scholarly journals Effects of preformed physical factors on blood rheology in patients with chronic post-embolic pulmonary hypertension

2021 ◽  
pp. 64-72
Author(s):  
Н.П. Александрова ◽  
И.В. Погонченкова
Keyword(s):  
Pulmonary Hypertension ◽  
Blue Light ◽  
Uv Irradiation ◽  
Blood Viscosity ◽  
Blood Rheology ◽  
Erythrocyte Aggregation ◽  
Physical Factors ◽  
Basic Therapy ◽  
Experimental Group ◽  
Basic Treatment

Введение. Основу взаимодействия физических факторов и организма составляют электрические и биоэнергетические процессы, вызывающие изменения показателей центральной и периферической гемодинамики, обменных процессов, трофики, дыхания, реактивности и сопротивляемости организма. К таким физическим факторам, в частности, относятся электромагнитные колебания оптического излучения или фототерапия. Цель исследования - оценка эффективности воздействия коротковолнового излучения (фотогемотерапии, ФГТ) и ультрафиолетового (УФ) облучения крови на ее реологические свойства в комплексной терапии больных хронической постэмболической легочной гипертензией (ХПЛГ). Методика. Проведено комплексное клинико-лабораторное обследование 64 пациентов (30 женщин и 34 мужчины), поступивших в клинику с симптомами хронической легочной недостаточности, развившейся после перенесенной тромбоэмболии легочной артерии. Больные ХПЛГ были распределены в 3 группы: 1-ю (контрольную) группу составили 15 пациентов, получавшие только базисное лечение; 2-ю (экспериментальную) группу - 26 больных, получавшие базисную терапию в комплексе с ФГТ; 3-ю (экспериментальную) группу - 23 пациента, которые получали базисную терапию в сочетании с воздействием на кровь УФ облучения. Для ФГТ синим светом и УФ воздействия на кровь применяли аппараты АФС-Соларис (Россия) со светодиодами, излучающими синий свет с длиной волны 450 ± 10 нм, и УФ лучи с длиной волны 365 ± 10 нм. Исследовали вязкость крови на ротационном вискозиметре RotoVisco-100 (Нааке GmbH, Германия) в диапазоне скоростей сдвига от 1 до 150 с-1, агрегацию эритроцитов на колориметре-нефелометре ФЭК-56 М (Россия), показатель гематокрита на гематокритной центрифуге (Autocrit, США). Результаты. У больных 1-й группы после базисного медикаментозного лечения отсутствовали статистически значимые изменения вязкости крови, агрегации эритроцитов и показателя гематокрита. У пациентов как 2-й, так и 3-й группы выявлены статистически значимые изменения реологических свойств крови: снижение вязкости крови, агрегации эритроцитов, показателя гематокрита. Заключение. Оптическое излучение синего света имеет выраженное физиологическое воздействие: вызывает медленный, но пролонгированный положительный эффект на реологические свойства крови. УФ облучение при воздействии на кровь также способствует улучшению гемореологии и циркуляции крови и активирует рудиментарные механизмы, запускающие адаптационные системы организма, ранее не функционирующие. Introduction. Electrical and bioenergetic processes that cause changes in central and peripheral hemodynamics, metabolic processes, trophism, respiration, reactivity, and body resistance are the basis of interaction between physical factors and the body. Such physical factors include, in particular, electromagnetic oscillations of the optical radiation or phototherapy. Aim: to assess the effectiveness of short-wave radiation (photohemotherapy, PHT) and ultraviolet (UV) irradiation of blood on its rheology in the complex treatment of chronic post-embolic pulmonary hypertension (CPPH). Methods. 64 patients (30 women and 34 men) with symptoms of chronic pulmonary insufficiency secondary to pulmonary embolism underwent a comprehensive clinical and laboratory examination. CPPH patients were divided into 3 groups: the 1st (control) group consisting of 15 patients who received only a basic treatment; the 2nd (experimental) group including 26 patients who received a basic therapy combined with PHT; and the 3rd (experimental) group consisting of 23 patients who received a basic therapy combined with UV irradiation of blood. AFS-Solaris devices (Russia) producing light-emitting diode-derived blue light with a wavelength of 450 ± 10 nm were used for FGT, and UV rays with a wavelength of 365 ± 10 nm were used for the UV exposure of blood. Blood viscosity was measured on a RotoVisco-100 (Нааке GmbH, Germany) rotational viscometer at shear rates ranging from 1 to 150 s-1; erythrocyte aggregation was studied with a FEK-56 M (Russia) colorimeter-nephelometer; and hematocrit was measured with a hematocrit centrifuge (Autocrit, USA). Results. There were no statistically significant changes in blood viscosity, erythrocyte aggregation, or hematocrit values in the 1st group after the basic treatment. Statistically significant changes in blood rheology parameters observed in both the 2nd and 3rd groups included decreases in blood viscosity, erythrocyte aggregation, and hematocrit values. Conclusion. Optical irradiation with blue light exerted a pronounced physiological effect evident as a slow but long-standing positive influence on blood rheology parameters. The UV irradiation of blood also improved hemorheology and blood circulation and activated rudimentary mechanisms triggering previously non-functional adaptive systems.

