scholarly journals Risk Factors of Asthma Among Children Attending Mosul Hospitals: عوامل الخطورة من الربو بين الأطفال في مستشفيات الموصل

2019 ◽  
Vol 3 (4) ◽  
Author(s):  
Abdalwahed Maher Abdalwahed
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Respiratory Infection ◽  
Educational Level ◽  
Airflow Obstruction ◽  
Inclusion Criteria ◽  
Small House ◽  
History Of ◽  
Group A ◽  
Group B

  Background: Asthma is a inflammatory condition of the lung airways resulting in episodic airflow obstruction. Symptoms are produced by irritation of small airways and may include bronchial hyper responsiveness, coughing, mainly at night or early morning. The mutable airflow obstruction is often adjustable, either spontaneously or by management . Objective: to find possible etiological risk factors and their links to Children asthma. Methods: This case-control study was conducted in four pediatric teaching hospitals for the period extending from 1st of April to end of November 2018. A total of 300 children > 15years were chosen randomly from the pediatric outpatient clinic, and divided in two group. Group A : one hundred fifty asthmatic patients were labeled as asthmatic . Group B : one hundred fifty children were matched to group A by age, sex, the group B without any history of asthma. Inclusion criteria for Group A were: Diagnosed as asthmatic by consultant pediatrician and should be respond well to anti asthmatic medication. Inclusion criteria for Group B were: Healthy or apparently healthy and without any history of medical problem or chronic diseases. Any child who is not accompanied by his /her mother or relative, and who didn't meet the selection criteria for the A and B groups will be excluded from the study . Results: After adjusting for possible cofounders; the study showed the factors which had significant association with childhood asthma were parent consanguinity 54%(P<0.001), low educational level of parents 63%, 58% (P<0.001), small house room 65% (P<0.001), presence of animals in the home57%(P<0.001), family history of asthma72% (P<0.001), , mother disease and medications 56%(P<0.001), household exposure 69% (P<0.001), respiratory infection during infant stage 81%(P<0.001) bottle feeding74%(P<0.001) . Conclusion: The independent risk factors after adjusting was were parent consanguinity, low educational level of parents, small house room, presence of animals in the home, family history of asthma, mother disease and drugs use through pregnancy, household exposure, recurrent respiratory infection during 1st year of life. Exclusive breast feeding (1st 6 months) appeared to be protective from asthma.    

scholarly journals Risk Factors for Early Wheezing in Preterm Infants: A Retrospective Cohort Study

2020 ◽  
Author(s):  
Xun Chen ◽  
Minjing Yang ◽  
Shengzhu Huang ◽  
Xiaolian Qin ◽  
Zhijian Pan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Preterm Infants ◽  
Gestational Age ◽  
Premature Delivery ◽  
Related Factors ◽  
Recurrent Wheezing ◽  
History Of ◽  
Group A ◽  
Group B

Abstract Background: The related factors that cause recurrent wheezing in children are complex, and premature delivery may be one of the reasons. Little is known about early wheezing in preterm infants. Methods: Data sourced from 1616 children born between 2007 and 2013 from 8 hospitals of Guangxi in China. All children were followed by telephone or questionnaire through the sixth year of life. Children were grouped by characters of age: Group A: gestational age (GA) ≤ 32 weeks, Group B: 32 weeks < GA < 37 weeks, Group C: 37 weeks ≤ GA < 42 weeks. Results: The incidence and the risk factors of early wheezing in preterm infants were analyzed. The incidence of early wheezing: Group A > Group B > Group C. In Group A, the proportion of small-for-gestational-age (SGA) infant was higher in early wheezing group than in normal group (P = 0.005). Male (95% CI: 1.611 to 4.601) and family history of allergy (95% CI: 1.222 to 3.411) were the risk factors for early wheezing in Group B. Conclusions: Newborns with younger GA had a higher risk of early wheezing. SGA was a possible factor influencing early wheezing in preterm infants with GA≤ 32 weeks. Male and family history of allergy were the risk factors for early wheezing in preterm infants with 32 weeks < GA < 37 weeks.

scholarly journals Risk factors for early wheezing in preterm infants: a retrospective cohort study

