scholarly journals Risk factors for metabolic syndrome in adolescents / Fatores de risco para síndrome metabólica em adolescentes /

2014 ◽  
Vol 3 (2) ◽  
pp. 1
Author(s):  
Ana Roberta Vilarouca da Silva
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Metabolic Syndrome ◽  
High Density Lipoprotein ◽  
International Diabetes Federation ◽  
Density Lipoprotein ◽  
High Density ◽  
Adult Treatment ◽  
Adult Treatment Panel ◽  
Sindrome Metabolica

No Brasil, a Síndrome Metabólica (SM) é desconhecida em várias regiões, e pouco estudada em diferentes populações. Isso porque, é proveniente da globalização, indicador inerente à modificação do estilo de vida da sociedade. Esta síndrome associa-se a Doenças Crônicas Não-Transmissíveis (DCNT), especialmente as cardiovasculares. E por ser multifatorial, destacam-se os níveis pressóricos e glicêmicos elevados, fatores-problema no desenvolvimento de complicações. A SM é um transtorno complexo representado por um conjunto de fatores de risco cardiovascular (a hipertensão arterial, a dislipidemia, a obesidade visceral e as manifestações de disfunção endotelial), usualmente relacionados à disposição central de gordura e à resistência à insulina(1). As três principais definições clínicas da SM em adultos utilizadas são as propostas pela Organização Mundial de Saúde (OMS), pelo National Cholesterol Education Program’s Adult Treatment Panel III (NCEP-ATP III) e pela International Diabetes Federation (IDF)(2). E em adolescentes existem adaptações(3-4). Assim, são fatores de risco para SM agregação de excesso de peso ou adiposidade central, hipertensão arterial, elevação dos triglicerídeos, diminuição do colesterol HDL (high density lipoprotein) e intolerância à glicose/resistência à insulina/diabetes mellitus tipo II (DMII). A prevalência de síndrome metabólica é variável, em função dos diferentes critérios diagnósticos utilizados. Na população pediátrica, as frequências de síndrome metabólica variam de 4,2% a 9,2%, com aumento na prevalência quando se consideram crianças e adolescentes obesos para 17,3% e 35,5%. Alguns estudos destacam que os componentes mais frequentes no diagnóstico de síndrome metabólica são a aumentada circunferência abdominal (88,1%) e pressão arterial (47,5%), seguidos de maior concentração de triglicerídeos (23,4%) e de baixo HDL-colesterol (23,3%)(5). Em se tratando do estado do Piauí, a busca à literatura revelou que até o presente momento, existe uma pesquisa em conclusão com foco na SM entre universitários e outras que iniciaram em 2014 com escolares, incluindo crianças e adolescentes de escolas públicas e privadas. Consequentemente, ainda não se conhece a sua prevalência nesses locais, assim como, não se conhece a prevalência da SM em populações específicas, como em adolescentes escolares. Levando em consideração as informações descritas anteriormente sobre os possíveis agravos que a SM pode causar, a associação às doenças cardiovasculares e ao DM2, acredita-se que a pesquisa sobre os fatores de risco para SM seja de extrema importância ao trazer dados iniciais sobre a SM, o que deverá suscitar o planejamento e a implementação de ações que tenham impacto na promoção da saúde dos estudantes.

Association of Metabolic Syndrome with the Number of Breastfed Children in Postmenopausal Korean women

2020 ◽  
Vol 23 ◽  
Author(s):  
Jeonghee Hwang ◽  
Jeonghee Chi
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Body Composition ◽  
High Density Lipoprotein ◽  
Postmenopausal Women ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Mineral Density

Background: Metabolic syndrome is closely related to cardiovascular disease, and the prevalence of metabolic syndrome in postmenopausal women is increasing rapidly. Objective: The purpose of this study is to investigate the association between the number of breastfed children and the risk factors for metabolic syndrome in postmenopausal women and to evaluate the association between metabolic syndrome and bone mineral density and body composition variables in postmenopausal women depending on the number of breastfed children. Methods: Data from KNHANES V-1 and 2 (2010-2011) were used, and a total of 939 PM women with 1 to 6 breastfed children aged 65-80 years participated in this study. We divided these women into three groups (group1 with 1-2, group2 with 3-4, group3 with 5-6) depending on the number of breastfed children. Result: In analysis of the associations between metabolic syndrome and its risk factors, high-density lipoprotein cholesterol was the most negatively strongly associated with group1 (OR=0.103 [0.047-0.225]), triglyceride showed the highest association with group2 (OR=7.760 [3.770-15.97]) and group3 (OR=7.668 [4.102-14.33]). The risk factors of metabolic syndrome except for high-density lipoprotein cholesterol and triglyceride was not associated with group1, while all risk factors of metabolic syndrome displayed a high association with group2 and group3. Conclusion: The findings of the present study suggest that the number of breastfed children is significantly associated with a greater number of risk factors of metabolic syndrome in postmenopausal women, and the association between metabolic syndrome and body composition variables may differ depending on the number of breastfed children.

scholarly journals High-Density Lipoprotein Reduction Differentially Modulates to Classical and Nonclassical Monocyte Subpopulations in Metabolic Syndrome Patients and in LPS-Stimulated Primary Human Monocytes In Vitro

