Diabetes epidemiology in Russia: what has changed over the decade?

The National diabetes register (NDR) was created as unified dynamic database in online format. It allows providing clinical and epidemiological monitoring of diabetes mellitus (DM) in the whole country. Aim. To analyze the epidemiological characteristics of diabetes over the past decade, to access the dynamics of the prevalence of acute (coma) and chronic (micro - and macrovascular) complications of DM. Materials and methods. The object of the study was the depersonized NDR database of DM patients. It consists of 84 regions of the Russian Federation (RF), included in the online registry system on 01.01.2019. Results and discussion. The total number of patients with DM in RF on 01.01.2019 was 4 584 575 (3.12% of the population), comprising 256.2 thousand patients with T1DM, 4.24 million with T2DM, 89.9 thousand other types of DM. Since 2000, the number of DM patients in RF has grown 2.2 times. 34.7% patients with T1DM reached target level of HbA1c

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Diabetes mellitus in Russian Federation: prevalence, morbidity, mortality, parameters of glycaemic control and structure of glucose lowering therapy according to the Federal Diabetes Register, status 2017

Diabetes Mellitus ◽

10.14341/dm9686 ◽

2018 ◽

Vol 21 (3) ◽

pp. 144-159 ◽

Cited By ~ 37

Author(s):

Ivan I. Dedov ◽

Marina V. Shestakova ◽

Olga K. Vikulova ◽

Anna V. Zheleznyakova ◽

Michail А. Isakov

Keyword(s):

Diabetes Mellitus ◽

Renal Failure ◽

Chronic Renal Failure ◽

Life Expectancy ◽

Russian Federation ◽

Diabetic Coma ◽

Glucose Lowering ◽

Number Of Patients ◽

Diabetes Register ◽

Epidemiological Characteristics

BACKGROUND: The enormous social lesion caused by high prevalence of diabetes mellitus (DM) determines the state importance of clinical and epidemiological monitoring organization. AIMS: To analyze epidemiological characteristics (prevalence, mortality, morbidity), the level ofHbA1c, evaluate the therapy in Russian Federation in 20132017. METHODS: We have used the database of the Russian Federal Diabetes register 81 regions included in the online register system. RESULTS: The total number of patients with DM was 4,498m. (3.06% RF population), including: Type 1 (T1) 5,7% (0,26 m), T2 92,1% (4,15m), other DM types 1,9% (83,8 ths). Distribution male/female: T1 53.5%/46.5%, T2 29%/71%, other DM types 24%/76%. The proportion of men decreases with aging. Number of patients 65 years was 2.293.520, including T1 21.97ths (3.6%), T2 2m271.5ths (54.7%). The prevalence 20132017 per 100,000 population was as follows: T1 159,8169,6; T2 2455.32775.6; other DM types 51,265,8. Morbidity: T1 9,87,0; T2 226,7185,2; other DM types 7,812,4. The structure of causes of death 20132017: T1: diabetic coma 2,01,5%, myocardial infarction 4,04,4%, cerebral circulation disorders 8,27,6%, cardiovascular insufficiency 18,516,4%, chronic renal failure 6,16,0%; T2 0,20,2%, 4,54,5%, 12,712,2%, 29,028,6%, 1,21,8%, respectively. Mortality: T1 2.3; T2 68.4, other DM types 0,8. Life expectancy (average age of death of patients): T1 male 50.350.2, female 60.257.2; T2 69.870.3, 75.175.9 respectively. The number of patients with targetHbA1clevel 7%: T1 22.334.0%, T2 38.052.4%;HbA1c9.0%: T1 29.221.1%, T2 12.68.8%. The most commonly prescribed classes of glucose lowering medications (GLM) in 2017: in monotherapy Metformin (57.3%), Sulfonilurea (SU) (41,1%); in combination of 2 GLM: Metformin+SU 92,58% Metformin+iDPP-4 5.63%; 3 or more GLM: Metformin+SU+iDPP-4 83,9%, Metformin+SU+iSGLT-2 8.98%. The proportion of patients on aGPP-1 therapy is 0.01%. CONCLUSIONS: We observed the growth of prevalence of DM in Russian Federation and decrease in registered morbidity rate; an increase in life expectancy in T2; decrease in mortality due to diabetic coms and stable mortality rate from cardiovascular events (heart attack, stroke, cv deficiency), gangrene, chronic renal failure in both types of DM; a steady improvement in glycemic control. In the structure of T2 therapy the oral GLMs are dominated, especially Metformin and SU. In the dynamics the prescription of Metformin, insulin, iDPP-4, iSGLT-2 has increased, the proportion of SU has decreased.