scholarly journals Peculiarities of blood rheology in patients with chronic generalized periodontitis combined with gastrointestinal tract disturbances

2003 ◽  
Vol 2 (4) ◽  
pp. 72-79
Author(s):  
V. F. Kiritchuk ◽  
V. Yu. Shirokov
Keyword(s):  
Duodenal Ulcer ◽  
Gastrointestinal Tract ◽  
Rheological Properties ◽  
Blood Viscosity ◽  
Oxygen Delivery ◽  
Blood Rheology ◽  
Erythrocyte Aggregation ◽  
Chronic Colitis ◽  
Nonspecific Ulcer ◽  
Rotary Viscometer

The aim of investigation is to study blood rheological properties in patients with chronic generalised periodontitis combined with gastrointestinal tract disturbances. 205 patients have been examined including those with erosive ulcerous involvement of gastroduodenal area — 51, with stomach ulcer and duodenal ulcer — 62, with chronic colitis — 39, with nonspecific ulcer colitis — 53. Blood viscosity properties, indices of erythrocyte aggregation and deformability, rate of oxygen delivery to tissues have been evaluated by rotary viscometer АBR-2 (Russia). It has been revealed that blood rheological properties in patients with chronic generalised periodontitis combined with gastrointestinal tract disturbances had been disturbed, that was accompanied with the blood viscosity rise, erythrocyte aggregation increase and with the decrease of deformability and rate of oxygen delivery to tissues. The degree of violations in blood rheology indices was mostly expressed under chronic and plural erosions of gastroduodenal area, duodenal ulcer and severe course of chronic nonspecific ulcer colitis.

Blood rheology in vegetarians

1986 ◽  
Vol 56 (3) ◽  
pp. 555-560 ◽  
Author(s):  
E. Ernst ◽  
L. Pietsch ◽  
A. Matrai ◽  
J. Eisenberg
Keyword(s):  
Blood Viscosity ◽  
Blood Rheology ◽  
Risk Groups ◽  
Plasma Viscosity ◽  
Erythrocyte Aggregation ◽  
Animal Products ◽  
In Vitro Measurements ◽  
Atherosclerotic Changes

1. Blood rheology has been quantified by measuring blood and plasma viscosity, packed cell volume (PCV), erythrocyte filterability and erythrocyte aggregation in forty-eight voluntary vegetarians and compared with matched controls.2. Results show that in vegetarians, values for PCV were lower than those in controls, leading to reduced native blood viscosity. In addition PCV-standardized blood viscosity was also decreased. This was brought about mostly by lower plasma viscosity. Erythrocyte rheology seemed to be unaltered. Stricter avoidance of animal products was associated with even lower values for these indices.3. These observations are in agreement with the fact that other low-cardiovascular-risk groups show better than average blood fluidity. They are consistent with the hypothesis that in vitro measurements of blood rheology may provide signs of early atherosclerotic changes in vivo.