2020 ◽  
Author(s):  
Xun Chen ◽  
Minjing Yang ◽  
Shengzhu Huang ◽  
Xiaolian Qin ◽  
Zhijian Pan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Family History ◽  
Preterm Infants ◽  
Full Term ◽  
Term Infants ◽  
History Of ◽  
Group A ◽  
Male Sex ◽  
Group B

Abstract Background: The factors that cause recurrent wheezing in children are complex, and premature delivery may be one of these factors. Little is known about early wheezing in preterm infants.Methods: Data were sourced from 1616 children born between 2007 and 2013 from 8 hospitals in Guangxi, China. All children were followed up by telephone or questionnaire through the sixth year of life. Children were grouped by gestational age (GA): Group A, GA ≤ 32 weeks; Group B, 32 weeks < GA < 37 weeks; and Group C, 37 weeks ≤ GA < 42 weeks.Results: The incidences and risk factors for early wheezing in preterm infants were analysed. The incidences of early wheezing were as follows: Group A > Group B > Group C. The incidence of persistent early wheezing in Group A or Group B was significantly higher than that in Group C, respectively. SGA (95% CI: 1.097 to 7.519) was a risk factor for early wheezing in group A. Male sex (95% CI: 1.595 to 4.501) and family history of allergies (95% CI: 1.207 to 3.352) were risk factors for early wheezing in group B.Conclusions: 1. New-borns with younger GAs had a higher risk of early wheezing. 2. The incidence of persistent early wheezing for preterm infants (GA ≤ 32 weeks and 32 weeks < GA < 37 weeks) was higher than that for full-term infants (37 weeks ≤ GA < 42 weeks). 3. SGA was a risk factor for early wheezing in preterm infants with a GA ≤ 32 weeks. 4. Male sex, personal history of allergies and family history of allergies were all possible factors affecting early wheezing in preterm infants with a GA > 32 weeks but < 37 weeks and full-term infants. Among them, male sex and family history of allergies were risk factors for early wheezing. 5. Mode of delivery, passive smoking, breastfeeding and invasive mechanical ventilation were not possible risk factors for early wheezing in infants of different GAs.

scholarly journals Phenotypes of JAK2-Mutated Polycythemia Vera and Essential Thrombocythemia with and without Thromboembolic Events: Results of the Hinc-207 (OSHO #91) Study

Blood ◽  
2020 ◽  
Vol 136 (Supplement 1) ◽  
pp. 13-13
Author(s):  
Tony Hennersdorf ◽  
Nadja Jaekel ◽  
Susann Schulze ◽  
Dietrich Kaempfe ◽  
Claudia Spohn ◽  
...  
Keyword(s):  
Risk Factors ◽  
Polycythemia Vera ◽  
Essential Thrombocythemia ◽  
Research Funding ◽  
Thrombotic Event ◽  
Patient Questionnaire ◽  
Allele Burden ◽  
History Of ◽  
Group A ◽  
Group B

