scholarly journals Correlation Differences between Sex and Stress Hormones in Men And Women

2021 ◽  
Vol 6 (1) ◽  
pp. 327-331
Author(s):  
L. D. Popova ◽  
I. M. Vasylyeva ◽  
O. A. Nakonechna
Keyword(s):  
Menstrual Cycle ◽  
Blood Serum ◽  
Sex Hormones ◽  
Negative Correlation ◽  
Luteal Phase ◽  
Stress Hormones ◽  
Follicular Phase ◽  
Sympathoadrenal System ◽  
Men And Women ◽  
Positive Correlations

The excessive aggression is an actual problem of modern society but the mechanisms of aggressiveness development have not been sufficiently investigated. Women aggression is considered to differ from men one and results obtained on males cannot be extrapolated on females. Sex hormones have a crucial role in the generation of sexually dimorphic aggression circuits during development and their maintenance during adulthood. Hypothalamic pituitary adrenal axis and sympathoadrenal system are major neuroendocrine systems that respond to stress. Stress hormones are involved into behavioral reactions of organism. Gonadal, hypothalamic pituitary adrenal axes, and sympathoadrenal system are tightly interrelated and every of them can influence another one. The purpose of the study was to estimate correlation differences between sex and stress hormones in men and women. Material and methods. Forty healthy young people aged 18 to 22 years with a body mass index of 19-24 (21 women and 19 men) were enrolled in the study. Hormone levels in blood serum were determined by Testosterone, Estradiol, Cortisol ELISA kits (Italy), Epinephrine/Norepinephrine (EPI) ELISA kit (China). Results and discussion. In all phases of the menstrual cycle, the level of cortisol in women was lower than in men, but in the luteal phase these differences were not statistically significant. In all phases of the menstrual cycle, the blood serum norepinephrine content in women was lower than in men, but in the follicular phase these differences were not statistically significant. The level of epinephrine in women during ovulation and luteal phase did not differ from the level of epinephrine in men, but in follicular phase it was significantly lower. Calculations of correlations between individual hormones revealed a significant difference between them in men and women. Positive correlations between testosterone and estradiol and between cortisol and epinephrine; a strong negative correlation between epinephrine and testosterone/norepinephrine ratio were found in men. Positive correlation between testosterone and cortisol and negative correlation between estradiol and cortisol/testosterone ratio were revealed in women. Conclusion. In women, strong correlations were found between cortisol and sex hormones; in men, strong interrelationship was revealed between cortisol and epinephrine. Both in men and in women (in all phases of the menstrual cycle), high positive correlations between testosterone/norepinephrine and cortisol/norepinephrine ratios were observed

Serum and urinary concentrations of sex hormones and genital swelling during the menstrual cycle of the gibbon

1993 ◽  
Vol 136 (3) ◽  
pp. 447-455 ◽  
Author(s):  
R. D. Nadler ◽  
J. F. Dahl ◽  
D. C. Collins
Keyword(s):  
Menstrual Cycle ◽  
Sex Hormones ◽  
Luteal Phase ◽  
Follicular Phase ◽  
Sex Hormone ◽  
Physiological Processes ◽  
Multimale Groups ◽  
The Relationship ◽  
Monitoring Progress ◽  
Female Genital

ABSTRACT The relationship between sex hormone concentrations and female genital swelling during the menstrual cycle in the monogamous gibbon was comparable with that of polygamous female primates, such as the chimpanzee, which live in multimale groups and have larger swellings. The data, therefore, support the hypothesis proposed by C. R. Carpenter more than 50 years ago, that the gibbon's genital swelling, like that of other female primates, reflects basic physiological processes associated with progress of the menstrual cycle. Genital swelling increased during the follicular phase with increasing concentrations of oestradiol and oestrone glucuronide, reached maximal swelling in association with the mid-cycle peaks in the oestrogens and LH and began detumescence with the initial increases in progesterone during the luteal phase. The data also suggest that the menstrual cycle of the gibbon is shorter than previously reported, since cycles of 19–22 days exhibited hormone patterns that are consistent with ovulation. The genital swelling of the female gibbon is a useful marker for monitoring progress of the menstrual cycle and the presumptive time of ovulation. Journal of Endocrinology (1993) 136, 447–455

scholarly journals Menstrual phase-dependent differences in neurobehavioral performance: the role of temperature and the progesterone/estradiol ratio

