scholarly journals Correlation between Chronic Kidney Disease Severity and Cognitive Function

2021 ◽  
Vol 31 (3) ◽  
pp. 139
Author(s):  
Epa Danisa Surbakti ◽  
Fasihah Irfani Fitri ◽  
Aldy Safruddin Rambe
Keyword(s):  
Chronic Kidney Disease ◽  
Cognitive Function ◽  
Kidney Disease ◽  
Disease Severity ◽  
Digit Span ◽  
Significant Negative Correlation ◽  
Cross Sectional ◽  
Trail Making ◽  
Cross Sectional Design ◽  
Spearman Test

<p>Chronic kidney disease (CKD) is an independent risk factor for cognitive impairment in all domains, especially delayed memory and executive function. The purpose of this study was to determine the correlation between chronic kidney disease severity and cognitive function. This study used a cross-sectional design in stage III, IV, and V CKD patients in the Nephrology Polyclinic of Haji Adam Malik Central General Hospital. Cognitive function tests were performed using the Montreal Cognitive Assessment (MoCA INA), digit span, and Trail Making Test A &amp; B. The Spearman test was used to analyze the correlation between CKD severity and cognitive function. This study involved 45 chronic kidney disease patients consisting of 28 (62.2%) males and 17 (37.8%) females with a mean age of 49.67±12.18 years. The results of statistical analysis showed that there was a significant positive correlation between CKD on the MoCA-INA examination (r=0.618, p=&lt;0.001), FDS (r=0.414, p=0.005), there was a significant negative correlation on the TMT A time examination (r=-0.425, p=0.004), TMT A error (r=-0.497, p=0.001), TMT B time (r=-0.618, p=&lt;0.001), TMT B error (r=-0.370, p=0.012). The results of this study prove a significant correlation between the severity of CKD and cognitive function.</p>

scholarly journals HUBUNGAN ANTARA MEROKOK DENGAN GAMBARAN FUNGSI GINJAL PADA KARYAWAN PT.X

2021 ◽  
Vol 7 (3) ◽  
pp. 147-152
Author(s):  
Nur Syamsi ◽  
Andi Alfia Muthmainnah Tanra ◽  
Mariani Rasjid HS
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Function ◽  
Kidney Disease ◽  
Analytical Study ◽  
Smoking Habit ◽  
Cross Sectional ◽  
Consecutive Sampling ◽  
Study Results ◽  
Cross Sectional Design ◽  
Global Health Problem

The chronic kidney disease is a global health problem with increasing prevalence and incidence and a poor prognosis. Therefore, those brought about by risk factors are primarily those which can be modified and controlled for their occurrence.  One of the risk factor is smoking habit. The objective of this study was to determine the associations between smoking and renal function profiles in PT.X employees. The study was conducted by using descriptive analytical study with a cross sectional design based on smoking habits and blood test samples of employees. The sample were 40 employees in PT.X which determined by consecutive sampling. The results showed that there were no associations between smoking with age (p = 0.222) and azotemia (p = 1.00) but there were associations between smoking and blood creatinine levels (p = 0.001), urea (p = 0.023), eGFR (p. = 0.001), and the stages of chronic kidney disease (p = 0.047).  Based on the study results, in can be concluded that there were associations between smoking and renal function profiles among employees of PT. X

scholarly journals Association between Protein-Bound Uremic Toxins and Asymptomatic Cardiac Dysfunction in Patients with Chronic Kidney Disease

Toxins ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 520 ◽  
Author(s):  
Shanmugakumar Chinnappa ◽  
Yu-Kang Tu ◽  
Yi Chun Yeh ◽  
Griet Glorieux ◽  
Raymond Vanholder ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Cardiac Dysfunction ◽  
Serum Levels ◽  
Significant Negative Correlation ◽  
Cross Sectional Study ◽  
Left Ventricular ◽  
Uremic Toxins ◽  
Cross Sectional ◽  
The Individual

Although the relationship between protein-bound uremic toxins (PBUTs) and cardiac structure and cardiac mortality in chronic kidney disease (CKD) has been studied in the past, the association between cardiac dysfunction and PBUTs has not yet been studied. We therefore evaluated the association between impaired peak cardiac performance and the serum free and total concentrations of potentially cardiotoxic PBUTs. In a cross-sectional study of 56 male CKD patients (stages 2–5 (pre-dialysis)) who were asymptomatic with no known cardiac diseases or diabetes we measured peak cardiac power (CPOmax), aerobic exercise capacity (VO2max), and echocardiographic parameters of cardiac morphology and evaluated their association with PBUTs. The serum total and free concentrations of indoxyl sulfate (IXS), p-cresyl sulfate (PCS), p-cresyl glucuronide, indole acetic acid, and hippuric acid showed significant negative correlation with CPOmax and VO2max. IXS and PCS were independently associated with CPOmax and VO2max even after controlling for eGFR. No correlation between left ventricular mass index (LVMI) and PBUTs was seen. The present study for the first time has demonstrated the association between subclinical cardiac dysfunction in CKD and serum levels of a panel of PBUTs. Further studies are required to evaluate the mechanism of cardiotoxicity of the individual uremic toxins.

