scholarly journals NSAID enteropathy

2020 ◽  
Vol 92 (2) ◽  
pp. 85-92
Author(s):  
E. N. Kareva
Keyword(s):  
Small Intestine ◽  
Therapeutic Strategy ◽  
Intestinal Flora ◽  
Nsaid Enteropathy ◽  
The World ◽  
Prevention And Treatment ◽  
Nsaid Gastropathy ◽  
Inflammatory Drugs ◽  
Very High

Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly used drugs in the world, and their side effects are very high. First of all, these are NSAID gastropathy, but in the long term, 5070% of NSAIDs cause damage to the small intestine (NSAID enteropathy), sometimes with serious consequences. To date, no drugs have been proposed with proven effectiveness to prevent this side effect. Apparently, this is not due to the fully clarified mechanism of pathogenesis. The most promising is the hypothesis of the participation of individual representatives of microflora in the development of enteropathy. Therefore, modulating the intestinal flora with the help of probiotics can be the basic therapeutic strategy for the prevention and treatment of such damage.

scholarly journals Ventilatory support and corticosteroid therapy in SARS-CoV-2

2021 ◽  
Vol 34 (Suppl 1) ◽  
pp. 52-56
Author(s):  
Fernando Martínez Sagasti ◽  
Alba Palazón Blanco ◽  
Sandra Catalina García-Perrote ◽  
Patricia Alonso Martínez ◽  
Keyword(s):  
Clinical Trials ◽  
Respiratory Failure ◽  
Therapeutic Strategy ◽  
Ventilatory Support ◽  
Short Review ◽  
World Health ◽  
Medical Community ◽  
The World ◽  
Inflammatory Drugs ◽  
Health Organization

It has been almost two years since COVID-19, a disease caused by a new coronavirus called SARS-CoV-2, was declared a pandemic by the World Health Organization. The entire scientific and medical community was put to the test during the following months to find the best therapeutic strategy to save lives. Although some antivirals and anti-inflammatory drugs are being tested in different clinical trials with some controversial results, this short review will focus on corticosteroids usefulness and ventilatory support principles, as they have become two essential therapeutic pillars for those patients who need hospital admission due to respiratory failure.

scholarly journals Citrus phytochemicals and their potential effects on the prevention and treatment of obesity: review and progress of the past 10 years

2018 ◽  
Vol 4 ◽  
Author(s):  
Shi Feng ◽  
Yu Wang
Keyword(s):  
Citrus Fruits ◽  
Active Components ◽  
Safety Assurance ◽  
The Past ◽  
The World ◽  
Prevention And Treatment ◽  
Life Threatening ◽  
Treatment Of Obesity ◽  
Obesity Drugs

Obesity is a chronic life-threatening disease throughout the world. Available anti-obesity drugs may have hazardous side effects and no long-term safety assurance is in place for patients. In recent decades, alternative natural therapeutics have been intensively investigated. Among them, phytochemicals from citrus fruits have shown tremendous potential to combat obesity through different mechanisms. To date, the most active biological constitutes identified in citrus fruits are flavonoids and p-synephrine. These exert anti-obesity effects through multiple mechanisms, including regulating energy intake and expenditure, regulating lipid metabolism and regulating adipogenesis. In this mini review, a survey focusing on citrus phytochemicals and their anti-obesity activities is presented, together with an update of findings over the last 10 years, including active components and mechanisms of anti-obesity activities.

scholarly journals Model Empiris Impor Garam Indonesia

2020 ◽  
Vol 11 (2) ◽  
pp. 125-135
Author(s):  
Abdul Hakim ◽  
Anissa Triyanti
Keyword(s):  
Time Series ◽  
Exchange Rate ◽  
Salt Content ◽  
Correction Model ◽  
Independent Variables ◽  
The World ◽  
Independent Variable ◽  
Very High ◽  
Analyze Data

Indonesia is the fourth longest coastal country in the world, so it has the potential to become a salt exporting country. But appareantly, Indonesia has very high salt imports. This paper seeks to raise the irony bya modeling Indonesian salt imports. Based on various theories and result of previous studies, this paper proposes the price of imported salt, the real exchange rate, the need for salt, and domestic production as an independent variable. The sample used stretches from 2001 to 2018. This paper uses a time series model to analyze data. With the conditional ECM (error correction model), this paper finds that in the short or long term, all selected independent variables have a significant effect on the volume of salt imports, although the exchange rate requires lag to influence the import. This paper suggests increasing the education of salt farmers related to the salt content desired by industry.

scholarly journals Comparative analysis of the cost of pharmacotherapy schemes for patients with rheumatoid arthritis

2020 ◽  
pp. 37-45
Author(s):  
N. L. Khanyk ◽  
O. R. Levytska ◽  
G. I. Bilushchak ◽  
T. Ya. Khanyk
Keyword(s):  
Rheumatoid Arthritis ◽  
Analysis Data ◽  
Two Component ◽  
Retail Prices ◽  
Inflammatory Drugs ◽  
The Cost ◽  
Comparative Content ◽  
Data Generalization ◽  
Very High

