scholarly journals Study of the effect of pvp k30 in the enhancement of solubility of telmisartan by polymer assisted crystal agglomeration using polymer enriched bridging liquid technique

2019 ◽  
Vol 10 (3) ◽  
pp. 2290-2299 ◽  
Author(s):  
Manoj K ◽  
Seenivasan P ◽  
Arul K ◽  
Senthil kumar M
Keyword(s):  
Flow Characteristics ◽  
Microscopic Analysis ◽  
Particle Size Analysis ◽  
Water Soluble ◽  
Dissolution Enhancement ◽  
Size Analysis ◽  
Hydrophilic Polymer ◽  
Electron Microscopic ◽  
Novel Approach ◽  
Poorly Water Soluble

Polymer Enriched Bridging liquid is a novel approach for enhancing the flow characteristics, properties, solubility and dissolution of poorly water-soluble drugs. is an orally effective II receptor antagonist used extensively for the effective management of hypertension. is a poorly water-soluble drug and an ideal candidate for this approach. PVPK30 is used as the hydrophilic polymer. Various formulations were prepared with the addition of PVPK30 in the bridging liquid by Polymer Enriched Bridging Liquid Technique (PEBL). The preparations were subjected to particle size analysis, characteristics, FTIR, differential scanning (DSC) and Scanning Electron microscopic analysis. The crystal agglomerates were found to be spherical in nature with excellent flow characteristics. The of the pure drug was found to be decreased without any drug-polymer interaction. The saturation solubility studies showed that the optimized formulation STP04 showed 30.695 folds increase in solubility in water and 29.462 folds enhancement in pH 7.5 phosphate buffer. The in drug release studies also confirmed the enhancement in dissolution rate. The stability of the prepared aggregates was determined by accelerated stability studies. The addition of polymer in the bridging liquid during crystallization stage improved the effective incorporation of the hydrophilic polymer in the aggregates. Polymer Enriched Bridging Liquid technique can be considered as an ideal technique for solubility and dissolution enhancement.

scholarly journals SPHERICAL CRYSTALLIZATION A NOVEL APPROACH FOR SOLUBILITY AND DISSOLUTION ENHANCEMENT OF SIMVASTATIN

2016 ◽  
Vol 9 (6) ◽  
pp. 65
Author(s):  
Rakesh Kumar Mishra
Keyword(s):  
Dissolution Rate ◽  
Xrd Analysis ◽  
Particle Size Analysis ◽  
Dissolution Enhancement ◽  
Size Analysis ◽  
Dissolution Profile ◽  
Scanning Calorimetry ◽  
Novel Approach ◽  
Stirring Time ◽  
Spherical Agglomerates

Simvastatin is commonly used antihyperlipidemic in the treatment of hypercholesterolemia and dyslipidemia. As evidenced form the scientific investigation, it is reported for its lower solubility and poor dissolution rate. The aim of the present investigation was to develop simvastatin spherical agglomerates to improve its solubility and dissolution characteristics by spherical agglomeration method. The crystallization media used was methanol, water and chloroform as bridging liquid and PVP K-30 as a polymer. The process variables such as amount and type of (bridging liquid and polymer), stirring speed and stirring time were optimized and reported. The spherical agglomerates were further subjected for determination of % drug content, particle size analysis, solubility and dissolution rate. The agglomerates were also characterized by Differential Scanning Calorimetry (DSC), Fourier Transform Infrared Spectroscopy (FTIR), and X-ray Powder Diffraction (XRD) analysis and affirmed. Among the entire parameters spherical agglomerates obtained with methanol (7ml), water (50ml), chloroform (1.5ml) and PVP K-30 (0.5%) showed improvement in solubility and dissolution rate in comparison with pure drug. The spherical agglomerates showed significant improvement in dissolution from a value of 25.53% for pure simvastatin to 91.31% of spherical agglomerate. The spherical agglomerates of optimized batch were directly compressed and dissolution profile was compared with marketed tablet. Such a technique can successfully be employed to improve solubility and dissolution characteristic of poorly soluble drugs.

