scholarly journals Understanding the Use of Radix Astragali Seu Hedysari in the Treatment of Edema Due to Renal Diseases

2021 ◽  
Vol 5 (5) ◽  
pp. 11-14
Author(s):  
Jinghua Lian ◽  
Genping Lei ◽  
Sheng Dong
Keyword(s):  
Clinical Practice ◽  
Good Effect ◽  
Renal Diseases ◽  
Radix Astragali ◽  
Modern Times ◽  
Single Drug ◽  
Supplementing Qi

Radix Astragali seu Hedysari is warm in nature and slightly sweet in taste. It belongs to the lung, spleen, and kidney meridians. It passes through a waterway, dredges the triple energizer, and has a significant effect on edema due to renal diseases. Ancient doctors believed that Radix Astragali seu Hedysari is excellent in tonifying the middle, supplementing Qi, and dredging through the triple energizer. In modern times, many doctors have found that whether it is used as a single drug or in combination with other drugs, it is widely used in clinical practice and has a good effect in inducing diuresis.

Women in otorhinolaryngology: a historical perspective

2018 ◽  
Vol 132 (8) ◽  
pp. 670-672 ◽  
Author(s):  
S Konstantinidou ◽  
M Adams
Keyword(s):  
Clinical Practice ◽  
Literature Review ◽  
Historical Perspective ◽  
Google Scholar ◽  
Modern Times ◽  
History Of ◽  
Ancient Times ◽  
Nineteenth And Twentieth Centuries ◽  
Women Pioneers ◽  
The Way

AbstractBackgroundOtorhinolaryngology has an extensive history that spans nearly five millennia, and the history of women as medical and surgical practitioners stretches back to at least 3500 BC.ObjectivesTo explore the history of women in ENT from ancient to modern times, and discover their fascinating role in this field over the years.MethodA literature review was conducted using Google Scholar and PubMed.ResultsIn ancient and medieval times, there were female doctors accomplished in areas pertaining to ENT. In the nineteenth and twentieth centuries, inspirational women pioneers paved the way for modern female ENT surgeons. This led to a rapid increase in the representation of female otorhinolaryngologists in clinical practice and authorship over the last fifty years.ConclusionThe contribution of women to otorhinolaryngology has evolved since ancient times and the greatest advancement has occurred within the last two hundred years.

Inherited renal diseases

2018 ◽  
Author(s):  
William G. Herrington ◽  
Aron Chakera ◽  
Christopher A. O’Callaghan
Keyword(s):  
Clinical Practice ◽  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Renal Involvement ◽  
Renal Diseases ◽  
Systemic Diseases ◽  
Polycystic Kidney ◽  
Adult Polycystic Kidney Disease

The causes of inherited renal diseases can be divided into cystic, glomerular, tubular, and systemic diseases. By far, the most common of these in clinical practice is adult polycystic kidney disease (APKD). This chapter reviews APKD, other inherited cystic renal diseases, inherited glomerular and tubular diseases, and inherited systemic diseases with renal involvement.

scholarly journals Performing an Ultrasound-Guided Percutaneous Needle Kidney Biopsy: An Up-To-Date Procedural Review

Diagnostics ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 2186
Author(s):  
Antonio Granata ◽  
Giulio Distefano ◽  
Francesco Pesce ◽  
Yuri Battaglia ◽  
Paola Suavo Bulzis ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Kidney Biopsy ◽  
Left Kidney ◽  
Renal Involvement ◽  
Observation Time ◽  
Current Evidence ◽  
Bleeding Complications ◽  
Renal Diseases ◽  
Safe Procedure ◽  
Ultrasound Guided

Ultrasound-guided percutaneous renal biopsy (PRB) has revolutionized the clinical practice of nephrology in the last decades. PRB remains an essential tool for the diagnosis, prognosis, and therapeutic management of several renal diseases and for the assessment of renal involvement in systemic diseases. In this study, we examine the different applications and provide a review of the current evidence on the periprocedural management of patients. PRB is recommended in patients with significant proteinuria, hematuria, acute kidney injury, unexpected worsening of renal function, and allograft dysfunction after excluding pre- and post-renal causes. A preliminary ultrasound examination is needed to assess the presence of anatomic anomalies of the kidney and to identify vessels that might be damaged by the needle during the procedure. Kidney biopsy is usually performed in the prone position on the lower pole of the left kidney, whereas in patients with obesity, the supine antero-lateral position is preferred. After preparing a sterile field and the injection of local anesthetics, an automatic spring-loaded biopsy gun is used under ultrasound guidance to obtain samples of renal parenchyma for histopathology. After the procedure, an ultrasound scan must be performed for the prompt identification of potential early bleeding complications. As 33% of complications occur after 8 h and 91% occur within 24 h, the ideal post-procedural observation time is 24 h. PRB is a safe procedure and should be considered a routine part of the clinical practice of nephrology.