SLEEP ◽  
2019 ◽  
Vol 43 (2) ◽  
Author(s):  
Leilah K Grant ◽  
Joshua J Gooley ◽  
Melissa A St Hilaire ◽  
Shantha M W Rajaratnam ◽  
George C Brainard ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Cognitive Performance ◽  
Sex Hormones ◽  
Luteal Phase ◽  
Light Exposure ◽  
Sleep Loss ◽  
Follicular Phase ◽  
Menstrual Phase ◽  
Nighttime Light

Abstract Study objectives Women in the luteal phase of the menstrual cycle exhibit better cognitive performance overnight than women in the follicular phase, although the mechanism is unknown. Given the link between core body temperature (CBT) and performance, one potential mechanism is the thermoregulatory role of progesterone (P4), estradiol (E2), and their ratio (P4/E2), which change across the menstrual cycle. We examined the role of P4/E2 in modulating performance during extended wake in premenopausal women. Additionally, we compared the acute effects of nighttime light exposure on performance, CBT, and hormones between the menstrual phases. Methods Participants were studied during a 50 h constant routine and a 6.5 h monochromatic nighttime light exposure. Participants were 16 healthy, naturally cycling women (eight follicular; eight luteal). Outcome measures included reaction time, attentional failures, self-reported sleepiness, CBT, melatonin, P4, and E2. Results As compared to women in the luteal phase, women in the follicular phase exhibited worse performance overnight. CBT was significantly associated with performance, P4, and P4/E2 but not with other sex hormones. Sex hormones were not directly related to performance. Light exposure that suppressed melatonin improved performance in the follicular phase (n = 4 per group) to levels observed during the luteal phase and increased CBT but without concomitant changes in P4/E2. Conclusions Our results underscore the importance of considering menstrual phase when assessing cognitive performance during sleep loss in women and indicate that these changes are driven predominantly by CBT. Furthermore, this study shows that vulnerability to sleep loss during the follicular phase may be resolved by exposure to light.

Effects of exercise and thermal stress on caffeine pharmacokinetics in men and eumenorrheic women

2002 ◽  
Vol 93 (4) ◽  
pp. 1471-1478 ◽  
Author(s):  
C. McLean ◽  
T. E. Graham
Keyword(s):  
Thermal Stress ◽  
Menstrual Cycle ◽  
Luteal Phase ◽  
Phase 1 ◽  
Follicular Phase ◽  
Lower Plasma ◽  
Caffeine Ingestion ◽  
Cycling Exercise ◽  
Men And Women

The influence of gender, exercise, and thermal stress on caffeine pharmacokinetics is unclear. We hypothesized that these factors would not have an effect on the metabolism of caffeine. Eight women participated in four 8-h trials and six men participated in two 8-h trials after the ingestion of 6 mg/kg caffeine. The women performed two resting trials (1 in the follicular phase and 1 in the luteal phase of the menstrual cycle) and two exercise trials (90 min of cycling exercise at 65% of maximal O2 uptake, 1 h after caffeine ingestion) in the follicular phase (1 without and 1 with an additional thermal stress). The men performed one exercise and one resting trial. Menstrual cycle, gender, and exercise, with or without an additional thermal stress, had no effect on the pharmacokinetic measurements or urine caffeine. There was a trend for higher plasma caffeine and lower plasma paraxanthine concentrations in the women. These results confirm that gender, exercise, and thermal stress have no effect on caffeine pharmacokinetics in men and women.

scholarly journals Influence of the Menstrual Cycle on Blood Markers of Muscle Damage and Inflammation Following Eccentric Exercise

2020 ◽  
Vol 17 (5) ◽  
pp. 1618
Author(s):  
Nuria Romero-Parra ◽  
Laura Barba-Moreno ◽  
Beatriz Rael ◽  
Víctor M. Alfaro-Magallanes ◽  
Rocío Cupeiro ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Muscle Damage ◽  
Sex Hormones ◽  
Eccentric Exercise ◽  
Interleukin 6 ◽  
Luteal Phase ◽  
Follicular Phase ◽  
Cycle Phase ◽  
Post Trial ◽  
Factor Α

