scholarly journals HYPERCHOLESTEROLEMIA;

2014 ◽  
Vol 21 (01) ◽  
pp. 111-115
Author(s):  
Zahidullah Khan ◽  
Inamullah Khan ◽  
Fazle Subhan
Keyword(s):  
Density Lipoprotein ◽  
Base Line ◽  
Inclusion Criteria ◽  
Blood Samples ◽  
Hospital Design ◽  
Single Center Study ◽  
Group A ◽  
The Mean ◽  
Group B ◽  
Study Setting

Objective: To compare the efficacy of Simvastatin with Atorvastatin in loweringLow Density Lipoprotein Cholesterol (LDL-C) in patients with Hypercholesterolemia in a tertiarycare hospital. Design: Prospective, observational, single center study. Setting: Department ofMedicine, Khyber Teaching Hospital, Peshawar. Period: December 2011 to December 2012.Subjects and Methods: A total of 200 cases having base line fasting LDL-C level of ≥ 130 mg/dland meeting the inclusion criteria were included in the study through both outpatient department(OPD) and admitted patient. After detailed history and clinical examination, all patients weredivided randomly into two groups, A and B. Patients in Group A were given Simvastatin20mg/day and Group B received Atorvastatin 20mg/day. Fasting blood samples were taken fromthe selected patients in the start of study and after 12 weeks. Results: A total of 200 subjects witha serum LDL-C level ≥ 130 mg/dL were included in the study. They were divided into 2 groupsrandomly, 100 in each group. Each group comprised of 75 male and 25 female. The mean age ingroup A was 52 years and in group B it was 54 years. The age ranges between 40 years and 73years. Mean base LDL-C level was 165 mg/dl in group A and 170mg/dl in group B. Simvastatin 20mg/dl reduced LDL-C level by 26% and Atorvastatin 20mg/dl reduced LDL-C level by 33% after 12weeks of treatment. Conclusions: Atorvastatin is a more effective drug to reduce serum LDLcholesterolthan Simvastatin in the same doses.

scholarly journals AB0393 EFFICACY OF HYDROXYCHLOROQUINE FOR LUPUS NEPHRITIS IN MAINTENANCE PHASE

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1496.2-1496
Author(s):  
M. Watanabe ◽  
Y. Haji ◽  
M. Kato ◽  
T. Ito ◽  
Y. Banno ◽  
...  
Keyword(s):  
Lupus Nephritis ◽  
Lupus Erythematosus ◽  
Therapeutic Option ◽  
Maintenance Phase ◽  
Base Line ◽  
Prednisolone Dose ◽  
Daily Urine ◽  
Group A ◽  
The Mean ◽  
Group B

Background:Hydroxychloroquine (HCQ) is an essential drug for systemic lupus erythematosus. But in Japan, chloroquine and HCQ remain unavailable until mid 2015 because of a series of lawsuits about its retinal toxicity in the 1970s. There is insufficient knowledge regarding renal protective effect of HCQ.Objectives:We aimed to investigate its efficacy of adding HCQ for Lupus nephritis (LN) as a maintenance-phase therapy.Methods:We conducted an observational retrospective cohort study included patients with LN (n=42) in maintenance-phase in Japan. We reviewed medical records of LN patients aged > 18 years who were initiated HCQ from May 2015 to May 2018. Maintenance phase was defined as stabilization in serum creatinine and urinary segment after induction therapy and who achieved complete or partial remission. The annual change of proteinuria was compared between patients on HCQ who have proteinuria (>0.5g/gCr) or not. Other outcome measures were disease flare, dose of steroids, renal and immunologic features.Results:A total of 42 patients were analyzed and allocated to two groups based on their amount of daily urine protein level: HCQ with proteinuria as group A (>0.5g/gCr, n=14) and HCQ without proteinuria as group B(≦0.5g/gCr, n=28). Both groups were comparable, with mean (SD) age of 36.1 (12.9) years and 37.5 (13.8), female 78.6% and 92.9% in each group, mean (SD) disease duration until HCQ of 3.5 (3.25) and 3.3 (2.9) years in group A and group B, with prednisolone dose at base line of 10.3 (7.1) mg and 7.9 (4.4) mg, respectively. The mean (SD) proteinuria at base line was 1.38 (1.11) g/gCr in group A and 0.20 (0.09) g/gCr in group B and after 12 months, proteinuria decreased in group A (-1.34 g/gCr in group A vs +0.03 g/gCr in group B; p<.001;95% CI,0.305-0.736). No relapse was experienced in group A during the study period.Conclusion:In patients with clinically stable LN but with proteinuria, hydroxychloroquine is a good therapeutic option for achievement of complete remission.Disclosure of Interests:None declared

