scholarly journals Combined Effects of Regular Aerobic Exercise with Vitamin D Supplementation on Some Apoptosis Indices in the Lung of Rats Exposed to Hydrogen Peroxide

2019 ◽  
Vol 13 (5) ◽  
pp. 44-49
Author(s):  
somayeh ramezani ◽  
Maghsoud peeri ◽  
Mohammad Ali Azarbaijani ◽  
Firoozeh Dehghan ◽  
◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Vitamin D ◽  
Aerobic Exercise ◽  
Vitamin D Supplementation ◽  
Combined Effects

scholarly journals Effect of Eight Weeks Aerobic Exercise and Vitamin-D Supplementation on Osteocalcin and Alkaline Phosphatase Gene Expression in Male Rats Poisoned with Hydrogen Peroxide

2021 ◽  
Author(s):  
Ramin Eimari Eskandari ◽  
Hassan Matin Homaee ◽  
Lida Moradi
Keyword(s):  
Gene Expression ◽  
Hydrogen Peroxide ◽  
Vitamin D ◽  
Alkaline Phosphatase ◽  
Aerobic Exercise ◽  
Bone Tissue ◽  
Interactive Effect ◽  
Systemic Effect ◽  
Vitamin D Supplementation ◽  
Male Rats

Introduction: Free radicals increase with age and disease, so the aim of this study was to investigate the effect of exercise and vitamin D on the expression of alkaline phosphatase and osteocalcin genes in bone tissue of rats poisoned with hydrogen peroxide. Methods: In this experimental trial, 36 adult male Wistar rats were randomized into six groups of six rats, 1) control; 2) hydrogen peroxide; 3) hydrogen peroxide + vitamin D; 4) hydrogen peroxide + exercise; 5) hydrogen peroxide + exercise and vitamin D and 6) Sham. For eight weeks, groups 2, 3, 4, and 5 were given daily dose of 1 mmol/kg hydrogen peroxide on even days, groups 3 and 5 received 0.5 mg / kg of Vitamin-D daily, and sham group received only vitamin D solvent intraperitoneally. Groups 4 and 5 performed aerobic exercise 3 day/week. Osteocalcin and alkaline phosphatase gene expression were measured by PCR and were analyzed using independent t-test, two-way analysis of variance and Boferroni’s post hoc test with SPSS 16 (p≤0.05). Results: The interactive effect of exercise and vitamin D on increasing alkaline phosphatase and osteocalcin was significant. (p≤0.05); exercise increased alkaline phosphatase and osteocalcin (p ≤ 0.05); vitamin D was also associated with increased alkaline phosphatase and osteocalcin (p=0.0001). The greatest effect on increasing osteocalcin and alkaline phosphatase showed in groups 5 and 3, respectively (p=0.001). Conclusion: Exercise and vitamin D had a positive effect on bone tissue, so that even the systemic effect of hydrogen peroxide could not change the results of this constructive effect.

scholarly journals The short-term effect of vitamin D supplementation on the response to muscle and liver damages indices by exhaustive aerobic exercise in untrained men: a quasi-experimental study

2022 ◽  
Vol 14 (1) ◽  
Author(s):  
Vahid Parvizi Mastali ◽  
Rastegar Hoseini ◽  
Mohammad Azizi
Keyword(s):  
Vitamin D ◽  
Aerobic Exercise ◽  
Repeated Measures ◽  
Vitamin D Supplementation ◽  
T Test ◽  
Gamma Glutamyl Transferase ◽  
Fat Percentage ◽  
Short Term ◽  
Damage Indices ◽  
Glutamyl Transferase

