scholarly journals Cardio-ankle vascular index (CAVI) in diagnostics, risk and severity evaluation of magistral vessels lesion in patients with cardio-vascular diseases and type 2 diabetes

2021 ◽  
Vol 93 (1) ◽  
pp. 87-93
Author(s):  
Vladimir A. Verner ◽  
Maria V. Mel’nik ◽  
Svetlana A. Knjazeva
Keyword(s):  
Type 2 Diabetes ◽  
Structural Changes ◽  
Arterial Wall ◽  
Vascular Diseases ◽  
Chronic Hypertension ◽  
Portable Devices ◽  
Wall Stiffness ◽  
Cardio Vascular ◽  
Pressure Changes

Assesment of arterial stiffness the substantional prognostic factor for evaluating complications of cardiovascular diseases (CVD) in patients with atherosclerosis, hypertension and type 2 diabetes, may be performed using different parameters, including cardio-ankle vascular index (CAVI). The main purpose of this review is to analyze data from studies where CAVI is used to test the arterial wall stiffness in magistral vessels. CAVI measurement is non-invasive and performed by portable devices which makes it comfortable for ambulatory use in patients who come for a check-up and also in those who already are hospitalized. It does not require any special knowledge from investigator and the test lasts a couple of minutes long. CAVI does not depend on blood pressure changes and is more specific in structural changes of arterial wall assessment than brachial-ankle pulse wave velocity (baPWV). CAVI shows considerable correlation with markers of CVD like atherosclerotic plaques in vessels, diastolic disfunction of left ventricle and angina pectoris. CAVI may be used for early monitoring and assessing the lesions of target organs in patients with atherosclerosis, chronic hypertension and type 2 diabetes. Establishing CAVI as a standart parameter in assessing patients who are at risk of CVD can help to improve complications prevention, reduce mortality and prolong their lifespan.

Arterial wall stiffness is associated with peripheral circulation in patients with type 2 diabetes

2003 ◽  
Vol 170 (1) ◽  
pp. 87-91 ◽  
Author(s):  
Akane Kizu ◽  
Hidenori Koyama ◽  
Shinji Tanaka ◽  
Takaaki Maeno ◽  
Miyoko Komatsu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Arterial Wall ◽  
Peripheral Circulation ◽  
Wall Stiffness

scholarly journals Statin and Spirulina: Will it be an Effective combination in Management of Type 2 Diabetes and it’s Complications

2020 ◽  
Vol 11 (4) ◽  
pp. 6589-6594
Author(s):  
Anand Vijaya Kumar P R ◽  
Kokul Rajan P ◽  
Seema A ◽  
Balashanmugam K
Keyword(s):  
Type 2 Diabetes ◽  
Scientific Evidence ◽  
Vascular Diseases ◽  
The Body ◽  
Hmg Coa Reductase ◽  
Blue Green Algae ◽  
Reductase Inhibitors ◽  
Cardio Vascular ◽  
Coa Reductase

Diabetes is a chronic disease that occurs either when the pancreas does not produce enough insulin or when the body cannot effectively use the insulin it produces. Type 2 diabetes results from the body’s ineffective use of insulin. Type 2 diabetes comprises most people with diabetes around the world and is associated with various complications such as diabetic , , nephropathy, cardio vascular diseases, depression, dementia, sexual dysfunction etc. classified as , or blue-green algae which has been used for centuries as a food source in other countries. is also being promoted to prevent, treat, or cure several conditions, including high cholesterol, hypertension, diabetes, depression, viral hepatitis, and malnutrition. A few assertions have been tested, but most trials have been small, poorly designed, or inconclusive. Statins suppress the enzyme HMG-CoA reductase via pathway. The health advantage of HMG-CoA reductase inhibitors is believed to expand behind their cholesterol lowering effects. Such effects of statins incorporate complimentary effects on endothelial function, systemic inflammation and oxidative stress. The above-mentioned effects were predicted to decrease the risk of diabetes, even though statins are supported by most patients, some study suggested it is affiliated with new onset of diabetes . Despite dispute discoveries, many studies suggest that different statins may relay distinct possibility of diabetes. The problem is, there's little or no scientific evidence to back up such claims. this review is under taken to the potential benefits if and statin in management of type 2 diabetes and its complications. Many previous studies were thoroughly, and it was found that combination of and statin is found to reduce the diabetes and its complications.

