scholarly journals Efektivitas Ekstrak Ikan Gabus sebagai Antihiperglikemik

2020 ◽  
Vol 2 (1) ◽  
pp. 65-70
Author(s):  
Firinda Soniya ◽  
Milatul Fauziah
Keyword(s):  
Diabetes Mellitus ◽  
Amino Acids ◽  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Cell Function ◽  
Essential Amino Acids ◽  
Glucose Levels ◽  
The World ◽  
Channa Striata ◽  
Diabetes Melitus

Diabetes melitus merupakan penyakit metabolik yang ditandai dengan meningkatkan kadar glukosa darah atau penderita dalam kondisi hiperglikemik. Jumlah penderita diabetes melitus di dunia mengalami peningkatan setiap tahunnya. Laporan WHO pada tahun 2015 menunjukkan 422 juta orang mengalami kondisi diabetes melitus. Indonesia merupakan negara dengan penderita diabetes tertinggi ke-7 di dunia dengan prevalensi kasus pada tahun 2016 sebesar 12.2 juta orang. Ikan gabus (Channa striata) diketahui memiliki kandungan protein yang tinggi dan diketahui dapat dimanfaatkan sebagai sumber antioksidan antihiperglikemik maupun antidiabetes. Kadar protein dalam 100 gram ikan gabus dapat mencapai 25.2%. Terdapat 15 jenis asam amino yang ditemukan pada protein ikan gabus yang meliputi 9 jenis asam amino esensial berupa histidin, treonin, arginin, metionin, valin, fenialanin, leusin, isoleusin, dan lisin. Arginin bekerja dengan meningkatkan fungsi sel beta, meningkatkan pengeluaran energi dan sensitivitas insulin. Sedangkan leusin bekerja dalam transkripsi gen dan sintesis protein pada sel beta pankreas. Kandungan senyawa albumin pada ikan gabus juga dilaporkan memiliki aktivitas antioksidan pada sel beta pankreas. Kata kunci: channa striata, hiperglikemik, diabetes, asam amino EFFECTIVENESS OF SNAKEHEAD FISH (Channa striata) EXTRACT AS AN ANTI-HYPERGLYCEMIC                                                                 ABSTRACT Diabetes mellitus is a metabolic disease characterized by increasing blood glucose levels or hyperglycemic conditions. The number of people with diabetes mellitus in the world has increasing every year. The WHO report in 2015 showing 422 million people had diabetes mellitus. Indonesia is the 7th highest diabetes sufferer in the world with a case prevalence in 2016 of 12.2 million people. Snakehead (Channa striata) has been sources have a high protein content and is known to be used as a source of antihyperglycemic and antidiabetic antioxidants. Protein levels in 100 grams of snakehead fish can reach 25.2%. There are 15 types of amino acids found in snakehead protein which include 9 types of essential amino acids in the form of histidine, threonine, arginine, methionine, valine, phenialanine, leucine, isoleucine, and lysine. Arginine works by increasing beta cell function, increasing energy expenditure and insulin sensitivity. Whereas leucine works in gene transcription and protein synthesis in pancreatic beta cells. The content of albumin compounds in snakehead fish is also reported to have antioxidant activity on pancreatic beta cells.  Keyword : channa striata, hyperglycemic, diabetes, amino acids

scholarly journals The Potency of Senggani (Melastoma malabathricum L) Leaves in Repair of Pancreatic Beta Cells for Diabetes Mellitus Patients: A Narrative Review

2020 ◽  
Vol 7 (2) ◽  
pp. 61-70
Author(s):  
Galuh Rizal Prayoga ◽  
Aziz Syamsul Huda ◽  
Syndilona Br Sitepu
Keyword(s):  
Diabetes Mellitus ◽  
Binding Site ◽  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Docking Simulation ◽  
The Body ◽  
Inhibition Mechanism ◽  
Active Compounds ◽  
Glucose Levels ◽  
Melastoma Malabathricum