scholarly journals Effect of modified hydrotalcites on flame retardancy and physical properties of paper

BioResources ◽  
2019 ◽  
Vol 14 (2) ◽  
pp. 3991-4005
Author(s):  
Songlin Wang ◽  
Xuxu Yang ◽  
Fei Wang ◽  
Zongjia Song ◽  
Hehe Dong ◽  
...  
Keyword(s):  
Heat Release ◽  
Heat Release Rate ◽  
Release Rate ◽  
Coupling Agent ◽  
Microscopic Analysis ◽  
Particle Size Analysis ◽  
Size Analysis ◽  
Cone Calorimetry ◽  
Electron Microscopic ◽  
Limiting Oxygen Index

Functionalized layered double hydroxides (LDHs) based on a multi-modifier system composed of itaconic acid (ITA) and titanate coupling agent (NDZ-201) were designed and fabricated in this paper with the aim to develop high-performance fire retardant paper. The structure of LDHs were characterized using Fourier transform infrared spectroscopic analysis, X-ray diffraction analysis, thermogravimetric analysis (TGA), scanning electron microscopic analysis, cone calorimetry, and laser particle size analysis. The results showed that carbonate anions were partially replaced by ITA, whereas the titanate coupling agent was attached to the surfaces of the hydrotalcites. The limiting oxygen index (LOI), TGA curves, total heat release rate (THR), and heat release rate (HRR) indicated that as the addition of hydrotalcites increased, the modified LDHs’ LOI value and thermal stability noticeably increased compared to the unmodified hydrotalcites, and the HRR and THR of the material decreased. When the addition amount was 25%, the LOI of ITA-LDHs was 26.9%. However, the Mg-Al hydrotalcites adversely affected the strength index of flame-retardant paper; the modified hydrotalcites clearly reduced this effect, and the whiteness of paper increased and reached 83%.

NANO-SIZED SOLID DISPERSION OF A POORLY WATER-SOLUBLE DRUG

2012 ◽  
pp. 31-35
Author(s):  
Truong Dinh Thao Tran ◽  
Ha Lien Phuong Tran ◽  
Nghia Khanh Tran ◽  
Van Toi Vo
Keyword(s):  
Drug Release ◽  
Droplet Size ◽  
Solid Dispersion ◽  
Water Soluble ◽  
Drug Dissolution ◽  
Dissolution Enhancement ◽  
Particle Size Reduction ◽  
Water Soluble Drug ◽  
Poorly Water Soluble ◽  
Poorly Water Soluble Drug

Purposes: Aims of this study are dissolution enhancement of a poorly water-soluble drug by nano-sized solid dispersion and investigation of machenism of drug release from the solid dispersion. A drug for osteoporosis treatment was used as the model drug in the study. Methods: melting method was used to prepare the solid dispersion. Drug dissolution rate was investigated at pH 1.2 and pH 6.8. Drug crystallinity was studied using differential scanning calorimetric and powder X-ray diffraction. In addition, droplet size and contact angle of drug were determined to elucidate mechanism of drug release. Results: Drug dissolution from the solid dispersion was significantly increased at pH 1.2 and pH 6.8 as compared to pure drug. Drug crystallinity was changed to partially amorphous. Also dissolution enhancement of drug was due to the improved wettability. The droplet size of drug was in the scale of nano-size when solid dispersion was dispersed in dissolution media. Conclusions: nano-sized solid dispersion in this research was a successful preparation to enhance bioavailability of a poorly water-soluble drug by mechanisms of crystal changes, particle size reduction and increase of wet property.