Cognitive Impairment in Advanced Chronic Kidney Disease: The Canadian Frailty Observation and Interventions Trial

2016 ◽  
Vol 44 (6) ◽  
pp. 473-480 ◽  
Author(s):  
Rukhsana Foster ◽  
Simon Walker ◽  
Ranveer Brar ◽  
Brett Hiebert ◽  
Paul Komenda ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Kidney Disease ◽  
High Rate ◽  
Control Group ◽  
Cross Sectional ◽  
History Of ◽  
Poor Nutrition

Background: Chronic kidney disease (CKD) affects more than one third of older adults, and is a strong risk factor for vascular disease and cognitive impairment. Cognitive impairment can have detrimental effects on the quality of life through decreased treatment adherence and poor nutrition and results in increased costs of care and early mortality. Though widely studied in hemodialysis populations, little is known about cognitive impairment in patients with pre-dialysis CKD. Methods: Multicenter, cross-sectional, prospective cohort study including 385 patients with CKD stages G4-G5. Cognitive function was measured with a validated tool called the Montreal Cognitive Assessment (MoCA) as part of a comprehensive frailty assessment in the Canadian Frailty Observation and Interventions Trial. Cognitive impairment was defined as a MoCA score of ≤24. We determined the prevalence and risk factors for cognitive impairment in patients with CKD stages G4-G5, not on dialysis. Results: Two hundred and thirty seven participants (61%) with CKD stages G4-G5 had cognitive impairment at baseline assessment. When compared to a control group, this population scored lower in all domains of cognition, with the most pronounced deficits observed in recall, attention, and visual/executive function (p < 0.01 for all comparisons). Older age, recent history of falls and history of stroke were independently associated with cognitive impairment. Conclusions: Our study uncovered a high rate of unrecognized cognitive impairment in an advanced CKD population. This impairment is global, affecting all aspects of cognition and is likely vascular in nature. The longitudinal trajectory of cognitive function and its effect on dialysis decision-making and outcomes deserves further study.

scholarly journals FAKTOR- FAKTOR YANG BERHUBUNGAN DENGAN PENURUNAN NAFSU MAKAN PADA PASIEN GAGAL GINJAL KRONIK YANG MENJALANI TERAPI HEMODIALISIS (Studi Kasus di RSUD Prof. Dr. Margono Soekarjo)

2017 ◽  
Vol 1 (01) ◽  
pp. 23
Author(s):  
Umi Faza ◽  
Dyah Umiyarni Purnamasari ◽  
Saryono Yono
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Fisher Exact Test ◽  
Chi Square ◽  
Cross Sectional ◽  
Exact Test ◽  
Factors Associated ◽  
Consecutive Sampling ◽  
Chi Square Test ◽  
Cross Sectional Design