Thrombosis is the major cause of morbidity and mortality in polycythemia vera (PV) and essential thrombocythemia (ET). Age ≥60 years (y) and/or history of thrombosis labels patients (pts) as high-risk for thrombosis. Yet, thrombosis frequently occurs prior to the diagnosis of PV/ET. In a multicenter study of the East German Study Group (HINC-207; OSHO #091), the interaction between age and time occurrence of the first thrombosis as risk factors for thrombosis after diagnosis was studied. Methods After IRB approvals, JAK2 mutated adults with PV or ET were prospectively enrolled in 9 centers and centrally stratified in a one to two ratio (group A: pts with a history of thrombosis; group B: pts without thrombosis) with a pre-planned minimum of 60:120 pts. Based on a longitudinal and cross-sectional design, clinical and laboratory data at diagnosis, last follow-up, and thrombosis (for group A) were collected. Thrombosis prior to diagnosis was labeled as A1 and thrombosis after diagnosis as A2. Thrombosis risk factors were grouped into age-, previous thrombosis-, thrombosis prior to PV/ET-, cardiovascular (CV)-, thrombophilia-, and disease- (JAK2 allele burden, Hct, and WBC) related. Additionally, therapies [aspirin (ASS), anticoagulation, phlebotomy, and cytoreduction] and data from a study-own patient questionnaire were included. All pts signed informed consent. The primary endpoint was the phenotypic diversity in JAK2-mutated ET and PV pts with or without thrombosis. Results From April to Dec, 2019, 246 pts were recruited. Data on 237 pts (median age 62y; 59% females, 58% PV) are available. At diagnosis, pts in group A (n=71, median age 59.5y) tended to be younger than those in group B (n=166, median age 63y) (p=0.07). Yet, 70.4% thrombotic events (venous: median age 46.5y; arterial: median age 57y) occurred in A1 and correlated with younger age (p=0.03). Only 3 pts developed a second event after diagnosis. These were counted in A2 (n=24, median age at thrombosis: 61y). Overall, thrombosis occurred either prior to or within the first 3y after diagnosis in 63/71 (89%) pts. Age&gt;60y could not be identified as a risk factor for thrombosis or type of thrombosis at any time point. The 5 y probability of no thrombotic event after diagnosis in pts &gt;60y was 90.4% vs. 89.2% for pts &lt;60y (p=0.8) and that of a thrombotic event &gt;3y after diagnosis in pts &gt;60y was 3.7% vs. 4.9% for pts &lt;60y (p=0.7). Similarly, A1 did not correlate with A2 (p=0.3). With 1691 patient-years for the entire cohort, the incidence of thrombosis after PV/ET diagnosis was 0.7 for arterial and 0.6 for venous events per 100 patient-years. Smoking was more prevalent in pts &gt;60y (p=0.003) and was not associated with thrombosis. Irrespective of age, hypertension (65%, p=0.03), hyperlipidemia (19%, p=0.008), and diabetes (16.4%, p=0.05) were frequent and correlated with A2 while atrial fibrillation (p=0.03) and inherited thrombophilia risk factors (p&lt;0.00) with A1. JAK2 allele burden (median 19%) and Hct &gt;45% (median 45%) at diagnosis correlated strongly with age &gt;60y (p=0.005) but not with A, A1, or A2, although Hct &gt;45% at diagnosis correlated with A2 in PV (p=0.001). Surprisingly, a Hct &gt;45% at thrombosis was more frequently present in A1 (55%) vs A2 (30%) (p&lt;0.00). Median WBC at diagnosis was higher in B compared to A (p=0.004), strongly associated with age &gt;60y (p&lt;0.00) but not with A2. WBC &gt;15% at thrombosis did not correlate with A. Age rather than thrombosis was the trigger for cytoreduction [82% hydroxyurea (HU) in B pts &gt;60y vs 53% in A pts &lt;60y] (p&lt;0.00). In PV, ASS did not correlate with thrombosis (25% of pts in B did not receive ASS). Cytoreduction, interval between diagnosis and cytoreduction, nor the duration of exposure correlated with thrombosis. Conclusions: The majority of thrombotic events occurred prior to or within the first 3 years after the diagnosis of JAK2 mutated PV/ET and were associated with CV-risk factors rather than older age. Phenotypic features such as Hct &gt;45%, high WBC, and JAK2 allele burden were associated with age &gt;60y and less with thrombosis. Their value as surrogate markers for therapeutic interventions to reduce thrombosis needs to be critically evaluated in larger series. Whether adequate PV/ET- or CV-risk- treatments account for the low rate of CV events after diagnosis (despite a higher incidence of CV-risk factors) compared to the general population could not be answered due to study design and needs to be addressed prospectively. Disclosures Al-Ali: Novartis: Honoraria, Research Funding; Celgene: Honoraria, Research Funding.

scholarly journals CLEFT LIP AND PALATE

2016 ◽  
Vol 23 (05) ◽  
pp. 516-521
Author(s):  
Tajammal Abbas Shah
Keyword(s):  
Family History ◽  
Soft Palate ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Study Results ◽  
History Of ◽  
Group A ◽  
Group B ◽  
Surgical Unit ◽  
Palatal Defect

