Improving the territorial location of the agro-industrial complex on the basis of considering the peculiarities of the labor, natural and climatic potential of municipal districts is an important factor in increasing the sustainability of rural development. In the present article, a study of the social, natural-climatic and economic-geographical prerequisites for the specialization of the agro-industrial complex of the Western macro-district was conducted. The results of the study were the definition of spatial development concept for the agro-industrial complex based on the formation and development of specialized agricultural zones in the Western macro-district of the Krasnoyarsk region. It was proved that in the conditions of a market economy, the need for scientifically based specialization of rural areas, the development of inter-district economic relations, the creation of combined industries that provide deep processing of agricultural raw materials becomes particularly relevant.