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Epidemiology of diabetes mellitus in Russian Federation: clinical and statistical report according to the federal diabetes registry

Diabetes Mellitus ◽

10.14341/dm8664 ◽

2017 ◽

Vol 20 (1) ◽

pp. 13-41 ◽

Cited By ~ 59

Author(s):

Ivan Ivanovich Dedov ◽

Marina Vladimirovna Shestakova ◽

Olga Konstantinovna Vikulova

Keyword(s):

Diabetes Mellitus ◽

Life Span ◽

Russian Federation ◽

Diabetic Complications ◽

Haemoglobin A1c ◽

Diabetes Registry ◽

Number Of Patients ◽

The Russian Federation ◽

Epidemiological Characteristics ◽

Hba1c Levels

Aim. We analysed the main epidemiological characteristics of diabetes mellitus (DM) in the Russian Federation (prevalence, incidence, mortality and mean life span), degree of diabetes control, and prevalence of diabetic complications (retinopathy, nephropathy, and diabetic foot syndrome and macrovascular pathology) according to the federal DM registry. Materials and methods. The database of the federal DM registry of 79 regions was included using the online system until 31.12.2016. Results. TThe total number of patients with DM in the Russian Federation on 31.12.2016 was 4.348 million (2.97% of the population), comprising 4 million patients with DM2 (92%), 255,000 with type 1 diabetes (T1DM) (6%), and 75,000 with other types of DM (2%). DM prevalence per 100,000 population was as follows: T1DM, 164.19/100,000; type 2 diabetes (T2DM), 2637.17/100,000; and other types of DM, 50.62/100. The incidence per 100,000 population was as follows: T1DM, 16.15/100,000; T2DM, 154.9/100,000; and other types of DM, 8.65/100,000. Mortality per 100,000 population was as follows: T1DM, 2.1/100,000; T2DM, 60.29/100,000; and other types of DM, 0.57/100,000. Mortality decreased in patients with T1DM by 6.6% and with T2DM by 3.6%. Mean life span in patients with T1DM was 50.3 years for men and 58.5 years for women. Mean life span in patients with T2DM was 70.1 years for men and 75.5 years for women. Glycated haemoglobin A1c (HbA1c) levels in T1DM was 7% in 33.4%, 7%7.9% in 28.3%, 8%8.9% in 16.2%, and 9.0% in 22.1% of patients. HbA1c levels in T2DM was 7% in 52.1%, 7%7.9% in 29.1%, 8%8.9% in 10%, and 9.0% in 8.7% of patients. Conclusions. This study evaluated the increase in DM prevalence in the Russian Federation in 2016 and in the dynamics of 20132016, which was mainly due to T2DM. An increase in patients with a target HbA1c level 7% and a decrease in the proportion of patients with severe uncontrolled DM was observed; however, the treatment effectiveness of this key indicator was unsatisfactory, i.e. less than a third of the patients with DM. In the dynamics of 20132016, an increase in mean life span for patients with T2DM and mortality reduction in patients with T1DM and T2DM was observed. The frequency of diabetic complications varied widely, which may reflect differences in the quality of specialised care in different regions.

