The Potency of Senggani (Melastoma malabathricum L) Leaves in Repair of Pancreatic Beta Cells for Diabetes Mellitus Patients: A Narrative Review

Diabetes mellitus is often caused by damage to pancreatic beta cells which play a role in secreting insulin in the body. Damage to pancreatic beta cells causes the body to lack insulin. Dipeptidyl peptidase-4 (DPP-4) is a peptidase enzyme complex located on the surface of the cell membrane. Inhibition of the DPP4 enzyme will increase blood GLP-1 levels and induce regeneration of pancreatic beta cells. Senggani leaf (Melastoma malabathricum) boiled water is believed by the people of the Ciamis area to be used as a diabetes medicine. There have been many studies and reviews related to Senggani (Melastoma malabathricum) and its potential. This review focuses on the discussion of Senggani as an antidiabetic by analyzing the reduction in glucose levels and the repair ability of pancreatic beta cells. The results of the literature study that show that senggani leaves have the ability to reduce blood glucose levels and repair activity of pancreatic beta cells through the DPP-4 enzyme inhibition mechanism supported by molecular docking simulation data. There are 12 active compounds that have a binding site similarity above 50% with the comparison compound vildagliptin. Rutin is the best active compound which has a 100% similarity of the binding site. Based on in vivo research and toxicity analysis on the admetsar database, senggani leaf extract and active compounds of senggani leaves have low toxicity, making it safe to be used as antidiabetic herbal preparations.

Download Full-text

Efektivitas Ekstrak Ikan Gabus sebagai Antihiperglikemik

Jurnal Penelitian Perawat Profesional ◽

10.37287/jppp.v2i1.45 ◽

2020 ◽

Vol 2 (1) ◽

pp. 65-70

Author(s):

Firinda Soniya ◽

Milatul Fauziah

Keyword(s):

Diabetes Mellitus ◽

Amino Acids ◽

Beta Cells ◽

Pancreatic Beta Cells ◽

Cell Function ◽

Essential Amino Acids ◽

Glucose Levels ◽

The World ◽

Channa Striata ◽

Diabetes Melitus

Diabetes melitus merupakan penyakit metabolik yang ditandai dengan meningkatkan kadar glukosa darah atau penderita dalam kondisi hiperglikemik. Jumlah penderita diabetes melitus di dunia mengalami peningkatan setiap tahunnya. Laporan WHO pada tahun 2015 menunjukkan 422 juta orang mengalami kondisi diabetes melitus. Indonesia merupakan negara dengan penderita diabetes tertinggi ke-7 di dunia dengan prevalensi kasus pada tahun 2016 sebesar 12.2 juta orang. Ikan gabus (Channa striata) diketahui memiliki kandungan protein yang tinggi dan diketahui dapat dimanfaatkan sebagai sumber antioksidan antihiperglikemik maupun antidiabetes. Kadar protein dalam 100 gram ikan gabus dapat mencapai 25.2%. Terdapat 15 jenis asam amino yang ditemukan pada protein ikan gabus yang meliputi 9 jenis asam amino esensial berupa histidin, treonin, arginin, metionin, valin, fenialanin, leusin, isoleusin, dan lisin. Arginin bekerja dengan meningkatkan fungsi sel beta, meningkatkan pengeluaran energi dan sensitivitas insulin. Sedangkan leusin bekerja dalam transkripsi gen dan sintesis protein pada sel beta pankreas. Kandungan senyawa albumin pada ikan gabus juga dilaporkan memiliki aktivitas antioksidan pada sel beta pankreas. Kata kunci: channa striata, hiperglikemik, diabetes, asam amino EFFECTIVENESS OF SNAKEHEAD FISH (Channa striata) EXTRACT AS AN ANTI-HYPERGLYCEMIC ABSTRACT Diabetes mellitus is a metabolic disease characterized by increasing blood glucose levels or hyperglycemic conditions. The number of people with diabetes mellitus in the world has increasing every year. The WHO report in 2015 showing 422 million people had diabetes mellitus. Indonesia is the 7th highest diabetes sufferer in the world with a case prevalence in 2016 of 12.2 million people. Snakehead (Channa striata) has been sources have a high protein content and is known to be used as a source of antihyperglycemic and antidiabetic antioxidants. Protein levels in 100 grams of snakehead fish can reach 25.2%. There are 15 types of amino acids found in snakehead protein which include 9 types of essential amino acids in the form of histidine, threonine, arginine, methionine, valine, phenialanine, leucine, isoleucine, and lysine. Arginine works by increasing beta cell function, increasing energy expenditure and insulin sensitivity. Whereas leucine works in gene transcription and protein synthesis in pancreatic beta cells. The content of albumin compounds in snakehead fish is also reported to have antioxidant activity on pancreatic beta cells. Keyword : channa striata, hyperglycemic, diabetes, amino acids