Blood rheology in acute mountain sickness and high-altitude pulmonary edema

1991 ◽  
Vol 71 (3) ◽  
pp. 934-938 ◽  
Author(s):  
W. H. Reinhart ◽  
B. Kayser ◽  
A. Singh ◽  
U. Waber ◽  
O. Oelz ◽  
...  
Keyword(s):  
Pulmonary Edema ◽  
High Altitude ◽  
Acute Mountain Sickness ◽  
Blood Rheology ◽  
Plasma Viscosity ◽  
Erythrocyte Deformability ◽  
Erythrocyte Aggregation ◽  
High Altitude Pulmonary Edema ◽  
Mountain Sickness ◽  
Low Altitude

The role of blood rheology in the pathogenesis of acute mountain sickness and high-altitude pulmonary edema was investigated. Twenty-three volunteers, 12 with a history of high-altitude pulmonary edema, were studied at low altitude (490 m) and at 2 h and 18 h after arrival at 4,559 m. Eight subjects remained healthy, seven developed acute mountain sickness, and eight developed high-altitude pulmonary edema. Hematocrit, whole blood viscosity, plasma viscosity, erythrocyte aggregation, and erythrocyte deformability (filtration) were measured. Plasma viscosity and erythrocyte deformability remained unaffected. The hematocrit level was lower 2 h after the arrival at high altitude and higher after 18 h compared with low altitude. The whole blood viscosity changed accordingly. The erythrocyte aggregation was about doubled 18 h after the arrival compared with low-altitude values, which reflects the acute phase reaction. There were, however, no significant differences in any rheological parameters between healthy individuals and subjects with acute mountain sickness or high-altitude pulmonary edema, either before or during the illness. We conclude that rheological abnormalities can be excluded as an initiating event in the development of acute mountain sickness and high-altitude pulmonary edema.

scholarly journals Microcirculatory injuries of patients with chronic generalized periodontitis and their correction with EHF-therapy

2003 ◽  
Vol 2 (2) ◽  
pp. 99-103
Author(s):  
V. F. Kiritchuk ◽  
A. V. Lepilin ◽  
I. P. Apalkov ◽  
N. L. Yerokina
Keyword(s):  
Rheological Properties ◽  
Blood Viscosity ◽  
Oral Fluid ◽  
Anticoagulant Activity ◽  
Wave Length ◽  
Biologically Active ◽  
Erythrocyte Aggregation ◽  
Time Activity ◽  
Hemostasis System ◽  
Fluid Ability

The aim is the study of EHF-therapy (extremely high frequency therapy) potential for the correction of microcirculatory injuries of patients with chronic generalized periodontitis in postsurgery period: in blood rheological properties and hemostasis system, change of oral fluid ability to coagulation. 42 patients have been examined and treated, including a complex periodontium examination: parodontal recess depth, stomatorrhagia at probing and gum capillary resistance. There have been determined a blood viscosity, erythrocyte aggregation, erythrocyte membrane deformability with rotation viscometer ABR-2; as well as activated partial thromboplastin time, prothrombin time, activity with coagulometer «Sola-Cey 2120» (Byelorussia) using reagents of «Tyekhnologiya-standart» company (Barnaul, Russia). An apparatus «Yavj-1» with wave-length of 5,6 mm with the exposure to biologically active face points (cv-26, cv-27, st-7, st-8) has been used for EHF-therapy. There has been demonstrated that patients with chronic generalized periodontitis had blood rheological and coagulation properties disturbed, that accompanied with the increase of blood viscosity, erythrocyte aggregation, tissue prothrombinase activity and the decrease of blood antithrombin and anticoagulant activity. Patients oral fluid components intensify the disturbances in blood rheological properties due to erythrocyte aggregation increase, and at the same time increase the blood coagulation potential. EHF-therapy recovers the blood rheological properties (its viscosity) more effectively, erythrocyte ability to aggregation and hemostasis system factors in comparison with the traditional treatment.

scholarly journals Role of Short-wavelength Blue Light in the Formation of Cataract and Expression of Caspase-1, -11 and Gasdermin D in rat Lens Epithelium Cells: Insight into the Novel Pathogenesis of Cataract.

2019 ◽  
Author(s):  
Yamin Wang ◽  
Min Zhang ◽  
Ying Sun ◽  
Xiaohui Wang ◽  
Zhaowei Song ◽  
...  
Keyword(s):  
Blue Light ◽  
Short Wavelength ◽  
Light Exposure ◽  
The Novel ◽  
Blue Led ◽  
Caspase 1 ◽  
Epithelium Cells ◽  
Experimental Group ◽  
Insight Into

