scholarly journals Pengembangan media pembelajaran matematika sigeru buku pop-up berbasis etnomatematika materi kubus dan balok

2020 ◽  
Vol 6 (1) ◽  
pp. 31
Author(s):  
Fatimah Dwie Hartanti ◽  
Sri Hariyani ◽  
Trija Fayeldi
Keyword(s):  
Data Collection ◽  
Research And Development ◽  
Phase I ◽  
Phase Ii ◽  
Random Sampling ◽  
Visual Display ◽  
Simple Random Sampling ◽  
Phase Iii ◽  
Practical Test ◽  
Is Research

<p><em>The </em><em>learning media pop-up book with based etnomathematic</em><em> use</em><em> method of reasearch is research and development with the model is 4D. The purpose of research is to occurred aspect validity and practicality. The reaseach helpful in learning media is to be held a student’s interest </em><em>and to </em><em>use visual display in cube and beam lesson. A data collection using questionarry. Sample taking technique using simple random sampling with the number of samples based on the Slovin formula were at a fault 5%. Phase I test are a process of media validation and learning validation. Phase II test are a process practical test I was conducted by teacher and 8 students. Phase III test are a process practical test II was conducted by 30 students. The value of media and learning percentage is 92,3% and 86,636%  in highly valid category. 90,909% and highly practice category by phase I test. And then, the value by 30 students is 85,83% in highly practice category. The based on the result is a learning media pop-up book based etnomathematic can be using a learning media in the school.</em><em></em></p>

scholarly journals Pengembangan Bahan Ajar Fisika Berbasis Scientific Approach

2018 ◽  
Vol 2 (1) ◽  
pp. 18-29
Author(s):  
Wulan Muji Lestari ◽  
Tri Ariani ◽  
Ovilia Putri Utami Gumay
Keyword(s):  
Data Collection ◽  
Research And Development ◽  
Random Sampling ◽  
Simple Random Sampling ◽  
Science Class ◽  
Physic Teaching ◽  
Light Waves ◽  
Scientific Approach ◽  
The Subject ◽  
Interview Questionnaire

The aim of the study was to develop physic teaching book with scientific approach based on light waves material for the eleventh grade students at SMA Negeri 5 Lubuklinggau. It was a research and development study. The subject in the study was all of the eleventh grade students of science class and the subject was the large group of students at XI IPA 2 at  SMA Negeri 5 Lubuklinggau consist of 34 students which was collected through simple random sampling. The data collection was executed from interview, questionnaire, and test. By the validation, it was found that the result was in 'good' category with percentage 76,58%. Students response on the teaching book with scientific approach based was 83,35%. Furthermore, by the daily examination results, 82% students got the average scores above 70 out of 10 questions. The score of ttable with degree of freedom n-1 = 34 ─ 1 = 33 and α = 0,05 tobtained = 6,53 and ttable = 1,692 because tobtained ≥ ttable so that Ha was accepted. In conclusion, the teaching book with scientific approach  based which was developed has been valid, practical and effective. Keywords: Teaching Book, Scientific Approach, Reseach and Development

scholarly journals Reducing Drinking Among People Experiencing Homelessness: Protocol for the Development and Testing of a Just-in-Time Adaptive Intervention

10.2196/15610 ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. e15610 ◽  
Author(s):  
Michael S Businelle ◽  
Scott T Walters ◽  
Eun-Young Mun ◽  
Thomas R Kirchner ◽  
Emily T Hébert ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Data Collection ◽  
Phase I ◽  
Phase Ii ◽  
Phase Iii ◽  
Just In Time ◽  
Pilot Test ◽  
Success Rates ◽  
Adaptive Intervention ◽  
Ecological Momentary