A prospective study was conducted to look for prevalence of cleft lip and palate ina population presenting to a surgical unit in a teaching hospital. Objectives: To see prevalenceof cleft lip and palate alone, lip and palate combined, right or left sided, male to femaledistribution, and possible factors responsible for clefting. Study Design: A prospective study.Setting: Surgical Unit II at Allied Hospital Faisalabad. Period: March 2009 to March 2010 forone year. Materials and Methods: Total 55 patients were treated in year 2009 out of total17900 (0.3 %) patients admitted in all surgical wards and 6508 patients admitted in surgicalunit II (0.8%). Patients were divided into three groups, cleft lip alone (group A), cleft palatealone (group B) and combined cleft lip and palate (group C). Children up to the age of 5 yearswith congenital abnormality were included in study. Results: Out of 6508 patients admitted insurgical unit II 55 patients (0.8%) had cleft lip and palate defect. 55 patients were divided inthree groups. In group A, 32 patients presented with cleft lip alone ( 58.1 % ), 16 ( 29 % ) weremales and 16 ( 29 % ) were females, 21 patients have left sided ( 38 % ), 4 right sided (7.27% )and 7 patients have bilateral ( 12.72 % ) defects. 2 patients (3.63 %) had family history of cleft lipand both were males. In group B, 12 patients ( 21.8 %) had cleft palate alone, 7 patients ( 12.72% ) were males and 5 patients ( 9 % ) were females, 10 patients ( 1.18 % ) had soft palate onlywhile 2 patients ( 3.63 % ) had compete ( hard and soft ) palatal defect. In group C, 11 patients,had cleft lip and palate combined ( 20 % ), 6 patients were males ( 10.9 % ) and 5 patients ( 9% ) were females, 8 patients ( 14.54 % ) had only soft palate defect while 3 patients ( 5.45 % )had complete palatal defect associated with 8 patients ( 14.54 % ) left sided unilateral lip defectand 3 patients ( 5.45% ) had bilateral cleft lip. All patients were operated without any mortality.Ages of mothers at earliest were 16 and 18 years, 3 cousin marriages, ( 5.45 % ) all fathers weresmokers, belonged to poor socio economic families and no history of mother’s exposure toradiation, drug abuse during gestational life. Conclusion: As it is obvious from this study thatall patients belongs to poor socio economics group, and all fathers were smokers, 3 patientsborn in parents who had cousin marriages ( 5.45 % ) 2 patients ( 3.63 % ) with family history,cleft lip and palate are multifactorial congenital abnormalities, runs in families and is influencedby various environmental factors.

Risk factors in central retinal vein occlusion: A multi-center case-control study conducted on the Italian population

2021 ◽  
pp. 112067212110644
Author(s):  
Trovato Battagliola Edoardo ◽  
Pacella Fernanda ◽  
Malvasi Mariaelena ◽  
Scalinci Sergio Zaccaria ◽  
Turchetti Paolo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Retinal Vein Occlusion ◽  
Central Retinal Vein Occlusion ◽  
Active Smoking ◽  
Vein Occlusion ◽  
History Of ◽  
Group A ◽  
Group B ◽  
Control Study ◽  
Central Retinal Vein

Purpose To explore the risk factors for central retinal vein occlusion (CRVO) by comparing a large sample of patients with healthy controls. Materials and Methods Multi-center case-control study. The study group includes patients affected by central retinal vein occlusion, confirmed angiographically, aged 50 years old or above (Group A). The control group includes healthy subjects without an history of retinal vein occlusion (Group B). Outcome measures: age, gender, active smoking, presence of uncontrolled arterial hypertension (uHTN), presence of the following comorbidities: diabetes mellitus type II (DMII), chronic liver disease (CLD), chronic kidney disease (CKD), thyroid disease (TD), systemic lupus erythematosus (SLE), hyperhomocystenemia (HHcy), dyslipidemia (DLip), carotid artery disease (CAD), glaucoma, atrial fibrillation (AF), migraine headache (MH), chronic obstructive pulmonary disease (COPD), obstructive sleep apnea syndrome (OSAS), history of myocardial infarction (MI). Odds-ratios were calculated with logistic regression analysis. Results A total of 203 patients (Group A) and 339 controls (Group B). Statistically-significant differences were found for the following variables: age (OR: 1.109 [1.081–1.138], p < .001), active smoking (OR: 2.048 [1.210- 3.466], p < .008), DMII (OR: 4.533 [2.097–9.803], p < .001), HHcy (OR: 4.507 [2.477–10.001 ], p < .001), DLip (OR: 2.255 [1.352–3.762], p  =  .002), CAD (OR: 6.632 [2.944- 14.942], p < .001), glaucoma (OR: 4.656 [2.031–10.673], < .001), OSAS (OR: 1.744 [1.023–2.975], < .041), uHTN (OR: 3.656 [2.247–5.949], < .001). No statistically-significant differences were found for the other variables. Conclusions Older age, active smoking, as well as presence of DMII, HHcy, DLip, CAD, glaucoma, OSAS, and uHTN, all increase the risk for CRVO. A comprehensive assessment of patients with CRVO is paramount. Adequate control of all the aforementioned risk factors is likely of great significance in reducing the incidence of CRVO among the general population, and it likely plays an important role in improving the prognosis following the occlusive event.

