The relationship of pre-operative laboratory parameters with endometrial cancer and prognostic factors

584 Background: Clinical and molecular characteristics are different between Right-side and left-sided colorectal cancer (CRC). The aim of this study was to clarify the significance of the correlation of the Sidedness of CRC and tumor immunity. Methods: A total of 116 patients who underwent curative colectomy for stage II/III CRC were included in this study. The expression of PD-1, PD-L1, FoxP3, TGF-b, and IDO was examined by immunohistochemistry and the relationship of sidedness to several prognostic factors was examined. Results: In clinicopathological factors, there were no significant difference between right sided and left sided CRC except for differentiation. Regarding tumor immunity, there were no significant difference in PD-1 and IDO expression. However, Fox P3 (right side 72% vs. left side 59%) and TGFβ (right side 72% vs. left side 57%) tended to be highly expressed in right side(p < 0.1). PDL1 was significantly highly expressed in right side(right side 65% vs. left side 35%, p < 0.05). In OS and DFS, the patients with right sided tumor tended to have poor prognosis compared with left side (p < 0.1). The PD-L1 positive patients of right-sided tumor had poor prognosis (p < 0.05). Conclusions: Sidedness is associated with tumor immunity in colorectal cancer.

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The relationship of angiogenesis with prognostic factors in non-small cell lung cancers

Journal of Current Pathology ◽

10.5146/jcpath.2018.19 ◽

2018 ◽

Vol 2 (1) ◽

pp. 10

Author(s):

Sevilay ÖZMEN ◽

Cemal GÜNDOĞDU

Keyword(s):

Prognostic Factors ◽

Small Cell ◽

Small Cell Lung ◽

Lung Cancers ◽

Relationship Of ◽

The Relationship

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The relationship of body mass index with quality of life among endometrial cancer survivors: A study from the population-based PROFILES registry

Gynecologic Oncology ◽

10.1016/j.ygyno.2012.12.041 ◽

2013 ◽

Vol 129 (1) ◽

pp. 216-221 ◽

Cited By ~ 33

Author(s):

Charlotte S. Oldenburg ◽

Dorry Boll ◽

Kim A.H. Nicolaije ◽

M. Caroline Vos ◽

Johanna M.A. Pijnenborg ◽

...

Keyword(s):

Quality Of Life ◽

Body Mass Index ◽

Endometrial Cancer ◽

Cancer Survivors ◽

Body Mass ◽

Population Based ◽

Relationship Of ◽

The Relationship

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The effect of myometrial invasion on prognostic factors and survival analysis in endometrial carcinoma

African Health Sciences ◽

10.4314/ahs.v19i4.47 ◽

1970 ◽

Vol 19 (4) ◽

pp. 3235-3241

Author(s):

Cem Dane ◽

Sait Bakir

Keyword(s):

Overall Survival ◽

Endometrial Cancer ◽

Prognostic Factors ◽

Survival Rate ◽

Endometrial Carcinoma ◽

Myometrial Invasion ◽

Stage Iv ◽

Progression Free Survival ◽

Free Survival ◽

The Relationship

Background: We investigated the relationship between myometrial invasion and the prognostic factors on overall and progression free survival in endometrial carcinoma.Methods: 122 cases operated with endometrial cancer were included into the study. Progression-free survival and overall survival were evaluated according to degree of myometrial invasion. We also investigated the relationship between myometrial invasion and prognostic factors. Results: The 5- year progression-free survival rate was 90 % in stage I, 66 % in stage II, 32 % in stage III and 60 % in stage IV. The 5- year overall survival rate was 95 % in stage I, 89 % in stage II, 49 % in stage III and 30 % in stage IV. The progression free survival and overall survival for patients with more than 50 % myometrial invasion were detected 67 % at 58 months and 66 % at 60 months, respectively. The clinicopathological variables that significantly correlated with myometrial invasion of more than 50 % were as follows: pelvic lymph node metastasis (p: 0,00029-OR: 11.2), cervical stromal invasion (p: 0008-OR:7.9), LVSI (p< 0.0001-OR: 16.5).Conclusion: The depth of myometrial invasion is one of the most important prognostic indicators and determinants of therapy in endometrial cancer. Keywords: Endometrial carcinoma; Progression free survival; Overall survival; Prognostic factors.

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37 The relationship of local and distant failure from endometrial cancer: Defining a clinical paradigm

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/s0360-3016(97)85378-3 ◽

1996 ◽

Vol 36 (1) ◽

pp. 177

Author(s):

Benjamin W. Corn ◽

Rachelle Lanciano ◽

Ralph D'Agostino ◽

Edward Kiggundu ◽

Phillip Purser ◽

...