scholarly journals GESTATIONAL DIABETES

2015 ◽  
Vol 22 (10) ◽  
pp. 1298-1303
Author(s):  
Tayyaba Majeed ◽  
Rabia Adnan ◽  
Irum Mubshar ◽  
Hamis Mahmood ◽  
Kanwal Saba ◽  
...  
Keyword(s):  
Oral Route ◽  
Outcome Study ◽  
Neonatal Hypoglycemia ◽  
Consecutive Sampling ◽  
Pregnant Females ◽  
Group A ◽  
The Mean ◽  
The Difference ◽  
Group B ◽  
Study Setting

Objectives: To compare the efficacy of Metformin with insulin in gestationaldiabetes mellitus in terms of fetomaternal outcome. Study Deign: Randomized clinicaltrial study. Setting: Lady Aitchison Hospital Lahore. Period: January 2014 to March 2015.Methodology: Total 500 pregnant females with GDM were included in the study through nonprobability,consecutive sampling. Patients were divided into 2 equal groups (A: B). Patientsin group A were given tablet metformin 500 mg by oral route and group B was administratedregular injection Insulin by subcutaneous route. Results: The mean age of females was32.14±6.13 years. The mean gestational age was 31.07±3.8 weeks. There were 78 (15.6%)females who had 0 parity, 107 (21.4%) females had parity 1, 175 (35%) females had parity2, 95 (19%) females had parity 3, 33 (6.6%) females had parity 4 and 12 (2.4%) femaleshad parity 5.There were 54 (10.8%) cases had PTB, out of which 12 (4.8%) had PTB withmetformin while 42 (16.8%) had PTB with insulin. There were 115 (23%) neonates requiredNICU admission, out of which 37 (14.8%) neonates with metforminand78 (31.2%) neonateswith insulin. There were 87 (17%) neonates who had neonatal hypoglycemia, out of which23 (9.2%) neonates with metformin and64 (25.6%) neonates with insulin. The difference wassignificant between both groups for all fetal outcomes (P<0.05). Conclusion: The metforminis more effective in preventing adverse fetal and maternal outcome as compared to insulin.

scholarly journals Comparison of septoplasty with and without packing and splints.

2021 ◽  
Vol 28 (04) ◽  
pp. 459-463
Author(s):  
Amrat Kumar ◽  
Ashok Kumar ◽  
Shabir Mehar ◽  
Dileep Kumar ◽  
Muhammad Wasi Ullah Khan
Keyword(s):  
Comparative Study ◽  
Nasal Packing ◽  
Treatment Results ◽  
New Techniques ◽  
Before And After ◽  
Group A ◽  
Vas Scores ◽  
The Mean ◽  
Group B ◽  
Study Setting

Objective: During septoplasty, nasal packing is routinely used by surgeons for hemostasis and balancing the cartilage and bony skeleton of the nose. However, these new techniques are not totally mild and therefore new ways are adopted to check their efficiency and reason their value. The study was performed to compare the use of plastic intranasal splints with or without anterior nasal packing to determine the need of nasal packing after septoplasty. Study Design: Comparative Study. Setting: ISRA University Hyderabad. Period: March 2018 to April 2019. Material & Methods: A total of 50 patients presenting with nasal septum in this period were prospectively examined. For the purpose of comparative study, we divided the patients into two groups: Group A –Patients who underwent septoplasty with packing and Group-B –Patients who underwent septoplasty without packing. We recorded the pain felt using Visual analogue scale before and after the surgery and also noted the Mean Age gender wise and recorded treatment results for statistical analysis using SPSS Version-20. Results: In our data, a total fifty (50) patients comprising 28 Males (68%) and 22 Females (32%) were listed in the study. The mean± standard deviation VAS scores of Group-A was at 5.2 ±0.9 and Group-B is 2.9±0.61 showing less pain in Group B-without splints and packing. However the complication rate in patients without Splints and packing was only 18%. Conclusion: Thus we find septoplasty without nasal splints and packing is more effective and cause lesser bleeding and pain to patients.

scholarly journals Comparison of the efficacy and safety of circumcision by freehand technique and Plastibell device in children

