scholarly journals POTENTIAL RISK OF INVESTIGATED DRUGS FOR THE TREATMENT OF COVID-19: DRUGS INTERACTIONS

2020 ◽  
Vol 6 ◽  
Author(s):  
José Virgulino De Oliveira Lima ◽  
Gisele Lopes Cavalcante ◽  
Nayara Soares de Mendonça Braga ◽  
Alan Rodrigues da Silva ◽  
Tiago Medeiros da Silva ◽  
...  
Keyword(s):  
Potential Risk ◽  
Corona Virus

Introdução: O coronavírus provoca infecções nas vias aéreas inferiores e com casos de infecções precedentes pelo SARS-CoV (corona vírus da síndrome respiratória aguda) e por MERS-CoV (síndrome respiratória do Oriente Médio). Delineamento: Caracteriza-se como uma pesquisa documental, que utiliza a base de dados Drugs®, para a obtenção das informações cruzadas dos bancos de dados com outros fármacos, conforme artigos de periódicos indexados nos grandes buscadores PubMed, Science Direct e BVS. Para a determinação de Interação medicamentosa, foram utilizados apenas os dados que dispunham de no mínimo “boa documentação” e apenas as interações “expressamente contraindicadas”, “maiores” e “moderadas” as interações leves foram omitidas. Resultados: A hidroxicloroquina e a cloroquina estão associadas a muitas interações medicamentosas e com doenças, juntamente a azitromicina, que também, possui um grau alto de riscos. Contudo, a nitazoxanida, ivermectina, oseltamivir estão do outro lado da margem, com pequenas interações e riscos a segurança do tratamento. Os anticorpos monoclonais e os antirretrovirais possui risco benefício equilibrado. Conclusão: A maioria dos medicamentos atualmente investigados no tratamento da covid-19 apresentam diversas interações medicamentosas e interações com doenças preexistentes.

Vaccine Targeted Prophylaxis For Covid-19: A Comprehensive Review

2021 ◽  
Vol 12 (3) ◽  
pp. 1850-1860
Author(s):  
Sonia Goswami ◽  
Nagarajan K ◽  
Praveen K. Dixit ◽  
Vidhu Saxena ◽  
Richa Goel ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Potential Risk ◽  
Well Being ◽  
World Health ◽  
Comprehensive Review ◽  
Corona Virus ◽  
The World ◽  
The Face ◽  
Health Organization ◽  
Game Changer

The Severe acute respiratory syndrome coronavirus-2, the contamination that prompts sickness19(covid-19), has spread quickly from the initially known cases in china in December 2019 to nations round the globe. On March 10,2020, the world health organization reported that there have been 113,702 affirmed instances of corona virus -19 round the globe, additionaly to 4,012 passing. Due to this worldwide well being emergency analysts are handling build up a corona virus immunization. Protected and compelling immunizations are going to be a game changer: yet for years to return we should always wearing covers, genuinely separating and staying faraway from swarms. Being inoculated doesn't imply that we will laugh in the face of any potential risk and put ourselves as well as other people in danger, especially in light of the very fact that it is as yet not satisfactory what proportions the antibodies can ensure against sickness also as against contamination and transmission. Vaccine for corona virus are basic devices for managing the pandemic when joined with compelling testing and existing anticipation measures. The general undertaking to form a secure and effective coronavirus vaccine is proving to be fruitful. A handful of vaccines now are authorized round the globe, may more in development. Antibodies save an excellent many lives per annum.

Pulmonary emboli due to venous aneurysm of extremities

VASA ◽  
2011 ◽  
Vol 40 (4) ◽  
pp. 327-332 ◽  
Author(s):  
Gabrielli ◽  
Rosati ◽  
Vitale ◽  
Millarelli ◽  
Siani ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Surgical Resection ◽  
Potential Risk ◽  
Acute Pulmonary Embolism ◽  
Prophylactic Surgery ◽  
Venous Aneurysm ◽  
Pulmonary Emboli ◽  
Thromboembolic Events ◽  
Thromboembolic Complications ◽  
Risk Patients

Venous aneurysms are uncommon but they can have devastating consequences, including pulmonary embolism, other thromboembolic events and death. We report six cases of venous aneurysm of the extremities, in which the first sign of presence was acute pulmonary embolism. Surgical resection is recommended whenever possible. Our experience suggests that prophylactic surgery is cautiously recommended for low-risk patients with venous aneurysms of the abdomen and strongly recommended for extremity deep and superficial venous aneurysms for their potential risk of developing thromboembolic complications despite adequate anticoagulation. Other venous aneurysms should be excised only if they are symptomatic or enlarging.