Abstract Background Exercise-induced muscle damage typically caused by unaccustomed exercise results in pain, soreness, inflammation, and muscle and liver damages. Antioxidant supplementation might be a useful approach to reduce myocytes and hepatocytes damages. Therefore, the present study was conducted to investigate the effect of short-term vitamin D (Vit D) supplementation on the response to muscle and liver damages indices by Exhaustive Aerobic Exercise (EAE) in untrained men. Methods In this clinical trial, 24 untrained men were randomly divided into experimental (Exp; n = 12) and control (C; n = 12) groups. Exp received 2000 IU of Vit D daily for six weeks (42 days), while C daily received a lactose placebo with the same color, shape, and warmth percentage. Two bouts of EAE were performed on a treadmill before and after six weeks of supplementation. Anthropometric characteristics (Bodyweight (BW), height, Body Fat Percentage (BFP), Body Mass Index (BMI), waist to hip ratio (WHR)) were measured at the Pre 1 and Pre 2. Blood samples were taken to measure the Creatine Kinase (CK), Lactate Dehydrogenase (LDH), Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Gamma-Glutamyl Transferase (GGT), Alkaline Phosphatase (ALP), and Vit D levels at four stages: Pre 1 (before the first EE session), Post 1 (after the first EE session), Pre 2 (before the second EE session), and Post 2 (after the second EE session). The data were analyzed using repeated-measures ANOVA, Bonferroni's post hoc test, independent t test, and dependent t-test at the significant level of P < 0.05 using SPSS version 26. Results The results show significant differences between Exp and C in alterations of BW (P = 0.039), BMI (P = 0.025), BFP (P = 0.043), and WHR (P = 0.035). The results showed that EAE increased muscle and liver damage indices and Vit D (P < 0.05). Compared with C, the results of the independent t-test showed significantly lower ALT (P = 0.001; P = 0.001), AST (P = 0.011; P = 0.001), GGT (P = 0.018; P = 0.001), and ALP (P = 0.001; P = 0.001); while significantly higher Vit D (P = 0.001, P = 0.001) in the Exp in both Pre 2 and Post 2; receptivity. The independent t test showed significantly lower ALT (P = 0.001; P = 0.001), AST (P = 0.011; P = 0.001), GGT (P = 0.018; P = 0.001), and ALP (P = 0.001; P = 0.001) and considerably greater Vit D (P = 0.001, P = 0.001) in the Exp in both Pre 2 and Post 2 compared to C. The results of an independent t test showed that LDH and CK levels in the Exp were significantly lower than those in the Post 2 (P = 0.001). Conclusions Short-term Vit D supplementation could prevent myocytes and hepatocytes damage induced by EAE.

scholarly journals The interaction effect of aerobic exercise and vitamin D supplementation on inflammatory factors, anti-inflammatory proteins, and lung function in male smokers: a randomized controlled trial

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Leila Nikniaz ◽  
Morteza Ghojazadeh ◽  
Hooman Nateghian ◽  
Zeinab Nikniaz ◽  
Mahdieh Abbasalizad Farhangi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Lung Function ◽  
Aerobic Exercise ◽  
Serum Levels ◽  
Vitamin D Supplementation ◽  
Inflammatory Factors ◽  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D ◽  
Tnf Α ◽  
Inflammatory Proteins

Abstract Background This study aimed to investigate the interaction effect of aerobic exercise and vitamin D supplementation on inflammation (TNF-α, IL-6, CC16, SP-D, and CC16/SP-D ratio) and lung function (FEV1, FVC, and FEV1/FVC ratio) in male smokers. Methods After applying inclusion criteria, a total of 40 healthy male smokers were recruited in this study. The participants were randomly divided into four groups as follows: Aerobic Exercise + vitamin D Supplementation (AE + VitD, n = 10), Aerobic Exercise (AE, n = 10), vitamin D Supplementation (VitD, n = 10), and Control (C, n = 10). The participants in the AE + VitD and AE groups performed aerobic exercise training (running) up to 50% of the maximum heart rate, three times a week for four weeks. Participants in AE + VitD and VitD groups received 6000 IU/w vitamin D3 for four weeks. The participants in control group did not receive any intervention. Serum tumor necrosis factor (TNF)-α, interleukin (IL)-6, Clara cell protein (CC16), surfactant protein (SP)-D, CC16/SP-D ratio, and lung function (FEV1, FVC, and FEV1/FVC ratio) were measured before and after four weeks of intervention. Results Serum levels of TNF-α, IL-6, and CC16 decreased significantly in AE + VitD, VitD, and AE groups after four weeks (P < 0.05). Serum SP-D level decreased significantly only in the AE + VitD group (P = 0.011). In addition, FEV1 and FVC increased significantly (P < 0.05) in AE + VitD and AE groups after four weeks of intervention. However, the interventions did not have a significant effect on CC16/SP-D ratio and FEV1/FVC ratio (P > 0.05). Furthermore, serum levels of 1,25-dihydroxyvitamin D increased significantly in AE + VitD and VitD groups (P < 0.05) after four weeks of intervention. However, except for TNF-α, between-group comparisons showed no significant differences in levels of IL-6, CC16, SP-D, CC16/SP-D ratio, FEV1, FVC, FEV1/FVC, and 1,25-dihydroxyvitamin D (P > 0.05). Conclusions The results of present study were that aerobic exercise combined with vitamin D supplementation can reduce serum inflammatory factors and anti-inflammatory proteins and improve lung function after four weeks of intervention. Further trials with larger sample size and longer duration are suggested to confirm these results. Trial registration Retrospectively registered. IRCT20180513039637N4. Registration date: 2020/10/20. URL: https://www.irct.ir/search/result?query=IRCT20180513039637N4

scholarly journals The effect of aerobic exercise and vitamin D supplementation on inflammatory factors, anti-inflammatory proteins, and lung function in male smokers: A randomized controlled trial