Abstract  The aim of this study was to determine factors associated with diminished appetite in CKD patients undergoing hemodialysis therapy. This study is an observational analytic research with cross sectional design. Population of this study was CKD outpatients undergoing hemodialysis therapy in July- August 2016 in Prof. Dr. Margono Soekarjo Hospitals. Amount of 58 subjects taken by consecutive sampling. Appetite, sex, age, length of hemodialysis, frequency of nausea/vomiting, and depression were measured using questionnaire. Subjects who diminished appetite were 58,6%. More than half subjects were male (56,9%). Amount of 84,5% subjects were adults (19-59 years), 63,8% undergoing hemodialysis >1year, 39,7% experienced nausea/ vomiting and 53,4% were depression. Based on Chi-Square Test/ Fisher Exact Test, diminished appetite significantly associated with length of hemodialysis (p=0,041), frequency of nausea/vomiting (p=0,014), and depression (p=0,002). Dominant factors affected diminished appetite were depression and length of hemodialysis. Diminished appetite in CKD patients undergoing hemodialysis therapy associated with length of hemodialysis, frequency of nausea/vomit, and depression. Keyword : appetite, chronic kidney disease, hemodialysi  Abstrak Penelitian ini bertujuan untuk mengetahui faktor- faktor yang berhubungan dengan penurunan nafsu makan pada pasien Gagal Ginjal Kronik (GGK) yang menjalani terapi hemodialisis. Penelitian ini merupakan penelitian analitik observasional dengan pendekatan cross sectional. Populasi dari penelitian ini adalah pasien GGK rawat jalan yang menjalani terapi hemodialisis pada bulan Juli- Agustus 2016 di RSUD Prof. Dr. Margono Soekarjo Purwokerto. Sebanyak 58 subjek diambil dengan cara consecutive sampling. Nafsu makan, jenis kelamin, usia, lama hemodialisis, frekuensi mual/muntah, dan depresi diukur menggunakan kuesioner. Responden yang mengalami penurunan nafsu makan sebanyak 58,6%. Lebih dari separuh responden (56,9%) berjenis kelamin laki- laki dan 84,5% responden berusia dewasa (19-59 tahun). Sebanyak 63,8% responden menjalani hemodialisis >1tahun. Responden yang mengalami mual/muntah berat sebanyak 39,7% dan 53,4% mengalami depresi. Berdasarkan analisis bivariat menggunakan Uji Chi- Square/ Fisher Exact diperoleh hasil bahwa nafsu makan berhubungan secara signifikan dengan lama hemodialisis (p=0,041), frekuensi mual/ muntah (p=0,014), dan depresi (p=0,002). Faktor dominan yang mempengaruhi penurunan nafsu makan adalah depresi dan lama hemodialisis. Penurunan nafsu makan pada pasien GGK yang menjalani terapi hemodialisis berhubungan dengan lama hemodialisis, frekuensi mual/muntah, dan depresi. Kata kunci : gagal ginjal, hemodialisa, nafsu makan  

scholarly journals GAMBARAN FUNGSI KOGNITIF PADA PASIEN RAWAT JALAN DENGAN RIWAYAT STROKE DI POLIKLINIK SARAF RSUP PROF. DR. R.D. KANDOU MANADO

2013 ◽  
Vol 5 (1) ◽  
Author(s):  
Tirzha N. Paparang ◽  
Corry N. Mahama ◽  
Denny J. Ngantung
Keyword(s):  
Cognitive Function ◽  
Mini Mental State Examination ◽  
Trail Making Test ◽  
Cross Sectional ◽  
Clock Drawing Test ◽  
Clock Drawing ◽  
Drawing Test ◽  
Trail Making ◽  
Cross Sectional Design ◽  
State Examination

Abstract: Stroke is a major cause of cognitive dysfunction. The incidences of cognitive dysfunction increase three-fold after strokes, usually involving impairement of abilities in visuo-spacial, memory, orientation, speech, attention, and performance functions. The rapid, practical, and approved examinations used to evaluate and confirm the decline in cognitive functions are the Mini Mental State Examination (MMSE), the Clock Drawing Test (CDT), and the Trail Making Test (TMT). This study aimed to reveal the cognitive functions of outpatients with stroke histories in the Neurology Polyclinic, Prof. Dr. R.D. Kandou Hospital Manado by using the above mentioned examinations. This was a descriptive study with a cross-sectional design conducted in November 2012. The results showed that there were 51 respondents who fulfilled the inclusion criteria consisting of 32 males and 19 females. The highest decline of cognitive function by age, the educational level, and employment was 60-79 years, more than 9 years of education, and retired workers, respectively. The results of the MMSE, CDT, and TMT examinations for cognitive impairment evaluation were as follow: MMSE 62.75%, CDT 56.86%, TMT A 96.08%, and TMT B 84.31%. Conclusion: Most of the outpatients with stroke histories in the Neurology Polyclinic, Prof. Dr. R.D. Kandou Hospital Manado showed cognitive impairments. Keywords: CDT, cognitive function, MMSE, stroke, TMT-A and B.   Abstrak: Stroke merupakan penyebab utama gangguan fungsi kognitif. Insiden gangguan kognitif meningkat tiga kali lipat setelah stroke, dan biasanya melibatkan kemampuan visuospasial, memori, orientasi, bahasa, perhatian dan fungsi eksekutif. Pemeriksaan yang digunakan untuk mengevaluasi dan mengonfirmasi penurunan  fungsi kognitif yang cepat dan praktis namun bernilai tinggi ialah Mini Mental State Examination (MMSE), Clock Drawing Test (CDT), dan Trail Making Test (TMT). Penelitian ini bertujuan untuk mengetahui gambaran fungsi kognitif pada pasien rawat jalan dengan riwayat stroke di Poliklinik Saraf RSUP Prof. Dr. R.D. Kandou Manado. Penelitian ini bersifat deskriptif dengan cross-sectional design dan dilaksanakan selama bulan November 2012. Hasil penelitian memperlihatkan bahwa 51 responden memenuhi kriteria inklusi, terdiri dari 32 laki-laki dan 19 perempuan. Berdasarkan usia, tingkat pendidikan, dan pekerjaan, penurunan fungsi kognitif terbanyak pada usia 60-79 tahun, tingkat pendidikan terakhir >9 tahun, dan pekerjaan pensiunan. Hasil pemeriksaan MMSE, CDT, dan TMT terhadap fungsi kognitif responden ialah: MMSE 62,75%, CDT 56,86%, TMT A 96,08%, dan TMT B 84,31%. Simpulan: Sebagian besar pasien rawat jalan dengan riwayat stroke di Poliklinik Saraf RSUP Prof. Dr. R.D. Kandou Manado telah memperlihatkan gagguan fungsi kognitif.Kata kunci: stroke, fungsi kognitif, MMSE, CDT, TMT-A dan B.