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Johanna L. Grün ◽  
Aaron N. Manjarrez-Reyna ◽  
Angélica Y. Gómez-Arauz ◽  
Sonia Leon-Cabrera ◽  
Felix Rückert ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
High Density Lipoprotein ◽  
Density Lipoprotein ◽  
Human Monocyte ◽  
High Density ◽  
Human Monocytes ◽  
Low Hdl ◽  
Monocyte Subpopulations

The effect of metabolic syndrome on human monocyte subpopulations has not yet been studied. Our main goal was to examine monocyte subpopulations in metabolic syndrome patients, while also identifying the risk factors that could directly influence these cells. Eighty-six subjects were divided into metabolic syndrome patients and controls. Monocyte subpopulations were quantified by flow cytometry, and interleukin- (IL-) 1β secretion levels were measured by ELISA. Primary human monocytes were cultured in low or elevated concentrations of high-density lipoprotein (HDL) and stimulated with lipopolysaccharide (LPS). The nonclassical monocyte (NCM) percentage was significantly increased in metabolic syndrome patients as compared to controls, whereas classical monocytes (CM) were reduced. Among all metabolic syndrome risk factors, HDL reduction exhibited the most important correlation with monocyte subpopulations and then was studied in vitro. Low HDL concentration reduced the CM percentage, whereas it increased the NCM percentage and IL-1β secretion in LPS-treated monocytes. The LPS effect was abolished when monocytes were cultured in elevated HDL concentrations. Concurring with in vitro results, IL-1β serum values significantly increased in metabolic syndrome patients with low HDL levels as compared to metabolic syndrome patients without HDL reduction. Our data demonstrate that HDL directly modulates monocyte subpopulations in metabolic syndrome.

scholarly journals Prevalence and Risk Factors of Metabolic Syndrome among the Homeless in Taipei City: A Cross-Sectional Study

2021 ◽  
Vol 18 (4) ◽  
pp. 1716
Author(s):  
Ming Gu ◽  
Chi-Jie Lu ◽  
Tian-Shyug Lee ◽  
Mingchih Chen ◽  
Chih-Kuang Liu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
High Density Lipoprotein ◽  
Social Issues ◽  
Density Lipoprotein ◽  
Homeless People ◽  
Cross Sectional Study ◽  
High Density ◽  
Cross Sectional ◽  
Taipei City

The safety and health of homeless people are important social issues. Metabolic syndrome (MetS) is a sub-health-risk phenomenon that has been severely aggravated worldwide in recent years. The purpose of this study was to investigate the prevalence and risk factors of MetS among the homeless in Taipei City, Taiwan. In this study, a convenience sampling was conducted at homeless counseling agencies in Taipei City from April 2018 to September 2018. A total of 297 homeless participants were recruited, from whom clinical indicators and questionnaire information were collected. Through statistical verification, analysis of variance (ANOVA), and logistic regression, we found the following main conclusions for homeless adults in Taipei: (1) The prevalence of MetS was estimated to be 53%, with 50% meeting four or more diagnostic conditions. (2) Dyslipidemia (high-density lipoprotein (HDL) deficiency and elevated triglyceride (TG)) showed the strongest association with the prevalence of MetS; more than 83% of people with HDL deficiency or hypertriglyceridemia had MetS. For the patient groups meeting more MetS diagnostic conditions, the values of high-density lipoprotein cholesterol (HDL-C), TG, and total cholesterol (TC) increased significantly. (3) The deterioration of MetS was significantly related to the high prevalence of hyperlipidemia (HL). (4) The homeless who were divorced, separated or widowed were more likely to suffer from MetS.

scholarly journals Investigating The Definitions of Metabolic Syndrome Among High School Students in Taipei and The Optimal Cutoff Points of Relevant Risk Factors

2020 ◽  
Author(s):  
Shao Chia Chiu Lin ◽  
Mei-Ju Chen
Keyword(s):  
Risk Factors ◽  
High School ◽  
Metabolic Syndrome ◽  
High School Students ◽  
International Diabetes Federation ◽  
Density Lipoprotein ◽  
Discriminatory Power ◽  
School Students ◽  
Optimal Cutoff ◽  
Cutoff Points

Abstract Background: The effects of different definitions for metabolic syndrome (MetS) on its prevalence were examined, and the differences in the discriminatory power, as well as the optimal cutoff points of relevant risk factors, were analyzed in this study. Methods: 45,756 health checkup data sets from 2011 to 2014 of high school students aged between 15 to 17 years were sourced in Taipei city. The database included the students’ gender, age, height, weight, waist circumference (WC), systolic and diastolic blood pressure, as well as biochemical markers such as triglycerides (TG), high-density lipoprotein cholesterol, and fasting glucose (FG) levels. The ROC curve statistical approach was used to analyze the discriminatory power and optimal cutoff points of the relevant MetS risk factors. Results: The prevalence of MetS among adolescents in Taipei was 2.3% and 1.2%, according to the criteria of the modified National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) and the International Diabetes Federation (IDF) respectively. The prevalence increased to 4.3% when this study’s criteria were used. Among the components of MetS analyzed, WC and TG had stronger discriminatory powers, while FG had the weakest. The optimal cutoff point for WC was approximately the 90 th percentile, while that for the TG was similar to the criteria of the modified NCEP ATP III. About 44.6% of adolescents had at least one MetS component. Body mass index also had good discriminatory power. Conclusions: The prevalence of MetS differs depending on the diagnostic criteria used. Redefining the cutoff points for the components of MetS in adolescents in different regions, as well as further screening and intervention, are crucial to prevent cardiovascular disease and type 2 diabetes mellitus in the future.

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