scholarly journals Estrogen receptor 1 gene polymorphisms (PvuII and XbaI) are associated with type 2 diabetes in Palestinian women

PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e7164 ◽  
Author(s):  
Suheir Ereqat ◽  
Stéphane Cauchi ◽  
Khaled Eweidat ◽  
Muawiyah Elqadi ◽  
Abedelmajeed Nasereddin
Keyword(s):  
Type 2 Diabetes ◽  
Estrogen Receptor ◽  
Vascular Diseases ◽  
Control Group ◽  
Dominant Model ◽  
Palestinian Women ◽  
Cardio Vascular ◽  
Palestinian Population ◽  
Estrogen Receptor 1

Background Type 2 diabetes mellitus (T2DM) is a multifactorial disease where both genetic and environmental factors contribute to its pathogenesis. The PvuII and XbaI polymorphisms of the estrogen receptor 1 (ESR1) gene have been variably associated with T2DM in several populations. This association has not been studied in the Palestinian population. Therefore, the aim of this study was to investigate the association between the PvuII and XbaI variants in the ESR1 and T2DM and its related metabolic traits among Palestinian women. Methods This case–control study included 102 T2DM and 112 controls in which PvuII and XbaI variants of the ESR1 gene were genotyped using amplicon based next generation sequencing (NGS). Results Allele frequencies of both PvuII and XbaI variants were not significantly different between patients and control subjects (P > 0.05). In logestic regression analysis adjusted for age and BMI, the ESR1 PvuII variant was associated with risk of T2DM in three genotypic models (P < 0.025) but the strongest association was observed under over-dominant model (TT+CC vs. TC) (OR = 2.32, CI [1.18–4.55] adjusted P = 0.013). A similar but non-significant trend was also observed for the ESR1 XbaI variant under the over-dominant model (AA+GG vs. AG) (OR = 2.03, CI [1.05–3.95]; adjusted P = 0.035). The frequencies of the four haplotypes (TA, CG, CA, TG) were not significantly different in the T2DM patients compared with control group (P > 0.025). Among diabetic group, an inverse trend with risk of cardio vascular diseases was shown in carriers of CG haplotype compared to those with TA haplotype (OR = 0.28, CI [0.09–0.90]; adjusted P = 0.035). Further, stratified analyses based on ESR1 PvuII and XbaI genotypes revealed no evidence for association with lipid levels (TC, TG, HDL, LDL). Conclusions This is the first Palestinian study to conclude that ESR1 PuvII and XbaI variants may contribute to diabetes susceptibility in Palestinian women. Identification of genetic risk markers can be used in defining high risk subjects and in prevention trials.

Cardio-ankle vascular index in persons with prediabetes and diabetes mellitus in a population sample of Western Siberia of the Russian Federation

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
AN Sumin ◽  
N Bezdenezhnykh ◽  
AV Bezdenezhnykh ◽  
GV Artamonova
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Russian Federation ◽  
Arterial Wall ◽  
Population Sample ◽  
Factors Affecting ◽  
Wall Stiffness ◽  
The Russian Federation ◽  
Diabetes Patients

