Hubungan Asupan Protein dengan Kadar Ureum dan Kreatinin pada Pasien Gagal Ginjal Kronik yang Sedang Menjalani Hemodialisa di Unit Hemodialisa RS PKU Muhammadiyah Yogyakarta

2017 ◽  
Vol 19 (1) ◽  
pp. 1-6
Author(s):  
Irma Ibrahim ◽  
Isti Suryani ◽  
Elza Ismail
Keyword(s):  
Kidney Disease ◽  
Protein Intake ◽  
Terminal Illness ◽  
Control Volume ◽  
Waste Product ◽  
Creatinine Concentration ◽  
Cross Sectional ◽  
Hemodialysis Unit ◽  
Spearman Test ◽  
Determine Relation

Background: Chronic Kidney Disease (CKD) is complication of progressive kidney disease. Kidney will lose its function to control volume and body fluids. Patient CKD will be at terminal illness in various term from 2-3 months until 30-40 years. Hemodialysis is needed for CKD stadium terminal when kidney is unable to excrete waste of metabolism, control electrolyte and fluids balance, and secrete hormone. This condition will lead cumulative Nitrogen as waste product of metabolism. Objective: To determine relation between protein intake with ureum and creatinine concentration on CKD patient with hemodialysis at Hemodialysis Unit in PKU Muhammadiyah Yogyakarta Hospital. Methods: This is a descriptive analytic research using cross sectional research design. It was held on August 2016 at PKU Muhammadiyah Yogyakarta Hospital. Population is all CKD patients with Hemodialysis. Subject is chosen by inclusion criteria: want to join research and has 30-60 years old. Results: There is no significant correlation both protein intake with ureum concentration p=0.438 and protein intake with creatinin concentration p=0.205 based on Rank Spearman test. Conclusion: There is no significant correlation both protein intake with ureum concentration, and protein intake with creatinin concentration on patients with CKD at Hemodialysis Unit in PKU Muhammadiyah Yogyakarta Hospital.   Keywords: Protein intake, Ureum, Creatinin

scholarly journals HUBUNGAN ANTARA LAMANYA MENJALANI HEMODIALISIS DENGAN TINGKAT KECEMASAN PADA PASIEN DENGAN PENYAKIT GINJAL KRONIK DI RSUP PROF. Dr. R. D. KANDOU MANADO

e-CliniC ◽  
2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Befly F. Tokala ◽  
Lisbeth F. J. Kandou ◽  
Anita E. Dundu
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Analytical Study ◽  
Cross Sectional ◽  
Hemodialysis Unit ◽  
Spearman Test ◽  
The Relationship

Abstract: The incidence of chronic kidney disease (CKD) has increased. Efforts are being made to deal with this problem by using hemodialysis. CKD patients undergo hemodialysis for years. This can result in disorders such as anxiety. This study aimed to obtain the relationship between the duration of hemodialysis and levels of anxiety in patients with CKD in hemodialysis unit at Prof. Dr. R. D. Kandou Hospital, Manado. This was an observational analytical study using cross sectional approach. Data were socio-demographic status and the HARS questionnaire which were processed by using SPSS 20. From a total of 34 respondents, 18 people (52.9%) experienced varying degrees of anxiety. The Spearman test resulted in p = 0.462 > 0.05 which meant that there was no relationship between the duration of hemodialysis and levels of anxiety in patients with CKD. Conclusion: There was no relationship between the duration of hemodialysis and levels of anxiety in patients with CKD in hemodialysis unit, however, there were some respondents who experienced anxiety.Keywords: anxiety, hemodialysis, CKDAbstrak: Kejadian Penyakit ginjal kronik (PGK) semakin meningkat. Upaya yang dilakukan untuk menangani masalah ini salah satunya dengan hemodialisis. Pasien PGK membutuhkan waktu bertahun – tahun untuk menjalani hemodialisis. Hal ini dapat mengakibatkan gangguan psikologi seperti kecemasan. Penelitian ini bertujuan untuk mengetahui hubungan antara lamanya menjalani hemodialisis dengan tingkat kecemasan pada pasien PGK di unit hemodialisis RSUP Prof. R. D. Kandou Manado. Penelitian ini bersifat observasional analitik dengan pendekatan potong lintang. Data dikumpulkan melalui pengisian data sosiodemografi dan wawancara dengan kuesioner HARS kemudian diolah dengan SPSS 20. Dari total 34 responden, ditemukan 18 orang (52,9%) mengalami kecemasan dengan derajat yang berbeda-beda, akan tetapi pada uji Spearman menunjukan hasil p = 0,462 yaitu > 0,05 yang artinya tidak terdapat hubungan antara lamanya menjalani hemodialisis dengan tingkat kecemasan pada pasien dengan PGK. Simpulan: Tidak terdapat hubungan antara lamanya menjalani hemodialisis dengan tingkat kecemasan pada pasien PGK di unit hemodialisis, walaupun demikian terdapat sebagian responden yang mengalami cemas.Kata kunci: kecemasan, hemodalisis, penyakit ginjal kronik