2020 ◽  
Vol 26 (1) ◽  
Author(s):  
Babatunde K. Hamza ◽  
Muhammed Ahmed ◽  
Ahmad Bello ◽  
Tunde Talib Sholadoye ◽  
Musliu Adetola Tolani ◽  
...  
Keyword(s):  
Randomized Study ◽  
Operating Time ◽  
Time Cost ◽  
Efficacy And Safety ◽  
Inclusion Criteria ◽  
Age Related ◽  
Freehand Technique ◽  
Group A ◽  
The Mean ◽  
Group B

Abstract Background Circumcision has been practiced since antiquity and is one of the most commonly performed surgical procedures. The aim of the study was to compare the efficacy and safety of the two most common techniques: Freehand and Plastibell techniques of circumcision. Methods The study was a prospective randomized study that was conducted on uncircumcised males at or below the age of 5 years that presented for circumcision. All boys who satisfied the inclusion criteria and whose parents consented, were randomized into two groups. Group A had freehand circumcision, while Group B had Plastibell circumcision. Patients were followed up at day 7 and day 28 postoperatively. The variables compared were operating time, cost, complications and parents’ satisfaction. All the data obtained were entered into a proforma. The data obtained were analyzed using SPSS version 20. Results A total of 110 boys were circumcised, 55 boys in each group. The median ages in the Plastibell and freehand groups were one and three months respectively. The mean operating time was significantly shorter in the Plastibell group compared to freehand (3.53 min versus 16.7 min). Total cost implication per procedure was also cheaper in Plastibell compared to freehand (₦3700 versus ₦6600). However, complications were more in the Plastibell group compared to freehand (29.1% versus 9.1%; P = 0.008). These complications in Plastibell group were age related. Parents in both groups were equally satisfied with the outlook on day 28. Conclusion Plastibell circumcision has the advantage of being faster and cheaper than freehand circumcision. Complications were more in the Plastibell group, and they were found to be age related.

scholarly journals The use of folic acid in dengue: has it any value?

2019 ◽  
Vol 49 (2) ◽  
pp. 85-87 ◽  
Author(s):  
Ahsan Ali Syed ◽  
Saad Bin Zafar ◽  
Asif Ali Shah ◽  
Safia Awan
Keyword(s):  
Folic Acid ◽  
Medical Records ◽  
Dengue Infection ◽  
Inclusion Criteria ◽  
Time Period ◽  
Significant Difference ◽  
Group A ◽  
The Mean ◽  
Group B ◽  
Mean Time

Folic acid is used in dengue patients. Our study aims to compare the duration of recovery of thrombocytopenia in patients with dengue infection who received folic acid and those who did not. We retrospectively reviewed the medical records of adult patients admitted over six years with a diagnosis of dengue. Of 2216 patients, 1464 fulfilled the inclusion criteria. Group A were those patients who received folic acid and group B were those who did not. A total of 1322 (90.3%) patients received folic acid. The mean time period required for platelets to double the nadir was 1.7 (±2.2) days in both groups A and B ( P = 0.89). In conclusion, there is no significant difference in the recovery of thrombocytopenia in patients with dengue fever who received folic and those who did not receive folic acid.

scholarly journals Transient Hypothyroxinaemia in Full Term Low Birth Weight Neonates

1970 ◽  
Vol 6 (1) ◽  
pp. 8-11
Author(s):  
Z Parveen ◽  
N Begum ◽  
MM Hossain
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Low Birthweight ◽  
Full Term ◽  
Military Hospital ◽  
Control Group ◽  
Base Line ◽  
Group A ◽  
The Mean ◽  
Group B

This prospective study was done in Combined Military Hospital, Dhaka from July 2002 to June 2003 todocument the postnatal changes of thyroid hormones in full term low birth weight (LBW) neonates. Theparameters were- serum TT4 (total thyroxin), TT3 (total triiodothyronine), FT4 (free thyroxin) and TSH(thyroid stimulating hormone). Twenty seven healthy full term neonates formed the control group (group A)who were studied on day 5 to observe the base line data. Study group (group B) consisted of 27 low birthweight (LBW) neonates. They were studied twice on day 5 (B1) and day 45 (B2). The mean ± SD gestational agewas 38.41±0.93 and 38.63±1.08 weeks in group A and B respectively. The mean ± SD birth weight were3.41±0.55 and 2.11±0.33 kg in group A and B respectively and the difference was statistically significant (p<0.0001). All neonates of group A had normal serum levels of TT4, TT3, FT4 and TSH on day 5 but in LBW fullterm neonates though FT4 level remained within normal range, 48% neonates of group B had significantlydecreased levels of TT4, TT3 and TSH (p<0.001) but on day 45 all of these hormone levels were significantlyincreased (p<0.001) and attained normal values. This study showed that 48% LBW neonates had transienthypothyroxinaemia on day 5 which was corrected spontaneously by day 45.Key words: Hypothyroxinaemia; Low birth weight (LBW).DOI: 10.3329/jafmc.v6i1.5984Journal of Armed Forces Medical College, Bangladesh Vol.6(1) 2010 p.8-11

scholarly journals Is Nasogastric Tube essential in abdominal surgeries? Randomized controlled trail.