Download Full-text

Effect of Pleurotus Ostreatus on Pancreatic Beta Cells of Diabetes Mellitus Mice Model

JURNAL ILMU KEFARMASIAN INDONESIA ◽

10.35814/jifi.v15i2.507 ◽

2017 ◽

Vol 15 (2) ◽

pp. 155 ◽

Cited By ~ 1

Author(s):

Ningrum Wahyuni ◽

Syafrudin Ilyas ◽

Alya Amila Fitrie

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Beta Cells ◽

Pleurotus Ostreatus ◽

Pancreatic Beta Cells ◽

Low Dose ◽

Ethanol Extract ◽

Glucose Levels ◽

Blood Glucose Levels ◽

One Way Anova

Over the last 30 years, the number of people suffering from diabetes mellitus has doubled globally. Adipose tissue dysfunction plays an important role in insulin resistance. Mushroom has been traditionally used to prevent diabetes. This research aims to study the anti-oxidative effect of Pleurotus ostreatus on pancreatic beta cells. This study is an experimental posttest only control group design. The subjects were 24 male wistar mice, divided into six groups. Group P0 was given distilled water and citrate buffer. Group P1 was given high fat diet (HFD) and low dose streptozotocin (STZ). Group P2 and 3 were given HFD and low dose STZ along with Pleurotus ostreatus ethanol extract. Group P4 and P5 were given HFD and low dose STZ, and then given Pleurotus ostreatus ethanol extract. Blood glucose levels and pancreatic beta cells area count were done after treatment. Data obtained was analyzed using one-way ANOVA test. One-way ANOVA test showed signifi cant difference in all the groups (p<0.05). Post Hoc test results showed difference in blood glucose levels and pancreatic beta cells area count. Pleurotus ostreatus ethanol extract can prevent cellular damage to murine pancreatic beta cells but unable to reverse the damage to the beta cells.

Download Full-text

PENGARUH PEMBERIAN SARI TOMAT (Solanum lycopersicum L) DAN INSULIN TERHADAP KADAR GLUKOSA, KADAR LDL, KADAR KOLESTEROL DAN BERAT BADAN LAHIR TIKUS PUTIH STRAIN WISTAR (Rattus Norvegicus) BUNTING DENGAN MODEL DIABETES MELLITUS TIPE 2

Journal Of Issues In Midwifery ◽

10.21776/ub.joim.2021.005.01.2 ◽

2021 ◽

Vol 5 (1) ◽

pp. 10-23

Author(s):

Faradea Ubaidurrohmah Savitri ◽

◽

Risma Andani Ayu Safitri ◽

Wening Pangesthi Maharani ◽

Lela Dwi Andriani ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Birth Weight ◽

Solanum Lycopersicum ◽

The Body ◽

Control Group ◽

Glucose Levels ◽

Solanum Lycopersicum L ◽

Cholesterol Levels

Diabetes Mellitus is a chronic disease caused by abnormal working insulin, insulin secretion or both so that the body tends to have high glucose levels. Type 2 diabetes mellitus can cause elevated levels of LDL and cholesterol. Risks obtained by fetuses with type 2 diabetes can be in the form of macrosomia due to hyperglycemia and hyperinsulin in the body of the fetus. Insulin is the first choice pharmacological therapy for type 2 DM that can be given during pregnancy. Non-pharmacological therapy as recommended by the World Health Organization (WHO) on a healthy diet by increasing consumption of fruits and vegetables. Good fruit consumed for pregnant women with diabetes mellitus (DM) type 2 is tomatoes (Solanum lycopersicum L). The purpose of this study was to determine the administration of tomato extract (Solanum lycopersicum L) and insulin can affect glucose levels, LDL levels, cholesterol levels and birth weight of white wistar galur (Rattus norvegicus) pregnant women with type 2 diabetes mellitus models. experimental design using the pre post test only control group design and post test only control group design. Termination was done on the 17th day of pregnancy and then followed by measurements of LDL levels, cholesterol and birth weight. Data analysis using the One Way Anova test and Kruskal Wallis then continued with the Post Hoc test using. The results showed that there were significant differences between glucose levels, LDL levels, cholesterol levels and BW born in the insulin treatment group and the tomato juice treatment (p value = 0.00 <α = 0.05). The conclusion of giving insulin and tomato juice affects a decrease in glucose levels, LDL levels, cholesterol levels and birth weight.