scholarly journals Influence of dietary protein intake on body composition in chronic kidney disease patients in stages 3–5: A cross-sectional study

Nefrología ◽  
2018 ◽  
Vol 38 (6) ◽  
pp. 647-654
Author(s):  
Guillermina Barril ◽  
Angel Nogueira ◽  
Mar Ruperto López ◽  
Yone Castro ◽  
José Antonio Sánchez-Tomero
Keyword(s):  
Chronic Kidney Disease ◽  
Body Composition ◽  
Kidney Disease ◽  
Dietary Protein ◽  
Protein Intake ◽  
Cross Sectional Study ◽  
Dietary Protein Intake ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Relationships of Fat and Muscle Mass with Chronic Kidney Disease in Older Adults: A Cross-Sectional Pilot Study

2020 ◽  
Vol 17 (23) ◽  
pp. 9124
Author(s):  
Bokun Kim ◽  
Hyuntae Park ◽  
Gwonmin Kim ◽  
Tomonori Isobe ◽  
Takeji Sakae ◽  
...  
Keyword(s):  
Older Adults ◽  
Chronic Kidney Disease ◽  
Pilot Study ◽  
Kidney Disease ◽  
Muscle Mass ◽  
Estimated Glomerular Filtration Rate ◽  
Fat Free Mass ◽  
Creatinine Concentration ◽  
Cross Sectional ◽  
Assess Body Composition

This cross-sectional pilot study aimed to assess the relationships of fat and muscle mass with chronic kidney disease (CKD) in older adults. Serum creatinine concentration was used to measure estimated glomerular filtration rate (mL/min/1.73 m2) in the 236 subjects, who were allocated to three groups: a normal (≥60.0), a mild CKD (45.0–59.9), and a moderate to severe CKD (<45.0) group. The Jonckheere-Terpstra test and multivariate logistic regression were employed to assess body composition trends and the relationships of % fat mass (FM) or % muscle mass index (MMI) with moderate-to-severe CKD. Body weight, fat-free mass, MMI, and %MMI tended to decrease with an increase in the severity of CKD, but the opposite trend was identified for %FM. No relationship with BMI was identified. The participants in the middle-high and highest quartile for %FM were 6.55 and 14.31 times more likely to have moderate to severe CKD. Conversely, the participants in the highest quartile for %MMI were 0.07 times less likely to have moderate to severe CKD. Thus, high fat and low muscle mass may be more strongly associated with CKD than obesity per se.

scholarly journals Hubungan Umur dan Lamanya Hemodialisis dengan Status Gizi pada Penderita Penyakit Ginjal Kronik yang menjalani Hemodialisis di RS. Dr. M. Djamil Padang

2014 ◽  
Vol 3 (3) ◽  
Author(s):  
Hannie Qalbina Syaiful ◽  
Fadil Oenzil ◽  
Rudy Afriant
Keyword(s):  
Kidney Disease ◽  
Nutritional Status ◽  
Nutritional Assessment ◽  
Disease Patient ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Thickness Skin ◽  
Skin Fold ◽  
Hemodialysis Unit