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Epidemiological characteristics of diabetes mellitus in the Russian Federation: clinical and statistical analysis according to the Federal diabetes register data of 01.01.2021

Diabetes Mellitus ◽

10.14341/dm12759 ◽

2021 ◽

Vol 24 (3) ◽

pp. 204-221

Author(s):

I. I. Dedov ◽

M. V. Shestakova ◽

O. K. Vikulova ◽

A. V. Zheleznyakova ◽

M. А. Isakov

Keyword(s):

Diabetes Mellitus ◽

Russian Federation ◽

Dynamic Assessment ◽

Point Of View ◽

Sex Characteristics ◽

Glucose Lowering ◽

Patients With Diabetes ◽

The Russian Federation ◽

Diabetes Register ◽

Epidemiological Characteristics

BACKGROUND. One of the priority directions in the development of the health care system is to reduce the medical and social damage caused by the increase in the prevalence of diabetes mellitus (DM). From this point of view, the development of a diabetes register is very important as the main information and analytical platform for clinical and epidemiological monitoring of diabetes in the Russian Federation (RF).AIMS. The aim of our study was to analyze a dynamic (2016–2020) of the epidemiological characteristics of diabetes mellitus in the Russian Federation (prevalence, morbidity, mortality), the prevalence of complications, the level of HbA1c and the dynamics of the structure of glucose-lowering therapy (GLT) according to the Federal Diabetes Register (FDR).MATERIALS AND METHODs. The database of FRD (http://diaregistry.ru) 84 regions of the RF. The data are presented in dynamics 2016→2020.RESULTS. The total number of DM patients in the RF as of 01.01.2021 was 4,799,552 (3.23% of the population), including: Type 1 (T1) — 5.5% (265.4 ths) , T2 — 92.5% (4.43 million), other DM types — 2.0% (99.3 ths). The dynamics of prevalence was 168.7→180.9/100 ths people with T1, and 2709 → 3022/100 ths people with T2; morbidity in T1 10.5→7.7/100 ths population, in T2 219.6→154.2/100 ths population. Age and sex characteristics: the proportion of men in T1 — 54%, in T2 — 30%; the max proportion of patients with T1 at the age of 30–39 years, T2 65–69 years. Mortality: T1 3.0 → 2.7/100 ths population, T2 87.7→93.9/100 ths of the population, the main cause of death was cardiovascular: in T1 38,1% cases, in T2 — 52,0%. Life expectancy (average age of death of patients): T1 was 53.2years, the dynamics in males 50.7 → 50.5years, females 58.7→55.2years; in T2 — 73.5 years, males 70.2→70.1years, females 75.7→75.4 years. The dynamic of DM duration until the death: in T1 17.4→19.0 years; in T2 11→11.4 years. The incidence of diabetic complications in T1 and T2 patients: neuropathy 43.3% and 24.4%, nephropathy (CKD) 25.9% and 18.4%, retinopathy 31.7% and 13.5%, respectively. The proportion of patients with HbA1c <7%: in T1 32.3%→36.9%, in T2 51.9%→52.1%, with HbA1c ≥ 9.0% in T1 23.1%→18.7% , in T2 8.9%→8.0%. The structure GLT in T2 patients: glucose lowering medications (GLM) — 76.2% (monotherapy — 44.1%; combination of 2 GLM — 28.9%, 3 GLM — 3.2%), insulin therapy in 18,8%, without drug therapy in 4.9%.CONCLUSIONS. The performed analysis demonstrates the importance of dynamic assessment of epidemiological characteristics and monitoring of clinical data on patients with diabetes through a registry for assessing the quality of diabetes care and the prospects for its development.

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The psychiatric services of Saratov region and directions of its’ improvement (Clinical, statistical and epidemiological aspects)

European Psychiatry ◽

10.1016/j.eurpsy.2017.01.835 ◽

2017 ◽

Vol 41 (S1) ◽

pp. S568-S569

Author(s):

Y. Barylnik ◽

D. Samoylova ◽

S. Pakhomova ◽

J. Abrosimova ◽

E. Kolesnichenko ◽

...