Diabetes mellitus is often caused by damage to pancreatic beta cells which play a role in secreting insulin in the body. Damage to pancreatic beta cells causes the body to lack insulin. Dipeptidyl peptidase-4 (DPP-4) is a peptidase enzyme complex located on the surface of the cell membrane. Inhibition of the DPP4 enzyme will increase blood GLP-1 levels and induce regeneration of pancreatic beta cells. Senggani leaf (Melastoma malabathricum) boiled water is believed by the people of the Ciamis area to be used as a diabetes medicine. There have been many studies and reviews related to Senggani (Melastoma malabathricum) and its potential. This review focuses on the discussion of Senggani as an antidiabetic by analyzing the reduction in glucose levels and the repair ability of pancreatic beta cells. The results of the literature study that show that senggani leaves have the ability to reduce blood glucose levels and repair activity of pancreatic beta cells through the DPP-4 enzyme inhibition mechanism supported by molecular docking simulation data. There are 12 active compounds that have a binding site similarity above 50% with the comparison compound vildagliptin. Rutin is the best active compound which has a 100% similarity of the binding site. Based on in vivo research and toxicity analysis on the admetsar database, senggani leaf extract and active compounds of senggani leaves have low toxicity, making it safe to be used as antidiabetic herbal preparations.

Pemberian Pijat Refleksi Pada Penderita Diabetes Melitus Tipe Ii Dengan Masalah Keperawatan Ketidak Stabilan Kadar Gula Darah Di Tiyuh Dayaasri Tumijajar Tulang Bawang Barat

2021 ◽  
Vol 4 (1) ◽  
pp. 26-30
Author(s):  
Widia Afira ◽  
Prima Dian Furqoni ◽  
Rahma Elliya ◽  
Usastiawaty Cik Ayu Saadiah Isnainy ◽  
Eka Yudha Crisanto ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Sugar ◽  
International Diabetes Federation ◽  
Rest Period ◽  
The Body ◽  
Glucose Levels ◽  
The World ◽  
Reduce Blood Glucose ◽  
Diabetes Melitus

ABSTRAK Menurut International Diabetes Federation (IDF) (2015), saat ini Indonesia merupakan negara dengan urutan ke-7 jumlah penderita diabetes terbanyak di dunia yaitu sebanyak 10,0 juta jiwa, dan pada tahun 2020 diperkirakan penderita diabetes di Indonesia akan naik ke nomor enam terbanyak di dunia dengan jumlah penderita 16,2 juta jiwa, dan dilaporkan bahwa kota-kota besar seperti Jakarta, Surabaya, sudah hampir 10 % penduduknya menderita diabetes. Diabetes merupakan penyakit kronis yang serius dan terjadi baik saat pankreas tidak menghasilkan cukup insulin (hormon yang mengatur glukosa darah) maupun jika tubuh tidak dapat menggunakan insulin yang dihasilkan secara efektif. pengobatan bisa dilakukan secara non farmakologi, diantaranya dengan menggunakan terapi pijat refleksi. Tujuan setelah penyuluhan dan demonstrasi, diharapkan pemberian pijat refleksi dapat untuk menurunkan glukosa darah. Adapun kegiatan yang dilakukan berupa penyuluhan menggunakan leaflet dan demonstrasi terapi pijat refleksi. Terdapat penurunan gula darah pada klien diabetes melitus setelah pemberian terapi pijat refleksi selama 3 hari di Tiyuh Dayaasri Tumijajar Tulang bawang barat. Dari evaluasi hari terakhir pemeriksaan kadar glukosa darah terjadi penurunan yaitu antara sebelum diberikan terapi dan sesudah diberikan terapi, diperoleh data pada nilai glukosa darah sebelum diberikan asuhan keperawatan yaitu hari pertama GDS: 215 mg/dl, setelah diberikan intervensi pijat refleksi selama kurun waktu 3 hari dan di beri waktu istirahat selama 4 hari tetapi tetap dalam pengontrolan pola makan, untuk memberikan efek rileks kemudian di cek gula darah kembali di hari ke 7 (tujuh),  dari hasil pemeriksaan didapatkan yaitu GDS: 189 mg/dl. Saran agar dapat menerapkan terapi pijat refleksi kepada penderita diabetes melitus dan sebagai pengobatan alternatif untuk menjaga kestabilan glukosa darah, untuk mengurangi efek samping penggunaan obat jangka panjang. Dengan demikian, pemberian pijat refleksi pada klien diabetes melitus sangat efektif dalam menurunkan gula darah.Kata kunci : Diabetes Melitus, Gula Darah, Terapi Pijat Refleksi   ABSTRACT According to the International Diabetes Federation (IDF) (2015), Indonesia is currently the 7th largest number of diabetics in the world with 10.0 million people, and 2020 estimated that diabetics at Indonesia will rise to number 6th in the world with 16.2 million sufferers, and it is reported that big cities like Jakarta, Surabaya, already almost 10% the population suffer of diabetes. Diabetes is a serious chronic disease and occurs both when the pancreas does not produce enough insulin (a hormone that regulates blood glucose) or if the body cannot use insulin produced effectively. treatment can be non-pharmacologically, including by reflexology therapy. The purpose after counseling and demonstration, is expected to provide reflexology to reduce blood glucose. The activities carried out in the form of counseling used leaflets and demonstration of reflexology therapy. There is a decrease in blood sugar in diabetes mellitus clients after giving reflexology therapy for 3 days at Tiyuh Dayaasri Tumijajar West Tulang Bawang. From evaluation of the last day,examination of blood glucose levels there was a decrease between before being given therapy and after being given therapy, obtained data on blood glucose values before being given nursing care that is the first day of GDS: 215 mg / dl, after being given a reflexology intervention for a period of 3 days and given a rest period of 4 days but still in control of eating patterns, to provide a relaxing effect then checked for blood sugar again on day 7 (seven), from the examination results obtained namely GDS: 189 mg / dl. Suggestions for adjust reflexology therapy to people with diabetes mellitus and alternative treatment to maintain blood glucose stability, to reduce the side effects of long-term drug use. Thus, giving reflexology to diabetes mellitus's client is very effective of lowering blood sugar. Keywords: Diabetes Mellitus, Blood Sugar, Reflexology Therapy

