Bacterial sepsis

Abstract Fulminant bacterial sepsis has been described in patients with Hodgkin disease who have undergone splenectomy for staging purposes. The organisms commonly associated with sepsis in this setting include Streptococcus pneumoniae and Haemophilus influenzae. Polyvalent pneumococcal vaccine (Merck) has recently been licensed and has been suggested for use in patients with Hodgkin disease who are at risk for postsplenectomy sepsis. We administered 14-valent pneumococcal vaccine to 24 patients with Hodgkin disease and 24 normal controls, and measured antibody response to 13 antigens at time of immunization and at 3 wk and 3 mo following immunization. Our results indicate that patients who have been previously treated for Hodgkin disease, with chemotherapy, radiotherapy, or both, have severe impairment of antibody response. Untreated patients, however, respond in a manner similar to normal controls.

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Enhanced Survival During Murine Gram-negative Bacterial Sepsis by Use of a Murine Monoclonal Antibody

Archives of Surgery ◽

10.1001/archsurg.1985.01390250044007 ◽

1985 ◽

Vol 120 (1) ◽

pp. 50 ◽

Cited By ~ 17

Author(s):

David L. Dunn

Keyword(s):

Monoclonal Antibody ◽

Murine Monoclonal Antibody ◽

Bacterial Sepsis ◽

Gram Negative

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THE EPIDEMIOLOGY OF BACTERIAL SEPSIS

Infectious Disease Clinics of North America ◽

10.1016/s0891-5520(05)70076-3 ◽

1999 ◽

Vol 13 (2) ◽

pp. 299-312 ◽

Cited By ~ 72

Author(s):

M. Sigfrido Rangel-Frausto

Keyword(s):

Bacterial Sepsis

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Discovery and Validation of a 3-Gene Transcriptional Signature to Distinguish COVID-19 and Other Viral Infections from Bacterial Sepsis in Adults; A Case-Control then Observational Cohort Study

SSRN Electronic Journal ◽

10.2139/ssrn.3766286 ◽

2021 ◽

Author(s):

Ho Kwong Li ◽

Myrsini Kaforou ◽

Jesus Rodriguez-Manzano ◽

Samuel Channon-Wells ◽

Ahmad Moniri ◽

...

Keyword(s):

Cohort Study ◽

Viral Infections ◽

Case Control ◽

Observational Cohort Study ◽

Bacterial Sepsis ◽

Transcriptional Signature ◽

Observational Cohort

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NOSOCOMIAL INFECTION WITH ECHOVIRUS TYPE II IN HANDICAPPED AND PREMATURE INFANTS

PEDIATRICS ◽

10.1542/peds.51.4.603 ◽

1973 ◽

Vol 51 (4) ◽

pp. 603-607

Author(s):

Henry G. Cramblett ◽

Ralph E. Haynes ◽

Parvin H. Azimi ◽

Milo D. Hilty ◽

Michael H. Wilder

Keyword(s):

Infectious Disease ◽

Premature Infants ◽

Index Case ◽

Hand Washing ◽

Type Ii ◽

Bacterial Sepsis ◽

Infectious Disease Unit ◽

Short Period ◽

Echovirus Type ◽

Disease Unit

This report describes an outbreak of nosocomial infections due to echovirus type 11 among premature and/or handicapped infants in an intensive care unit. Four patients became ill within a short period of time and echovirus 11 was recovered from several of their specimens. The illnesses were clinically suggestive of bacterial sepsis and/or bacterial meningitis. Each of the four infants who became ill was in an isolette for a period of from 20 to 54 days before onset of illness. Three of the four patients became ill within 24 hours of one another which suggested a common exposure at nearly the same time. No index case could be identified, but it appears that this outbreak of enteroviral infections was due to inadequate hand washing by personnel. The outbreak was halted by removing the infants to an infectious disease unit and by closing the involved unit to new admissions for seven days.

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Estimation of Mortality Risk in Chronically Ventilated Infants With Bronchopulmonary Dysplasia

PEDIATRICS ◽

10.1542/peds.88.6.1153 ◽

1991 ◽

Vol 88 (6) ◽

pp. 1153-1160 ◽

Cited By ~ 1

Author(s):

Debora W. Overstreet ◽

J. Craig Jackson ◽

Gerald van Belle ◽

William E. Truog

Keyword(s):

Mechanical Ventilation ◽

Bronchopulmonary Dysplasia ◽

Airway Pressure ◽

Life Support ◽

Water Pressure ◽

Accurate Estimation ◽

Regression Equations ◽

Bacterial Sepsis ◽

Mean Airway Pressure ◽

Predictors Of Mortality

Bronchopulmonary dysplasia is a chronic, sometimes fatal lung disease, which primarily affects premature infants and often leads to a dependence on mechanical ventilation lasting many months. To identify prognostic factors of mortality at 1 and 2 months of age, the authors reviewed the medical records of the 144 neonates admitted to two neonatal intensive care units in Seattle from January 1, 1986, through December 31, 1988, who required mechanical ventilation throughout the first month of life. Likely predictors of mortality were tested by logistic regression analysis. The calculated mean airway pressure at 30 days of age (MAP30) and the diagnosis of bacterial sepsis at any time during the first month of life (Bact0-30) were statistically significant predictors of mortality (P < .001 and P = .018, respectively) and had the lowest deviance in the regression model. The probability of mortality was estimated by 1/(1 + e-x, where x = -6.510 + 0.4588 (MAP30) + 1.475 (Bact0-30), and where MAP30 is expressed as centimeters of water pressure (1 cm H2O = 0.0978 kPa) and the presence or absence of bacteremia is 1 and 0, respectively. The records of the 57 infants who still required mechanical ventilation at 60 days of age were reanalyzed with clinical data available during the first 2 months of life. Mean airway pressure (MAP60) and the fraction of inspired oxygen (F60) at 60 days of age combined to form the best predictors of mortality, where x = -7.668 + 0.2940 (MAP60) + 5.935 (F60). The occurrence of bacterial sepsis during the first 2 months of life, the degree of hypochloremia, and the duration of chronic sedative use were also significant predictors of survival, even controlling of MAP60 and F60. These regression equations allow more accurate estimation of the likelihood of survival for chronically ventilated infants and may facilitate decisions regarding withdrawal or continuation of life support.

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