scholarly journals Value of influenza vaccine during an outbreak of influenza A in a nursing home, Pyrénées Atlantiques, France, November-December 1995

1996 ◽  
Vol 1 (5) ◽  
pp. 35-37 ◽  
Author(s):  
A Infuso ◽  
S Baron ◽  
H Fauveau ◽  
M Melon ◽  
H Fleury ◽  
...  
Keyword(s):  
Public Health ◽  
Nursing Home ◽  
Influenza Vaccine ◽  
Influenza A ◽  
Respiratory Illness ◽  
Acute Respiratory Illness ◽  
Health Officer

A public health officer of the Direction Départementale de l'Action Sanitaire et Sociale des Pyrénées Atlantiques in France was notified of an outbreak of acute respiratory illness among residents of a nursing home on 4 December, 1995. Over 50 of the 69 r

Concurrent Summer Influenza and Pertussis Outbreaks in a Nursing Home in Sydney, Australia

2004 ◽  
Vol 25 (11) ◽  
pp. 962-966 ◽  
Author(s):  
Mark J. Ferson ◽  
Keira Morgan ◽  
Peter W. Robertson ◽  
Alan W. Hampson ◽  
Ian Carter ◽  
...  
Keyword(s):  
Public Health ◽  
Nursing Home ◽  
Influenza A ◽  
Respiratory Illness ◽  
Case Definition ◽  
Acute Respiratory Illness ◽  
Public Health Response ◽  
Pertussis Infection ◽  
Eastern Australia ◽  
Sydney Australia

AbstractObjective:To report on the investigation of a summer outbreak of acute respiratory illness among residents of a Sydney nursing home.Design:An epidemiologic and microbiological investigation of the resident cohort at the time of the outbreak and medical record review 5 months later.Setting:A nursing home located in Sydney, Australia, during February to July 1999.Patients:The cohort of residents present in the nursing home at the time of the outbreak.Interventions:Public health interventions included recommendations regarding hygiene, cohorting of residents and staff, closure to further admissions, and prompt reporting of illness; and virologic and serologic studies of residents.Results:Of the 69 residents (mean age, 85.1 years), 35 fulfilled the case definition of acute respiratory illness. Influenza A infection was confirmed in 19 residents, and phylogenetic analysis of the resulting isolate, designated H3N2 A/Sydney/203/99, showed that it differed from strains isolated in eastern Australia during the same period. Serologic evidence ofBordetellainfection was also found in 10 residents; however, stratified epidemiologic analysis pointed to influenza A as the cause of illness.Conclusions:The investigation revealed an unusual summer outbreak of influenza A concurrent with subclinical pertussis infection. Surveillance of acute respiratory illness in nursing homes throughout the year, rather than solely during epidemic periods, in combination with appropriate public health laboratory support, would allow initiation of a timely public health response to outbreaks of acute respiratory illness in this setting.

scholarly journals Effectiveness of seasonal influenza vaccine in preventing influenza primary care visits and hospitalisation in Auckland, New Zealand in 2015: interim estimates

2016 ◽  
Vol 21 (1) ◽  
Author(s):  
A Bissielo ◽  
N Pierse ◽  
QS Huang ◽  
MG Thompson ◽  
H Kelly ◽  
...  
Keyword(s):  
Primary Care ◽  
General Practice ◽  
New Zealand ◽  
Influenza Vaccine ◽  
Influenza A ◽  
Seasonal Influenza ◽  
Respiratory Illness ◽  
Influenza Viruses ◽  
Acute Respiratory Illness ◽  
Seasonal Influenza Vaccine

Preliminary results for influenza vaccine effectiveness (VE) against acute respiratory illness with circulating laboratory-confirmed influenza viruses in New Zealand from 27 April to 26 September 2015, using a case test-negative design were 36% (95% confidence interval (CI): 11–54) for general practice encounters and 50% (95% CI: 20–68) for hospitalisations. VE against hospitalised influenza A(H3N2) illnesses was moderate at 53% (95% CI: 6–76) but improved compared with previous seasons.

scholarly journals The Effects of Social Distancing Policies on non-SARS-CoV-2 Respiratory Pathogens

2021 ◽  
Author(s):  
Jeff Nawrocki ◽  
Katherine Olin ◽  
Martin C Holdrege ◽  
Joel Hartsell ◽  
Lindsay Meyers ◽  
...  
Keyword(s):  
Public Health ◽  
Influenza A ◽  
Detection Rate ◽  
Respiratory Illness ◽  
Respiratory Pathogens ◽  
Public Health Response ◽  
Mixed Effect ◽  
Detection Rates ◽  
Social Distancing ◽  
The Impact