scholarly journals PREVALENCE OF UNDIAGNOSED HYPERTENSION AND ASSOCIATED RISK FACTORS AMONG ADULTS IN GAJIDA TOWN, NIGERIA

2017 ◽  
Vol 6 (1) ◽  
pp. 28-35
Author(s):  
Mukhtar Yakubu Gajida ◽  
Dr. Shumaila Hanif ◽  
Aishat Shittu
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Family History ◽  
Occupational Stress ◽  
Educational Level ◽  
Dietary Habits ◽  
World Health ◽  
Undiagnosed Hypertension ◽  
History Of ◽  
Associated Risk Factors

Hypertension is a world health problem which is strongly related with cardiovascular disease (CVD) and premature deaths. The purpose of this cross-sectional study was to determine the prevalence of undiagnosed hypertension and associated risk factors among adults in Gajida town. The blood pressure (BP) of 364 participants was measured. Risk factors of high BP (age, gender, obesity, occupational stress, family history, educational level, dietary habits and smoking) were assessed. The data obtained was analyzed using both descriptive and interferential statistics. The descriptive (mean, standard deviation & percentage) and inferential (Pearson, Spearman & Mann-Whitney-U) statistics were used to summarize/analyze the data at P<0.05 using Statistical Package for Social Science (SPSS) (version 16.0). Out of 364 participants, 185 (50.8%) were males and 179 (49.2%) were females. On average, participant’s age was 33 years, systolic blood pressure (SBP) was 110 mm Hg, diastolic blood pressure (DBP) was 80 mm Hg and BMI was 19.96 kg/m2. About 153 (41.9%) of the participants were housewives and 138 (37.9%) were not educated. Prevalence of undiagnosed HTN was 23.6%. Gender, age, BMI, and educational level were found to be associated significantly (P ≤ 0.05) with HTN. Occupational stress, history of HTN, family history of HTN, dietary habits and smoking showed no significant relationship (p ≥ 0.05). A moderate prevalence of undiagnosed hypertension was found among adults in Gajida town. Hypertension is associated with gender, age, BMI, and educational level. There is a need to detect and manage cases of undiagnosed hypertension through regular measurements.

scholarly journals The prevalence of traditional risk factors for cardiovascular disease in the Omsk region: data of the ESSE-RF2 study

2020 ◽  
Vol 25 (6) ◽  
pp. 3815
Author(s):  
I. A. Viktorova ◽  
N. G. Shirlina ◽  
V. L. Stasenko ◽  
G. A. Muromtseva
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Alcohol Consumption ◽  
Abdominal Obesity ◽  
Positive Family History ◽  
Region Data ◽  
History Of ◽  
Group A ◽  
Traditional Risk Factors ◽  
Group B