Background Adults who are homeless are more likely to have alcohol use disorders (AUDs) compared with domiciled adults. Although AUD treatments are commonly available, many factors (eg, transportation limitations and inability to schedule appointments) contribute to low treatment completion rates and low success rates of these interventions among adults experiencing homelessness. Most adults who are homeless own mobile phones; however, no interventions have been developed that use mobile devices to deliver and support AUD interventions for this population. Mobile phone–based AUD interventions may reduce barriers that have limited the use and utility of traditional interventions. Objective The aim of this study is to (1) identify variables (eg, affect, stress, geolocation, and cravings) that predict drinking among homeless adults (phase I), (2) develop a mobile intervention that utilizes an algorithm to identify moments of risk for drinking and deliver treatment messages that are tailored to the individual’s current needs in real time (phase II), and (3) pilot test the intervention app (phase III). Methods In phase I, adults experiencing homelessness with an AUD (N=80) will complete baseline, equipment, 2-week, and 4-week follow-up visits in person. Participants will be prompted to complete five daily ecological momentary assessments on a study-provided smartphone for 28 days. The smartphone app will collect GPS coordinates every 5 min for the entire 28-day study period. Participants will wear a transdermal alcohol sensor that will objectively measure alcohol use. In phase II, we will use phase I data to develop an algorithm that identifies moments of heightened risk for drinking and develop treatment messages that address risk factors for drinking. Phase III will pilot test the intervention in 40 adults experiencing homelessness with AUD. Results This project was funded in June 2018. IRB approval was obtained in October 2018, and data collection for phase I began in February 2019. Phase III data collection is expected to conclude in 2020. To date, 80 participants have consented to the study, and data analysis for phase I will begin in early 2020. Conclusions This research will highlight intervention targets and develop a novel intervention for understudied and underserved adults experiencing homelessness with AUD. International Registered Report Identifier (IRRID) DERR1-10.2196/15610

scholarly journals Innovative post mastectomy bra for increasing self-convenience and confidence patients

MEDISAINS ◽  
2019 ◽  
Vol 17 (1) ◽  
pp. 20
Author(s):  
Oting Susilawati ◽  
Agus Santosa
Keyword(s):  
Body Image ◽  
Research And Development ◽  
Phase I ◽  
Social Relationships ◽  
Phase Ii ◽  
The Body ◽  
Phase Iii ◽  
Self Confidence

Background: The act of mastectomy can affect body image because it loses part of the body and affects their social relationships with others. The existed bra is felt uncomfortable when worn so it is necessary to develop a special post mastectomy bra to increase the confidence and comfort of post mastectomy patients.Purpose: This study aimed to examine and develop a special post mastectomy bra to increase self-confidence in post-mastectomy patients.Research Methods: This is a Research and Development (R & D) research. This study consisted of 3 phase, namely research phase I, phase II, and phase III or product testing.Results: The results of a post mastectomy special bra tested to 10 respondents mentioned that a special post mastectomy bra is comfortable to wear and they are not ashamed anymore do activities outside the home.Conclusion: Special post mastectomy bras are proven to increase post-mastectomy patients' convenience and confidence.

scholarly journals A Qualitative Look at Faculty Perspectives on Ergonomics in Dental Education

2021 ◽  
Vol 2 (2) ◽  
pp. 36-49
Author(s):  
Cynthia Senior ◽  
Angela Burrell
Keyword(s):  
Data Collection ◽  
Phase I ◽  
Phase Ii ◽  
Dental Students ◽  
Phase Iii ◽  
Clinical Environment ◽  
Clinical Practices ◽  
School Of Dentistry ◽  
Ergonomic Evaluation ◽  
Three Phases

Due to the high-risk nature of musculoskeletal disorder development in dentistry, ergonomic education and evaluation are needed in predoctoral programs.  The purpose of this pilot study is to investigate perceptions of ergonomics within the School of Dentistry (SOD), current ergonomic clinical practices among third- and fourth-year dental students, and dental students' level of knowledge of ergonomics.  The study was conducted utilizing an explanatory sequential mixed methods design to collect both quantitative and qualitative data.  While the data collection occurred in three phases, this article will primarily focus on Phase III.  The three phases of data collection were: Phase I consisted of a questionnaire distributed to all dental students; Phase II consisted of clinical observations of third- and fourth-year dental students' ergonomic postures during patient care, and Phase III consisted of SOD faculty focus groups to determine perceptions of ergonomic education with the predoctoral curriculum.  Data revealed three overarching themes: (1) Didactic to clinical disconnect, (2) Elective impacts, and (3) A ready commitment.  Phase I yielded a response rate of 84% (n=135).  Phase I responses noted that 81.5% (n=110) of the dental students reported experiencing musculoskeletal pain.  Ninety-three dental students reported receiving one or two lectures on ergonomics; however, 60% (n=27) failed to implement proper ergonomic postures while caring for patients in the clinical environment during Phase II.  Phase III, revealed faculty support of ergonomic evaluation and correction among dental students.  The results indicated a need to establish and implement an ergonomic evaluation and corrective program within the SOD

scholarly journals Reducing Drinking Among People Experiencing Homelessness: Protocol for the Development and Testing of a Just-in-Time Adaptive Intervention (Preprint)

2019 ◽  
Author(s):  
Michael S Businelle ◽  
Scott T Walters ◽  
Eun-Young Mun ◽  
Thomas R Kirchner ◽  
Emily T Hébert ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Data Collection ◽  
Phase I ◽  
Phase Ii ◽  
Phase Iii ◽  
Just In Time ◽  
Pilot Test ◽  
Success Rates ◽  
Adaptive Intervention ◽  
Ecological Momentary