Abstract Background The initial focus of the US public health response to COVID-19 was the implementation of numerous social distancing policies. While COVID-19 was the impetus for imposing these policies, it is not the only respiratory disease affected by their implementation. This study aimed to assess the impact of social distancing policies on non-SARS-CoV-2 respiratory pathogens typically circulating across multiple US states. Methods Linear mixed-effect models were implemented to explore the effects of five social distancing policies on non-SARS-CoV-2 respiratory pathogens across nine states from January 1 through May 1, 2020. The observed 2020 pathogen detection rates were compared week-by-week to historical rates to determine when the detection rates were different. Results Model results indicate that several social distancing policies were associated with a reduction in total detection rate, by nearly 15%. Policies were associated with decreases in pathogen circulation of human rhinovirus/enterovirus and human metapneumovirus, as well as influenza A, which typically decrease after winter. Parainfluenza viruses failed to circulate at historical levels during the spring. Total detection rate in April 2020 was 35% less than historical average. Many of the pathogens driving this difference fell below historical detection rate ranges within two weeks of initial policy implementation. Conclusion This analysis investigated the effect of multiple social distancing policies implemented to reduce transmission of SARS-CoV-2 on non-SARS-CoV-2 respiratory pathogens. These findings suggest that social distancing policies may be used as an impactful public health tool to reduce communicable respiratory illness.

scholarly journals Influenza Vaccine Prevents Medically Attended Influenza-Associated Acute Respiratory Illness in Adults Aged ≥50 Years

2014 ◽  
Vol 211 (7) ◽  
pp. 1045-1050 ◽  
Author(s):  
Qingxia Chen ◽  
Marie R. Griffin ◽  
Hui Nian ◽  
Yuwei Zhu ◽  
John V. Williams ◽  
...  
Keyword(s):  
Influenza Vaccine ◽  
Respiratory Illness ◽  
Acute Respiratory Illness

Optimization of M2e cassette amino acid composition for the development of universal influenza vaccine

2021 ◽  
Vol 21 (3) ◽  
pp. 127-130
Author(s):  
Daria А. Mezhenskaya ◽  
Irina N. Isakova-Sivak ◽  
Anastasiya E. Katelnikova ◽  
Larisa G. Rudenko
Keyword(s):  
Public Health ◽  
Amino Acid ◽  
Influenza Vaccine ◽  
Influenza A ◽  
Wide Spectrum ◽  
Qualitative Assessment ◽  
Influenza A Viruses ◽  
Duration Of Action ◽  
Natural Reservoir ◽  
Universal Influenza Vaccine

The development of a universal influenza vaccine with a wide spectrum and duration of action is one of the serious public health problems. This study is dedicated to optimization of an immunogen covering the M2e epitopes of influenza A viruses circulating in the natural reservoir, as well as the creation of a prototype of a universal influenza vaccine with subsequent quantitative and qualitative assessment of the induced anti-M2e responses in ferrets.

Statin use and medically attended acute respiratory illness among influenza vaccine recipients

Vaccine ◽  
2019 ◽  
Vol 37 (44) ◽  
pp. 6707-6713 ◽  
Author(s):  
James B. Cutrell ◽  
Henning Drechsler ◽  
Roger Bedimo ◽  
Carlos A. Alvarez ◽  
Ishak A. Mansi
Keyword(s):  
Influenza Vaccine ◽  
Respiratory Illness ◽  
Acute Respiratory Illness ◽  
Statin Use

scholarly journals Vaccine effectiveness against influenza-associated hospitalization among children aged < 13 years using a hospital-based surveillance system in Minnesota, 2013 – 2016

2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S60-S60
Author(s):  
Ashley Fowlkes ◽  
Hannah Friedlander ◽  
Andrea Steffens ◽  
Kathryn Como-Sabetti ◽  
Dave Boxrud ◽  
...  
Keyword(s):  
Influenza Vaccine ◽  
Influenza Vaccination ◽  
Influenza A ◽  
Respiratory Illness ◽  
Vaccine Effectiveness ◽  
Influenza Viruses ◽  
Point Estimate ◽  
Influenza B ◽  
Current Season ◽  
Immunization Registry