Aim. To study the prevalence of some traditional risk factors for cardiovascular disease (CVD) in the Omsk region.Material and methods. The prevalence of traditional risk factors for CVD in a representative sample of the Omsk region population aged 25-64 years (n=1,648) was estimated as a part of the ESSE-RF2 study in 2017.Results. It was established that the mean age of CVD detection in the Omsk region is 46,3 years, the prevalence of overweight is 35,0%, obesity — 30,3%. Abdominal obesity was detected in 56,8% of subjects. Smoking was reveled in 21,2% of the population, former smoking — 20,0%. Alcohol consumption more than 2 times a month was observed in one third of respondents (30,5%). In the group of healthy people, compared with CVD patients, the percentage of smokers and alcohol consumers was detected significantly more often: smoking — 25,2±1,26% vs 17,1±0,86% and 32,9±1,6% vs 28,1±1,4%, respectively. Perhaps it was the diseases the reason for smoking cessation and alcohol abstinence among people with CVD. It should be noted that among 70% of alcohol consumers, both with/ without CVD, strong drinks were the preferred type of alcohol. Hypertension (HTN) was observed in 47,9% of subjects, and in 43,1% the diagnosis was verified. In 4,8% of HTN individuals, blood pressure increase was detected for the first time in this study. The prevalence of diabetes of both types in the Omsk region was 6,7%, and in group A (with CVD) it was much higher than in group B (without CVD): 10,7% vs 2,8%. Type 2 diabetes prevailed in people with CVD (p=0,000005). This was not characteristic of type 1 diabetes.Conclusion. The most common risk factors for CVD in the Omsk region population were HTN (47,9%), abdominal obesity (56,8%), a positive family history of early CVD (62,0%), alcohol consumption over the past 12 months (71,7%) and strong alcohol drinking (72,0%). However, a significant portion of the subjects (41,3%) consumed alcohol no more than 1 time per month.

Predictors of Von Willebrand Disease In Children: A Case-Control Study

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 712-712
Author(s):  
Heather L. Bujnicki ◽  
Robert F. Sidonio ◽  
Charity G. Moore ◽  
Christine L. Kempton ◽  
Peter A. Kouides ◽  
...  
Keyword(s):  
Family History ◽  
Iron Deficiency ◽  
Area Under The Curve ◽  
Von Willebrand Disease ◽  
Personal History ◽  
Deficiency Anemia ◽  
History Of ◽  
Group A ◽  
Bleeding Score ◽  
Group B

Abstract Abstract 712 Background: Von Willebrand disease (VWD) is the single most common congenital bleeding disorder. The Tosetto Bleeding Score (BS), a quantitative measure of bleeding, has improved specificity of diagnosis, but symptoms are variable, and, among children a diagnosis of VWD may be missed as they may not have lived long enough to experience symptoms on which the score is based. As many as 25% of affected children come to clinical attention after postoperative bleeding: thus, a better diagnostic tool is needed in children. A Tosetto BS modified for children by one additional question on early life bleeding, known as the James BS, has been validated for a small cohort of VWD children, but its utility in type 1 VWD diagnosed by the 2008 NHLBI-defined VWF:RCo<30 or in children <11 years of age remains unknown. Further, the role of family bleeding history or personal history of anemia in VWD diagnosis has not been studied. Methods: We conducted a case-control study to determine predictors of VWD in children younger than 11 years of age. Cases included 40 children with VWF:RCo<30 IU/dL (Group A) and 39 children with VWF:RCo=30-50 IU/dL (Group B). Controls included 80 children without VWD, age-, sex-, race-matched to CASES<30. Tosetto and James bleeding scores, family history of VWD or bleeding, and personal history of anemia were determined by prospective data extraction from charts of cases at the time of VWD diagnosis, and by parental interview of controls. Results: Group A included 52% male, 90% Caucasian, and age 7.5 years (median), not different from Group B, p=0.91, p=0.67, and p=0.26; or controls, p=0.90; p=1.00, and p=0.78, respectively. The median Tosetto BS in Group A was 2, greater than in controls, median 0, p<0.0001, but similar to Group B, median 1, p=0.10. The median James BS in Group A was 2, greater than in controls, median 0, p<0.0001, but not different from Group B, median 1, p=0.06. The majority of Group A had a family history of VWD or bleeding, 97%, similar to Group B, 85.0%, p=0.06; but higher than in controls, 0%, p<0.0001. In Group A, 47.5% had a personal history of iron deficiency anemia (by history and/or MCV<80), higher than Group B, 18%, p=0.005, and higher than controls, 1.3%, p<0.0001. The most common bleeding symptom in Group A was cutaneous bleeding, in 60%, similar to Group B, 44%, p=0.14, but higher than controls, 2.5%, p<0.0001. Comparing Group A with controls, a composite score of four variables, 1) Tosetto BS>1, 2) a family history of VWD or bleeding, 3) a personal history of iron deficiency (by history and/or MCV<80), and/or 4) a James ‘other' early event bleeding, was predictive of VWD, p<0.0001, with 100% specificity and 75% sensitivity if at least 2 variables were present; similarly, a composite of three variables, excluding Tosetto BS>1, was also predictive of VWD, p<0.0001, with 98.8% specificity and 100% sensitivity if at least one variable was present. Comparing Groups A and B (all cases) with controls, a composite score of all four variables, was predictive of VWD, p<0.0001, with 100% specificity and 58.2% sensitivity if at least 2 variables were present; similarly, a composite of three variables, excluding Tosetto BS >1, was predictive of VWD, p<0.0001, with 98.8% specificity and 92.4% sensitivity if at least 1 variable was present. The area under the curve for diagnosing VWD in Group A by the Tosetto BS was AUC=0.872, Wald 95% CI (0.804−0.940), and by the James BS was AUC=0.885 (Wald 95% CI 0.820–0.950), and not different from the area under the curve for diagnosing VWD in Group B, AUC=0.801, Wald 95% CI (0.721−0.881), for each score. Conclusion: The AUC for the Tosetto bleeding score for diagnosing VWD in children < 11 years of age, exceeds 0.87, and the James exceeds 0.80, and both appear to be independent of VWF level <30 vs. 30–50. Combining a family history of VWD or bleeding, a personal history of iron deficiency anemia (by history or MCV<80) improves the Tosetto BS in children, independent of VWF level. These findings should be validated in a larger group of children. Disclosures: Kulkarni: Novo Nordisk: Membership on an entity's Board of Directors or advisory committees, Participate in clinical trials. Yee:Novo Nordisk: Consultant. Ragni:Novo Nordisk, Inc.: Research Support for this study.

