scholarly journals The myocardial infarction size measuring using modern methods

2020 ◽  
Vol 92 (4) ◽  
pp. 105-110
Author(s):  
E. A. Shigotarova ◽  
V. A. Galimskaja ◽  
A. V. Golubeva ◽  
V. E. Oleynikov

An accurate quantitative assessment of myocardium necrosis area and the viable zone (stunned and hibernating) in patients with myocardial infarction is crucial for the preoperative patient selection and predicting the cardiac surgery effectiveness. Currently, researchers and clinicians are most interested in the problem of determining the viable myocardium zone. However, only the necrosis zone area directly correlates with the patients prognosis and determines the heart pathological remodeling processes. In the distant period, the data obtained can be used to predict the post-infarction period course or for analysis the relationship of the necrosis zone with arrhythmogenesis, and a number of other indicators. Thus, the necrosis zone and the viable myocardium zone are two parameters that need to be monitored in dynamics in all patients after myocardial infarction. The most accurate and reproducible method for determining the necrosis area is contrast magnetic resonance imaging of the heart, however, this technique is still inaccessible in most hospitals. In this regard, it remains relevant to estimate the necrotic myocardium area by ubiquitous non-invasive methods such as electrocardiography and echocardiography.

2021 ◽  
Author(s):  
Jefferson Ortega ◽  
Chelsea Reichert Plaska ◽  
Bernard A Gomes ◽  
Timothy M Ellmore

Spontaneous eye blink rate (sEBR) has been found to be a non-invasive indirect measure of striatal dopamine activity. Dopamine (DA) neurons project to the prefrontal cortex (PFC) through the mesocortical dopamine pathway and their activity is implicated in a range of cognitive functions, including attention and working memory (WM). The goal of the present study was to understand how fluctuations in sEBR during different phases of a working memory task relate to task performance. Across two experiments, with recordings of sEBR inside and outside of a magnetic resonance imaging bore, we observed sEBR to be positively correlated with WM performance during the WM delay period. Additionally we investigated the non-linear relationship between sEBR and WM performance, and modeled a proposed Inverted-U-shape relationship between DA and WM performance. We also investigated blink duration, which is proposed to be related to sustained attention, and found blink duration to be significantly shorter during the encoding and probe periods of the task. Taken together, these results provide support towards sEBR as an important correlate of working memory task performance. The relationship of sEBR to DA activity and the influence of DA on the PFC during WM maintenance is discussed.


2015 ◽  
Vol 9 (S7) ◽  
Author(s):  
Bolshova Alina Sergeevna ◽  
Krushelnickii Anatoliy Aleksandrovich ◽  
Stepanova Ekaterina Vladimirovna ◽  
Degterev Dmitrii Nickolaevich

2022 ◽  
Author(s):  
Salman Razvi ◽  
Avais Jabbar ◽  
Arjola Bano ◽  
Lorna Ingoe ◽  
Peter Carey ◽  
...  

Objectives: To study the relationship between serum free T3 (FT3), C-reactive protein (CRP), and all-cause mortality in patients with acute myocardial infarction (AMI). Design: Prospective multicentre longitudinal cohort study. Methods: Between December 2014 and December 2016, thyroid function and CRP were analysed in AMI (both ST- and non-ST-elevation) patients from the ThyrAMI-1 study. The relationship of FT3 and CRP at baseline with all-cause mortality up to June 2020 was assessed. Mediation analysis was performed to evaluate if CRP mediated the relationship between FT3 and mortality. Results: In 1919 AMI patients [29.2% women, mean (SD) age 64.2 (12.1) years and 48.7% STEMI] followed over a median (inter-quartile range) period of 51 (46 to 58) months, there were 277 (14.4%) deaths. Overall, lower serum FT3 and higher CRP levels were associated with higher risk of mortality. When divided into tertiles based on levels of FT3 and CRP, the group with the lowest FT3 and highest CRP levels had 2.5-fold increase in mortality risk [adjusted hazard ratio (95% confidence interval) of 2.48 (1.82 to 3.16)] compared to the group with the highest FT3 and lowest CRP values. CRP mediated 9.8% (95% confidence interval 6.1 to 15.0%) of the relationship between FT3 and mortality. Conclusions: In AMI patients, lower serum FT3 levels on admission are associated with a higher mortality risk, which is partly mediated by inflammation. Adequately designed trials to explore potential benefits of T3 in AMI patients are required.


2013 ◽  
Vol 21 (4) ◽  
pp. 509-516 ◽  
Author(s):  
Carole A. McBride ◽  
Sarah A. Hale ◽  
Meenakumari Subramanian ◽  
Gary J. Badger ◽  
Ira M. Bernstein

Diabetologia ◽  
1988 ◽  
Vol 31 (4) ◽  
pp. 201-205 ◽  
Author(s):  
J. S. Yudkin ◽  
G. A. Oswald ◽  
P. M. McKeigue ◽  
R. D. Forrest ◽  
C. A. Jackson

2014 ◽  
Vol 986-987 ◽  
pp. 2176-2179
Author(s):  
Li Li Sui ◽  
Yong Ming Yang ◽  
Peng Liu ◽  
Jia Liang Chen ◽  
Zhi Shun Ge ◽  
...  

In order to solve complex problems of traditional methods used to evaluate the rock fracability, the relationship between fractal dimension, rock brittleness and fracture density these three parameters was studied. The multiple linear regression is reasonable through nine kinds cores. The regression coefficients demonstrate both rock brittleness and surface fracture density play positive roles on fractal dimension value, the larger they are, the better the fracability. Therefore, the two parameters can be converted to consider only one parameter that is the fractal dimension of rock. The larger the fractal dimension, the better the fracability is, that is using fractal dimension represents brittle index and surface density to participate in fracability evaluation.


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