Abstract Background Cataracts have been verified to be associated with a number of risk factors. The sun and artificial light sources, including light-emitting diode (LED) and fluorescent light tubes, are the primary sources of short-wavelength blue light. With the increasing popularity of blue-rich LED-backlit display devices, our eyes are now exposed to more short-wavelength blue light than they were in the past. The goal of this study was to evaluate the role of short-wavelength blue light in the formation of cataract. Additionally, the pathogenesis of cataracts after short-wavelength light exposure was investigated.Methods SD rats were randomly divided into 2 main groups: a control group (10 rats each for the 4-, 8-, and 12-week groups) and an experimental group (10 rats each for the 4-, 8-, and 12-week groups). The rats in the experimental group were exposed to a short-wavelength blue LED lamp for 12 hours per day. After exposure to the blue LED lamp, the rats were maintained in total darkness for 12 hours, after which a 12-hour light/dark cycle was resumed. The intensity of the lamp was 3000 lux. At the end of the short-wavelength blue LED lamp exposure (for 4, 8, and 12 weeks), the expression levels of caspase-1, caspase-11 and gasdermin D (GSDMD) in rat epithelium cells (LECs) were examined in rat epithelial cells (LECs) using qRT-PCR and Western blotting analyses. Results After 6 weeks, cataracts had developed in the experimental rats (4/20 eyes). The clarity of the lens then gradually worsened with the duration of exposure. Twelve weeks later, all of the rat eyes had developed cataracts. Then the expression levels of caspase-1, caspase-11 and GSDMD at 4, 8, and 12 weeks were significantly higher in samples from rats exposed to a short-wavelength blue LED lamp than samples from control rat (p˂0.05). Conclusion The data indicate that pyroptosis play a key role of in cataracts induced by short-wavelength blue light exposure, highlighting caspase-1, caspase-11 and GSDMD as possible therapeutic targets for cataract treatment. This study might provide new insight into the novel pathogenesis of cataracts.

The role of hemorheological disorders in the pathogenesis of hemorrhagic pancreonecrosis

2021 ◽  
Author(s):  
Н.П. Александрова ◽  
В.И. Карандашов ◽  
А.В. Варданян
Keyword(s):  
Sialic Acid ◽  
Shear Rate ◽  
Electrophoretic Mobility ◽  
Blood Viscosity ◽  
Proteolytic Enzymes ◽  
Biologically Active ◽  
Erythrocyte Aggregation ◽  
Control Group ◽  
Mechanical Resistance