Abstract Background Due to marked variability in circulating influenza viruses each year, annual evaluation of the vaccine’s effectiveness against severe outcomes is essential. We used the Minnesota Department of Health’s (MDH) Severe Acute Respiratory Illness (SARI) surveillance to evaluate vaccine effectiveness (VE) against influenza-associated hospitalization over three influenza seasons. Methods Residual respiratory specimens from patients admitted with SARI were sent to the MDH laboratory for influenza RT-PCR testing. Medical records were reviewed to collect patient data. Vaccination history was verified using the state immunization registry. We included patients aged ≥6 months to &lt; 13 years, after which immunization reporting is not required, hospitalized from the earliest influenza detection after July through April each year. We defined vaccinated patients as those ≥1 dose of influenza vaccine in the current season. Children aged &lt; 9 years with no history of vaccination were considered vaccinated if 2 were doses given a month apart. Partially vaccinated children were excluded. We estimated VE as 1 minus the adjusted odds ratio (x100%) of influenza vaccination among influenza cases vs. negative controls, controlling for age, race, days from onset to admission, comorbidities, and admission month. Results Among 2198 SARI patients, 763 (35%) were vaccinated for influenza, 180 (8.2%) were partially vaccinated, and 1255 (57%) were unvaccinated. Influenza was detected among 202 (9.2%) children, and significantly more frequently among children aged ≥5 years (17%) compared with younger children (7.4%). The adjusted VE in 2013–14 was 68% (95% Confidence Interval: 34, 85), but was non-significant during the 2014–15 and 2015–16 seasons (Figure). Estimates of VE by influenza A subtypes varied substantially by year; VE against influenza B viruses was significant, but could not be stratified by year. VE was impacted when live attenuated influenza vaccine recipients were excluded. Conclusion We report moderately high influenza VE in 2013–14 and a point estimate higher than other published estimates from outpatient data in 2014–15. These results, underscore the importance of influenza vaccination to prevent severe outcomes such as hospitalization. Disclosures All authors: No reported disclosures.

scholarly journals 899. Influenza Vaccine Effectiveness Against Laboratory-Confirmed Influenza in Children Hospitalized with Respiratory Illness in the United States, 2016–2017 and 2017–2018 Seasons

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S26-S27
Author(s):  
Angela P Campbell ◽  
Constance E Ogokeh ◽  
Craig McGowan ◽  
Brian Rha ◽  
Rangaraj Selvarangan ◽  
...  
Keyword(s):  
Influenza Vaccine ◽  
Influenza A ◽  
Respiratory Illness ◽  
The United States ◽  
Vaccine Effectiveness ◽  
Severe Illness ◽  
Surveillance Network ◽  
Pediatric Hospitals ◽  
Significant Difference ◽  
National Estimates

Abstract Background Annual national estimates of influenza vaccine effectiveness (VE) typically measure protection against outpatient medically attended influenza illness. We assessed influenza VE in preventing laboratory-confirmed influenza hospitalization in children across two influenza A(H3N2)-predominant seasons. Methods Children < 18 years hospitalized with acute respiratory illness were enrolled at 7 pediatric hospitals in the New Vaccine Surveillance Network. We included subjects ≥6 months with ≤10 days of symptoms enrolled during the 2016–2017 and 2017–2018 seasons (date of first through last influenza-positive case for each site). Combined mid-turbinate and throat swabs were tested using molecular assays. We estimated age-stratified VE from a test-negative design using logistic regression to compare the odds of vaccination among cases positive for influenza with controls testing negative, adjusting for age, enrollment month, site, underlying comorbidities, and race/ethnicity. Full/partial vaccination was defined using ACIP criteria. We verified vaccine receipt from state immunization registries and/or provider records. Results Among 3441 children with complete preliminary data, in 2016–2017, 156/1,710 (9%) tested positive for influenza: 91 (58%) with influenza A(H3N2), 5 (3%) with A(H1N1), and 60 (38%) with B viruses. In 2017–2018, 193/1,731 (11%) tested positive: 87 (45%) with influenza A(H3N2), 47 (24%) with A(H1N1), and 58 (30%) with B. VE for all vaccinated children (full and partial) against any influenza was 48% (95% confidence interval, 26%–63%) in 2016–2017 and 45% (24%–60%) in 2017–2018. Combining seasons, VE for fully and partially vaccinated children against any influenza type was 46% (32%–58%); by virus, VE was 30% (4%–49%) for influenza A(H3N2), 71% (46%–85%) for A(H1N1), and 57% (36%–70%) for B viruses. There was no statistically significant difference in VE by age or full/partial vaccination status for any virus (table). Conclusion Vaccination in the 2016–2017 and 2017–2018 seasons nearly halved the risk of children being hospitalized with influenza. These findings support the use of vaccination to prevent severe illness in children. Our study highlights the need for a better understanding of the lower VE against influenza A(H3N2) viruses. Disclosures All Authors: No reported Disclosures.

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