Micro-Treatment Mechanism Study on Ionic Soil Stabilizer Improving Clay

2015 ◽  
Vol 667 ◽  
pp. 370-375 ◽  
Author(s):  
Xiao Hua Luo ◽  
Xin Qiu ◽  
Yu Jie Wang ◽  
Jin Hong Wu ◽  
Shang Lin Xiao
Keyword(s):  
Organic Matter Content ◽  
Emission Spectra ◽  
Particle Size Analysis ◽  
Matter Content ◽  
Water Soluble ◽  
Size Analysis ◽  
Physical Parameters ◽  
Mechanism Study ◽  
Soil Stabilizer ◽  
Typical Soil

In order to study the treatment mechanism of the ionic liquid soil stabilizer, a series tests were performed for a typical soil, the red-brown clay. The basic physical parameters of typical soil were conducted by variety of tests, including particle size analysis, crucial water content coefficient, loss on ignition, organic matter content, etc. Furthermore, the treatment mechanism of the ionic soil stabilizer was analyzed, involving PH, conductivity, plasma emission spectra, scanning electron microscopy, X-ray diffraction and BET test. The results indicate: Firstly, the ionic soil stabilizer is a sulfonated oleoresin with the features of water soluble, high conductivity and strongly acidic, which exchanged with cations adsorbed on the surface of clay particles to reduce the thickness of hydrated film and the electric double layer thickness. Secondly, it reduced the mutual repulsion energy between soil particles and made the flaky particles of clay minerals contact closely. Finally, it made the particles of clay be close to each other and gradually formed larger particles. Hence, the clay became denser. Therefore, the research provided a theoretical foundation and practical basis for the wide application of the ionic soil stabilizer in China's highway construction.

scholarly journals Engineering cocrystals of Paliperidone with enhanced solubility and dissolution characteristics

2021 ◽  
Vol 71 (5) ◽  
pp. 393-409
Author(s):  
Earle Radha-Rani ◽  
Gadela Venkata-Radha
Keyword(s):  
Benzoic Acid ◽  
Aqueous Solubility ◽  
Water Soluble ◽  
X Ray Diffraction ◽  
X Ray ◽  
Water Soluble Drug ◽  
Novel Approach ◽  
Enhanced Solubility ◽  
Poorly Water Soluble ◽  
Poorly Water Soluble Drug

In the present study, co-crystals (CCs) of Paliperidone (PPD) with coformers like benzoic acid (BA) and P-amino benzoic acid (PABA) were synthesized and characterized to improve the physicochemical properties and dissolution rate. CCs were prepared by the solvent evaporation (SE) technique and were compared with the products formed by neat grinding (NG) and liquid assisted grinding (LAG) in their enhancement of solubility. The formation of CCs was confirmed by the IR spectroscopy, powder X-ray diffraction and thermal analysis methods. The saturation solubility studies indicate that the aqueous solubility of PPD-BA and PPD-PABA CCs was significantly improved to 1.343±0.162mg/ml and 1.964±0.452mg/ml, respectively, in comparison with the PPD solubility of 0.473mg/ml. This increase in solubility is 2.83-and 3.09-fold, respectively. PPD exhibited a poor dissolution of 37.8% in 60min, while the dissolution of the CCs improved tremendously to 96.07% and 89.65% in 60min. CCs of PPD with BA and PABA present a novel approach to overcome the solubility challenges of poorly water-soluble drug PPD.

scholarly journals Low Temperature Soft Chemical Synthesis of Bright Blue CoAl2O4 Spinel Particles

1970 ◽  
Vol 25 ◽  
pp. 62-69 ◽  
Author(s):  
K. Christine Stella ◽  
A. Samson Nesara
Keyword(s):  
Low Temperature ◽  
Chemical Society ◽  
Particle Size Analysis ◽  
Size Analysis ◽  
X Ray Diffraction ◽  
Soft Chemistry ◽  
Electron Microscopic ◽  
Chemical Route ◽  
Soft Chemical Synthesis ◽  
Bright Blue

Present work reports the preparation of bright blue CoAl2O4 spinel particles by lowtemperature soft chemical route using urea or glycine as fuel in this paper. Thecharacterization of the resulting powder was done using x-ray diffraction (XRD), particlesize analysis and scanning electron microscopic (SEM) techniques. Pure CoAl2O4 spinelparticles were prepared at relatively low temperature using this soft chemistry route at avery short duration (< 10 minutes) which is also very simple than other techniques such assolid state reaction, ceramic methods and so on. From the particle size analysis, it wasfound that the spinel particles with low diameter (below 35 μm) were formed. The SEMphotographs showed the formation of fluffy morphology with porous structure.Keywords: Cobalt aluminate spinel, low temperature soft chemistry route, XRD, SEM.DOI:  10.3126/jncs.v25i0.3302Journal of Nepal Chemical Society Volume 25, 2010 pp 62-69

scholarly journals Insoluble Polymers in Solid Dispersions for Improving Bioavailability of Poorly Water-Soluble Drugs