The aim of this study was to evaluate whether the menstrual cycle and its underlying hormonal fluctuations affect muscle damage and inflammation in well-trained females following an eccentric exercise. Nineteen eumenorrheic women performed an eccentric squat-based exercise in the early follicular phase, late follicular phase and mid-luteal phase of their menstrual cycle. Sex hormones and blood markers of muscle damage and inflammation –creatine kinase, myoglobin, lactate dehydrogenase, interleukin-6, tumoral necrosis factor-α, and C reactive protein– were analyzed in each phase. No effect of menstrual cycle phase was observed (p > 0.05), while an interaction for interleukin-6 was shown (p = 0.047). Accordingly, a moderate effect size [0.68 (0.53)–0.84 (0.74)], indicated that interleukin-6 values 2 h post-trial (2.07 ± 1.26 pg/mL) were likely to be higher than baseline (1.59 ± 0.33 pg/mL), 24 h (1.50 ± 0.01 pg/mL) and 48 h (1.54 ± 0.13 pg/mL) in the mid-luteal phase. Blood markers of muscle damage and inflammation were not affected by the menstrual cycle in well-trained women. The eccentric exercise barely triggered muscle damage and hence, no inflammation was observed, possibly due to participants training status. The mid-luteal phase was the only phase reflecting a possible inflammatory response in terms of interleukin-6, although further factors than sex hormones seem to be responsible for this finding.

EVALUATION OF CHANGES IN CARDIORESPIRATORY FUNCTIONS DURING DIFFERENT PHASES OF THE MENSTRUAL CYCLE IN YOUNG WOMEN

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Shehnaz Shaikh
Keyword(s):  
Menstrual Cycle ◽  
Sample Size ◽  
Young Women ◽  
Luteal Phase ◽  
Uterine Wall ◽  
Normal Weight ◽  
Follicular Phase ◽  
Menstrual Phase ◽  
Granulose Cells ◽  
Efficiency Test

Introduction: Menstrual cycle or menstruation involved discharge of sanguinous fluid and a sloughing of uterine wall. In women menstruation occurs at regular intervals on an average of 28 days, although most women gave a history of regular intervals of 28 to 30 days. About 10% -15% of women showed cycle at the precise 28 ± 2 days intervals when menstrual calendar was utilized. Normally in young women in different phases of ovarian cycles the plasma levels of estrogen vary. Ovulation occurs in the first 12-13th day of menstrual cycle, which is termed estrogen surge and second occurs in mid-luteal phase. During mid cycle or follicular phase of menstrual cycle the plasma concentration of progesterone is very low about 0.9 ng/mL. its level starts rising owing to secretion from the granulose cells. During luteal phase progesterone level reaches its peak value of 18 ng/mL and its level fall to a minimum value toward the end of the cycle. Estrogen affects local and systemic vasodilation. The menstrual cycle envelops two fundamental stages, the follicular stage (FP) and the luteal stage (LP). The follicular stage can part advance into two substages; the early FP, which is characterised with moo concentrations of both the key hormones estrogen and progesterone; and the mid FP where estrogen is tall autonomously from progesterone. The LP is epitomized by tall concentration of both estrogen and progesterone. These two fundamental stages are isolated by a soak surge in luteinizing hormone activating ovulation. These recurrent changes are said to be frequency unsurprising while long time. Aim: The main aim of this study is to evaluate the Cardiorespiratory functions changes during different Phases of Menstrual Cycle.   Material and methods: In this study, 20 with normal weight, 20 with obese and 20 with overage were included and taken them as a sample size. In this study all the young women those were recruited as a sample size are unmarried, undergraduate female student with the between the age group of 18-22years, having regular 28+6 days menstrual cycle for at least last 6months prior to this study. For the collection of data all the participants were instructed to attend the physiology lab department during each of three different phases. Day-2 during menstrual phase, Day-7, during follicular phase and Day-22 during luteal phase and the following parameters were recorded as Anthropometric measurements, measuring of pulse rate and blood pressure and cardiac efficiency test. Result: In general, work out proficiency changed essentially amid the distinctive stages of the menstrual cycle with the most elevated amid luteal stage and least amid menstrualo stage. There was no critical contrast in impact test amid menstrual stage, follicular stage and luteal stage of menstrual cycle among three bunches of people. Conclusion: We have watched noteworthy increment in cardiac and respiratory proficiency within the luteal stage of the menstrual cycle in ordinary weight people. Lower wellness levels were watched in overweight and stout females. In this manner hone of customary work out and admissions of solid slim down which offer assistance in lessening the weight and in turn the BMI will offer assistance in improving the physical wellness of the people. Keywords: Cardiorespiratory, Menstrual cycle, expiratory blast test

scholarly journals Influence of Menstrual Cycle Estradiol-β-17 Fluctuations on Energy Substrate Utilization-Oxidation during Aerobic, Endurance Exercise