Keyword(s):

Endometrial Cancer ◽

Distant Failure ◽

Clinical Paradigm ◽

Relationship Of ◽

The Relationship

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Outcome Expectations, Expectancy Accessibility, and Exercise in Endometrial Cancer Survivors

Journal of Sport and Exercise Psychology ◽

10.1123/jsep.31.6.776 ◽

2009 ◽

Vol 31 (6) ◽

pp. 776-785 ◽

Cited By ~ 2

Author(s):

Heidi Y. Perkins ◽

Andrew J. Waters ◽

George P. Baum ◽

Karen M. Basen-Engquist

Keyword(s):

Endometrial Cancer ◽

Cancer Survivors ◽

Response Times ◽

Exercise Program ◽

Outcome Expectations ◽

Exercise Behavior ◽

Self Report ◽

Outcome Expectation ◽

Relationship Of ◽

The Relationship

Studies have shown that expectations about exercise outcomes are associated with exercise behavior. Outcome expectations can be assessed by self-report questionnaires, but a new method—the expectancy accessibility task—may convey unique information about outcome expectations that is less subject to respondent biases. This method involves measuring the reaction time to endorse or reject an outcome We examined the relationship of self-reported outcome expectations and expectancy accessibility tasks in a pilot study of sedentary endometrial cancer survivors (N = 20). After measuring outcome expectations and expectancy accessibility, participants were given an exercise program and asked to monitor exercise for 7 days using diaries and accelerometers. Analyses revealed no relationship between outcome expectation scores and exercise, but shorter response times to endorse positive exercise outcomes was related to more exercise in the next week (p = .02).

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AB0136 ASSESSING THE RELATIONSHIP AMONG OBESITY, GENETIC POLYMORPHISM, AND CLINICAL PARAMETERS IN PATIENTS WITH RHEUMATOID ARTHRITIS

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2021-eular.2962 ◽

2021 ◽

Vol 80 (Suppl 1) ◽

pp. 1096.1-1096

Author(s):

K. Yoshida ◽

S. Hatachi ◽

S. Takahashi ◽

N. Amano ◽

M. Katayama ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Logistic Regression ◽

Genetic Polymorphism ◽

Gene Mutation ◽

Nucleotide Polymorphisms ◽

Laboratory Parameters ◽

Methotrexate Dose ◽

Relationship Of ◽

The Impact ◽

The Relationship

Background:Several study suggested body mass index(BMI) may influence development of rheumatoid arthritis(RA). There are conflicting reports concerning the impact of high BMI on development of RA, but several reports of obese on drug resistance and functional impairment. The relationship of genetic polymorphism on obesity is unclear in RA.Objectives:To examine the relationship among BMI, genetic polymorphism of obesity, disease activity of RA, laboratory parameters, and therapeutic agent of RA.Methods:We have carried out a retrospective observational study by systematically analyzing medical records of total 289 patients diagnosed with RA in Shinko Hospital between March 2016 and December 2019. We also conducted genotyping single nucleotide polymorphisms (SNPs) including FTO (rs1558902 and rs9939609), UCP1 (rs1800592), ADR2(rs1042713) and ADR3(rs4994) after informed consent. Obesity was defined as BMI over than 25 and patients were divided between obese (“Ob”) and non-obese (“non-Ob”). These SNPs, DAS28CRP, laboratory parameters, methotrexate dose, use of biological DMARDs were compared between Ob and non-Ob patients.Results:Of these 289 patients, 82.7% was female, mean age was 61.9 years and BMI was 22.4. Univariate logistic regression showed differences (p<0.1) between Ob and non Ob groups in UCP1 gene mutation(63.6% vs 78%, P=0.018), DAS(2.24 vs 1.99, P=0.033),triglyceride abnormality(23.8% vs 9.3%, P=0.021), HDL(56 vs 71, P=0.00009), HbA1c abnormality(26.5% vs 12.1%, P=0.019),γGTP(32 vs 21, P=0.00037), ALP (253 vs 230, P=0.0058), ALT (26.5 vs 20, P=0.029),and MTX dose(6 vs 8, P=0.066). Multivariate logistic regression showed that Ob group was significantly associated with HDL(OR=0.976, 95%CI 0.958 to 0.995), UCP1 gene mutation(OR=0.446, 95%CI 0.202 to 0.984), γGTP(OR=2.321, 95%CI 1.269 to 4.245), and MTX dose(OR=0.866, 0.784 to 0.957).Conclusion:Obesity in patients with RA had significant positive correlation with γGTP, and negative correlation with HDL, UCP gene mutation and MTX dose.Disclosure of Interests:None declared

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