Keyword(s):

Mental Disorders ◽

Russian Federation ◽

Psychiatric Services ◽

Saratov Region ◽

The Past ◽

Number Of Patients ◽

Competing Interest ◽

Services Effectiveness ◽

Epidemiological Characteristics

IntroductionThe determining of the actual number of people with mental disorders and their spreading by nosology still remains actual, especially according to different regions.ObjectivesThe determining of the psychiatric services effectiveness in Saratov region on the basis of comprehensive analysis of its’ clinical, statistical and epidemiological characteristics.MethodsThe analysis of mental state indicators based on the example of adults’ schizophrenia Saratov region in dynamics for 10 years (2005–2015) in comparison with Russian Federation.ResultsOver the past 10 years the number of clinically supervised patients with schizophrenia decreased at 0.9% in the city and 2.2% in region population. This is consistent with the tendency of schizophrenia morbidity in Russian Federation over the same period. The number of supervised adult patients with primary diagnosed schizophrenia in Russia remained at the same level and amounted to 10.8 per 100 thousand population. At the same time the noticeable fluctuations in the number of this patients’ category were observed in Saratov and Saratov region. Over the past 10 years, the proportion of patients with primary diagnosed schizophrenia disability in the class structure of mental disorders is quite high, averaging of 41.1% in Saratov region. Analyzing the number of patients with re-confirmed disabilities the gradual decline from 1846 to 755 people (at 59.1%) was found.ConclusionsThe mental health analysis of Saratov region population allows to suggest the long-term forecast of mental disorders’ morbidity, to analyze the level of disability due to schizophrenia, to develop recommendations for the optimal regional model of psychiatric services.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Meningococcal infection: clinical and epidemiological characteristics in modern conditions

Vestnik of Russian military medical Academy ◽

10.17816/brmma12356 ◽

2018 ◽

Vol 20 (4) ◽

pp. 186-191

Author(s):

V V Sharabkhanov ◽

K V Zhdanov ◽

S M Zakharenko ◽

N I L’vov ◽

K V Kozlov ◽

...

Keyword(s):

Russian Federation ◽

Meningococcal Disease ◽

Armed Forces ◽

Meningococcal Infection ◽

The Past ◽

The Face ◽

The Russian Federation ◽

The One ◽

Epidemiological Characteristics ◽

Epidemiological Situation

The problems of the incidence of meningococcal disease and the epidemiological situation in the world, in the Russian Federation and in the Armed Forces are consecrated. In the past decade, there has been a global decline in the incidence of meningococcal disease, but there is still the possibility of new outbreaks and epidemics. From 1996 to 2016, a decrease in the incidence of meningococcal disease was also noted in Russia. In certain regions of the Russian Federation, an increase in incidence was recorded, which did not affect the general trend. Against this background, the idea was formed that in the coming years, thanks to a favorable epidemiological situation and the possibility of preventing meningococcal infection with the help of a vaccine, it is possible to achieve control of this infection. However, meningococcus showed all the classic properties of variability and fitness. Changes in the structure of circulating serogroups of meningococcus led to the formation of a non-immune layer of the population in the face of increasing pathogenicity of the dominant serogroups. The activity of the epidemic process is indirectly indicated by the high diversity of genetic and serological clonal complexes, serogroups and serotypes of the pathogen. The incidence of meningococcal disease over the past ten years in the Armed Forces of the Russian Federation can be assessed as low, but mortality has high values. The peak incidence was in 2010, but the maximum percentage of mortality was in 2017-18,2%. The increase in mortality from invasive forms of meningococcal infection, on the one hand, is associated with an increase in the total number of sources of this infection, on the other hand, with errors in early diagnosis and, as a consequence, in the incorrect provision of emergency care at the prehospital stage, which recur from year to year and are of a similar nature.

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National register of diabetes mellitus in Russian Federation.