Abstract Funding Acknowledgements Type of funding sources: Public Institution(s). Main funding source(s): Federal State Budgetary Scientific Institution “Research Institute for Complex Issues of Cardiovascular Diseases” The aim of this study was to evaluate the level of cardio-ankle vascular index (CAVI) in the presence of pre-diabetes and diabetes mellitus in the population sample of the Russian Federation, as well as to investigate the factors associated with pathological CAVI in these subjects. Methods 1628 (age 25-64 years) were recruited in a observational cross-sectional study ESSE-RF in the period from 2012 to 2013. The standard protocol of the ESSE-RF has been extended with additional study of CAVI. The final sample included 1617 people, they are divided into 3 groups: group 1 - patients with type 2 diabetes mellitus (n = 272), group 2 - patients with prediabetes - IFG, IGT or their combination (n = 44), and group 3 - persons without CMD (n = 1301). Results The median CAVI was higher in diabetes and pre-diabetes groups (p = 0.009 and p &lt;0.001, respectively, compared with group without CMD). Pathological CAVI (≥9.0) was detected in 16.8% of diabetes patients, in 15.9% of those with prediabetes, and in 9.0% of those without CMD (p &lt;0.001 when comparing diabetes group and group without CMD). The groups with diabetes and prediabetes also did not differ in factors affecting the level of arterial wall stiffness (gender, blood pressure, age, dyslipidemia, uric acid level). According to the result of the correlation analysis in the general sample, CAVI positively correlated with age (p &lt;0.001), male sex (p &lt;0.001), type 2 diabetes (p &lt;0.001), prediabetes (p = 0.002), waist circumference (p &lt;0.001), visceral obesity (p &lt;0.001), total cholesterol (p &lt;0.001), triglycerides (p &lt;0.001), LDL cholesterol (p &lt;0.001), and with the inverse correlation - with glomerular filtration rate (GFR, p &lt;0.001). In multivariate analysis, age and the presence of arterial hypertension were independently associated with pathological CAVI in the groups of patients with CMD, and in the group without CMD, in addition to these factors - a decrease in GFR. Conclusions In the population sample of the Russian Federation, the CAVI index values in the prediabetes and diabetes patients were higher than in the normoglycemia persons. The groups with diabetes and prediabetes also did not differ in factors affecting the level of arterial wall stiffness. Since the identified disorders of arterial stiffness in prediabetes are similar to those in diabetes, their identification is important to prevent further cardiovascular complications.

scholarly journals Correlation between arterial wall stiffness, N-terminal prohormone of brain natriuretic peptide, functional and structural myocardial abnormalities in patients with type 2 diabetes mellitus and cardiac autonomic neuropathy

2013 ◽  
Vol 16 (4) ◽  
pp. 72-77
Author(s):  
Viktoriya Alexandrovna Serhiyenko ◽  
Alexander Alexandrovich Serhiyenko ◽  
Boris Nikitich Mankovsky
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Brain Natriuretic Peptide ◽  
Plasma Levels ◽  
Arterial Wall ◽  
Vascular Wall ◽  
Cardiac Autonomic Neuropathy ◽  
Wall Stiffness

Aim. To assess arterial wall stiffness, plasma levels of of N-terminal prohormone of brain natriuretic peptide (NT-proBNP), as well as functional state and structure of the myocardium in patients with type 2 diabetes mellitus (T2DM) and cardiac autonomic neuropathy (CAN). Materials and Methods. The study involved a total of 65 patients with T2DM. 12 had no evidence of cardiovascular disease (CVD) or CAN, 14 were diagnosed with subclinical stage of CAN, 18 ? with functional stage, and 21 ? with organic stage. We measured aortic pulse wave velocity (PWV), aortic augmentation index (AIx), brachial artery AIx, ambulatory arterial stiffness index (AASI) and plasma levels of NT-proBNP. Clinical examination included ECG, Holter monitoring, ambulatory BP measurement and echocardiography. Results.  Patients with isolated T2DM showed a trend for increased vascular wall stiffness. PWV was increased in patients with subclinical stage of CAN. Aortic and brachial AIx, PWV and AASI were elevated in patients with functional stage of CAN, PWV being significantly higher vs. subclinical CAN subgroup. Organic stage was characterized by pathologically increased values of all primary parameters; PWV and AASI were significantly higher compared with other groups. Development and progression of CAN was accompanied by an increase in NT-proBNP plasma levels. Concentration of NT-proBNP was in direct correlation with left ventricular mass (LVM) and PWV. PWV and LVM values also directly correlated between themselves. Conclusion. Development and progression of CAN in patients with T2DM is accompanied by an increase in vascular wall stiffness. The elevation of plasma NT-proBNP in patients with T2DM correlates with the development of CAN and is significantly and independently associated with an increase in LVM and PWV. Our data suggests the pathophysiological interconnection between metabolic, functional and structural myocardial abnormalities in patients with T2DM and CAN.

scholarly journals Evaluate the relation between microalbuminuria and with other biochemical parameters related to complications of type 2 Diabetes