2020 ◽  
Author(s):  
Leila Nikniaz ◽  
Morteza Ghojazadeh ◽  
Hooman Nateghian ◽  
Mahdieh Abbasalizadeh Farhangi ◽  
Hadi pourmanaf
Keyword(s):  
Vitamin D ◽  
Lung Function ◽  
Aerobic Exercise ◽  
Vitamin D Supplementation ◽  
Inflammatory Factors ◽  
Cell Protein ◽  
Control Group ◽  
Tnf Α ◽  
Inflammatory Proteins ◽  
Anti Inflammatory

Abstract BackgroundThis study aimed to investigate the effect of aerobic exercise and vitamin D supplementation on inflammation (TNF-α, IL-6, CC16, SP-D, and CC16/SP-D ratio) and lung function (FEV1, FVC, and FEV1/FVC ratio) in male smokers.MethodsAfter applying inclusion criteria, a total of 40 healthy male smokers were recruited in this study. The subjects were randomly divided into four groups as follows: Aerobic Exercise + vitamin D Supplementation (AE + VitD, N = 10), Aerobic Exercise (AE, N = 10), vitamin D Supplementation (VitD, N = 10), and Control (C, N = 10). The subjects in the AE + VitD and AE groups performed aerobic exercise training (running) up to 50% of heart rate (HR) max, three times a week for four weeks. Subjects in AE + VitD and VitD groups received 6000 UI/w vitamin D3 for four weeks. The subjects in control group did not receive any intervention. Serum tumor necrosis factor (TNF)-α, interleukin (IL)-6, Clara cell protein (CC16), surfactant protein (SP)-D, CC16/SP-D ratio, and lung function (FEV1, FVC, and FEV1/FVC ratio) were measured before and after four weeks of intervention.ResultsSerum levels of TNF-α, IL-6, CC16, and SP-D decreased significantly in AE + VitD and AE groups after four weeks (P < 0.05), but serum SP-D level in the AE group did not decrease significantly. In addition, FEV1 and FVC increased significantly (P < 0.05) in AE + VitD and AE groups after four weeks of intervention. However, AE + VitD and AE did not have a significant effect on CC16/SP-D ratio and FEV1/FVC ratio. Furthermore, serum levels of TNF-α, IL-6, and CC16 decreased significantly after vitamin D supplementation (P < 0.05).ConclusionsThe results of present study demonstrates that aerobic exercise combined with vitamin D supplementation can reduce inflammatory factors and anti-inflammatory proteins in the blood and improve lung function after four weeks. Further larger trials with higher sample size and longer duration are suggested to confirm these results.Trial registrationRetrospectively registered. IRCT20180513039637N4. Registration date: 2020/10/20. URL: https://www.irct.ir/search/result?query=IRCT20180513039637N4

scholarly journals Combined Effects of Vitamin D Supplementation and Endurance Exercise Training on Insulin Resistance in Newly Diagnosed type 2 Diabetes Mellitus Patients with Vitamin D Deficiency : Study Protocol for a Randomized Controlled Trial

2021 ◽  
Author(s):  
Mi Xiang ◽  
Xiaomin Sun ◽  
Junxiang Wei ◽  
Zhen-Bo Cao
Keyword(s):  
Vitamin D ◽  
Exercise Training ◽  
Vitamin D Deficiency ◽  
Endurance Exercise ◽  
Controlled Trial ◽  
Ankle Brachial Index ◽  
Training Group ◽  
Vitamin D Supplementation ◽  
Control Group ◽  
Combined Effects