The bimodal effect of interleukin 1 on rat pancreatic beta-cells – stimulation followed by inhibition – depends upon dose, duration of exposure, and ambient glucose concentration

1988 ◽  
Vol 119 (2) ◽  
pp. 307-311 ◽  
Author(s):  
Giatgen A. Spinas ◽  
Jerry P. Palmer ◽  
Thomas Mandrup-Poulsen ◽  
Henrik Andersen ◽  
Jens Høiriis Nielsen ◽  
...  
Keyword(s):  
Beta Cells ◽  
Insulin Release ◽  
Glucose Concentration ◽  
Pancreatic Beta Cells ◽  
Cell Function ◽  
Interleukin 1 ◽  
Glucose Levels ◽  
Lower Glucose ◽  
In Vivo Effects

Abstract. To investigate the hypothesis that interleukin 1 initially stimulates and then suppresses beta-cell function and that this sequential effect is directly related to interleukin 1 dose, duration of exposure, and ambient glucose concentration, insulin release was measured from cultured newborn rat islets exposed for 6 h to 6 days to interleukin 1 at doses ranging from 20 to 2000 ng/l at glucose concentrations of 3.3, 5.5 and 11 mmol/l. After 6 h of exposure and at all three glucose levels, all doses of interleukin 1 stimulated insulin release, maximal stimulation (370% of control) being observed at 5.5 mmol/l glucose and 100 ng/l interleukin 1. In contrast, after 6 days, all doses of interleukin 1 were inhibitory irrespective of glucose level, maximal inhibition (90%) being observed at 11 mmol/l glucose and 2000 ng/l interleukin 1. At 24 and 48 h of exposure, the biphasic effect of interleukin 1 was observed: lower doses of interleukin 1 at lower glucose concentrations at 24 h being more stimulatory with transition to inhibition directly related to higher glucose levels, higher interleukin 1 doses, and longer exposure. After 48 h, 200 ng/l of interleukin 1 increased insulin release to 220% at 3.3 mmol/l glucose, but at 11 mmol/l glucose a 60% suppression was seen. On the basis of these data we suggest that interleukin l's effect on beta-cells is bimodal: stimulation followed by inhibition. Increasing interleukin 1 dose and ambient glucose concentration shift this response to the left. Experimental results will, and in vivo effects may, depend upon these three variables.

scholarly journals Amino acid transformation of oscillatory Ca2+ signals in mouse pancreatic beta-cells

1999 ◽  
Vol 160 (2) ◽  
pp. 191-195 ◽  
Author(s):  
M Ahmed ◽  
E Grapengiesser ◽  
B Hellman
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Cell Function ◽  
Rhythmic Activity ◽  
Oscillatory Activity ◽  
Voltage Dependent ◽  
Individual Mouse ◽  
Amino Acid Concentrations