Rheumatoid arthritis (RA) is an unpredictable and progressive inflammatory disease of the joints of an immune nature, which in general for various reasons reduces the life expectancy of patients by 5 to 10 years. Pharmacotherapy of RA is based on long-term use of a large number of drugs of different pharmacotherapeutic groups, the cost of which varies significantly. The above makes the study of economic parameters of RA treatment an urgent problem. The aim of the study was to analyse the cost characteristics of pharmacotherapy of inpatients with RA in a hospital in order to optimize the cost of medication for these patients. The data of medical cards and medical records of 89 and 108 inpatients with RA, which were treated in the rheumatology department of the 4th Lviv City Clinical Hospital in 2009 and 2019, respectively, were selected as objects of the study. The methods of information retrieval, mathematical statistics, frequency, comparative, content analysis, data generalization, cost analysis were used. Disease-modifying antirheumatic drugs (DMARDs), glucocorticosteroids (GCs), and nonsteroidal anti-inflammatory drugs (NSAIDs) were grouped into six schemes for the RA pharmacotherapy in 2009 and 2019. An increase in the number of appointments of those schemes in which DMARDs were used has been established. The maximum share in both analysed periods was occupied by the triple pharmacotherapy scheme, which included all the above-mentioned drugs. This scheme was also the most expensive and its value at average retail prices (ARP) increased the most (9.4 times) from 2009 till 2019. During the analysed period, the average salary in Lviv region increased in 5.4 times, while the cost change indices (Ic) of different pharmacotherapy schemes, calculated on the basis of ARP, ranged from 6.9 for the two-component scheme with DMARDs and NSAIDs to 9.4 for the three-component scheme with DMARDs, GCs and NSAIDs. The analysis of affordability indices (Ia) showed that the most accessible was a two-component scheme, which included DMARDs and NSAIDs (Ia = 0.78). The study of the influence of the cost of the treatment schemes on the frequency of their prescribing using correlation analysis showed a very high dependence of these indices (R = 0.97). Pairwise correlations of pharmacotherapy appointment change indices (Iap) from Ic based on minimum (RPmin), maximum (RPmax) or average retail prices in Lviv pharmacies made it possible to establish a very high pair dependence of Iap from Ic calculated only on the basis of RPmax or ARP (R = 0.90). Thus, the analysis of patients' consumption of drugs for pharmacotherapy RA in the hospital allowed us to establish that in 2019 the treatment of RA became less available in comparison to 2009.

scholarly journals The improvement of treatment efficacy of gastropathy associated with the use of nonsteroidal anti-inflammatory drugs in Helicobacter pylori-negative patients with osteoarthritis

2014 ◽  
Vol 27 (4) ◽  
pp. 237-239
Author(s):  
Antonina V. Antonenko ◽  
Tetyana V. Beregova
Keyword(s):  
Gastric Mucosa ◽  
Initial Step ◽  
Colon Tissue ◽  
Nsaid Enteropathy ◽  
Osteoarthritis Treatment ◽  
Direct Injury ◽  
Treatment Changes ◽  
Nsaid Gastropathy ◽  
Inflammatory Drugs ◽  
Gastric Mucous

Abstract Among the more common side effects of osteoarthritis treatment are NSAID-gastropathy and NSAID-enteropathy. NSAIDs can cause direct injury to colon tissue and also impair synthesis of prostaglandins, reduce mucosal integrity, increase permeability and promote an influx of bacteria and toxins. Alterations in gastrointestinal permeability are considered as an initial step in the development of lesions of the gastric mucosa such as erosions and ulcers. The mechanisms underlying the ability of NSAIDs to cause ulceration in the stomach and proximal duodenum are well understood and this injury can be largely be prevented through suppression of gastric acid secretion. However, our work showed that 28-day administration of the anti-secretory preparation pantoprazole (20 mg 2 times per day) resulted in a statistically significant increase of dysbiosis. Monitoring of patients with osteoarthritis who used NSAIDs for more than three months showed that, in comparison to the situation before the beginning of treatment, changes in colonic microbiota were present. Multiprobiotic “Symbiter® acidophilic concentrated” introduced simultaneously with pantoprazole during 20 days prevented formation of dysbiotic changes and led to the quicker healing of gastric mucous healing, in comparison with patients who used only pantoprazole alone. Moreover, it brought about total healing of the gastric mucosa within 4 weeks from the beginning of treatment.

scholarly journals Nutraceutical Approach to Chronic Osteoarthritis: From Molecular Research to Clinical Evidence

2021 ◽  
Vol 22 (23) ◽  
pp. 12920
Author(s):  
Alessandro Colletti ◽  
Arrigo F. G. Cicero
Keyword(s):  
Molecular Mechanisms ◽  
Clinical Evidence ◽  
Joint Stiffness ◽  
Efficacy And Safety ◽  
The World ◽  
Inflammatory Drugs ◽  
Arthritic Joints ◽  
Current Guidelines ◽  
Heterogeneous Class