Diabetes Mellitus ◽

10.14341/dm201535-22 ◽

2015 ◽

Vol 18 (3) ◽

pp. 5-22 ◽

Cited By ~ 48

Author(s):

Ivan Ivanovich Dedov ◽

Marina Vladimirovna Shestakova ◽

Olga Konstantinovna Vikulova

Keyword(s):

Diabetes Mellitus ◽

Russian Federation ◽

Diabetic Complications ◽

Diabetes Care ◽

Research Centre ◽

Reference Center ◽

Epidemiological Monitoring ◽

Diabetes Register ◽

Related Mortality ◽

Online Software

Clinical and epidemiological monitoring of diabetes in Russian Federation (RF) is carried out by the National diabetes register, which methodological and organizational reference center is Federal Endocrinology Research Centre. Since 2014 initiated the translation the National diabetes register on online software system in order to increase the effectiveness of the register as a scientific and analytical platform. The article include the analysis of DM prevalence, incidence,DM-related mortality,the prevalence of diabetic complications and analysis of effectiveness of diabetes care (included HbA1c) and according to the data of online register.

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Prevalence of tuberculosis in Russian Federation in 1970–2019 and factors influencing its level

Medical alphabet ◽

10.33667/2078-5631-2021-18-23-33 ◽

2021 ◽

pp. 23-33

Author(s):

M. V. Shilova

Keyword(s):

Drug Resistance ◽

Hiv Infection ◽

Russian Federation ◽

Tuberculosis Patients ◽

The Past ◽

Factors Influencing ◽

Number Of Patients ◽

The Russian Federation ◽

Detection Quality

The data on the prevalence of tuberculosis in the Russian Federation are presented. A decrease in the prevalence of tuberculosis over the past 49 years, from 1970 to 2019, and a decrease in the number of patients with tuberculosis are shown. The factors influencing the prevalence of tuberculosis infection in the Russian Federation are considered: timely detection, quality of diagnosis and treatment of tuberculosis patients, MBT drug resistance, HIV infection in tuberculosis patients. The reliability of indicators characterizing the prevalence of tuberculosis has been studied.

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Basic principles of management of patients with diabetes mellitus type 2 in outpatient practice. Part 1. Diagnostics

Russian Family Doctor ◽

10.17816/rfd62679 ◽

2021 ◽

Vol 25 (1) ◽

pp. 19-25

Author(s):

Ludmila N. Degtyareva

Keyword(s):

Diabetes Mellitus ◽

Russian Federation ◽

Primary Care Physicians ◽

Vascular Complications ◽

High Rate ◽

Global Epidemic ◽

Number Of Patients ◽

Patients With Diabetes ◽

The Russian Federation ◽

Outpatient Practice

Worldwide, there is a high rate of growth in the incidence of diabetes mellitus. In the Russian Federation, the prevalence of diabetes is also high. According to some data, the number of patients with this disease in the Russian Federation can reach at least 9 million people (about 6% of the population). The most dangerous consequences of the global epidemic of diabetes mellitus are the development of its systemic vascular complications-nephropathy, retinopathy, lesions of the main vessels of the heart, brain, and arteries of the lower extremities. To prevent the development of complications of diabetes mellitus, its timely diagnosis is extremely important. Primary care physicians play a key role in early detection of diabetes. In this lecture, the risk factors for the development of diabetes mellitus, prevention of this disease, diagnostic approaches that allow timely detection of diabetes mellitus and start its treatment are considered. Diagnostic criteria for various disorders of the glycemic profile are presented. The role of glycated hemoglobin as a diagnostic criterion for diabetes mellitus is noted.

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Epidemiology of cardiovascular diseases among patients with diabetes mellitus according to the federal diabetes register of the Russian Federation (2013–2016)

Diabetes Mellitus ◽

10.14341/dm10167 ◽

2019 ◽

Vol 22 (2) ◽

pp. 105-114 ◽

Cited By ~ 1

Author(s):

Viktor Y. Kalashnikov ◽

Olga K. Vikulova ◽

Anna V. Zheleznyakova ◽

Mikhail А. Isakov ◽

Irina Z. Bondarenko ◽

...