Glucose-induced increase of cytoplasmic Ca2+ in pancreatic beta-cells is usually manifested as slow oscillations from the basal level. The significance of this rhythmicity for maintaining normal beta-cell function with periodic variations of circulating insulin made it of interest to investigate how the oscillatory Ca2+ signal was affected by various amino acids. Individual mouse beta-cells were very sensitive to alanine, glycine and arginine, sometimes responding with a transformation of the oscillations into sustained elevation of cytoplasmic Ca2+ at amino acid concentrations as low as 0.1 mM. Stimulation of the entry of Ca2+, obtained either by raising the extracellular concentration or by prolonging the open state of the voltage-dependent Ca2+ channels with BAY K 8644, resulted in reappearance of the rhythmic activity in the presence of the amino acids. Oscillatory Ca2+ signals in intact islets were more resistant to transformation by amino acids than those of individual beta-cells. It is therefore suggested that signals from the adjacent cells make it possible for beta-cells situated in islets to overcome a suppression of the oscillatory activity otherwise seen in the presence of alanine, glycine or arginine.

scholarly journals Penyuluhan manfaat buah naga merah dalam menurunkan kadar gula darah pada penderita diabetes melitus

2020 ◽  
Vol 1 (2) ◽  
pp. 89-94
Author(s):  
Eka Yudha Chrisanto ◽  
Megah Rachmawati ◽  
Rika Yulendasari
Keyword(s):  
Diabetes Mellitus ◽  
Fruit Juice ◽  
International Diabetes Federation ◽  
Glucose Levels ◽  
Dragon Fruit ◽  
The World ◽  
Diabetes Melitus

Abstrak. Menurut International Diabetes Federation (IDF) pada tahun 2015, prevalensi jumlah DM di dunia sebesar 8,8 persen dengan jumlah penderita sebesar 415 juta penderita dan pada 2040 diperkirakan akan meningkat sejumlah 642 juta penderita (10,4 persen) (IDF, 2015). Sedangkan Indonesia menempati peringkat ke-7 penderita diabetes terbanyak di dunia. Salah satu buah yang dapat dimanfaatkan untuk perbaikan diet penderita diabetes melitus adalah buah naga yang memiliki keunggulan yaitu kaya serat dan antioksidan. Tujuan setelah penyuluhan dan demonstrasi, diharapkan pembuatan jus buah naga merah dapat untuk menurunkan kadar glukosa pada klien diabetes melitus. Adapun kegiatan yang dilakukan berupa penyuluhan menggunakan leaflet dan demonstrasi pemberian buah naga merah. Terdapat penurunan kadar glukosa pada klien diabetes melitus setelah pemberian buah naga merah selama 10 hari di Bandar Lampung. Dengan demikian, pemberian buah naga merah pada klien diabetes melitus sangat efektif dalam menurunkan glukosa.  Abstract: According to the International Diabetes Federation (IDF) in 2015, the prevalence of DM in the world (8.8 percent) with the number of sufferers at 415 million and 2040 it was expected to increase by 642 million patients (10.4 percent). While Indonesia ranks 7th most diabetics in the world. One of the fruits that can be used to improve the diet of diabetics is a dragon fruit that has the advantage of being rich in fiber and antioxidants. The Purpose after counseling and demonstration is expected to make red dragon fruit juice can reduce glucose levels in diabetes mellitus clients. The activities carried out in the form of counseling using leaflets and demonstrations giving red dragon fruit. There is a decrease in glucose levels in diabetes mellitus clients after giving red dragon fruit for 10 days at Bandar Lampung. Thus, giving red dragon fruit to diabetes mellitus clients is very effective in reducing glucose. 

scholarly journals Effect of Pleurotus Ostreatus on Pancreatic Beta Cells of Diabetes Mellitus Mice Model

2017 ◽  
Vol 15 (2) ◽  
pp. 155 ◽  
Author(s):  
Ningrum Wahyuni ◽  
Syafrudin Ilyas ◽  
Alya Amila Fitrie
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Beta Cells ◽  
Pleurotus Ostreatus ◽  
Pancreatic Beta Cells ◽  
Low Dose ◽  
Ethanol Extract ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
One Way Anova

Over the last 30 years, the number of people suffering from diabetes mellitus has doubled globally. Adipose tissue dysfunction plays an important role in insulin resistance. Mushroom has been traditionally used to prevent diabetes. This research aims to study the anti-oxidative effect of Pleurotus ostreatus on pancreatic beta cells. This study is an experimental posttest only control group design. The subjects were 24 male wistar mice, divided into six groups. Group P0 was given distilled water and citrate buffer. Group P1 was given high fat diet (HFD) and low dose streptozotocin (STZ). Group P2 and 3 were given HFD and low dose STZ along with Pleurotus ostreatus ethanol extract. Group P4 and P5 were given HFD and low dose STZ, and then given Pleurotus ostreatus ethanol extract. Blood glucose levels and pancreatic beta cells area count were done after treatment. Data obtained was analyzed using one-way ANOVA test. One-way ANOVA test showed signifi cant difference in all the groups (p<0.05). Post Hoc test results showed difference in blood glucose levels and pancreatic beta cells area count. Pleurotus ostreatus ethanol extract can prevent cellular damage to murine pancreatic beta cells but unable to reverse the damage to the beta cells.