BACKGROUND Adults who are homeless are more likely to have alcohol use disorders (AUDs) compared with domiciled adults. Although AUD treatments are commonly available, many factors (eg, transportation limitations and inability to schedule appointments) contribute to low treatment completion rates and low success rates of these interventions among adults experiencing homelessness. Most adults who are homeless own mobile phones; however, no interventions have been developed that use mobile devices to deliver and support AUD interventions for this population. Mobile phone–based AUD interventions may reduce barriers that have limited the use and utility of traditional interventions. OBJECTIVE The aim of this study is to (1) identify variables (eg, affect, stress, geolocation, and cravings) that predict drinking among homeless adults (phase I), (2) develop a mobile intervention that utilizes an algorithm to identify moments of risk for drinking and deliver treatment messages that are tailored to the individual’s current needs in real time (phase II), and (3) pilot test the intervention app (phase III). METHODS In phase I, adults experiencing homelessness with an AUD (N=80) will complete baseline, equipment, 2-week, and 4-week follow-up visits in person. Participants will be prompted to complete five daily ecological momentary assessments on a study-provided smartphone for 28 days. The smartphone app will collect GPS coordinates every 5 min for the entire 28-day study period. Participants will wear a transdermal alcohol sensor that will objectively measure alcohol use. In phase II, we will use phase I data to develop an algorithm that identifies moments of heightened risk for drinking and develop treatment messages that address risk factors for drinking. Phase III will pilot test the intervention in 40 adults experiencing homelessness with AUD. RESULTS This project was funded in June 2018. IRB approval was obtained in October 2018, and data collection for phase I began in February 2019. Phase III data collection is expected to conclude in 2020. To date, 80 participants have consented to the study, and data analysis for phase I will begin in early 2020. CONCLUSIONS This research will highlight intervention targets and develop a novel intervention for understudied and underserved adults experiencing homelessness with AUD. INTERNATIONAL REGISTERED REPORT DERR1-10.2196/15610

Bewegungstherapie und körperliche Aktivität bei Patienten mit Herzinsuffizienz

Praxis ◽  
2018 ◽  
Vol 107 (17-18) ◽  
pp. 951-958 ◽  
Author(s):  
Matthias Wilhelm
Keyword(s):  
Phase I ◽  
Phase Ii ◽  
Körperliche Aktivität ◽  
Phase Iii

Zusammenfassung. Herzinsuffizienz ist ein klinisches Syndrom mit unterschiedlichen Ätiologien und Phänotypen. Die überwachte Bewegungstherapie und individuelle körperliche Aktivität ist bei allen Formen eine Klasse-IA-Empfehlung in aktuellen Leitlinien. Eine Bewegungstherapie kann unmittelbar nach Stabilisierung einer akuten Herzinsuffizienz im Spital begonnen werden (Phase I). Sie kann nach Entlassung in einem stationären oder ambulanten Präventions- und Rehabilitationsprogramm fortgesetzt werden (Phase II). Typische Elemente sind Ausdauer-, Kraft- und Atemtraining. Die Kosten werden von der Krankenversicherung für drei bis sechs Monate übernommen. In erfahrenen Zentren können auch Patienten mit implantierten Defibrillatoren oder linksventrikulären Unterstützungssystemen trainieren. Wichtiges Ziel der Phase II ist neben muskulärer Rekonditionierung auch die Steigerung der Gesundheitskompetenz, um die Langzeit-Adhärenz bezüglich körperlicher Aktivität zu verbessern. In Phase III bieten Herzgruppen Unterstützung.

PENGARUH KEPEMIMPINAN DAN KOMPETENSI TERHADAP KINERJA ORGANISASI PT. SAMICK INDONESIA

2019 ◽  
Vol 7 (2) ◽  
Author(s):  
Donny Dharmawan, MM. ◽  
Erfan Esnawan
Keyword(s):  
Data Analysis ◽  
Data Collection ◽  
Organizational Performance ◽  
Multiple Regression ◽  
Significant Influence ◽  
Random Sampling ◽  
Simple Random Sampling ◽  
Validity And Reliability ◽  
Data Analysis Technique ◽  
Analysis Technique