2021 ◽  
Vol 18 (13) ◽  
pp. 7209
Author(s):  
Hannah N. Willett ◽  
Kristen J. Koltun ◽  
Anthony C. Hackney
Keyword(s):  
Menstrual Cycle ◽  
Athletic Performance ◽  
Luteal Phase ◽  
Substrate Utilization ◽  
Follicular Phase ◽  
Exercise Session ◽  
Future Research ◽  
Physically Active ◽  
Energy Substrate ◽  
Fat Utilization

This study examined the effect of estradiol-β-17 across the menstrual cycle (MC) during aerobic exercise on energy substrate utilization and oxidation. Thirty-two eumenorrheic (age = 22.4 ± 3.8 y (mean ± SD)), physically active women participated in two steady-state running sessions at 65% of VO2max, one during the early follicular and one during the luteal phase of the MC. Blood samples were collected at rest before each exercise session and analyzed for Estradiol-β-17 to confirm the MC phase. Carbohydrate (CHO) utilization and oxidation values were significantly lower (p < 0.05) in the luteal (utilization: 51.6 ± 16.7%; oxidation: 1.22 ± 0.56 g/min; effect size (ES) = 0.45, 0.27) than follicular phase (utilization: 58.2 ± 15.1%; oxidation: 1.38 ± 0.60 g/min) exercise sessions. Conversely, fat utilization and oxidation values were significantly (p < 0.05) higher in the luteal (utilization: 48.4 ± 16.7%; oxidation: 0.49 ± 0.19 g/min; ES = 0.45,0.28) than follicular phase (utilization: 41.8 ± 15.1%; oxidation: 0.41 ± 0.14 g/min). Estradiol-β-17 concentrations were significantly (p < 0.01) greater during the luteal (518.5 ± 285.4 pmol/L; ES = 0.75) than follicular phase (243.8 ± 143.2 pmol/L). Results suggest a greater use of fat and reduced amount of CHO usage during the luteal versus follicular phase, directly related to the change in resting estradiol-β-17. Future research should investigate the role these changes may play in female athletic performance.

Urinary melatonin, LH, oestradiol, progesterone excretion during the menstrual cycle or in women taking oral contraceptives

1987 ◽  
Vol 116 (1) ◽  
pp. 145-149 ◽  
Author(s):  
Jocelyne Brun ◽  
Bruno Claustrat ◽  
Michel David
Keyword(s):  
Oral Contraceptive ◽  
Menstrual Cycle ◽  
Urinary Excretion ◽  
Oral Contraceptives ◽  
Coefficient Of Variation ◽  
Luteal Phase ◽  
Positive Relationship ◽  
Follicular Phase ◽  
The Other ◽  
Normal Women

Abstract. Nocturnal urinary excretion of melatonin, LH, progesterone and oestradiol was measured by radioimmunoassay in nine normal women during a complete cycle. In addition, these hormonal excretions were studied in two women taking an oral contraceptive. A high within-subject coefficient of variation was observed for melatonin excretion in the two groups. In the nine normal cycling women, melatonin excretion was not decreased at the time of ovulation, but was significantly increased during the luteal phase compared with that of the follicular phase (P < 0.01). These data are consistent with a positive relationship between melatonin and progesterone during the luteal phase. In the two women under an oral contraceptive, melatonin excretion was found within the same range as for the other nine. The results are discussed in terms of pineal investigation in human.

scholarly journals Methodological Approach of the Iron and Muscular Damage: Female Metabolism and Menstrual Cycle during Exercise Project (IronFEMME Study)

2021 ◽  
Vol 18 (2) ◽  
pp. 735
Author(s):  
Ana B. Peinado ◽  
Victor M. Alfaro-Magallanes ◽  
Nuria Romero-Parra ◽  
Laura Barba-Moreno ◽  
Beatriz Rael ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Resistance Exercise ◽  
Muscle Damage ◽  
Sex Hormones ◽  
Iron Metabolism ◽  
Female Athletes ◽  
Methodological Approach ◽  
Follicular Phase ◽  
Cycle Phase ◽  
Exercise Protocol