scholarly journals Status of Chronic Kidney Disease Patients Registered in National Kidney Center, Banasthali, Kathmandu

2015 ◽  
Vol 1 (4) ◽  
pp. 19-23 ◽  
Author(s):  
D Mishra ◽  
P Koirala
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Preventive Measures ◽  
Public Health Problem ◽  
Medication Cost ◽  
Cross Sectional ◽  
Average Patient ◽  
The Mean ◽  
Cross Sectional Design ◽  
The Needy

Chronic kidney disease is a worldwide public health problem. In Nepal, Chronic kidney disease patients are increasing and the management of this disease is very expensive compared to other chronic diseases? We assessed the socioeconomic status of chronic kidney disease patients registered in National Kidney Centre, Banasthali, Kathmandu. The study used descriptive cross sectional design. Ninety six samples were collected between 15- 31 October, 2012.The mean age of the patients was 47 years, with almost half of the patients (46%) from 41-60 years age group. Among the patients, 65 % were male, 85% were married, 80% were literate, 57% were past smoker and 75% were drinker and 59% were from Kathmandu valley. Likewise, most of them were Newar, work as housewife as the main occupation. One third (37%) had to sell their property for the treatment. On an average patient spent Rs.240000 per year in dialysis. Similarly, medication cost was Rs.180000 and transplantation cost was Rs.500000 to 1000000. Preventive measures of the disease and subsidy in the treatment will be beneficial for the needy people. DOI: http://dx.doi.org/10.3126/jmmihs.v1i4.11997Journal of Manmohan Memorial Institute of Health Sciences Vol. 1, Issue 4, 2015Page : 19-23 

scholarly journals LONG OF HEMODIALYSIS THERAPY WITH QUALITY LIFE PATIENT FAILS OF KIDNEY CHRONIC IN RS GATOEL MOJOKERTO: STUDY CROSS-SECTIONAL

2017 ◽  
Vol 1 (1) ◽  
pp. 56-64
Author(s):  
Arif Wicaksono ◽  
Muhammad Sajidin
Keyword(s):  
Quality Of Life ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Cross Sectional ◽  
Quality Life ◽  
Cross Sectional Design ◽  
The Individual ◽  
The Relationship

Hemodialysis therapy of patients with chronic kidney disease can changes the patients physically, psychological, social and economics because they have to deal with it for the rest of their life. This can affect the quality of life of the patients because of the long-term of hemodialysis therapy, this is one of the factors that affect the quality of life of the patients with chronic kidney disease. Quality of life is focused on the assessment of the individual against conditions acceptance. Each individual takes different phases to accept the condition. The purposes of the study were to determine if the relationship between the duration of hemodialysis and quality of life of the patients with chronic kidney disease at Gatoel Hospital Mojokerto. This research used cross-sectional design. The patient's population with chronic kidney disease undergoing hemodialysis is 150 people. The research sample is drawn using sampling techniques with the type of nonprobability purposive sampling with 130 people as a sample. Data obtained from questionnaires KDQoL 36. The result using Spearman rho test using SPSS V.16 shows p < α (0,006 < 0,05). H0 rejected, this means that there is a relationship between the duration of hemodialysis and quality of life with chronic kidney disease at Gatoel Hospital Mojokerto. The quality of life of the patients fluctuated based on the stage adaptation of the hemodialysis and disease. However, most patients with the duration of hemodialysis for more than 12 months had a sufficient quality of life and their therapy are already familiar with the symptoms and complications, but there are other factors that affect the quality of life such as gender, marital status, and education level. Patients are also expected to cooperate in what to do and not to do to improve the quality of life of the patients.