Polymers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 1679
Author(s):  
Thao T.D. Tran ◽  
Phuong H.L. Tran
Keyword(s):  
Solid Dispersion ◽  
Solid Dispersions ◽  
Water Soluble ◽  
Dissolution Enhancement ◽  
Formulation Development ◽  
Poorly Water Soluble Drugs ◽  
Water Soluble Drugs ◽  
Poorly Water Soluble ◽  
Insoluble Polymers

In recent decades, solid dispersions have been demonstrated as an effective approach for improving the bioavailability of poorly water-soluble drugs, as have solid dispersion techniques that include the application of nanotechnology. Many studies have reported on the ability to change drug crystallinity and molecular interactions to enhance the dissolution rate of solid dispersions using hydrophilic carriers. However, numerous studies have indicated that insoluble carriers are also promising excipients in solid dispersions. In this report, an overview of solid dispersion strategies involving insoluble carriers has been provided. In addition to the role of solubility and dissolution enhancement, the perspectives of the use of these polymers in controlled release solid dispersions have been classified and discussed. Moreover, the compatibility between methods and carriers and between drug and carrier is mentioned. In general, this report on solid dispersions using insoluble carriers could provide a specific approach and/or a selection of these polymers for further formulation development and clinical applications.

Galai-CIS-1—A novel approach to aerosol particle size analysis

1986 ◽  
Vol 17 (3) ◽  
pp. 530-536 ◽  
Author(s):  
Ephraim F. Aharonson ◽  
Nir Karasikov ◽  
Moshe Roitberg ◽  
Joseph Shamir
Keyword(s):  
Particle Size ◽  
Aerosol Particle ◽  
Particle Size Analysis ◽  
Size Analysis ◽  
Novel Approach ◽  
Aerosol Particle Size

Modification of hydrophilic polymer network to design a carrier for a poorly water‐soluble substance

2020 ◽  
Vol 60 (10) ◽  
pp. 2496-2510
Author(s):  
Maja D. Markovic ◽  
Vesna V. Panic ◽  
Sanja I. Seslija ◽  
Pavle M. Spasojevic ◽  
Vukasin Dj. Ugrinovic ◽  
...  
Keyword(s):  
Polymer Network ◽  
Water Soluble ◽  
Hydrophilic Polymer ◽  
Soluble Substance ◽  
Water Soluble Substance ◽  
Poorly Water Soluble

Research on High Ductility Cementitious Composites Improved by Water-Soluble Polymer and Micro-Fibers

2013 ◽  
Vol 800 ◽  
pp. 284-289 ◽  
Author(s):  
Li Ping Guo ◽  
Wen Xiao Zhang ◽  
Bo Chen ◽  
Li Hui Zhang ◽  
Lin Hong Jin
Keyword(s):  
Basalt Fiber ◽  
Microscopic Analysis ◽  
Water Soluble ◽  
Cementitious Composites ◽  
Environmental Scanning ◽  
Electron Microscopic ◽  
Water Soluble Polymer ◽  
Bending Load ◽  
Scanning Electron Microscopic Analysis ◽  
Styrene Butadiene

The toughness of cement-based materials, related to the performance such as durability and strength, attracts much more attention nowadays. In this paper, the curve of bending load-deflection was adopted to research the influencesof polymers (dispersibility emulsion powder, PVA and styrene butadiene latex) and fibers (PVAF, steel fiber,basalt fiber) on basic mechanical properties and toughness. The results show that the PVAF pre-incorporate in cement motor could improve the toughness of cement motor. In addition, an environmental scanning electron microscopic analysis (ESEM) and hardness were adopted to analyze the microscope morphology of polymer films inside of hardened cementitious composites.

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