2019 ◽  
Vol 6 (5) ◽  
pp. 1663
Author(s):  
S. A. Vaidya ◽  
B. B. Gupta ◽  
Mahak Bhandari ◽  
Simran Behl ◽  
Susmit Kosta
Keyword(s):  
Type 2 Diabetes ◽  
Biochemical Parameters ◽  
General Medicine ◽  
Vascular Diseases ◽  
Initial Finding ◽  
Increased Risk ◽  
Cardio Vascular ◽  
Overt Proteinuria ◽  
Stage Renal Disease

Background: Type 2 Diabetes (T2D) with microalbuminuria have increased risk of progression to overt proteinuria, and after some time, renal failure. It is the leading cause of end-stage renal disease as a sequalae of Diabetic Nephropathy (DN) and an independent risk factor for Cardio-Vascular Diseases (CVD). Initial finding for microalbuminuria can prevent long-term complications. The objective of the present investigation was to study the relation between microalbuminuria and with other biochemical parameters related to complications of T2D.Methods: This observational study was conducted among 150 T2D patients attending to the OPD, Department of General Medicine during the time period March 2018 to April 2019. The patients were interviewed for socio-demographic details, history and clinical examination and subjected to blood investigations and Electrocardiogram (ECG).Results: Microalbuminuria was present in 47(31.3%) of the diabetics. The age group 48-63 years 18(38.3%), male gender 33(70.2%) duration of diabetes >5 years 11(23.4%). The smokers, Diabetic Retinopathy, Peripheral Neuropathy, Ischemic Heart Disease, SBP 160-170 mmHg, DBP 95-100 mmHg and 100-105 mmHg, BMI 30-35 Kg/m2, TG >250 mg/dl, LDL >110 mg/ dl and HbA1c 7.5-9 % showed a greater odds ratio and significant association (p<0.001) with microalbuminuria.Conclusions: There was an increased prevalence of microalbuminuria among patients with T2D. It also showed a significant association of major microvascular and macrovascular complications of T2D and microalbuminuria.

scholarly journals Endothelial dysfunction and arterial wall stiffness: New targets in diabetic nephropathy

2017 ◽  
Vol 89 (10) ◽  
pp. 87-94
Author(s):  
I T Murkamilov ◽  
I S Sabirov ◽  
V V Fomin ◽  
F A Yusupov
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Chronic Kidney Disease ◽  
Type 2 Diabetes Mellitus ◽  
Endothelial Dysfunction ◽  
Kidney Disease ◽  
Endothelial Function ◽  
Arterial Wall ◽  
Wall Stiffness

In recent years, one of the promising areas in clinical medicine is the study of impaired ments in endothelial function and arterial wall stiffness, which can be referred to as one of the important predictors of cardiovascular events in patients with chronic kidney disease, including that of diabetic etiology. There is strong evidence that endothelial function and great artery stiffness may be used as reliable clinical and instrumental indicators to evaluate the efficiency of therapeutic measures and the rate of progression of cardiovascular disorders in type 2 diabetes mellitus. The article presents data on the role of endothelial dysfunction and arterial wall stiffness in the progression of chronic kidney disease in type 2 diabetes mellitus and discusses the possibility of their correction with pharmacological agents.

scholarly journals Metabolic syndrome as a prothrombogenic state

2009 ◽  
Vol 6 (3) ◽  
pp. 3-9
Author(s):  
M A Berkovskaya ◽  
S A Butrova
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Type 2 Diabetes Mellitus ◽  
Scientific Knowledge ◽  
Vascular Diseases ◽  
Prevalence Of Obesity ◽  
Cardio Vascular

The prevalence of obesity has reached epidemic proportions nowadays. Abdominal obesity is the most unfavorable one, because of its association with the complex of markers and risk factors ofcardiovascular diseases and type 2 diabetes mellitus, which is called metabolic syndrome (MS). MS also increases risk of atherothrombosis because it is characterized by low fibrinolysis and prothrombogenic changes in coagulation and platelet hemostasis. The review highlights the mechanisms of hemostatic disturbances in MS, which eхends our scientific knowledge about pathogenesis of cardio vascular diseases

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