Transmyocardial Laser Revascularisation - A Potential Risk in Acute Situation?

Swiss Surgery ◽  
2000 ◽  
Vol 6 (2) ◽  
pp. 65-68
Author(s):  
Mueller ◽  
Tevaearai ◽  
Genton ◽  
Bettex ◽  
von Segesser
Keyword(s):  
Potential Risk ◽  
Transmyocardial Laser Revascularisation ◽  
Analyse Morphométrique

Les effets morphologiques et fonctionnels de la revascularisation transmyocardique au laser (RTML) sont analysés en conditions aiguës sur un modèle porcin. La paroi latérale du ventricule gauche de 15 porcs (poids moyen: 73 +/- 4kg) a été percée de 10 canaux laser (laser: Ho-YAG; longueur d'onde: 2.1 u, diamètre de la sonde: 1.75 mm). Une échocardiographie a été effectuée avant, ainsi que 5 min et 30 min après la procédure. Les paramètres échocardiographiques ont été enregistrés en court axe à la hauteur des canaux laser. Ils comprenaient la fraction d'éjection, la fraction de raccourcissement et la motilité segmentaire de la région lasérisée (échelle de 0 à 3: 0 = normal, 1 = hypokinésie, 2 = akinésie, 3 = dyskinésie). Après sacrifice de l'animal, la région lasérisée a été coupée dans un plan perpendiculaire aux canaux pour histologie et analyse morphométrique. Après 5 min, tous les index échocardiographiques ont montré une aggravation significative par rapport aux valeurs de base (p < 0.01). Après 30 min, plus aucun des paramètres ne présentait de variation significative par rapport aux valeurs de base. La surface de section des lésions mesurait 8.8 +/- 2.4 mm2 soit plus du triple de celle de la sonde laser elle-même (p < 0.01). En conditions aiguës, les lésions dues à la sonde de RTML sont nettement plus grande que la sonde elle-même et entraînent une baisse transitoire de la contractilité segmentaire sur un coeur sain. Ces résultats suggèrent que la RTML doit être utilisée avec prudence en clinique chez les patients avec une mauvaise fonction ventriculaire.

Indikationen für chinesische Arzneimitteltherapie bei Covid-19-Erkrankungen

2020 ◽  
Vol 12 (03) ◽  
pp. 18-18
Author(s):  
Christian Thede
Keyword(s):  
Virus Disease ◽  
Traditionelle Chinesische Medizin ◽  
Chinesische Medizin ◽  
Corona Virus ◽  
Chinesische Arzneimitteltherapie

SummaryIn Reaktion auf den massiven Ausbruch von Covid-19-Erkrankungen in der Region Wuhan wurde von staatlicher Seite bereits Ende Januar 2020 eine Expertenkommission namhafter chinesischer TCM-Fachleute berufen. Nach der Sichtung einer größeren Anzahl von Patienten in Wuhan wurdenTherapieprotokolle für verschiedene Krankheitsstadien formuliert, die in den „Guidance for Corona Virus Disease 2019“ des Generalbüros der Nationalen Hygiene und Gesundheitskommission und des Büros der staatlichen Verwaltung für traditionelle chinesische Medizin aufgenommen wurden.

