scholarly journals Production and characterization of Green Iron Oxide nanoparticles with antifungal properties against fungal pathogens

2020 ◽  
Vol 11 (2) ◽  
pp. 2308-2314
Author(s):  
Momanyi Kerubo Rachael ◽  
Rajiv P
Keyword(s):  
Iron Oxide ◽  
Green Chemistry ◽  
Iron Oxide Nanoparticles ◽  
Fungal Pathogens ◽  
Crystal Surface ◽  
Fungal Infections ◽  
Alternative Methods ◽  
Oxide Nanoparticles ◽  
X Ray ◽  
Antifungal Properties

In this study, iron oxide nanoparticles were synthesized throughthe green chemistry method. It involved the use of plant extract for synthesis of metal oxide nanomaterials. Aqueous extract of Tridaxprocumbenswas employed for the production of iron oxide nanoparticles.  T. procumbens is a weed and it has good medicinal properties.The green chemistry approach provides a simple, cost-effective and eco-innovative method to the synthesis of nanomaterials as compared to the other alternative methods. Phase, crystal, surface chemistry, size, shape and element composition of nanoparticles were assessed and determined by various techniques like Fourier transform infrared spectroscopy (FTIR),X-Ray diffraction (XRD),Scanning Electron Microscopy (SEM) and Energy dispersion X-Ray (EDX). In addition, the antifungal properties of the biosynthesized nanoparticles were investigated against plant fungal pathogens. Spherical-shaped nanoparticles with a size of 26 ± 5 nm were obtained using the extract of T. procumbens.  Bio-molecules from T. procumbens served as reducing, cappingand stabilizing agents for the fabrication of nanoparticles. The highest zone of inhibition was obtained in S. rolfsii(16.5 ± 0.5)at 50 µg/ml of concentration of TFeONPs. Biosynthesized TFeONPs were capable of inhibiting the growth of fungal pathogens such as S. rolfsii and F. oxysporumand they might beemployed as antifungal agents in agriculture to control fungal infections.

scholarly journals Effects of Antifungal Carriers Based on Chitosan-Coated Iron Oxide Nanoparticles on Microcosm Biofilms

Antibiotics ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 588
Author(s):  
Anne Caroline Morais Caldeirão ◽  
Heitor Ceolin Araujo ◽  
Camila Miranda Tomasella ◽  
Caio Sampaio ◽  
Marcelo José dos Santos Oliveira ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Lactic Acid ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Laser Scanning ◽  
Fungal Infections ◽  
Mutans Streptococci ◽  
Laser Scanning Microscopy ◽  
Confocal Laser ◽  
Oxide Nanoparticles

Resistance of Candida species to conventional therapies has motivated the development of antifungal nanocarriers based on iron oxide nanoparticles (IONPs) coated with chitosan (CS). This study evaluates the effects of IONPs-CS as carriers of miconazole (MCZ) or fluconazole (FLZ) on microcosm biofilms. Pooled saliva from two healthy volunteers supplemented with C. albicans and C. glabrata was the inoculum for biofilm formation. Biofilms were formed for 96 h on coverslips using the Amsterdam Active Attachment model, followed by 24 h treatment with nanocarriers containing different concentrations of each antifungal (78 and 156 µg/mL). MCZ or FLZ (156 µg/mL), and untreated biofilms were considered as controls. Anti-biofilm effects were evaluated by enumeration of colony-forming units (CFUs), composition of the extracellular matrix, lactic acid production, and structure and live/dead biofilm cells (confocal laser scanning microscopy-CLSM). Data were analyzed by one-way ANOVA and Fisher LSD’s test (α = 0.05). IONPs-CS carrying MCZ or FLZ were the most effective treatments in reducing CFUs compared to either an antifungal agent alone for C. albicans and MCZ for C. glabrata. Significant reductions in mutans streptococci and Lactobacillus spp. were shown, though mainly for the MCZ nanocarrier. Antifungals and their nanocarriers also showed significantly higher proportions of dead cells compared to untreated biofilm by CLSM (p < 0.001), and promoted significant reductions in lactic acid, while simultaneously showing increases in some components of the extracellular matrix. These findings reinforce the use of nanocarriers as effective alternatives to fight oral fungal infections.