AbstrakPenyakit Ginjal Kronik (PGK) masih merupakan masalah kesehatan dunia karena prevalensinya yang meningkat, “ireversible” dan progresif. Malnutrisi lebih banyak ditemukan pada PGK. Sebanyak 40% malnutrisi ditemukan pada penderita pada awal hemodialisis. Penelitian ini bertujuan untuk melihat hubungan umur dan lamanya hemodialisis dengan status gizi pada penderita penyakit ginjal kronik yang menjalani hemodialisis. Ini adalah suatu penelitian Cross Sectional Study yang dilakukan pada bulan Oktober 2013 di Unit Hemodialisis RS Dr. M. Djamil Padang. Telah Diteliti sebanyak 59 orang penderita PGK. Penilaian gizi diukur dengan Lingkaran Lengan Atas (LILA) dan Tebal Lipat Kulit (Skin Fold). Data dianalisa dengan program SPSS. Hasil penelitian memperlihatkan bahwa umur penderita berkisar 22-75 tahun dengan rata-rata 52,39 ±10,39 tahun dan terbanyak umur 50-59 tahun yaitu sebesar 50,86%. Lamanya menjalani hemodialisis berkisar 1-97 bulan dengan rata-rata 24,54 ± 24,69 bulan. Malnutrisi pada penderita PGK berdasarkan LILA dan Skin Fold, didapatkan berturut-turut 33 orang (55,93%) dan32 orang (54,24%). Tidak didapatkan hubungan yang bermakna antara gambaran gizi dengan umur dan lamanya menjalani hemodialisis (p>0,05, r<1). Kesimpulan dari studi ini adalah malnutrisi pada PGK yang menjalani hemodialisis berkisar antara 54,24% – 55,93%. Tidak terdapat hubungan antara status gizi dengan umur dan lamanya menjalani hemodialisisKata kunci: PGK, malnutrisi, umurAbstractChronic Kidney Disease (CKD) is still a global health problem due to its increasing prevalence Its irreversible and progressive state. Malnutrition is more common in CKD patients. A total of 40% malnutrition case is found in patients at the beginning of their hemodialysis. The objective of this study was to observe the relationships of age and duration of hemodialysis with regard to nutritional status in chronic kidney disease patient on hemodialysis. This was a cross sectional study conducted in October 2013 at Hemodialysis Unit of Dr. M. Djamil General Hospital, Padang. A total of 59 patients with CKD were analyzed. Nutritional assessment was measured by Upper Arm Circles (UAC) and Skin Fold’s thickness (Skin Fold). Data were analyzed using SPSS. Results: Ages of patients were ranged from 22-75 years with an average of 52.39 ± 10.39 years, and most patients were aged 50-59 years that was equal to 50.86%. The long of hemodialysis was ranged 1-97 months with an average of 24.54 ± 24.69 months. Malnutrition in patients with CKD based on UAC and Skin Fold were obtained successively in 33 people (55.93%) and 32 people (54.24%). There was no significant association between nutritional figure with age and duration of hemodialysis (p>0.05, r<1). Conclusion from ths study is malnutrition in CKD patients that undergo hemodialysis is ranged from 54.24% to 55.93%. There is no relationship between nutritional status with age and duration of undergoing hemodialysis.Keyword: CKD, Malnutrition, age

scholarly journals P1000URINE MYO-INOSITOL AS A NOVEL PROGNOSTIC BIOMARKER FOR DIABETIC KIDNEY DISEASE

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Chun Soo Lim ◽  
Soie Kwon ◽  
Jung Pyo Lee
Keyword(s):  
Kidney Disease ◽  
Diabetic Kidney Disease ◽  
Additive Effect ◽  
Renal Disease Progression ◽  
Creatinine Concentration ◽  
Cross Sectional ◽  
Cox Models ◽  
Urine Metabolites ◽  
Predictive Values ◽  
Diabetic Kidney

Abstract Background and Aims Diabetic kidney disease (DKD) is a leading cause of chronic kidney disease (CKD) and end-stage kidney disease (ESRD). Metabolomics has been increasingly applied to identify the cause of CKD, as it can present epigenetics and suggest corresponding treatment options. Only a few metabolomics studies were conducted in DKD patients, and the results are inconclusive. We investigated the association between urine metabolites and renal disease progression and mortality in DKD, using 800 MHz NMR spectroscopy based targeted metabolomics profiling. Method Prospectively stored urine samples from consecutive patients with DKD stage 1 to 5 (n=208) and their healthy controls (n=26) were analyzed. Cross-sectional associations were evaluated between eGFR or urine protein creatinine ratio (UPCR) and 26 urinary metabolites. Multivariable adjusted Cox models were conducted for the risk prediction of ESRD and mortality. The receiver-operating characteristic (ROC) analyses were used to assess the additive effect of each metabolite to predict the progression to ESRD. Results ESRD occurred in 103 (44.0%) patients and 65 (27.8%) deaths occurred during median 4.5 years (IQR, 2.06–6.58) follow-up period. The median fold change in 9 metabolites (glucose, mannose, myo-inositol, glycerol, lactate, fumarate, creatine, taurine and choline) in patient group revealed a trend corresponding to DKD stages. Linear regression showed that myo-inositol had a strongest association with eGFR. The relationship between the competitive metabolites and outcomes (ESRD and mortality) was investigated by multivariate Cox models after adjusting for the baseline covariates. Of these, 4 metabolites (myo-inositol, glycerol, fumarate, oxoisocaproate) had predictive values for ESRD, and among them, only myo-inositol retained predictive significance in mortality (adjusted HR 1.004, 95% confidence interval 1.002-1.006, P &lt; 0.001). At ROC analysis, urinary myo-inositol had additive effect to serum creatinine concentration and UPCR in the prediction for ESRD progression (NRI = 2.9%, P = 0.03; IDI = 35.1%, P = 0.02). Conclusion These results suggest that myo-inositol can be a predictive biomarker for the risk of ESRD progression and mortality in DKD. Further studies are needed to elucidate the pathophysiological roles of myo-inositol in DKD.

