scholarly journals Clinical Analysis of Gemcitabine Combined with Tegafur Chemotherapy after Radical Surgery on Pancreatic Cancer

2021 ◽  
Vol 5 (3) ◽  
Author(s):  
Wei Zheng ◽  
Xiang Yan ◽  
Xiaoxue Song

Objective: To study and analyze the clinical efficacy of gemcitabine combined with Tegafur chemotherapy after radical resection of pancreatic cancer. Methods: The subjects of the study were 200 patients who were admitted to the hospital from January 2018 to February 2021 requiring chemotherapy after radical resection of pancreatic cancer. According to the different treatment methods, they were divided into a experimental group (gemcitabine combined with Tegafur chemotherapy) and a control group (single gemcitabine chemotherapy), and the treatment efficacy of the two groups of patients was observed and compared. Results: Compared with the control group, patients in the experimental group had significantly better treatment efficacy, quality of life scores and post-treatment anxiety and depression scores. The difference between the groups was significant (p<0.05). Conclusion: Gemcitabine combined with Tegafur chemotherapy for patients requiring chemotherapy after radical resection of pancreatic cancer can significantly improve the treatment efficacy for the disease, improve the patient's quality of life, and ensure that the patient's emotional state during treatment is more positive.

2021 ◽  
Vol 5 (2) ◽  
Author(s):  
Wei Zheng ◽  
Huilin Chang ◽  
Xin Chen

Objective: To study and analyze the clinical efficacy of gemcitabine combined with Tegafur chemotherapy after radical resection of pancreatic cancer. Methods: The subjects of the study were 200 patients who were admitted to the hospital from January 2018 to February 2021 requiring chemotherapy after radical resection of pancreatic cancer. According to the different treatment methods, they were divided into a experimental group (gemcitabine combined with Tegafur chemotherapy) and a control group (single gemcitabine chemotherapy), and the treatment efficacy of the two groups of patients was observed and compared. Results: Compared with the control group, patients in the experimental group had significantly better treatment efficacy, quality of life scores and post-treatment anxiety and depression scores. The difference between the groups was significant (p<0.05). Conclusion: Gemcitabine combined with Tegafur chemotherapy for patients requiring chemotherapy after radical resection of pancreatic cancer can significantly improve the treatment efficacy for the disease, improve the patient's quality of life, and ensure that the patient's emotional state during treatment is more positive.


2020 ◽  
Vol 4 (3) ◽  
Author(s):  
Rongrong Dong ◽  
Huaqin Chen

Objective: To explore the effect of functional exercise nursing plan based on evidence-based nursing in patients after hip replacement. Methods: A total of 150 patients who underwent hip replacement in the orthopedic second ward of our hospital during the research period from January 2010 to January 2020 were selected as the research object. The random number expression method was applied to achieve grouping of patients. Among them, the control group received conventional rehabilitation treatment; the experimental group guided rehabilitation exercises according to the functional exercise nursing plan after hip replacement, and the rehabilitation conditions of the two groups were compared. Results: Compared with the patients in the control group, the bed time (7.45 ± 2.10) days and average hospital stay (15.84 ± 3.29) of the experimental group were relatively shorter. The incidence of complications in the experimental group and the control group was 6.67% and 16.00%, which are significantly different. The difference in Harris hip score before surgery was small, and the difference when discharge and after discharge was gradually increased, showing a better care effect in the experimental group. There was no significant difference in preoperative quality of life scores between the two groups before surgery (P > 0.05). The life quality of the experimental group was significantly higher than that of the control group at discharge, 1 month after discharge and 3 months after discharge, and showed most significantly after 3 months. Conclusion: The effect of functional exercise nursing plan based on evidence-based nursing in patients after hip replacement is remarkable, which can promote the recovery of patients, improve the quality of life, reduce the hospitalization time, reduce the incidence of postoperative complications, and has a positive significance in promoting clinical development in China.


