Targeting Cannabidiol to the Intestinal Lymphatic System for Enhanced Immunomodulatory Effects in the Treatment of Autoimmune Diseases

2016 ◽  
Author(s):  
Atheer Zgair
Keyword(s):  
Autoimmune Diseases ◽  
Lymphatic System ◽  
Immunomodulatory Effects

scholarly journals Immunoregulation by Artemisinin and Its Derivatives: A New Role for Old Antimalarial Drugs

2021 ◽  
Vol 12 ◽  
Author(s):  
Feifei Qiu ◽  
Junfeng Liu ◽  
Xiumei Mo ◽  
Huazhen Liu ◽  
Yuchao Chen ◽  
...  
Keyword(s):  
Autoimmune Diseases ◽  
Molecular Mechanisms ◽  
Transplant Rejection ◽  
Antimalarial Drugs ◽  
Therapeutic Effects ◽  
Immunomodulatory Effects ◽  
Clinical Safety ◽  
The Past ◽  
Tremendous Progress ◽  
Anti Inflammatory

Artemisinin and its derivatives (ARTs) are known as conventional antimalarial drugs with clinical safety and efficacy. Youyou Tu was awarded a Nobel Prize in Physiology and Medicine due to her discovery of artemisinin and its therapeutic effects on malaria. Apart from antimalarial effects, mounting evidence has demonstrated that ARTs exert therapeutic effects on inflammation and autoimmune disorders because of their anti-inflammatory and immunoregulatory properties. In this aspect, tremendous progress has been made during the past five to seven years. Therefore, the present review summarizes recent studies that have explored the anti-inflammatory and immunomodulatory effects of ARTs on autoimmune diseases and transplant rejection. In this review, we also discuss the cellular and molecular mechanisms underlying the immunomodulatory effects of ARTs. Recent preclinical studies will help lay the groundwork for clinical trials using ARTs to treat various immune-based disorders, especially autoimmune diseases.

scholarly journals The Immunomodulatory Effect of Alpha-Lipoic Acid in Autoimmune Diseases

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Wei Liu ◽  
Lian-jie Shi ◽  
Sheng-guang Li
Keyword(s):  
Autoimmune Diseases ◽  
Lipoic Acid ◽  
Human Body ◽  
Innate Immune ◽  
Immunomodulatory Effect ◽  
Alpha Lipoic Acid ◽  
Immunomodulatory Effects ◽  
Immune Systems ◽  
Beneficial Effects ◽  
Naturally Occurring

Αlpha-lipoic acid is a naturally occurring antioxidant in human body and has been widely used as an antioxidant clinically. Accumulating evidences suggested that α-lipoic acid might have immunomodulatory effects on both adaptive and innate immune systems. This review focuses on the evidences and potential targets involved in the immunomodulatory effects of α-lipoic acid. It highlights the fact that α-lipoic acid may have beneficial effects in autoimmune diseases once the immunomodulatory effects can be confirmed by further investigation.

Immunomodulatory effects of probiotics: Can they be used to treat allergies and autoimmune diseases?

Maturitas ◽  
2019 ◽  
Vol 119 ◽  
pp. 25-38 ◽  
Author(s):  
Narges Dargahi ◽  
Joshua Johnson ◽  
Osaana Donkor ◽  
Todor Vasiljevic ◽  
Vasso Apostolopoulos
Keyword(s):  
Autoimmune Diseases ◽  
Immunomodulatory Effects

scholarly journals Immunomodulatory Effects of Green Tea Polyphenols

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3755
Author(s):  
Shuzhen Wang ◽  
Zhiliang Li ◽  
Yuting Ma ◽  
Yan Liu ◽  
Chi-Chen Lin ◽  
...  
Keyword(s):  
Autoimmune Diseases ◽  
Immune Function ◽  
Green Tea ◽  
Molecular Mechanisms ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
Bioactive Components ◽  
Immunomodulatory Effects ◽  
Health Promoting ◽  
Main Components

Green tea and its bioactive components, especially polyphenols, possess many health-promoting and disease-preventing benefits, especially anti-inflammatory, antioxidant, anticancer, and metabolic modulation effects with multi-target modes of action. However, the effect of tea polyphenols on immune function has not been well studied. Moreover, the underlying cellular and molecular mechanisms mediating immunoregulation are not well understood. This review summarizes the recent studies on the immune-potentiating effects and corresponding mechanisms of tea polyphenols, especially the main components of (–)-epigallocatechin-3-gallate (EGCG) and (–)-epicatechin-3-gallate (ECG). In addition, the benefits towards immune-related diseases, such as autoimmune diseases, cutaneous-related immune diseases, and obesity-related immune diseases, have been discussed.

scholarly journals A Comprehensive Review on Autoimmune Diseases

2021 ◽  
Vol 9 (9) ◽  
pp. 1477-1489
Author(s):  
Shivani Bahri
Keyword(s):  
Immune System ◽  
Autoimmune Diseases ◽  
Immune Cells ◽  
Lupus Erythematosus ◽  
Lymphatic System ◽  
The Body ◽  
Keywords Autoimmunity ◽  
The 19Th Century ◽  
Paul Ehrlich