<em><span lang="EN-US">This study aims to determine the magnitude of the influence of leadership and competence on the organizational performance of PT. Samick Indonesia. This study uses Simple Random Sampling. The population in this study were employees of PT. Samick Indonesia. With 156 samples. Data collection techniques using questionnaires which then have been tested for validity and reliability. The data analysis technique used to answer the hypothesis is multiple regression. The results of this study indicate that, Leadership is able to improve Organizational Performance. Competence is able to improve organizational performance thus it can be concluded that leadership and competence have a positive and significant influence on the organizational performance of PT. Samick Indonesia.</span></em>

PENGEMBANGAN MEDIA PEMBELAJARAN INTERAKTIF BERBASIS ADOBE FLASH CS3 PROFESSIONAL PADA MATERI PENYAJIAN DATA

2020 ◽  
Vol 2 (2) ◽  
pp. 70-76
Author(s):  
Savitri Septiara Pratiwi ◽  
Ana Setiani ◽  
Novi Andri Nurcahyono
Keyword(s):  
Data Analysis ◽  
Junior High School ◽  
Random Sampling ◽  
Interactive Learning ◽  
Simple Random Sampling ◽  
Mathematical Understanding ◽  
Test Results ◽  
Analysis Techniques ◽  
Adobe Flash ◽  
Is Research

The purpose of this research are : 1) knowing the process of developing interactive with using Adobe Flash CS3 Professional media, 2) knowing the effectiveness of interactive learning with using Adobe Flash CS3 Professional media, 3). knowing the ability of students' mathematical understanding after using the Adobe Flash CS3 Professional media. The type of research is Research and Development (R & D) with One-Group Pretest-Posttest. The research was conducted at Mardi Waluya 2 Sukabumi Junior High School in the 2018/2019 semester event. The writer take the population of this study is on VII class. The sample used simple random sampling and for the instruments used were validation questionnaires media and tests. Data analysis techniques are using the Likert scale for validation questionnaires media, using the T test to determine effectiveness, and N-Gain to determine the increase in students' mathematical understanding skills. Interactive learning media are valued by media experts and material experts, with the results obtained that are valid so that they can be used in learning. The results of the effectiveness test are Thit (8.78)> T table (1,699) with a significant level used which is 5%. With high criteria of N-Gain test results are 75.61. Based on the results of these studies, interactive learning with using Adobe Flash CS3 Professional media can be effective in learning and can improve students' of mathematical understanding skills.

scholarly journals AB0332 IMMUNOSUPPRESSIVE AND IMMONOMODULATING AGENTS IN RHEUMATOID ARTHRITIS: A SYSTEMATIC REVIEW OF CLINICAL TRIALS AND THEIR CURRENT DEVELOPMENT STAGE

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1464.1-1465
Author(s):  
J. Blaess ◽  
J. Walther ◽  
J. E. Gottenberg ◽  
J. Sibilia ◽  
L. Arnaud ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Systematic Review ◽  
B Cells ◽  
Phase I ◽  
Phase Ii ◽  
Clinical Development ◽  
Phase Iii ◽  
Jak Inhibitors ◽  
Exclusion Criteria ◽  
Immunomodulating Drugs

