scholarly journals Effectiveness of combined antihypertensive treatment depending on the phenomenon of salt sensitivity in patients with refractory arterial hypertension

2015 ◽  
Vol 12 (4) ◽  
Author(s):  
V.V. Skibitskiy ◽  
E.S. Garkusha ◽  
A.V. Fendrikova
Keyword(s):  
Arterial Hypertension ◽  
Antihypertensive Treatment ◽  
Salt Sensitivity

scholarly journals Tactical approaches to the treatment of arterial hypertension in the European part of the Russian Federation. EPOHA study 2017

Kardiologiia ◽  
2019 ◽  
Vol 59 (11S) ◽  
pp. 77-84
Author(s):  
Yu. V. Badin
Keyword(s):  
Arterial Hypertension ◽  
Antihypertensive Therapy ◽  
Russian Federation ◽  
Antihypertensive Treatment ◽  
Antihypertensive Drugs ◽  
European Part ◽  
Frequency Of Use ◽  
Two Component ◽  
The Russian Federation ◽  
Real Clinical Practice

Aim. Analysis of antihypertensive treatment among different groups of patients with arterial hypertension from “EPOCHA” study 2017. Materials and methods. EPOCHA study is a representative sample of the European part of the Russian Federation was created in 2002 and re-examined in 2017. Results. 34.6% of the effectively treated (ET) patients had one antihypertensive drug and 32,2% of the ineffective treatment (IT) patients, p=0.16. Two-component antihypertensive therapy was 45.9% and 44.9%, respectively, p=0.56. Three antihypertensive drugs had 17.9% of the ET patients and 20.7% of the IT patients, p=0.05. Four antihypertensive drugs had 1.6% of the ET patients and 2.2% of the IT patients. The frequency of use of renin-angiotensin-aldosterone system blockers in the group of ET patients was 85.0%, which was significantly lower than 91.6% in the group of IT patients, р<0.0001. Conclusion. EPOCHA study shows that structure of antihypertensive therapy does not differ between ET and IT patients what is caused lack of medical supervision for patients with hypertension in real clinical practice.

scholarly journals Clinical profile and drug therapy of outpatients with arterial hypertension

2020 ◽  
Vol 16 (2) ◽  
pp. 206-212
Author(s):  
N. V. Izmozherova ◽  
A. A. Popov ◽  
V. M. Bakhtin ◽  
M. A. Shambatov
Keyword(s):  
Arterial Hypertension ◽  
Antiplatelet Therapy ◽  
Antihypertensive Therapy ◽  
Antihypertensive Treatment ◽  
Myocardial Hypertrophy ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Mean Value ◽  
Target Organ ◽  
Very High

Aim. To study clinical profile and antihypertensive treatment features in outpatients observed in ambulatory facilities.Material and methods. 140 arterial hypertension (AH) outpatients were examined, questioning and anthropometry were performed. Blood pressure (BP) was measured on both hands, then twice on the hand with larger value, the medium value was calculated. Tests results were obtained from outpatient cards.Results. The sampling included 100 (71.4%) females and 40 (28.6%) males. Median of systolic BP at first measurement was 140.0 mm Hg (130.0;150.0), mean value of three BP measurements was 138.0 mm Hg (127.0;150.0) (p<0.001); median diastolic BP at first measurement was 83.0 mm Hg (80.0;90.0), mean BP value was 82.0 mm Hg (78.0;88.0) (p<0.001). Grade 1 AH was identified in 11.4% of patients, Grade 2 – in 35.7%, Grade 3 in 52.9%. No target organ damage was found in 26.4% of AH patients, asymptomatic target organ damage was diagnosed in 26.4%, and 61.4% had associated clinical conditions. Cardiovascular event risk was assessed as moderate in 13.6%, high – in 24.3% and very high – in 62.1% of patients. Every third patient had myocardial hypertrophy signs; Cornell index was detected more often than Sokolov-Layon index (p=0.006). Chronic kidney disease was diagnosed in 65.1% of patients: 44.0% of them had stage C2, 13.8% – stage C3A, 6.5% – stage C3B, and 1.8% – stage C4. 97.9% of AH patients received antihypertensive treatment. Daily medication consumption was reported by 127 people, and 10 patients reported taking medication as needed. Monotherapy was prescribed in 14.3% of patients; combined treatment was performed in 83.6% people. BP target value was achieved in 59 patients (42.1%) at first measurement results and in 71 (50.7%) ones at calculated mean value (p=0.002). Indications for statin use were identified in 86.4% of patients. Statins were administered in 56.2% patients having indications and in 21.1% of subjects without indications (p=0.006). Indications for antiplatelet therapy use were identified in 56.4% of patients. Antiplatelet treatment was administered in 58.2% of patients with indications and in 23.0% of subjects without indications (p<0.001).Conclusion. Glomerular filtration rate and left ventricular myocardial hypertrophy amplitude criteria calculation allow to diagnose subclinical target organ damage in outpatients at physician visit without additional costs. Compliance with the current antihypertensive therapy guidelines allows to achieve target BP in current practice. Compliance with the BP measuring rules allows to adequately assess the effectiveness of antihypertensive therapy. A significant proportion of AH outpatients have a very high cardiovascular risk, which requires lipid-lowering and antiplatelet therapy.