Abstract: Immunity refers to the inbuilt ability of the organism to resist a particular disease or to be able to protect itself from disease causing microorganisms by preventing its development. Immune system includes WBCs which includes all the neutrophils, lymphocytes including the T-cells, the B-cells & the natural killer cells, all together make up the lymphatic system, antibodies, the spleen, the thymus, the bone marrow; our skin, mucous glands, hair, tears etc. also protect our body. By autoimmunity we understand that it is misallocated response of our immune system when it releases autoantibodies to attack the healthy cells of the body. Scientists have studied a lot about autoimmunity and its disorders. By the end of the 19th century, it was first believed that our immune system has the inability to react against its own body tissue until in 20th century the concept of “horror autotoxicus” was proposed by the German immunologist Paul Ehrlich. The autoimmune disease occurs when the immune system reacts and attacks its own cells in the body as a result of breakdown of immunologic tolerance to auto reactive immune cells. Many times, genetic as well as environmental factors are the key reason for autoimmune diseases. Many kinds of research are going through as to find out the actual cause of autoimmunity; till now no actual or exact cause is known. There are at least 80 types of autoimmune diseases recognized by our scientists; some of the commonly known autoimmune diseases are: type 1 diabetes, systemic lupus erythematosus, scleroderma, thyroiditis, multiple sclerosis, autoimmune vasculitis, rheumatoid arthritis, and many more. With unusual autoimmune diseases, diagnosis may not be done instantly; the patients may suffer years before getting diagnosed properly. Most of the diseases don't have any cure; some even need lifelong treatment to ease the symptoms. The diseases will be discussed in detail in the further sections. Keywords: autoimmunity, immune system, cells, disease, disorder, diabetes, arthritis, lupus, ITP

Scanning electron microscopy of freeze-fractured prescapular lymph node of caprine

1984 ◽  
Vol 42 ◽  
pp. 244-245
Author(s):  
O. Faroon ◽  
F. Al-Bagdadi ◽  
T. G. Snider ◽  
C. Titkemeyer
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Lymphatic System ◽  
Three Dimensional ◽  
Meat Products ◽  
The Body ◽  
Morphological Data ◽  
The World ◽  
Cellular Constituent ◽  
Scanning Electron

The lymphatic system is very important in the immunological activities of the body. Clinicians confirm the diagnosis of infectious diseases by palpating the involved cutaneous lymph node for changes in size, heat, and consistency. Clinical pathologists diagnose systemic diseases through biopsies of superficial lymph nodes. In many parts of the world the goat is considered as an important source of milk and meat products.The lymphatic system has been studied extensively. These studies lack precise information on the natural morphology of the lymph nodes and their vascular and cellular constituent. This is due to using improper technique for such studies. A few studies used the SEM, conducted by cutting the lymph node with a blade. The morphological data collected by this method are artificial and do not reflect the normal three dimensional surface of the examined area of the lymph node. SEM has been used to study the lymph vessels and lymph nodes of different animals. No information on the cutaneous lymph nodes of the goat has ever been collected using the scanning electron microscope.

Laryngeal Manifestations of Autoimmune Diseases

2020 ◽  
Vol 5 (2) ◽  
pp. 439-456
Author(s):  
Jenny L. Pierce
Keyword(s):  
Autoimmune Disease ◽  
Autoimmune Diseases ◽  
Patient Outcomes ◽  
Correct Diagnosis ◽  
Upper Airway ◽  
Clinical Implications ◽  
Laryngeal Function ◽  
The Past ◽  
Referral Practices ◽  
Timely Referral

Purpose This review article provides an overview of autoimmune diseases and their effects on voice and laryngeal function. Method A literature review was conducted in PubMed. Combinations of the following keywords were used: “autoimmune disease and upper airway,” “larynx,” “cough,” “voice,” “dysphonia,” and “dyspnea.” Precedence was given to articles published in the past 10 years due to recent advances in this area and to review articles. Ultimately, 115 articles were included for review. Results Approximately 81 autoimmune diseases exist, with 18 of those highlighted in the literature as having laryngeal involvement. The general and laryngeal manifestations of these 18 are discussed in detail, in addition to the clinical implications for a laryngeal expert. Conclusions Voice, breathing, and cough symptoms may be an indication of underlying autoimmune disease. However, these symptoms are often similar to those in the general population. Appropriate differential diagnosis and timely referral practices maximize patient outcomes. Guidelines are provided to facilitate correct diagnosis when an autoimmune disease is suspected.

725 Immunomodulatory effects of thymulin in monocrotalin-induced pulmonary hypertension

2006 ◽  
Vol 5 (1) ◽  
pp. 168-169
Author(s):  
S OLIVEIRA ◽  
T HENRIQUESCOELHO ◽  
F LAFUENTECARVALHO ◽  
A BRANDAONOGUEIRA ◽  
M SANTOS ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Immunomodulatory Effects
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