Author(s):  
Flávia Tatiana Pedrolo Hortense ◽  
Cristiane Decat Bergerot ◽  
Edvane Birelo Lopes De Domenico

Abstract OBJECTIVE To evaluate an educational program based on the principles of self-management with a conventional educational program through quality of life, anxiety and depression instruments within 12 months of starting cancer treatment. METHOD An experimental, randomized, controlled study conducted with head and neck cancer patients treated at a university hospital in the city of São Paulo, Brazil. Patients were randomly divided into two groups: the control group submitted to the conventional educational plan, and the experimental group submitted to the educational plan for self-management. Descriptive and analytical statistics were used for the analyzes using the t-test, Fischer’s exact test and Repeated Measures ANOVA. RESULTS Twenty (20) patients were selected. Most participants were male, in advanced stages of disease and undergoing three therapeutic modalities. The control group showed a gradual decrease in quality of life scores during treatment, while the experimental group progressively increased. The correlation was significant between the presence of anxiety and depression symptoms and poor quality of life. Patients in the control group had a significant worsening in social/family well-being (P = 0.02) and the prevalence of additional head and neck cancer-related additional concerns (P = 0.01), while the experimental group had reduced anxiety symptoms (P = 0.001) and improved emotional well-being (P = 0.01). CONCLUSION The educational intervention based on building self-management skills favored quality of life and reduced anxiety and depression. Brazilian Registry of Clinical Trials (RBR 2q53ct).


2020 ◽  
pp. 014556132090285 ◽  
Author(s):  
Li-Xin Wang ◽  
Zhi-Chao Yang ◽  
Zhao-Peng Kang ◽  
Ling-Ling Di ◽  
Yan Tan ◽  
...  

Objective: To investigate the effect of drug treatment combined with psychological intervention on mental disorders in patients with persistent moderate–severe allergic rhinitis. Methods: Sixty patients with persistent moderate–severe allergic rhinitis who met the criteria were randomly divided into 2 groups: control group and experimental group. The control group was only given medication, whereas the experimental group was given psychological intervention on the basis of the same medication. Cognitive behavioral therapy was used for psychological intervention. After 12 weeks of treatment, Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS), and rhinoconjunctivitis quality of life questionnaire (RQLQ) were used to evaluate the changes in anxiety, depression, and quality of life before and after treatment. Results: The SAS and SDS scores of the control group after treatment were lower than those before treatment, and the difference was statistically significant. Similarly, the SAS and SDS scores of the experimental group after treatment were lower than those before treatment with statistically significant difference. In addition, after treatment, the SAS and SDS scores of the experimental group were statistically lower than those of the control group. The results of RQLQ showed that the scores of each dimension in the control group after treatment were lower than those before treatment, and the difference was statistically significant. Similar results were found in the experimental group. After treatment with these 2 different schemes, the RQLQ scores of sleep, nonnasal/eye symptoms, and emotion in the experimental group were statistically lower than those in the control group. Conclusion: Drug therapy or drug therapy combined with psychological intervention can alleviate anxiety and depression of patients with persistent moderate–severe allergic rhinitis and improve their quality of life. Moreover, based on the effect of improving mental disorder and quality of life of patients, drug therapy combined with psychological intervention is better than drug treatment alone.


2021 ◽  
Vol 7 (4) ◽  
pp. 469-473
Author(s):  
Ting Fang ◽  
Nian Wang ◽  
Meng Chen ◽  
Hongmei Ma

Objective Explore the impact of personalized nursing services and hospice care on the quality of life of elderly patients with advanced cancer. Method We selected 80 elderly cancer patients admitted to our hospital from September 2020 to May 2021, and divided these patients into a study group and a control group using a random number table method. The patients in the control group used conventional nursing methods to treat and care for the patients, and the patients in the study group used hospice care measures and combined personalized nursing measures. The quality of life and pain treatment effects of the two groups of patients before and after treatment were compared. Result Before treatment, the quality-of-life scores of the two groups of patients were low, and there was no statistical difference (P>0.05); After treatment, the quality of life of the two groups of patients improved, but compared with the control group, the improvement was more obvious in the study group, and the difference was statistically significant (P<0.05). In terms of pain treatment effect, the total effective rate of pain treatment in the study group was 87.5%, which was significantly better than the 62.5% in the control group. The difference was statistically significant (P<0.05). Conclusion Personalized nursing services and hospice care are conducive to improving the survival and treatment of elderly patients with advanced cancer, and can be used as a clinical application program for the care of advanced cancer patients.