Osteoarthritis (OA) is a degenerative inflammatory condition of the joint cartilage that currently affects approximately 58 million adults in the world. It is characterized by pain, stiffness, and a reduced range of motion with regard to the arthritic joints. These symptoms can cause in the long term a greater risk of overweight/obesity, diabetes mellitus, and falls and fractures. Although the current guidelines for the treatment of OA suggest, as the gold standard for this condition, pharmacological treatment characterized by non-steroidal anti-inflammatory drugs (NSAID), opioids, and cyclooxygenase (COX)-2-specific drugs, a great interest has been applied to nutraceutical supplements, which include a heterogeneous class of molecules with great potential to reduce inflammation, oxidative stress, pain, and joint stiffness and improve cartilage formation. The purpose of this review is to describe the potential application of nutraceuticals in OA, highlighting its molecular mechanisms of actions and data of efficacy and safety (when available).

scholarly journals An Ongoing Blended Long-Term Vegetation Health Product for Monitoring Global Food Security

Agronomy ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1936
Author(s):  
Wenze Yang ◽  
Felix Kogan ◽  
Wei Guo
Keyword(s):  
Food Security ◽  
Infrared Imaging ◽  
Global Food Security ◽  
The World ◽  
Health Concepts ◽  
Vegetation Health ◽  
Global Vegetation ◽  
Very High ◽  
Global Food

Remotely observing global vegetation from space has endured for nearly 50 years. Many datasets have been developed to monitor vegetation status. Tailored to specifically monitor global food security concerning drought and crop yield, a suite of datasets based on vegetation health concepts and Advanced Very High Resolution Radiometer (AVHRR) observation was developed in the 1980s and utilized throughout the world. Nowadays, satellites based imaging radiometers have evolved into the Visible Infrared Imaging Radiometer Suite (VIIRS) era. With proper algorithm development, the blended version of the data suite, composed of the AVHRR dataset from 1981 to 2012 and VIIRS dataset from 2013 and afterwards, has bridged the long-term AVHRR observation and high-quality VIIRS data. This paper explains the blended version of the data suite.

scholarly journals Practical use of non-steroidal anti-inflammatory drugs in relieving recurrent headaches

2021 ◽  
Vol 23 (2) ◽  
pp. 148-153
Author(s):  
Gyuzyal R. Тabeeva ◽  
◽  
Ekaterina A. Kiryanova ◽  
Keyword(s):  
Medication Overuse ◽  
Medication Overuse Headache ◽  
Tension Headache ◽  
The World ◽  
Headache Treatment ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Rule Out

The main burden of headache in the world falls on primary cephalalgia (tension headache, migraine). However, there is often a need to rule out a secondary cause of the headache. This review presents the main options for the differential diagnosis of cephalgias, taking into account the patient’s age, headache characteristics, and anamnestic information. The role of non-steroidal anti-inflammatory drugs in headache treatment, the safety of its long-term use and prevention of medication overuse headache are discussed.

scholarly journals Small intestinal damage associated with the use of nonsteroidal anti-inflammatory drugs

2019 ◽  
Vol 47 (6) ◽  
pp. 559-567 ◽  
Author(s):  
A. E. Karateev ◽  
E. V. Moroz ◽  
E. V. Kryukov
Keyword(s):  
Small Intestine ◽  
Capsule Endoscopy ◽  
Mucosal Inflammation ◽  
Intestinal Damage ◽  
Short Term ◽  
Iron Deficient ◽  
Nsaid Enteropathy ◽  
Inflammatory Drugs ◽  
Small Intestinal ◽  
Anti Inflammatory

The use of nonsteroidal anti-inflammatory drugs (NSAID), even if short-term, may be associated to small intestinal complications, such as erosions, ulcers and chronic mucosal inflammation. Video capsule endoscopy allows for identification of such lesions in 20 to 55% of the patients who have taken nonselective NSAID for 2 to 4  weeks. The pathophysiology of NSAID-induced enteropathy is related to a reduced reparative potential of the mucosa and abnormalities of the microbial balance in the small intestine. In real world practice, NSAID enteropathy is commonly asymptomatic, and its manifestations, such as bleeding, perforation and ileus, are quite rare (about 0.3 episodes per 100  patient-years). The main manifestation of NSAID enteropathy is chronic iron deficient anemia. The use of rebamipide, sulfasalazine, mesalazine, and rifaximin has been discussed in the treatment of NSAID enteropathy, whereas its prevention implies preferential administration of coxibs, the use of rebamipide and probiotics.

Thoughts on the Long-Term Strategy, Science and Democracy

2006 ◽  
pp. 4-19 ◽  
Author(s):  
L. Abalkin
Keyword(s):  
Strategy Development ◽  
Russian Science ◽  
Global Trends ◽  
The World ◽  
World Development ◽  
Crucial Condition

The article covers unified issues of the long-term strategy development, the role of science as well as democracy development in present-day Russia. The problems of budget proficit, the Stabilization Fund issues, implementation of the adopted national projects, an increasing role of regions in strengthening the integrity and prosperity of the country are analyzed. The author reveals that the protection of businessmen and citizens from the all-embracing power of bureaucrats is the crucial condition of democratization of the society. Global trends of the world development and expert functions of the Russian science are presented as well.

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