Download Full-text

Alterations in basal and glucose-stimulated voltage-dependent Ca2+ channel activities in pancreatic beta cells of non-insulin-dependent diabetes mellitus GK rats.

Journal of Clinical Investigation ◽

10.1172/jci118688 ◽

1996 ◽

Vol 97 (11) ◽

pp. 2417-2425 ◽

Cited By ~ 46

Author(s):

S Kato ◽

H Ishida ◽

Y Tsuura ◽

K Tsuji ◽

M Nishimura ◽

...

Keyword(s):

Diabetes Mellitus ◽

Beta Cells ◽

Pancreatic Beta Cells ◽

Insulin Dependent Diabetes Mellitus ◽

Insulin Dependent Diabetes ◽

Dependent Diabetes Mellitus ◽

Gk Rats ◽

Voltage Dependent ◽

Insulin Dependent

Download Full-text

Molecular Mechanism of Corticosteroid-Induced Hyperglycemia

Pharmacy Reports ◽

10.51511/pr.1 ◽

2021 ◽

Author(s):

Destika Ambar Sari ◽

Galih Samodra ◽

Ikhwan Yuda Kusuma

Keyword(s):

Skeletal Muscle ◽

Protein Kinase ◽

Beta Cells ◽

Pancreatic Beta Cells ◽

Immunosuppressive Drugs ◽

Hormone Sensitive Lipase ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Hormone Sensitive ◽

Beta Cell Response

Corticosteroids are widely used as strong anti-inflammatory and immunosuppressive drugs to treat various diseases. However, the use of corticosteroids can cause several side effects, such as hyperglycemia. This review aims to examine the effect of corticosteroids on increasing glucose in molecular levels based on literature studies. A literature searching was carried out on the PubMed, Science Direct, and Google Scholar databases published in 2010-2020. Corticosteroids can cause an increase in blood glucose levels by several mechanisms. In the liver, glucocorticoids increase endogenous plasma glucose and stimulate gluconeogenesis. Glucocorticoids increase the production of non-esterified fatty acids which affect the signal transduction of insulin receptor substrate-1 in skeletal muscle. In adipose, glucocorticoids increase lipolysis and visceral adiposity through increased transcription and expression of protein adipose triglyceride lipase and hormone-sensitive lipase. In pancreatic beta cells, glucocorticoids directly inhibit the beta cell response to glucose through the role of protein kinase B and protein kinase C. At the molecular level, corticosteroids can cause hyperglycemia through mechanisms in the liver, skeletal muscle tissue, adipose tissue, and pancreatic beta cells.

Download Full-text

STUDY OF HBA1C, LIPID PROFILE AND CYCLOPHILIN-A IN DIABETES MELLITUS

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v3i12.825 ◽

2019 ◽

Vol 3 (12) ◽

Author(s):

Rakesh Kumar Jha ◽

Badade ZG ◽

Sandeep Rai ◽

Badade VZ

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Lipid Profile ◽

Glycosylated Hemoglobin ◽

General Medicine ◽

Cyclophilin A ◽

The Body ◽

Glucose Levels

Introduction: Diabetes is a chronic disease that occurs when not enough insulin is produced by the pancreas or the body does not use the insulin produced. Because of increased blood glucose levels in the body, serious heart, kidneys, blood vessels, nerves and eyes damage are caused. Report says about 400 million people suffer from diabetes. Therefore present study is aimed to assess levels of HbA1c, Lipid profile and Cyclophilin A in diabetic patient. Material and Methods: The present study includes total 126 subjects comprising of 66 type 2 Diabetes Mellitus patients and 60 healthy individual. Blood samples are collected from the all subjects were processed for HbA1c, Lipid Profile and Cyclophilin A estimation, from OPD and General Medicine Wards. HbA1c is estimated by HPLC, lipid Profile by AU480 and the Cyclophilin A by ELISA method using commercially available Qayee-bio ELISA kit. Conclusion: Present study showed significantly increased levels of HbA1c, Lipid Profile and Cyclophilin A in T2DM patients. The elevated lipid profile may be due to the complication of Diabetic mellitus. CyA is increased as an inflammation marker. Keywords: T2DM: Type 2 diabetes mellitus, HbA1c: Glycosylated Hemoglobin, CyA: Cyclophilin-A

Download Full-text