scholarly journals Diabetes mellitus in childhood: an emerging condition in the 21st century

2016 ◽  
Vol 62 (6) ◽  
pp. 594-601 ◽  
Author(s):  
Thais Della Manna ◽  
Nuvarte Setian ◽  
Roberta Diaz Savoldelli ◽  
Dulce Rondina Guedes ◽  
Hilton Kuperman ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Cell Function ◽  
Meta Analysis ◽  
Vascular Complications ◽  
International Diabetes Federation ◽  
Public Health Problem ◽  
Pediatric Diabetes ◽  
Genetic And Environmental Factors

Summary The International Diabetes Federation (IDF-2015) estimates the existence of 30,900 children under 15 years old with type 1 diabetes mellitus (DM1) in Brazil, and an increase of 3.0% per year is expected. This review focused on meta-analysis and pediatric diabetes update articles in order to draw attention to the need of planning coping strategies to support this serious public health problem in coming years. DM1 is considered an immuno-mediated disease with a complex transmission influenced by genetic and environmental factors responsible for a gradual destruction of the insulin producing pancreatic beta cells. Seroconversion to DM1-associated autoantibodies and abnormalities in metabolic tests that assess insulin secretion and glucose tolerance can be used as predictive criteria of beta cells functional reserve and the onset of the clinical disease. Symptomatic DM1 treatment is complex and the maintenance of good metabolic control is still the only effective strategy for preserving beta cell function. Disease duration and hyperglycemia are both risk factors for the onset of chronic vascular complications that negatively affect the quality of life and survival of these patients. In this regard, health teams must be trained to provide the best possible information on pediatric diabetes, through continuing education programs focused on enabling these young people and their families to diabetes self-management.

scholarly journals Natural history of glucose tolerance, beta-cell function and peripheral insulin sensitivity in cystic fibrosis patients with fasting euglycemia

2003 ◽  
Vol 149 (1) ◽  
pp. 53-59 ◽  
Author(s):  
F Lombardo ◽  
F De Luca ◽  
M Rosano ◽  
C Sferlazzas ◽  
C Lucanto ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Insulin Sensitivity ◽  
Natural History ◽  
Glucose Tolerance ◽  
Pancreatic Beta Cells ◽  
Cell Function ◽  
Glucose Levels ◽  
Peripheral Insulin Resistance ◽  
History Of ◽  
Over Time

OBJECTIVE: The loss of pancreatic beta-cells is thought to be one of the principal causes of diabetes mellitus (DM) in cystic fibrosis (CF), but the role of peripheral insulin resistance (IR) in the pathogenesis of DM in CF remains unclear. The aim of this study was to evaluate whether eventual changes of glucose tolerance (GT) over time were associated with modifications of insulin secretion or sensitivity. METHODS: Plasma glucose and insulin responses to an oral GT test (OGTT) were investigated and reinvestigated 13 Years later in 14 CF patients with initial and persistent fasting euglycemia and no history of insulin treatment. Insulin sensitivity (IS) at both tests was assessed on the basis of insulin and glucose levels both in the fasting state and during OGTTs. RESULTS: From the 1st to the 2nd OGTT: (a) the prevalence of DM responses significantly increased; (b) the areas beneath the respective glucose and insulin curves significantly increased and decreased respectively; (c) IR and IS indices decreased and increased respectively, even in the patients who developed DM; (d) pulmonary function significantly worsened in the entire series, especially in the patients who developed DM. CONCLUSIONS: (i) the natural history of glyco-metabolic status in CF is characterized by deteriorating GT over time; (ii) insulinopenia plays a prominent role in the pathogenesis of GT worsening; (iii) IR does not play any significant part in the pathogenesis of DM development; (iv) deterioration of lung function tests is more severe in the subjects who develop DM over time.

scholarly journals PENGARUH JUS LIDAH BUAYA TERHADAP KADAR GLUKOSA DARAH PUASA DAN 2 JAM PP(Post Prandial) PADA PENDERITA DIABETES MELITUS