scholarly journals The effect of hypothyroidism on serum irisin level in patients with nondiabetic chronic kidney disease: A pilot study with a cross-sectional design

2018 ◽  
Vol 29 (4) ◽  
pp. 911
Author(s):  
JayaPrakash Sahoo ◽  
MilindMachhindra Patil ◽  
Sreejith Parameswaran ◽  
Sadishkumar Kamalanathan ◽  
Karthik Balachandran ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Pilot Study ◽  
Kidney Disease ◽  
Cross Sectional ◽  
Cross Sectional Design

scholarly journals Effect of Hemodialysis Adequacy on Quality of Life in Older adults with Chronic Kidney Disease

2021 ◽  
Vol 6 (1) ◽  
pp. 28
Author(s):  
Virgianti Nur Faridah ◽  
Muhamad Syukri Ghozali ◽  
Arifal Aris ◽  
Siti Sholikhah ◽  
Masunatul Ubudiyah
Keyword(s):  
Quality Of Life ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Statistical Tests ◽  
Life Assessment ◽  
P Value ◽  
Cross Sectional ◽  
Important Indicator ◽  
Spearman Test

Introduction: Assessment of hemodialysis adequacy is an important indicator to assess the effectiveness of hemodialysis measures that can affect the patient's quality of life with chronic kidney disease. This study aims to determine the relationship between adequate hemodialysis and the quality of life of patients with chronic kidney disease undergoing hemodialysis therapy.Method: This type of research is a correlational study with a cross sectional approach. The population in this study were 86 elderly patients who underwent hemodialysis at the Muhammadiyah Lamongan Hospital. In this study, the independent variables were adequate hemodialysis and quality of life as the dependent variable. Measurement of hemodialysis adequacy was carried out using the URR formula, and the assessment of quality of life using the SF 36 questionnaire. Data analysis methods used the Spearman test using SPSS Ver. 16Result: The results of measurement of adequacy of 86 respondents, namely 13.9% achieved adequate and 86% did not achieve adequacy. The results of the quality of life assessment showed that 17.4% had a good quality of life and 82.5% had a poor quality of life. The results of statistical tests showed that there was a significant relationship between adequate hemodialysis and quality of life (p value = 0.000).Conclusion: The role of nurses is very important in improving the quality of care in achieving adequate adequacy so that it will improve the quality of life in patients with chronic kidney disease undergoing hemodialysis therapy.

scholarly journals LONG OF HEMODIALYSIS THERAPY WITH QUALITY LIFE PATIENT FAILS OF KIDNEY CHRONIC IN RS GATOEL MOJOKERTO: STUDY CROSS-SECTIONAL

2017 ◽  
Vol 1 (1) ◽  
pp. 56-64
Author(s):  
Arif Wicaksono ◽  
Muhammad Sajidin
Keyword(s):  
Quality Of Life ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Cross Sectional ◽  
Quality Life ◽  
Cross Sectional Design ◽  
The Individual ◽  
The Relationship

Hemodialysis therapy of patients with chronic kidney disease can changes the patients physically, psychological, social and economics because they have to deal with it for the rest of their life. This can affect the quality of life of the patients because of the long-term of hemodialysis therapy, this is one of the factors that affect the quality of life of the patients with chronic kidney disease. Quality of life is focused on the assessment of the individual against conditions acceptance. Each individual takes different phases to accept the condition. The purposes of the study were to determine if the relationship between the duration of hemodialysis and quality of life of the patients with chronic kidney disease at Gatoel Hospital Mojokerto. This research used cross-sectional design. The patient's population with chronic kidney disease undergoing hemodialysis is 150 people. The research sample is drawn using sampling techniques with the type of nonprobability purposive sampling with 130 people as a sample. Data obtained from questionnaires KDQoL 36. The result using Spearman rho test using SPSS V.16 shows p < α (0,006 < 0,05). H0 rejected, this means that there is a relationship between the duration of hemodialysis and quality of life with chronic kidney disease at Gatoel Hospital Mojokerto. The quality of life of the patients fluctuated based on the stage adaptation of the hemodialysis and disease. However, most patients with the duration of hemodialysis for more than 12 months had a sufficient quality of life and their therapy are already familiar with the symptoms and complications, but there are other factors that affect the quality of life such as gender, marital status, and education level. Patients are also expected to cooperate in what to do and not to do to improve the quality of life of the patients.

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