Comparative Study Between Clean Intermittent Self-Catheterization (Cisc) and Continuous Indwelling Catheterization (Cidc) in Relieving Acute Refractory Retention of Urine Due to Benign Enlargement of Prostate (Bep)

2020 ◽  
Vol 21 (2) ◽  
pp. 105-110
Author(s):  
Md Shawkat Alam ◽  
Sudip Das Gupta ◽  
Hadi Zia Uddin Ahmed ◽  
Md Saruar Alam ◽  
Sharif Muhammod Wasimuddin
Keyword(s):  
Comparative Study ◽  
Acute Urinary Retention ◽  
Bladder Capacity ◽  
Inclusion Criteria ◽  
College Hospital ◽  
Medical College ◽  
High Incidence ◽  
Group A ◽  
Group B ◽  
Better Than

Objective: To compare the clean intermittent self-catheterization (CISC) with continuous indwelling catheterization (CIDC) in relieving acute urinary retention (AUR) due to benign enlargement of prostate (BEP). Materials and Methods :A total 60 patients attending in urology department of Dhaka Medical college hospital were included according to inclusion criteria ,Patients were randomized by lottery into two groups namely group –A and group –B for CISC and IDC drainage respectively . Thus total 60 patients 30 in each group completed study. Results : Most men can safely be managed as out-patients after AUR due to BPH. The degree of mucosal congestion and inflammation within the bladder was found to be lower in those using CISC and the bladder capacity in these patients was also found higher.Patients with an IDC had a high incidence of UTIs then that of patients with CISC. During the period of catheterization the incidence of UTI was 43.3% in group B in comparison to 40% in group A; before TURP 36% in group B in comparison to 10% incidence in group A.According to patient’s opinion CISC is better than IDC in the management of AUR. Experiencing bladder spasm, reporting blood in urine, management difficulties, incidence and severity of pain were less in CISC group, and the method of CISC was well accepted by patients as well as their family members. Conclusion: From the current study it may be suggested that CISC is better technique for management of AUR patient due to BPH than IDC. It can also be very helpful when surgery must be delayed or avoided due to any reasons in this group of patients. Bangladesh Journal of Urology, Vol. 21, No. 2, July 2018 p.105-110

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