THE STUDY ON SERUM WITH eGFR IN PATIENTS OF CHRONIC KIDNEY DISEASE

2021 ◽  
pp. 23-25
Author(s):  
Brahmarshi Das ◽  
Narendranath Hait ◽  
Titol Biswas ◽  
Debarshi Jana
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Serum Creatinine ◽  
Cross Sectional Study ◽  
Newly Diagnosed ◽  
Creatinine Concentration ◽  
Cross Sectional ◽  
Ckd Stage ◽  
The Mean ◽  
Stage 1

INTRODUCTION: Chronic Kidney Disease (CKD) is dened as a disease characterized by alterations in either kidney structure or function or both for a minimum of 3 months duration. According to the National Kidney Foundation criteria, 1 CKD has been classied into ve stages with stage 1 being the earliest or mildest CKD state and stage 5 being the most severe CKD stage. To stage CKD, it is necessary to estimate the GFR rather than relying on serum creatinine concentration. Glomerular ltration rate (GFR), either directly measured by computing urinary clearance of ltration marker such as inulin or estimated by calculating from different equations using serum creatinine. is the most commonly used parameter to assess kidney function. AIM AND OBJECTIVES: a) Establish relationship between serum CKD and eGFR MATERIAL AND METHOD: A Cross-sectional study on 100 cases of newly diagnosed Chronic Kidney Disease patients and matched control subjects is undertaken to study.100 Patients who are newly diagnosed as CKD are selected after proper initial screening. RESULT AND ANALYSIS: In case, the mean eGFR (mean± s.d.) of patients was 25.1500 ± 11.8929. In control, the mean eGFR (mean± s.d.) of patients was 87.2200 ± 17.8295. Difference of mean eGFR in two groups was statistically signicant (p<0.0001). In case, the mean creatinine (mean± s.d.) of patients was 3.6350 ± 2.4419 mg/dl. In control, the mean creatinine (mean± s.d.) of patients was .9435 ± .1317 mg/dl. Difference of mean creatinine in two groups was statistically signicant (p<0.0001). CONCLUSION: eGFR was strongly associated with CKD that also statistically signicant. The positive correlation was found in eGFR.

scholarly journals Correlation between Chronic Kidney Disease Severity and Cognitive Function

2021 ◽  
Vol 31 (3) ◽  
pp. 139
Author(s):  
Epa Danisa Surbakti ◽  
Fasihah Irfani Fitri ◽  
Aldy Safruddin Rambe
Keyword(s):  
Chronic Kidney Disease ◽  
Cognitive Function ◽  
Kidney Disease ◽  
Disease Severity ◽  
Digit Span ◽  
Significant Negative Correlation ◽  
Cross Sectional ◽  
Trail Making ◽  
Cross Sectional Design ◽  
Spearman Test

<p>Chronic kidney disease (CKD) is an independent risk factor for cognitive impairment in all domains, especially delayed memory and executive function. The purpose of this study was to determine the correlation between chronic kidney disease severity and cognitive function. This study used a cross-sectional design in stage III, IV, and V CKD patients in the Nephrology Polyclinic of Haji Adam Malik Central General Hospital. Cognitive function tests were performed using the Montreal Cognitive Assessment (MoCA INA), digit span, and Trail Making Test A &amp; B. The Spearman test was used to analyze the correlation between CKD severity and cognitive function. This study involved 45 chronic kidney disease patients consisting of 28 (62.2%) males and 17 (37.8%) females with a mean age of 49.67±12.18 years. The results of statistical analysis showed that there was a significant positive correlation between CKD on the MoCA-INA examination (r=0.618, p=&lt;0.001), FDS (r=0.414, p=0.005), there was a significant negative correlation on the TMT A time examination (r=-0.425, p=0.004), TMT A error (r=-0.497, p=0.001), TMT B time (r=-0.618, p=&lt;0.001), TMT B error (r=-0.370, p=0.012). The results of this study prove a significant correlation between the severity of CKD and cognitive function.</p>

scholarly journals Effect of Hemodialysis Adequacy on Quality of Life in Older adults with Chronic Kidney Disease