Введение. Вопросы патогенеза острого панкреатита и панкреонекроза до настоящего времени остаются в центре внимания исследователей и клиницистов. До сих пор до конца не выяснена роль изменений в системе гемостаза и гемореологических нарушений в развитии этого заболевания. Цель исследования: установить роль гемореологических нарушений в патогенезе геморрагического панкреонекроза и изучить специфику механизма этих расстройств. Материалы и методы. Обследовано 29 пациентов с геморрагическим панкреонекрозом (12 женщин и 17 мужчин) в возрасте от 23 до 60 лет. Исследовали вязкость крови, показатель гематокрита, количество эритроцитов и их диаметр, агрегацию, электрофоретическую подвижность, деформируемость и механическую резистентность эритроцитов, белковый состав плазмы, содержание сиаловой кислоты в плазме и в эритроцитах, параметры липидного обмена, содержание кальция и фибриногена в крови,фибринолитическую активность крови и агрегационную активность тромбоцитов, гемокоагуляционная активность исследована методом тромбоэластографии. Для определения нормальных значений исследованных показателей было обследовано 15 практически здоровых лиц (7 женщин и 8 мужчин). Результаты. У больных панкреонекрозом самым грубым нарушениям подвергаются эритроциты: их механическая резистентность снижалась в 2 раза, объем увеличивался на 18,7%, деформируемость падала на 43,8%, количество снижалось на 8,75%, показатель гематокрита при этом оставался на уровне нормальных значений по причине увеличенного объема (сферичности) клеток; в 1,8 раза возрастала агрегация эритроцитов. Вязкость крови при скорости сдвига 1 c–1 увеличивалась в 3,3 раза, а при скорости сдвига 150 c–1 — в 1,58 раза по сравнению с нормой. Причиной повышения агрегации эритроцитов являлось снижение их электрофоретической подвижности на 35,9% из-за десиализации их мембран: концентрация сиаловой кислоты в клеточных мембранах была снижена на 20,8%, а содержание конъюгированной сиаловой кислоты в плазме увеличено в 2,25 раза по сравнению с нормальными значениями. Заключение. Гемореологические расстройства, которые возникают первоначально у больных геморрагическим панкреонекрозом как результат некротических изменений поджелудочной железы, с определенного, довольно раннего этапа сами становятся фактором патогенеза данного заболевания. Доминирующим фактором прогрессивного увеличения вязкости крови у больных панкреонекрозом является нарушение морфофункциональных и физико-химических свой ств эритроцитов на фоне высокой активности протеолитических ферментов, биологически активных аминов и крайней степени токсемии. Background. The pathogenesis of acute pancreatitis and pancreonecrosis is still the focus of researchers and clinicians. The role of hemorheological disorders in these diseases remain uncertain until now. Objectives: to define the role of hemorheological disorders in the pathogenesis of hemorrhagic pancreonecrosis and to study the specifics of the mechanism of these disorders. Patients/Methods. This study included 29 patients (12 women and 17 men, age of 23 to 60 years old) with hemorrhagic pancreatic necrosis. We examined blood viscosity, hematocrit and some erythrocyte properties as count, diameter, aggregation, electrophoretic mobility, deformability and mechanical resistance; other investigated parameters were plasma protein composition, plasma and erythrocytes sialic acid concentrations, lipids, total calcium and fibrinogen concentrations, blood fibrinolytic activity, platelets aggregation activity; total hemocoagulation activity was studied with thromboelastography. Control group contained 15 practically healthy individuals (7 women and 8 men). Results. Expressed disturbances of blood rheological properties, mostly in erythrocytes were detected in patients with pancreonecrosis. Red blood cells (RBC) showed 2-times decreasing of mechanical resistance, of their volume by 18.7%, of deformability by 43.8%, of count by 8.75%. Hematocrit remained normal level due to RBC increased volume (sphericity). RBC aggregation had been increased by 1.8 times. Blood viscosity at the shear rate of 1 s–1 was increased by 3.3 times and at the shear rate of 150 s–1 by 1.58 times. Raised erythrocyte aggregation was caused by a decrease of RBC electrophoretic mobility of 35.9%. Sialic acid concentration in RBC membranes was lower of 20.8% whereas conjugated sialic acid in plasma showed increasing by 2.25 times. Conclusions. RBC morphofunctional and physicochemical disturbances cause the increase in blood viscosity in patients with pancreonecrosis. It is distinguishing feature of hemorheological disorders in hemorrhagic pancreonecrosis developing, seems, due to high activity of proteolytic enzymes and biologically active amines. Of particular importance in hemorrhagic pancreonecrosis belong to platelet involving into intravascular coagulation.

Study of the effect of menopausal hormone therapy in women with psoriasis type 2 in postmenopause

2016 ◽  
Vol 19 (5) ◽  
pp. 296-300
Author(s):  
Evgeniya P. Opruzhenkova ◽  
O. A Sidorenko ◽  
L. A Anisimova ◽  
V. V Starostenko
Keyword(s):  
Hormone Therapy ◽  
Clinical Manifestations ◽  
Menopausal Hormone Therapy ◽  
Control Group ◽  
Study Group ◽  
Hormonal Status ◽  
Basic Therapy ◽  
Basic Treatment

The results of comparative analysis of the hormonal status from 75 women aged from 49 to 60 years old (average age 54.04 ± 1.28 year) in postmenopause with psoriasis type 2 (study group) and 50 women of control group of the same age and menstrual status without psoriasis are presented. There were two subgroups in the main group: subgroup 1 received basic therapy in combination with menopausal hormone therapy (MHT) (estradiol 1 mg + drospirenone 2 mg), subgroup 2 - basic therapy. Psoriatic process was assessed according to PASI index and was evaluated by the dermatology quality of the life index (DIQL) and the content of gonadotropic and sex hormones before treatment and after 3 and 6 months of starting treatment in patients of both subgroups. More pronounced clinical efficacy in combination with reduced FSH level is 13.2% (p < 0.001), increased content of estradiol 69.3% (p < 0.001) was observed in patients from 1 subgroup. MHT supplement to the basic treatment decreased the PASI index after 3 months of starting treatment for 50.9% (p fter 6 months - at 94% (p < 0.001), and reduced DIQL in subgroup 1 compared to 2 subgroup after 3 months - 15.3% (p < 0.05) and after 6 months - 20.8% (p < 0.05). In postmenopausal women with psoriasis favorable changes of indexes reflecting the clinical manifestations of the disease were associated with the correction of hormonal status in MHT estradiol 1 mg + drospirenone 2 mg.

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