Background: The increase in exercise levels in the last few years among professional and recreational female athletes has led to an increased scientific interest about sports health and performance in the female athlete population. The purpose of the IronFEMME Study described in this protocol article is to determine the influence of different hormonal profiles on iron metabolism in response to endurance exercise, and the main markers of muscle damage in response to resistance exercise; both in eumenorrheic, oral contraceptive (OC) users and postmenopausal well-trained women. Methods: This project is an observational controlled randomized counterbalanced study. One hundered and four (104) active and healthy women were selected to participate in the IronFEMME Study, 57 of which were eumenorrheic, 31 OC users and 16 postmenopausal. The project consisted of two sections carried out at the same time: iron metabolism (study I) and muscle damage (study II). For the study I, the exercise protocol consisted of an interval running test (eight bouts of 3 min at 85% of the maximal aerobic speed), whereas the study II protocol was an eccentric-based resistance exercise protocol (10 sets of 10 repetitions of plate-loaded barbell parallel back squats at 60% of their one repetition maximum (1RM) with 2 min of recovery between sets). In both studies, eumenorrheic participants were evaluated at three specific moments of the menstrual cycle: early-follicular phase, late-follicular phase and mid-luteal phase; OC users performed the trial at two moments: withdrawal phase and active pill phase. Lastly, postmenopausal women were only tested once, since their hormonal status does not fluctuate. The three-step method was used to verify the menstrual cycle phase: calendar counting, blood test confirmation, and urine-based ovulation kits. Blood samples were obtained to measure sex hormones, iron metabolism parameters, and muscle damage related markers. Discussion: IronFEMME Study has been designed to increase the knowledge regarding the influence of sex hormones on some aspects of the exercise-related female physiology. Iron metabolism and exercise-induced muscle damage will be studied considering the different reproductive status present throughout well-trained females’ lifespan.

Haemodynamic responses to psychosocial stress during the menstrual cycle

1991 ◽  
Vol 81 (1) ◽  
pp. 17-22 ◽  
Author(s):  
Karin Manhem ◽  
Christina Jern ◽  
Martin Pilhall ◽  
Guy Shanks ◽  
Sverker Jern
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Menstrual Cycle ◽  
Systolic Blood Pressure ◽  
Psychosocial Stress ◽  
Mental Stress ◽  
Luteal Phase ◽  
Follicular Phase ◽  
Two Phases ◽  
Plasma Catecholamine Concentrations

1. The haemodynamic effects of hormonal changes during the menstrual cycle were examined in 11 normotensive women (age 20–46 years). The subjects were studied on days 2–8 (follicular phase) and days 18–26 (luteal phase) in a randomized order. A standardized mental stress test and a 24 h recording of ambulatory blood pressure and heart rate were performed. 2. Pre-stress resting levels of heart rate and blood pressure were similar during the two phases of the menstrual cycle. 3. During mental stress, the heart rate response was significantly greater during the luteal phase than during the follicular phase (14.7 versus 9.7 beats/min; P < 0.05). 4. Blood pressure, plasma catecholamine concentrations and subjective stress experience increased significantly in response to stress, without any significant differences between the two phases. 5. During 24 h ambulatory monitoring, higher levels of systolic blood pressure and heart rate were observed in the luteal phase than in the follicular phase (P < 0.005 and P < 0.0001, respectively). 6. These data indicate that cyclic variations in female sex hormones not only affect systolic blood pressure and heart rate, but also alter the haemodynamic responses to psychosocial stress.

scholarly journals Analysis of the physical performance of women in different motor skills during the phases of the menstrual cycle

2019 ◽  
Author(s):  
Isadora Cristina Ribeiro ◽  
Joao Paulo Borin
Keyword(s):  
Menstrual Cycle ◽  
Physical Performance ◽  
Motor Skills ◽  
Motor Skill ◽  
Luteal Phase ◽  
Follicular Phase ◽  
Lower Limbs ◽  
Performance Tests ◽  
Several Variables ◽  
The One

The training of a motor skill promotes physical performance and depends on several variables. For women, the menstrual cycle is the one to be highlighted. Studies have focused on the analysis motor skills during this period and emphasize hormonal issues with low attention to the physcal performance. Thus, the objective of this study was to verify the physical performance in different motor skills during the phases of the menstrual cycle in two different cycles. During eight weeks, twelve women, divided into a trained and begginer group, underwent training for different motor skills, and at each stage of the menstrual cycle performed performance tests. The results suggest a higher strength of the lower limbs and a greater capacity of endurance in the Luteal phase in relation to the Follicular phase, but for the flexibility there were no significant differences, suggesting that there is no influence of the menstrual cycle on this motor skill.

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