2015 ◽  
Vol 2 (2) ◽  
Author(s):  
Sheida Jabalameli ◽  
Hamid Taher Neshat Doost ◽  
Mohammad Bagher Kajbaf ◽  
Hossein Molavi

Generalized Anxiety Disorder (GAD) is one of the most common anxiety disorders. It has been reported that psychological treatments like Cognitive-Behavioral Therapy (CBT) is effective for patients with GAD. The purpose of the present research was to investigate the effectiveness of CBT on Quality of Life (QOL) and worry in patients with GAD. A sample of 30 patients with GAD who had been referred to psychiatry offices in Isfahan, Iran were selected and assigned into an experimental group (n=15) and a control group (n=15) randomly.  The experimental group received CBT in 8 weekly sessions. All participants completed the World Health Organization Quality Of Life-Brief (WHOQOL-BREF) questionnaire and the Penn State Worry Questionnaire (PSWQ) at pretest, posttest and follow up. The results of MANCOVA showed that the mean scores of QOL in the experimental group was significantly higher than the control group at the posttest and follow up (P<0.05) and the mean scores of worry in the experimental group was significantly lower than the control group at the posttest and follow up (P<0.05) It is concluded that CBT can be applied for the patients with GAD as a useful psychological treatment. In general, CBT can improve QOL and decrease worry in patients with GAD.


2020 ◽  
Vol 11 (4) ◽  
pp. 70-80
Author(s):  
M. M. Fedorchenko ◽  
V. V. Malina ◽  
V. A. Hryshko

The problem of complete mineral and vitamin nutrition in rabbit breeding is relevant today, despite new discoveries, and research in this direction continues both in Ukraine and around the world. The paper presents experimental data from the results of research to study the effect of different doses of vitamin and mineral supplement "Tekro" in the diets of young rabbits on their productivity, slaughter quality and biological value of rabbit meat. The obtained data of body growth, massometric indicators of carcasses and internal organs of rabbits of experimental groups after slaughter indicate a positive effect of vitamin-mineral supplement "Tekro" on the intensity of development of the body and individual internal organs, which contributes to increased metabolic processes and weight gain in animals research groups. Feeding vitamin and mineral supplements to rabbits of experimental groups of the New Zealand breed for 45 days contributed to a better transformation of feed nutrients into products. In rabbits of the 3rd experimental group, which together with basic ration were fed 3.5 % of the premix "Tekro" at 90 days of age, the highest rates of body weight were recorded, which differed by 8.89 % compared to the control group. In a set of indicators that characterize the nutritional value of rabbit meat, we studied sensory indicators that characterize the quality of rabbit meat: taste, color, pH, juiciness, moisture content, elasticity, aroma, "marbling", etc. It was found that in the appearance of carcasses and muscles in the control group, the samples scored 8.4 points. In the 3-rd and 4-th experimental groups, the number of points on this indicator was higher by 1.2 %. The difference was a trend. Examining the aroma of meat, it was found that in the control of this indicator, the samples scored 7.8 points. In meat samples from experimental groups 3 and 4, the aroma was more identical to natural, so the samples received 2.6 % higher scores. Samples from 3 experimental groups scored the most points in terms of taste. Compared with the control, the figure was higher by 3.6 %. Examining the juiciness of rabbit meat, it was found that samples obtained from carcasses 2 and 3 of the experimental group tended to increase this indicator. Summing up the data, it was found that the highest overall score was found in meat samples from 3 experimental groups. The difference with the control was within the trend and amounted to 2.4 %. Feeding rabbits vitamin and mineral supplements to rabbits helps to obtain good quality meat products with high culinary properties. No data were available to support the effect of vitamin and mineral supplements on compound feed on the synthesis of toxic substances in muscle tissue or the deterioration of rabbit meat. The biological value of muscle samples from rabbits of the 2-nd experimental group did not differ from the control data. The increase was only 0.11 %. It was found that the biological value of muscle tissue from animals of the 4th experimental group was greater than in the control. The difference was 2.6 % Meat obtained from rabbits of the 3rd experimental group, which were fed compound feed with a content of mineral-vitamin supplement "Tekro" 3.5 %, in biological value outweighed the control indicators. The difference was not significant and amounted to 4.1 %. The use of different doses of vitamin and mineral supplements in the feed of young rabbits did not lead to significant changes in the quality of raw hides and furs.