Superparamagnetic iron oxide nanoparticles enhance glioma radiosensitivity via inducing cell cycle arrest and apoptosis

2020 ◽  
Author(s):  
Jinning Mao ◽  
Meng Jiang ◽  
Xingliang Dai ◽  
Guodong Liu ◽  
Zhixiang Zhuang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Glioma Cells ◽  
Superparamagnetic Iron Oxide ◽  
Spherical Shape ◽  
Treated Group ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
X Ray

Abstract Aim: Superparamagnetic iron oxide nanoparticles (SPIONs) is a widely used biomedical material for imaging and targeting drug delivery. We synthesized SPIONs and tested their effects on the radiosensitization of glioma.Methods: Acetylated 3-aminopropyltrimethoxysilane (APTS)-coated iron oxide nanoparticles (Fe3O4 NPs) were synthesized via a one-step hydrothermal approach and the surface was chemically modified with acetic anhydride to generate surface charge-neutralized NPs. NPs were characterized by TEM and ICP-AES. Radiosensitivity of U87MG glioma cells was evaluated by MTT assay. Cell cycle and apoptosis in glioma cells were examined by flow cytometry. Results: APTS-coated Fe3O4 NPs had a spherical or quasi-spherical shape with average size of 10.5±1.1 nm. NPs had excellent biocompatibility and intracellular uptake of NPs reached the peak 24 hours after treatment. U87 cell viability decreased significantly after treatment with both X-ray and NPs compared to X-ray treatment alone. Compared to X-ray treatment alone, the percentage of cells in G2/M phase (31.83%) significantly increased in APTS-coated Fe3O4 NPs plus X-ray treated group (P<0.05). In addition, the percentage of apoptotic cells was significant higher in APTS-coated Fe3O4 NPs plus X-ray treated group than in X-ray treatment alone group (P<0.05). Conclusion: APTS-coated Fe3O4 NPs achieved excellent biocompatibility and increased radiosensitivity for glioma cells.

Magnetic and X-ray photo electron spectroscopic analysis of samarium doped iron oxide nanoparticles

2020 ◽  
pp. 1-8
Author(s):  
Hemalatha K ◽  
Alamelumangai K ◽  
Arulmozhi R ◽  
Parthiban G ◽  
Muralidharan Rajaram
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Spectroscopic Analysis ◽  
Oxide Nanoparticles ◽  
X Ray

Synthesis and Effect of Some Parameters through Reverse Micelles Route of Iron Oxide Nanoparticles

2009 ◽  
Vol 152-153 ◽  
pp. 205-208 ◽  
Author(s):  
H. Arabi ◽  
S. Nateghi ◽  
S. Sadeghi
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Reverse Micelles ◽  
Room Temperature ◽  
Molar Ratio ◽  
Oxide Nanoparticles ◽  
X Ray Diffraction ◽  
X Ray ◽  
Significant Difference ◽  
Vibration Sample Magnetometer

Iron oxide nanoparticles were synthesis by reverse micelle method. X-ray diffraction technique and vibration sample magnetometer were applied to characterize the produced samples at different conditions and parameters for synthesis route. There is no significant difference between samples prepared at 5°C and room temperature except a better crystalline at room temperature. The molar ratio of water to surfactant (w parameter) and concentration of the salt solution on size and magnetic properties of nanoparticles have been investigated. Increasing w leads to producing particles with larger size i.e. for w=16.83, 11.22, and 5.6, particles size are 15.22, 11.66 and 10.5 nm, respectively. The size of nanoparticles are in the range of 9 to 20 nanometers

Antibacterial activity of biochemically capped iron oxide nanoparticles: A view towards green chemistry

2017 ◽  
Vol 170 ◽  
pp. 241-246 ◽  
Author(s):  
Rabia Irshad ◽  
Kamran Tahir ◽  
Baoshan Li ◽  
Aftab Ahmad ◽  
Azka R. Siddiqui ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Iron Oxide ◽  
Green Chemistry ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles
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