2019 ◽  
Vol 10 (1) ◽  
pp. 77
Author(s):  
Febria Syafyu Sari ◽  
Ridhyalla Afnuhazi
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Sugar ◽  
Fasting Blood Glucose ◽  
Aloe Vera ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Patients With Diabetes ◽  
Paired T Test ◽  
Diabetes Melitus

ABSTRAK Diabetes Melitus merupakan penyakit yang paling menonjol yang disebabkan oleh gagalnya pengaturan gula darah. Lidah buaya berkhasiat untuk menurunkan kadar gula dalam darah bagi penderita diabetes dan dapat mengontrol tekanan darah. Tujuan penelitian untuk mengetahui pengaruh jus lidah buaya (AloeBarbadensis Miller) terhadap penurunan glukosa darah puasa GDP) dan 2 Jam PP (Post Prendial) pada penderita DM (Diabetes Melitus). Desain penelitian merupakan Quasi Eksperimental dengan pendekatan one group pretest – postest design. Sampel terbagi menjadi 14 responden. Data dianalisis dengan paired t-test. Hasil menunjukan rata-rata penurunan glukosa darah puasa pada intervensi (28,42 gr/dl) dan glukosa darah 2 jam pp pada intervensi (40,57 gr/dl). Untuk analisis bivariat terdapat perbedaan antara glukosa puasa dan 2 jam pp dengan glukosa darah puasa GDP) dan 2 Jam PP (Post Prendial) pada penderita DM (Diabetes Melitus). Kesimpulan didapatkanlidah buaya dapat menurunkan kadar glukosa darah.Berdasarkan hasil penelitian jus lidah buaya dapat menjadi salah satu alternatif keperawatan non farmakologi dalam penyakit diabetes melitus. Kata Kunci : Lidah Buaya ; Diabetes Mellitus THE EFFECT OF VEGETABLE VOCATIONAL JUICE ON FAST BLOOD GLUCOSE LEVELS AND 2 HOURS OF PP (Post Prandial) IN DIABETES MELLITUS  ABSTRACT Diabetes mellitus is the most prominent disease caused by the failure of blood sugar regulation. Aloe vera is efficacious can to  reduce blood sugar levels for diabetics and can control blood pressure. The purpose of this study was to determine the effect of Aloe Barbadensis Miller on the reduction of fasting blood glucose GDP and 2 hours of PP (post prendial) in patients with diabetes mellitus. The research design is Experimental Quasi with one group pretest - postest design approach. The sample is divided into 14 respondents. Data were analyzed by paired t-test. The results showed an average decrease in fasting blood glucose at intervention (28.42 gr / dl) and 2 hours pp blood glucose at intervention (40.57 gr / dl). For bivariate analysis there was a difference between fasting glucose and 2 hours pp with fasting blood glucose GDP) and 2 hours PP (Post Prendial) in patients with diabetes mellitus. The conclusion is that aloe vera can reduce blood glucose levels. Based on the results of research on aloe vera juice can be an alternative non-pharmacological nursing in diabetes mellitus. Keywords: Aloe Vera ; Diabetes Mellitus

scholarly journals Multi-Organ Crosstalk with Endocrine Pancreas: A Focus on How Gut Microbiota Shapes Pancreatic Beta-Cells

Biomolecules ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 104
Author(s):  
Elisa Fernández-Millán ◽  
Carlos Guillén
Keyword(s):  
Beta Cell ◽  
Beta Cells ◽  
Cell Biology ◽  
Pancreatic Beta Cells ◽  
Metabolic Diseases ◽  
Cell Function ◽  
Cell Mass ◽  
Beta Cell Mass ◽  
Short Chain Fatty Acids

Type 2 diabetes (T2D) results from impaired beta-cell function and insufficient beta-cell mass compensation in the setting of insulin resistance. Current therapeutic strategies focus their efforts on promoting the maintenance of functional beta-cell mass to ensure appropriate glycemic control. Thus, understanding how beta-cells communicate with metabolic and non-metabolic tissues provides a novel area for investigation and implicates the importance of inter-organ communication in the pathology of metabolic diseases such as T2D. In this review, we provide an overview of secreted factors from diverse organs and tissues that have been shown to impact beta-cell biology. Specifically, we discuss experimental and clinical evidence in support for a role of gut to beta-cell crosstalk, paying particular attention to bacteria-derived factors including short-chain fatty acids, lipopolysaccharide, and factors contained within extracellular vesicles that influence the function and/or the survival of beta cells under normal or diabetogenic conditions.

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