2015 ◽  
Vol 5 ◽  
pp. 46-54
Author(s):  
PARUL AGRAWAL ◽  
PRANAV PANDYA

Aim of the present study was to examine the effect of yogic practices in managing libidinal impulses among adolescents and improving their quality of life. Experimental and control group design was used. Eighty samples were collected through accidental sampling (40 in experimental group and 40 in control group) from Mother Teresa Public School, Delhi. The students those who had high levels of libidinal impulses were selected. The age of the subjects ranged from 14-19 years. The students in the experimental group were made to do yogic practices regularly for 40 days. Libidinal Impulses Scale and PGI General Wellbeing Scale were used. The obtained values of t-test for Libidinal Impulses and General Wellbeing are significant at 0.01 level of confidence. The  result  of  the  study  shows  that  yogic practices  are  significantly  effective  in  reducing  the  levels  of  libidinal impulses  and  improve the level of quality of life of adolescents.


2021 ◽  
Vol 9 (4) ◽  
pp. 75
Author(s):  
Weijie Qi

<p>Objective: to analyze the effect of health education intervention in clinical nursing of patients with skin diseases. Methods: from January 2018 to March 2019, 122 patients with skin diseases were admitted to our hospital and randomly divided into two groups, with 61 cases in each group. The selected patients gave informed consent to this study. The control group was given routine dermatological care, and the observation group was given systematic health education. The treatment effect, mood score and quality of life score of the two groups were compared. Results: the treatment time, recurrence times and outpatient treatment times of the observation group were lower than those of the control group, the difference was statistically significant (P &lt; 0.05); the HAMA score and HAMD score of the observation group after intervention were lower than the control group, the difference was statistically significant (P &lt; 0.05). Conclusion: the implementation of health education for patients with skin diseases during the nursing process can effectively promote the recovery of the condition and reduce the number of treatments and recurrences. At the same time, it can improve the patients’ bad mental mood and improve the quality of life of the patients.</p>


2005 ◽  
Vol 27 (4) ◽  
pp. 266-271 ◽  
Author(s):  
Hanna Karen Moreira Antunes ◽  
Sérgio Garcia Stella ◽  
Ruth Ferreira Santos ◽  
Orlando Francisco Amodeu Bueno ◽  
Marco Túlio de Mello

OBJECTIVE: Mood disorders are a frequent problem in old age, and their symptoms constitute an important public health issue. These alterations affect the quality of life mainly by restricting social life. The participation in a regular exercise program is an effective way of reducing or preventing the functional decline associated with aging. The aim of the present study was to examine the effects of fitness-endurance activity (at the intensity of Ventilatory Threshold 1 (VT-1)) in depression, anxiety and quality of life scores in seniors. METHODS: The study involved 46 sedentary seniors aged 60-75 (66.97 ± 4.80) who were randomly allocated to two groups: 1) Control group, which was neither asked to vary their everyday activities nor to join a regular physical fitness program; and 2) Experimental group, whose members took part in an aerobic fitness program consisting of ergometer cycle sessions 3 times a week on alternate days for six months working at a heart rate corresponding to ventilatory threshold (VT-1) intensity. Subjects were submitted to a basal evaluation using the geriatric depression screening scale - GDS, STAI trait/state (anxiety scale) and SF-36 (quality of life scale). RESULTS: Comparing the groups after the study period, we found a significant decrease in depressive and anxiety scores and an improvement in the quality of life in the experimental group, but no significant changes in the control group. CONCLUSION: The data suggest that an aerobic exercise program at VT-1 intensity suffices to promote favorable modifications in depressive and anxiety scores to improve the quality of life in seniors.


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