scholarly journals STUDY ON AGRYA AUSHADHI (FOREMOST SUBSTANCES) W.S.R TO CLINICAL PRACTICE IN AYURVEDA

2021 ◽  
Vol 9 (6) ◽  
pp. 1274-1282
Author(s):  
Paudel Kiran ◽  
Ramamurthy Aku ◽  
Sharma Gaurav
Keyword(s):  
Clinical Practice ◽  
Cost Effective ◽  
Single Drug ◽  
Drug Choice ◽  
Single Form

In Āyurveda, Agrya Sangraha means collection of leading or principle substances. AgryaAusadhi in Ayurveda is used to prevent diseases and maintain health. Charak Samhitā Sutrasthāna includes 152 AgryaAushadhi, Astanga Hridayam Uttarsthān includes Agrya Aushadhi and in Astanga Sangraha Sutrasthāna AgryaSangraha. Agrya Dravyas are the drugs that are used as first drug choice for the treatment of diseases. They are cost effective, eco- nomical, easy to use and safe. EkalaDravya is the dravya used in single form and single drug is mostly includes in AgryaPrakarana. The AgryaDravya mentioned in classical texts of Āyurveda are best in their respective class of action. The fact that Agrya are best drugs can be deduced from the fact that a single drug can do many functions, so a single drug will work instead of prescribing a bunch of drugs e.g. Pippali Moola will work alone for Dipana, Pāchana and Anahaprasamana and thus, no need to prescribe three different drugs each for a desired action. Keywords: Agrya, Dravyachikitshā, Aushadhi, EkalDravya

scholarly journals EFFECT OF COMBINATION OF TIOTROPIUM/ OLODATEROL ON PULMONARY FUNCTION IN PATIENTS WITH COPD IN THE REAL CLINICAL PRACTICE

2021 ◽  
Vol 29 (3) ◽  
pp. 28-30
Author(s):  
Y. M. Mostovoy ◽  
K. D. Dmytriiev ◽  
N. S. Slepchenko
Keyword(s):  
Clinical Practice ◽  
Pulmonary Function ◽  
Good Effect ◽  
Clinical Settings ◽  
Absolute Increase ◽  
The Real ◽  
Women Smokers ◽  
Significant Difference ◽  
Smoking Duration ◽  
Real Clinical Practice

EFFECT OF COMBINATION OF TIOTROPIUM/OLODATEROL ON PULMONARY FUNCTION IN PATIENTS WITH COPD IN THE REAL CLINICAL PRACTICE Y. M. Mostovoy, K. D. Dmytriiev, N. S. Slepchenko Abstract Aim — to evaluate the effect of combination therapy with tiotropium/olodaterol on pulmonary function in real clinical practice. Materials and methods. 100 patients with the diagnosis of COPD were included into the study (mean age was 64,09±1,94 years, 66 men and 34 women). Smokers — 68 %, mean smoking duration (24,44 ± 4,84) packyears. Average COPD duration was 9,35±2,42 years. All patients underwent spirometry at screening, 4-6 weeks and at 1 year after inclusion. FEV1, FVC, FEV1/FVC, FEF25, FEF50, FEF75, PEF, MMEF75/85, FEF75/85 were calculated. Results. There was statistically significant improvement in FEV1 and FVC values between visits 1 and 3 (p < 0,05). At visit 3 there was a statistically significant difference in FEV1 and FVC values when compared with same values at visit 1 after the inhalation of salbutamol, demonstrating better bronchodilation effect of tiotropium/olodaterol. Absolute increase of FEV1 between visits 1 and 3 was 221,31±34,9 ml; FVC — 411,01±66,08 ml. There was statistically significant increase of FEF75, MMEF75/25, FEF75/85 between visits 1 and 3 (p < 0,05). There was statistically significant increase of FEF75 at visits 2 and 3 in comparison with postBD FEF75 at visit, confirming better bronchodilation effect of tiotropium/olodaterol combination of at the level of small bronchi when compared with salbutamol (p < 0,05). Conclusions. Tiotropium/olodaterol combination showed good effect on pulmonary function in patients with COPD in real clinical settings. This combination demonstrated better bronchodilation than salbutamol, especially at the level of small bronchi. Key words: COPD, tiotropium/olodaterol, spirometry. Ukr. Pulmonol. J. 2020;29(3):28–30.

scholarly journals Animal models to evaluate analgesic effects using isobolographic analysis

2012 ◽  
Vol 1 (1) ◽  
Author(s):  
María Asunción Romero Molina
Keyword(s):  
Clinical Practice ◽  
Animal Models ◽  
Experimental Animal ◽  
Severe Pain ◽  
Preclinical Study ◽  
Isobolographic Analysis ◽  
Experimental Animal Models ◽  
Analgesic Effects ◽  
Single Drug ◽  
Accurate Design

In the daily clinical practice, combined pharmacotherapy is often used when a single drug (monotherapy) treatment is not enough to relief moderate-severe pain in patients. The use of experimental animal models offers us great tools for the translation of data from animals to human. However, the accurate design of the preclinical study is a requisite to obtain valid outcomes. Using the isobolographic analysis we can easily establish differences between synergistic or additive responses expected from drug combinations, improving the management and treatment of pain.