Keyword(s):

Diabetes Mellitus ◽

Cardiovascular Diseases ◽

Russian Federation ◽

Cerebrovascular Diseases ◽

Incidence Rates ◽

Prevention Measures ◽

Patients With Diabetes ◽

Large Heterogeneity ◽

The Russian Federation ◽

Diabetes Register

BACKGROUND: Cardiovascular diseases (CVD) are the main cause of death for patients with diabetes mellitus (DM). AIMS: To evaluate the CVD epidemiology: coronary heart disease (CHD), myocardial infarction (MI) and cerebrovascular diseases in adult patients with type 1 (T1DM) and type 2 (T2DM) diabetes, compare dynamics with data of implementation of the Federal Program Diabetes mellitus in 20072012 and over the online period 20132016. MATERIALS AND METHODS: The database of the Federal Diabetes register (81 regions at 12.2017). We estimated prevalence and incidence rates/10 thousand (th) adult DM patients over 18 years. RESULTS: The prevalence of CVD for the period 2007 2016 significant decreased in CHD for T1DM from 14,9% to 3,5%, for T2DM from 20,1% to 11,7%; MI for T1DM from 5,7% to 1,3%, for T2DM from 7,6% to 3,5%; cerebrovascular diseases for T1DM from 4,9% to 1,7%, for T2DM from 7,6% to 4,3%, respectively. In 20132016 positive trends continued: MI for T1DM 8,25,9/10th patients, for T2DM 19,214,7/10th patients, respectively; CVD for T1DM 11,310,5, for T2DM 29,425,4/10th patients, respectively. There was a large heterogeneity of the prevalence of CVD in the regions. MI varied in patients for T1DM from 319/10 th patients to absence, for T2DM from 800 to 7/10 th patients; the development of cerebrovascular diseases for T2DM from 900 to less than 100/10 th patients, which is largely due to differences in their registration. A small number of cases may be due to insufficient filling of the database, the facts of a huge number require further analysis. The average age of development of MI had increased: for T1DM 51,253 years, for T2DM 63,565 years, cerebrovascular diseases for T1DM 52,352.5 years, for T2DM 65,266,5, respectively. CONCLUSIONS: The prevalence of CVD significantly decreased in the Russian Federation compared to 20072012, as well as for the period 20132016: the prevalence of CHD and cerebrovascular diseases declined, the number of new cases of MI decreased, the average age and duration of DM before the development of CVD significantly increased. These data reflect the results of the program for improvement medical care and prevention measures for patients with diabetes.

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Epidemiological Situation on the Tick-Borne Viral Encephalitis in the Russian Federation in 2009-2011 and Prognosis for 2012

Problems of Particularly Dangerous Infections ◽

10.21055/0370-1069-2012-1(111)-30-33 ◽

2012 ◽

pp. 30-33

Author(s):

A. K. Noskov ◽

A. Ya. Nikitin ◽

N. D. Pakskina ◽

E. A. Sidorova ◽

M. V. Chesnokova ◽

...

Keyword(s):

Russian Federation ◽

Forest Fires ◽

Viral Encephalitis ◽

Early Summer ◽

The Past ◽

Epidemiological Monitoring ◽

Control And Prevention ◽

The Russian Federation ◽

Epidemiological Situation ◽

Weather Anomalies

Analysis of the epidemiological situation on the tick-borne viral encephalitis in the territory of the Russian Federation with due consideration to weekly epidemiological monitoring data (2009-2011), conducted by Rospotrebnadzor organizations in the corresponding constituent entities, testifies of the fact that continuous decrease in morbidity, characteristic of the early XXI century, has given way to a slight increase within the past three years. Given that there are no spring or early-summer weather anomalies or forest fires, morbidity rates among the population of the Russian Federation in 2012 can tend to exceed 2011 rates. Comprehensive set of measures applied for the disease control and prevention in the majority of endemic territories is quite effective in view of averting sharp upturn of morbidity rates, but nevertheless is not sufficient in view of the suppression of epidemiological situation.

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