2021 ◽  
Vol 6 (1) ◽  
pp. 28
Author(s):  
Virgianti Nur Faridah ◽  
Muhamad Syukri Ghozali ◽  
Arifal Aris ◽  
Siti Sholikhah ◽  
Masunatul Ubudiyah
Keyword(s):  
Quality Of Life ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Statistical Tests ◽  
Life Assessment ◽  
P Value ◽  
Cross Sectional ◽  
Important Indicator ◽  
Spearman Test

Introduction: Assessment of hemodialysis adequacy is an important indicator to assess the effectiveness of hemodialysis measures that can affect the patient's quality of life with chronic kidney disease. This study aims to determine the relationship between adequate hemodialysis and the quality of life of patients with chronic kidney disease undergoing hemodialysis therapy.Method: This type of research is a correlational study with a cross sectional approach. The population in this study were 86 elderly patients who underwent hemodialysis at the Muhammadiyah Lamongan Hospital. In this study, the independent variables were adequate hemodialysis and quality of life as the dependent variable. Measurement of hemodialysis adequacy was carried out using the URR formula, and the assessment of quality of life using the SF 36 questionnaire. Data analysis methods used the Spearman test using SPSS Ver. 16Result: The results of measurement of adequacy of 86 respondents, namely 13.9% achieved adequate and 86% did not achieve adequacy. The results of the quality of life assessment showed that 17.4% had a good quality of life and 82.5% had a poor quality of life. The results of statistical tests showed that there was a significant relationship between adequate hemodialysis and quality of life (p value = 0.000).Conclusion: The role of nurses is very important in improving the quality of care in achieving adequate adequacy so that it will improve the quality of life in patients with chronic kidney disease undergoing hemodialysis therapy.

scholarly journals Salivary creatinine as a diagnostic tool for evaluating patients with chronic kidney disease

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Dada Oluwaseyi Temilola ◽  
Karla Bezuidenhout ◽  
Rajiv Timothy Erasmus ◽  
Lawrence Stephen ◽  
Mogamat Razeen Davids ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Diagnostic Tool ◽  
Linear Regression Analysis ◽  
Strong Positive Correlation ◽  
Western Cape ◽  
Operating Characteristics ◽  
Creatinine Concentration ◽  
Cross Sectional ◽  
Non Invasive

Abstract Background Preliminary studies have shown the potential use of salivary creatinine concentration in the diagnosis of chronic kidney disease (CKD). For saliva to replace serum as a diagnostic tool, studies must be done to determine its effectiveness in the diagnosis and staging of CKD. The aim of the present study was to evaluate the use of salivary creatinine as a safe and non-invasive alternative for identifying patients with CKD. Methods A cross-sectional study was conducted at Tygerberg Hospital in Cape Town, on 230 patients, across all stages of CKD. Ethical approval to conduct the study was obtained from the University of the Western Cape Biomedical Research Ethics Committee, and written informed consent was provided by each participant. Saliva and serum samples were collected for creatinine analysis and the correlation determined using Spearman’s correlation. Receiver operating characteristics (ROC) analysis was used to determine the diagnostic ability of salivary creatinine. A cut-off value for optimal sensitivity and specificity of salivary creatinine to diagnose CKD with glomerular filtration rate (GFR) < 60 mL/min/1.73 m2 was obtained. Results Serum creatinine values ranged from 46 μmol/L to 1581 μmol/L, with a median value of 134 μmol/L. Salivary creatinine values ranged from 3 μmol/L to 400 μmol/L, with a median of 11 μmol/L. There was a strong positive correlation (r = 0.82) between serum and salivary creatinine values. Linear regression analysis of serum and salivary creatinine for CKD patients was significant in all CKD stages, except for stage 1. Area under the curve for salivary creatinine was 0.839. A cut-off value of 8.5 μmol/L yielded a sensitivity of 78.3% and specificity of 74.0% for classifying patients as having CKD based on estimated GFR < 60 mL/min/1.73 m2. Conclusions The results support the potential of salivary creatinine as a non-invasive diagnostic tool for estimating GFR and identifying patients with CKD.

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