Abstract BackgroundAlthough approximately 50% of Chinese T2DM patients have vitamin D deficiency, studies regarding vitamin D supplementation on IR have mainly focused on non-Asians. Endurance exercise training (ET) enhances insulin-mediated glucose metabolism, which plays a critical role in T2DM prevention and control. However, the combined effects of vitamin D supplementation and ET on IR in T2DM patients are unclear.Methods and analysisWe propose a randomized controlled trial among 60 T2DM patients with vitamin D deficiency to evaluate the combined effects of vitamin D supplementation and endurance training on IR. The participants will be randomly allocated to the vitamin D group, vitamin D combined with exercise training group, exercise training group, and control group (CG) using a computer-generated random number sequence. At baseline, participants will undergo a medical review, anthropometric measurements, dual X-ray absorptiometry, a 75-g oral glucose tolerance test, ankle-brachial index measurements, and physical fitness measurements and will complete related lifestyle questionnaires. In a 3-month intervention period, vitamin D intervention group will receive a dose of 1000IU daily; exercise group will perform a 1-hour endurance exercise 3 times per week (maximal heart rate, 60%–80%), and the control group will receive apparently identical tablets. Additionally, all participants will be advised to maintain their normal diet and physical activities during the intervention. All measurements will be repeated at 3-month follow-up after the intervention with the primary outcome measure expressed as a change from baseline in insulin sensitivity and secretion. Secondary outcome measures will compare the changes in anthropometry, ankle-brachial index, and physical fitness factors. Data will be managed and analyzed using the Statistical Package for the Social Sciences.DiscussionThis is the first study to conduct a randomized trial to clearly determine the independent and combined effects of vitamin D supplementation and endurance exercise trial on IR in Chinese T2DM patients as measured by OGTT. The findings from the proposed study will not only provide new evidences that vitamin D supplementation plays an important role in reducing IR but also develop a simple and efficient method to improve IR and associated metabolic diseases for T2DM patients.Trial registrationChinese Clinical Trial Registry, ChiCTR1800015383, Registered 28 March 2018, http://www.chictr.org.cn

scholarly journals Combined effects of vitamin D supplementation and endurance exercise training on insulin resistance in newly diagnosed type 2 diabetes mellitus patients with vitamin D deficiency: study protocol for a randomized controlled trial

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Mi Xiang ◽  
Xiaomin Sun ◽  
Junxiang Wei ◽  
Zhen-Bo Cao
Keyword(s):  
Vitamin D ◽  
Exercise Training ◽  
Endurance Exercise ◽  
Controlled Trial ◽  
Ankle Brachial Index ◽  
Training Group ◽  
Vitamin D Supplementation ◽  
Control Group ◽  
Combined Effects ◽  
And Control

Abstract Background Although approximately 50% of Chinese with type 2 diabetes mellitus (T2DM) patients have vitamin D deficiency, studies regarding vitamin D supplementation on insulin resistance (IR) have mainly focused on non-Asians. Endurance exercise training (ET) enhances insulin-mediated glucose metabolism, which plays a critical role in T2DM prevention and control. However, the combined effects of vitamin D supplementation and ET on IR in T2DM patients are unclear. The objectives of this study is to investigate the synergistic effect of vitamin D supplementation combined with exercise training intervention on IR in T2DM patients. Methods and analysis We propose a 3-month randomized controlled trial among 60 T2DM patients aged 40–65, newly diagnosed with T2DM ≤ 1 year, and with stable HbA1c level (≤ 8.0%) in the past 3 months. The participants will be randomly allocated to the vitamin D group, vitamin D combined with exercise training group, exercise training group, and control group (CG) using a computer-generated random number sequence. At baseline, participants will undergo a medical review, anthropometric measurements, dual X-ray absorptiometry, a 75-g oral glucose tolerance test (OGTT), ankle-brachial index measurements, and physical fitness measurements and will complete related lifestyle questionnaires. Fasting blood lipid and glucose levels were also measured. In a 3-month intervention period, vitamin D intervention group will receive a dose of 1000 IU daily; exercise group will perform a 1-h endurance exercise 3 times per week (maximal heart rate, 60–80%), and the control group will receive apparently identical tablets. Additionally, all participants will be advised to maintain their normal diet and physical activities during the intervention. All measurements will be repeated at 3-month follow-up after the intervention with the primary outcome measure expressed as a change from baseline in insulin sensitivity and secretion. Secondary outcome measures will compare the changes in anthropometry, ankle-brachial index, and physical fitness factors (e.g., peak oxygen uptake, hand grip strength). Data will be managed and analyzed using the Statistical Package for the Social Sciences. Discussion This is the first study to conduct a randomized trial to clearly determine the independent and combined effects of vitamin D supplementation and endurance exercise trial on IR in Chinese T2DM patients as measured by OGTT. The findings from the proposed study will not only provide new evidences that vitamin D supplementation plays an important role in IR management but also develop a simple and efficient method to improve IR-associated metabolic diseases for T2DM patients. Trial registration Chinese Clinical Trial Registry ChiCTR1800015383, Registered on 28 March 2018

Sign in / Sign up

Export Citation Format

Share Document