A rapid silver-impregnation technique on ultra-thin sections for Electron Microscopy

1993 ◽  
Vol 51 ◽  
pp. 242-243
Author(s):  
K. Chien ◽  
R.C. Heusser ◽  
M.L. Jones ◽  
R.L. Van de Velde
Keyword(s):  
Electron Microscopy ◽  
Silver Nitrate ◽  
Silver Impregnation ◽  
Sodium Borate ◽  
Renal Diseases ◽  
Distilled Water ◽  
Thin Sections ◽  
Impregnation Technique ◽  
Centrifuge Tube ◽  
Simplified Procedure

Silver impregnation techniques have been used for the demonstration of the complex carbohydrates in electron microscopy. However, the silver stains were believed to be technically sensitive and time consumming to perform. Currently, due to the need to more specifically evaluate immune complex for localization in certain renal diseases, a simplified procedure in conjunction with the use of the microwave has been developed and applied to renal and other biopsies. The procedure is as follows:Preparation of silver methenamine solution:1. 15ml graduated, clear polystyrene centrifuge tube (Falcon, No. 2099) was rinsed once with distilled water.2. 3% hexamethylene tetramine (methenamine) was added into the centrifuge tube to the 6ml mark.3. 3% silver nitrate was added slowly to the methenamine to the 7ml mark while agitating. (Solution will instantly turn milky in color and then clear rapidly by mixing. No precipitate should be formed).4. 2% sodium borate was added to the solution to the 8ml mark, mixed and centrifuged before use.

The miR-21 potential of serving as a biomarker for liver diseases in clinical practice

2020 ◽  
Vol 48 (5) ◽  
pp. 2295-2305
Author(s):  
Jiawei Zhang ◽  
Dandan Li ◽  
Rui Zhang ◽  
Peng Gao ◽  
Rongxue Peng ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Liver Diseases ◽  
Hepatic Disease ◽  
Noninvasive Detection ◽  
Diagnosis And Prognosis ◽  
Expected Performance ◽  
Potential Biomarker ◽  
Disease Condition ◽  
Complex Regulatory Network

The role of miR-21 in the pathogenesis of various liver diseases, together with the possibility of detecting microRNA in the circulation, makes miR-21 a potential biomarker for noninvasive detection. In this review, we summarize the potential utility of extracellular miR-21 in the clinical management of hepatic disease patients and compared it with the current clinical practice. MiR-21 shows screening and prognostic value for liver cancer. In liver cirrhosis, miR-21 may serve as a biomarker for the differentiating diagnosis and prognosis. MiR-21 is also a potential biomarker for the severity of hepatitis. We elucidate the disease condition under which miR-21 testing can reach the expected performance. Though miR-21 is a key regulator of liver diseases, microRNAs coordinate with each other in the complex regulatory network. As a result, the performance of miR-21 is better when combined with other microRNAs or classical biomarkers under certain clinical circumstances.

Meeting the Best Practice for Hearing Aid Verification in Children: Challenges and Future Directions

2019 ◽  
Vol 28 (4) ◽  
pp. 877-894
Author(s):  
Nur Azyani Amri ◽  
Tian Kar Quar ◽  
Foong Yen Chong
Keyword(s):  
Clinical Practice ◽  
Hearing Aids ◽  
Best Practice ◽  
Hearing Aid ◽  
Evidence Based ◽  
Future Directions ◽  
Major Barrier ◽  
Klang Valley ◽  
Age Range ◽  
Fitting Hearing Aids

Purpose This study examined the current pediatric amplification practice with an emphasis on hearing aid verification using probe microphone measurement (PMM), among audiologists in Klang Valley, Malaysia. Frequency of practice, access to PMM system, practiced protocols, barriers, and perception toward the benefits of PMM were identified through a survey. Method A questionnaire was distributed to and filled in by the audiologists who provided pediatric amplification service in Klang Valley, Malaysia. One hundred eight ( N = 108) audiologists, composed of 90.3% women and 9.7% men (age range: 23–48 years), participated in the survey. Results PMM was not a clinical routine practiced by a majority of the audiologists, despite its recognition as the best clinical practice that should be incorporated into protocols for fitting hearing aids in children. Variations in practice existed warranting further steps to improve the current practice for children with hearing impairment. The lack of access to PMM equipment was 1 major barrier for the audiologists to practice real-ear verification. Practitioners' characteristics such as time constraints, low confidence, and knowledge levels were also identified as barriers that impede the uptake of the evidence-based practice. Conclusions The implementation of PMM in clinical practice remains a challenge to the audiology profession. A knowledge-transfer approach that takes into consideration the barriers and involves effective collaboration or engagement between the knowledge providers and potential stakeholders is required to promote the clinical application of evidence-based best practice.

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