and pruritus. US and CT revealed dilatation of intrahepatic biliary tree and surgery was performed. Firm tumor mass was found above the conjunction of cystic duct and common hepatic duct (CHD) that caused obstruction and gallblader empyema. The patient underwent radical surgical procedure because Klatskin tumor was clinically suspected. Patohystology and immunohistochemistry confirmed granular cell tumor. Eight years after surgery the patient is wellbeing without symptoms. To our knowledge 69 cases of GCT of the extrahepatic biliary tree have been reported and none of the acute acalculous cholecystitis case accompanied by GCT of CHD. Granular cell tumors are rarely diagnosed preoperatively. Wide resection offers the best chance for cure.

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Transnasal endoscopic resection of nasal chondromesenchymal hamartoma in infancy: an analysis of 5 cases

BMC Pediatrics ◽

10.1186/s12887-021-03082-4 ◽

2022 ◽

Vol 22 (1) ◽

Author(s):

Zheng Jie Zhu ◽

Qi Huang ◽

Lan Cheng ◽

Jun Yang

Keyword(s):

Endoscopic Resection ◽

Tumor Resection ◽

Diagnostic Techniques ◽

Endoscopic Approach ◽

Benign Tumors ◽

Radiographic Findings ◽

Transnasal Endoscopic Approach ◽

Magnetic Resonance Imaging Mri ◽

Midfacial Degloving

Abstract Background Nasal chondromesenchymal hamartomas (NCMHs) are extremely rare benign tumors that most commonly affect children in the first year of life. The purpose of this study was to investigate and summarize the characteristics of NCMH cases and the efficacy of transnasal endoscopic resection of NCMHs. Methods This is a retrospective study including 5 cases of infant diagnosed as NCMH between April 2016 and April 2020. Diagnostic techniques include nasoendoscopy, computerized tomography (CT) scan, magnetic resonance imaging (MRI) with contrast and microscopic and immunohistologic studies. Data collected included patient demographics, patient symptoms, radiographic findings, characteristics of tumor growth, follow-up time, recurrence, and postoperative complications. Results In 5 cases, 3 were males and 2 were females who aged 1, 2, 3, 6 months and 1 year, respectively. The size of the mass measured 1.6 cm*1.9 cm*1.8 cm at its smallest and largest was 4.0 cm*3.5 cm*3.0 cm. All five patients underwent tumor resection via transnasal endoscopic approach. Four tumors were completely removed, and one underwent partial resection, which was completely resected by midfacial degloving operation 13 months after the first surgery. There was no postoperative complication. The current postoperative follow-up period was 1 to 4 years, and no recurrence has been observed. Conclusions Complete surgical resection of NCHM is necessary to resolve the symptoms and prevent recurrence. Transnasal endoscopic approach is a safe and effective choice for pediatric NCMH patients.

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Pediatric Granular Cell Tumor of the Breast: A Case Report and Review of the Literature

Case Reports in Surgery ◽

10.1155/2015/568940 ◽

2015 ◽

Vol 2015 ◽

pp. 1-6

Author(s):

Nathan P. Heinzerling ◽

Shannon M. Koehler ◽

Sara Szabo ◽

Amy J. Wagner

Keyword(s):

Granular Cell Tumor ◽

Granular Cell ◽

Excisional Biopsy ◽

Cell Tumor ◽

The Body ◽

Positive Staining ◽

Review Of The Literature ◽

Rare Presentation ◽

Breast Masses

Objective. Granular cell tumors arise from neurogenic mesenchymal stem cells and can occur anywhere throughout the body. They rarely present as breast masses and should be included in the differential diagnosis of pediatric breast neoplasms. We report a rare presentation of a pediatric breast granular cell tumor and a review of the literature.Participant. A 15-year-old female presented with an enlarging breast mass. She underwent ultrasound imaging and excisional biopsy, which revealed a granular cell tumor. Granular cell tumors of the breast are difficult to diagnose using ultrasound and mammography due to numerous similarities to other breast masses. Histopathologic staining best differentiates breast granular cell tumors from other breast masses with their positive staining for S100, CD68, and neurospecific enolase.Conclusion. Although rare, granular cell tumors of the breast should be considered as a possible diagnosis for pediatric breast masses to allow for proper management and follow-up for these patients. Although rare, these tumors do have malignant potential necessitating a correct and timely diagnosis.

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Biliary Duct Granular Cell Tumor: A Rare But Surgically Curable Benign Tumor

HPB Surgery ◽

10.1155/1993/68037 ◽

1993 ◽

Vol 6 (4) ◽

pp. 311-317 ◽

Cited By ~ 8

Author(s):

W. David Lewis ◽

Joseph F. Buell ◽

Roger L. Jenkins ◽

Peter A. Burke

Keyword(s):

Granulosa Cell ◽

Granular Cell Tumor ◽

Granulosa Cell Tumor ◽

Granular Cell ◽

Surgical Excision ◽

Biliary Tree ◽

Cell Tumor ◽

The Body ◽

Benign Tumors ◽

Biliary Duct

Granulosa cell tumors are rare benign tumors which may be found throughout the body. Rare cases are isolated within the biliary tree. If completely resected, surgical excision is curative.A case of biliary duct granulosa cell tumor is presented with review of the world’s literature on this topic.

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Abriks's tumor in a teenager's tongue - a case report

Polski Przegląd Otorynolaryngologiczny ◽

10.5604/01.3001.0012.7839 ◽

2018 ◽

Vol 7 (4) ◽

pp. 1-5

Author(s):

Przemysław Krawczyk ◽

Daniel Majszyk ◽

Antoni Bruzgielewicz ◽

Kazimierz Niemczyk

Keyword(s):

Case Report ◽

Children And Adolescents ◽

Malignant Transformation ◽

Surgical Resection ◽

Granular Cell Tumor ◽

Benign Neoplasm ◽

Granular Cell ◽

Cell Tumor ◽

Upper Airways

Granular cell tumor is benign neoplasm rarely diagnosed among young children and adolescents. The tumor developed commonly within mucous membrane of upper airways, but precise etiology is not known. Treatment is based on surgical resection of tumor and intense follow up due to risk of recurrence and malignant transformation.

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