scholarly journals Cardiovascular Risk and Atherosclerosis Progression in Hypertensive Persons Treated to Blood Pressure Targets

Hypertension ◽  
2019 ◽  
Vol 74 (6) ◽  
pp. 1436-1447 ◽  
Author(s):  
Janine Gronewold ◽  
Rene Kropp ◽  
Nils Lehmann ◽  
Andreas Stang ◽  
Amir A. Mahabadi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Arterial Hypertension ◽  
Treatment Efficacy ◽  
Cardiovascular Events ◽  
Antihypertensive Treatment ◽  
Coronary Event ◽  
Blood Pressure Targets ◽  
Atherosclerosis Progression

Arterial hypertension promotes atherosclerosis and cardiovascular events. We evaluated how cardiovascular risk and atherosclerosis progression are associated with blood pressure, antihypertensive treatment, and treatment efficacy. In 3555 participants of the population-based Heinz Nixdorf Recall study without previous cardiovascular disease (mean±SD; age, 58.9±7.6 years, 46.9% men), we analyzed associations of baseline antihypertensive treatment efficacy (normotension without antihypertensives, normotension with antihypertensives, hypertension without antihypertensives, hypertension with antihypertensives, based on 140/90 mmHg cutoffs) with incident coronary artery calcification (CAC) and CAC progression during 5-year-follow-up and with incident cardiovascular events during 13.5-year-follow-up. We further evaluated associations of incident arterial hypertension and efficacy of new antihypertensive treatment at the 5-year-follow-up with subsequent cardiovascular events. At baseline, 1706 participants had normotension without antihypertensives, 553 normotension with antihypertensives, 786 hypertension without antihypertensives, and 510 hypertension with antihypertensives. Six hundred forty-seven participants experienced rapid CAC progression. One hundred seven, 132, and 249 had incident stroke, coronary event, and cardiovascular event, respectively. Compared with normotensives without antihypertensives, normotensives with antihypertensives had an elevated stroke (hazard ratio, 2.33 [95% CI, 1.19–4.55]), coronary (2.04 [95% CI, 1.20–3.45]), and cardiovascular (2.23 [95% CI, 1.48–3.36]) risk, and increased baseline CAC, but not increased CAC progression. Participants without hypertension at baseline, who were newly hypertensive but achieved normotension with antihypertensives at the 5-year-follow-up, again exhibited elevated stroke (4.80 [95% CI, 1.38–16.70]) and cardiovascular (2.99 [95% CI, 1.25–7.16]) risk, whereas coronary risk was less elevated (2.24 [95% CI, 0.70–7.18]). Normotensives with antihypertensives have an elevated cardiovascular risk. They are characterized by elevated baseline CAC but show no signs of increased CAC progression.

scholarly journals ARTERIAL HYPERTENSION AND ANTIHYPERTENSIVE TREATMENT IN UNORGANIZED MOSCOW POPULATION

2019 ◽  
Vol 37 ◽  
pp. e164
Author(s):  
A. Agaeva ◽  
V. Kuznetsova ◽  
A. Dubov ◽  
E. Svirina ◽  
A. Tuchkova ◽  
...  
Keyword(s):  
Arterial Hypertension ◽  
Antihypertensive Treatment ◽  
Moscow Population

scholarly journals Antihypertensive treatment with telmisartan in a cat with amlodipine-induced gingival hyperplasia

2017 ◽  
Vol 3 (2) ◽  
pp. 205511691774523 ◽  
Author(s):  
Lien Desmet ◽  
Jeroen van der Meer
Keyword(s):  
Blood Pressure ◽  
Case Report ◽  
Arterial Hypertension ◽  
Antihypertensive Drug ◽  
Antihypertensive Treatment ◽  
Published Data ◽  
Gingival Hyperplasia ◽  
Middle Aged ◽  
Systemic Arterial Hypertension ◽  
Case Summary

Case summary Systemic arterial hypertension is commonly reported in middle-aged-to-older cats. Amlodipine is recommended as the initial antihypertensive drug in cats. In this case report, gingival hyperplasia secondary to the use of amlodipine in a cat is described. Benazepril as a monotherapy was unsuccessful in reducing blood pressure in this cat. After replacement of benazepril by telmisartan, gingival hyperplasia disappeared and blood pressure was well controlled. Relevance and novel information This case report describes the first reported case of reversible gingival hyperplasia as a result of the treatment with amlodipine. It also contains the first published data on the effect of telmisartan in a hypertensive cat.

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