Premature Arterial Disease Associated with Familial Antithrombin III Deficiency

1990 ◽  
Vol 63 (01) ◽  
pp. 013-015 ◽  
Author(s):  
E J Johnson ◽  
C R M Prentice ◽  
L A Parapia
Keyword(s):  
Risk Factors ◽  
Venous Thromboembolism ◽  
Potential Risk ◽  
Antithrombin Iii ◽  
Arterial Disease ◽  
Coagulation System ◽  
Early Age ◽  
Arterial Thromboembolism ◽  
Potential Risk Factors ◽  
Antithrombin Iii Deficiency

SummaryAntithrombin III (ATIII) deficiency is one of the few known abnormalities of the coagulation system known to predispose to venous thromboembolism but its relation to arterial disease is not established. We describe two related patients with this disorder, both of whom suffered arterial thrombotic events, at an early age. Both patients had other potential risk factors, though these would normally be considered unlikely to lead to such catastrophic events at such an age. Thrombosis due to ATIII deficiency is potentially preventable, and this diagnosis should be sought more frequently in patients with arterial thromboembolism, particularly if occurring at a young age. In addition, in patients with known ATIII deficiency, other risk factors for arterial disease should be eliminated, if possible. In particular, these patients should be counselled against smoking.

Beschaffung medizinischer Geräte und Verbrauchsmaterialien: Neue Gestaltungsspielräume des Ver gaberechts in Zeiten der Corona-Krise

2020 ◽  
Vol 02 (02) ◽  
pp. 54-55
Author(s):  
Isabel Langenbach
Keyword(s):  
Corona Virus ◽  
Sind Eine

Das Corona-Virus stellt für Kliniken nicht nur eine medizinische Herausforderung dar. Hinzu kommen Engpässe bei der Lieferung medizinischen Verbrauchmaterials (z. B. Schutzkleidung und Hygienemittel) oder medizinischer Geräte. Bei der Deckung des alltäglichen Bedarfs im Klinikbetrieb kommt auf (öffentliche) Kliniken, die an das Vergaberecht gebunden sind, eine Welle vergabe- und vertragsrechtlicher Fragen zu.

Facharzt für Infektiologie: Keimen auf der Spur

2020 ◽  
Vol 25 (06) ◽  
pp. 28-29
Author(s):  
Romy König
Keyword(s):  
Wird Eine ◽  
Corona Virus

Es mangelt in Deutschland an infektiologisch geschulten Medizinern – seit Jahren schon. Dabei hilft ihre Expertise nachweislich, die Überlebenschance von infektiös erkrankten Menschen zu steigern. Mit den Anstrengungen, eine Ausbreitung des Corona-Virus einzudämmen, wird eine alte Forderung laut: einen Facharzt für Infektiologie einzuführen.

Pneumologische Reha: Genesen bedeutet nicht gesund: Der lange Weg zurück ins Leben

2020 ◽  
Vol 25 (09) ◽  
pp. 70-71
Author(s):  
Alexandra Heeser
Keyword(s):  
Corona Virus

In Deutschland haben sich inzwischen mehr als 244 000 Menschen mit dem Corona-Virus infiziert. Ungefähr 216 200 davon gelten als genesen. Die Mediziner stehen vor der Frage: Wie behandelt man die Folgen einer Erkrankung, von der man noch so gut wie nichts weiß und für die es keine Studienlage gibt? Das ist auch ein spannendes Feld für die Rehabilitation von Corona-Patienten.

Dampak Covid 19 Terhadap Praktik Jual-Beli:

2020 ◽  
Vol 5 (1) ◽  
pp. 27-47
Author(s):  
Sitti Aisyah. M Aisyah ◽  
Sappaemi
Keyword(s):  
Qualitative Research ◽  
Research Methods ◽  
Business Strategy ◽  
Qualitative Research Methods ◽  
Business Practice ◽  
Corona Virus ◽  
The Impact ◽  
Islamic View

The Corona virus pandemic exploited by irresponsible elements.  They do a cunning business strategy, which is to hoard goods, in fiqhi terms known as iḥtikār. In the Islamic view, iḥtikār is a prohibited business practice and will be met with a painful punishment in the afterlife.  The purpose of this paper is to provide an understanding about the impact of COVID 19 on the practice of buying and selling (iḥtikār).  This paper uses qualitative research methods in the form of library reseach using the shar'i approach.  From this study it can be concluded that the behavior of hoarding goods with the aim of reselling them at high prices to obtain large profits.  In Islamic Shari'ah, iḥtikār‘s law is haram because it contains elements that harm others.  This is very clearly stated in QS al-Humazah/109: 1-2 and punished by sin as stipulated in the hadith of the Messenger of Allah.

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