Background:Rheumatoid arthritis (RA) is the most frequent chronic inflammatory diseases with an incidence of 0.5% to 1%. Therapeutic arsenal of RA has continuously expanded in recent years with the recent therapeutic progress with the arrival of conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs), biological (bDMARDs) and targeted synthetic (tsDMARDs), JAK inhibitors. However, there are still some unmet needs for patients who do not achieve remission and who continue to worsen despite treatments. Of note, only approximately 40% of patients are ACR70 responders, in most randomized controlled trials. For these patients, finding new therapeutic avenues is challenging.Objectives:The objective of our study was to analyze the whole pipeline of immunosuppressive and immunomodulating drugs evaluated in RA and describe their mechanisms of action and stage of clinical development.Methods:We conducted a systematic review of all drug therapies in clinical development in RA in 17 databases of international clinical trials. Inclusion criterion: study from one of the databases using the keywords “Rheumatoid arthritis” (search date: June 1, 2019). Exclusion criteria: non-drug trials, trials not related to RA or duplicates. We also excluded dietary regimen or supplementations, cellular therapies, NSAIDs, glucorticoids or their derivatives and non-immunosuppressive or non-immunomodulating drugs. For each csDMARD, bDMARD and tsDMARD, we considered the study at the most advanced stage. For bDMARDs, we did not take into account biosimilars.Results:The research identified 4652 trials, of which 242 for 243 molecules met the inclusion and exclusion criteria. The developed molecules belong to csDMARDs (n=21), bDMARDs (n=117), tsDMARDs (n=105).Among the 21 csDMARDs molecules: 8 (38%) has been withdrawn, 4 (19%) are already labelled in RA (hydroxychloroquine, leflunomide, methotrexate and sulfasalazine) and 9 (43%) are in development: 1 (11%) is in phase I/II, 5 (56%) in phase II, 3 (33%) in phase IV.Among the 117 bDMARDs molecules: 69 (59%) has been withdrawn, 9 (8%) are labeled in RA (abatacept, adalimumab, anakinra, certolizumab, etanercept, golimumab, infliximab, rituximab, sarilumab, tocilizumab) and 39 (33%) are in development: 9 (23%) in phase I, 3 (8%) in phase I/II, 21 (54%) in phase II, 5 (12%) are in phase III, 1 (3%) in phase IV. bDMARDs currently under development target B cells (n=4), T cells (n=2), T/B cells costimulation (n=2),TNF alpha (n=2), Interleukine 1 or his receptor (n=3), Interleukine 6 or his receptor (n=7), Interleukine 17 (n=4), Interleukine 23 (n=1), GM-CSF (n=1), other cytokines or chemokines (n=5), integrins or adhesion proteins (n=3), interferon receptor (n=1) and various other targets (n=4).Among the 105 tsDMARDs molecules: 64 (61%) has been withdrawn, 6 (6%) JAK inhibitors, have just been or will probably soon be labelled (baricitinib, filgotinib, peficitinib, tofacitinib and upadacitinib), 35 (33%) are in development: 8 (24%) in phase I, 26 (74%) in phase II, 1 (3%) in phase III and. tsDMARDs currently under development target tyrosine kinase (n=12), janus kinase (JAK) (n=3), sphingosine phostate (n=3), PI3K pathway (n=1), phosphodiesterase-4 (n=3) B cells signaling pathways (n=3) and various other targets (n=10).Conclusion:A total of 242 therapeutic trials involving 243 molecules have been or are being evaluated in RA. This development does not always lead to new treatments since 141 (58%) have already been withdrawn. Hopefully, some of the currently evaluated drugs will contribute to improve the therapeutic management of RA patients, requiring a greater personalization of therapeutic strategies, both in the choice of molecules and their place in therapeutic sequences.Disclosure of Interests:Julien Blaess: None declared, Julia Walther: None declared, Jacques-Eric Gottenberg Grant/research support from: BMS, Pfizer, Consultant of: BMS, Sanofi-Genzyme, UCB, Speakers bureau: Abbvie, Eli Lilly and Co., Roche, Sanofi-Genzyme, UCB, Jean Sibilia: None declared, Laurent Arnaud: None declared, Renaud FELTEN: None declared

scholarly journals Unconventional Anticancer Agents: A Systematic Review of Clinical Trials

2006 ◽  
Vol 24 (1) ◽  
pp. 136-140 ◽  
Author(s):  
Andrew J. Vickers ◽  
Joyce Kuo ◽  
Barrie R. Cassileth
Keyword(s):  
Clinical Trials ◽  
Phase I ◽  
Cancer Patients ◽  
Phase Ii ◽  
Dose Finding ◽  
Phase Iii ◽  
High Dose ◽  
Free Text ◽  
Phase Ii Trials ◽  
Off Label

Purpose A substantial number of cancer patients turn to treatments other than those recommended by mainstream oncologists in an effort to sustain tumor remission or halt the spread of cancer. These unconventional approaches include botanicals, high-dose nutritional supplementation, off-label pharmaceuticals, and animal products. The objective of this study was to review systematically the methodologies applied in clinical trials of unconventional treatments specifically for cancer. Methods MEDLINE 1966 to 2005 was searched using approximately 200 different medical subject heading terms (eg, alternative medicine) and free text words (eg, laetrile). We sought prospective clinical trials of unconventional treatments in cancer patients, excluding studies with only symptom control or nonclinical (eg, immune) end points. Trial data were extracted by two reviewers using a standardized protocol. Results We identified 14,735 articles, of which 214, describing 198 different clinical trials, were included. Twenty trials were phase I, three were phase I and II, 70 were phase II, and 105 were phase III. Approximately half of the trials investigated fungal products, 20% investigated other botanicals, 10% investigated vitamins and supplements, and 10% investigated off-label pharmaceuticals. Only eight of the phase I trials were dose-finding trials, and a mere 20% of phase II trials reported a statistical design. Of the 27 different agents tested in phase III, only one agent had a prior dose-finding trial, and only for three agents was the definitive study initiated after the publication of phase II data. Conclusion Unconventional cancer treatments have not been subject to appropriate early-phase trial development. Future research on unconventional therapies should involve dose-finding and phase II studies to determine the suitability of definitive trials.

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