2021 ◽  
Vol 28 (10) ◽  
pp. 1397-1400
Author(s):  
Muhammad Bilal ◽  
Viqar Aslam ◽  
Zaheeruddin ◽  
Waqas Jan
Keyword(s):  
Hospital Stay ◽  
Nasogastric Tube ◽  
P Value ◽  
Randomized Controlled ◽  
Group A ◽  
Randomized Controlled Trail ◽  
The Mean ◽  
Group B ◽  
Study Setting ◽  
Tube Study

Objective: Objective was to compare mean hospital stay in patients with abdominal surgeries with and without Nasogastric tube. Study Design: Randomized Controlled Trail study. Setting: DHQ Charsadda. Period: Jan to Nov 2018. Material & Methods: One hundred and thirty two patients who underwent abdominal surgeries according to a preset inclusion criteria were in this study. These Patients were randomly assigned using sealed opaque envelopes containing computer‐generated random numbers into with and without NG tube. Mean hospital stay was noted in both groups. Student ‘t’ test was used to compare the mean hospital stay of both groups. Results: Mean age of patients in group A was 28.50 ± 9.28 years and for group B was 30.12+_9.09 years. Mean hospital stay for group A was 5.64+_2.32days and for group B was 8.73+_3.43 days with a p-value of < 0.000. Conclusion: Patient with nasogastric tube stay longer in hospital than without tube.

scholarly journals EFFICACY OF CIPROFLOXACIN AND CEFOTAXIME IN PATIENTS WITH CIRRHOSIS LIVER PRESENTING WITH SPONTANEOUS BACTERIAL PERITONITIS TO A TERTIARY CARE HOSPITAL

2021 ◽  
Vol 29 (02) ◽  
Author(s):  
Zahidullah Khan ◽  
Ahmar Rashid ◽  
Iqbal Haider ◽  
Shams Suleman ◽  
Aliena Badshah ◽  
...  
Keyword(s):  
Spontaneous Bacterial Peritonitis ◽  
Tertiary Care ◽  
Care Hospital ◽  
Bacterial Peritonitis ◽  
Source Of Infection ◽  
Key Words Ciprofloxacin ◽  
Single Center Study ◽  
Group A ◽  
The Mean ◽  
Group B

Spontaneous Bacterial Peritonitis (SBP), a known complication of cirrhosis Liver is an acute bacterial infection of the peritoneum. Usually no source of infection is easily identifiable. Objective: To compare the efficacy of Ciprofloxacin and Cefotaxime in Cirrhosis Liver patients with SBP. Material and Methods: This prospective, comparative, single center study was conducted in the Department of Medicine, Khyber Teaching Hospital Peshawar from 1st October 2017 to 31st December 2018. A total of 300 admitted patients having Cirrhosis Liver with SBP were included in this study. The patients were randomized into Group A and Group B. Group A was treated with Intravenous Ciprofloxacin and Group B was treated with Intravenous Cefotaxime given twice daily for a period of 5 days. Diagnostic peritoneal paracentesis was done before the start of the treatment and repeated after 5 days therapy. Patients who were either non cirrhotic or had secondary bacterial peritonitis were excluded from the study. Results: A total of 300 Cirrhosis Liver patients with SBP were studied in two equal randomized groups. Out of these 168 were male and 132 were female. The mean age of patients in study was 51.14±11.9 years. The age ranged between 15-75 years. In Group A, 82 percent responded to ciprofloxacin and in group B, 86 percent responded to cefotaxime. Conclusion: Both intravenous ciprofloxacin and cefotaxime are effective in treating spontaneous bacterial peritonitis in patients with Cirrhosis Liver. Key Words: Ciprofloxacin, Cefotaxime, Spontaneous bacterial peritonitis, Efficacy.

Dexamethasone Versus Ondansetron in Preventing Postoperative Nausea and Vomiting In Laparoscopic Surgery

2021 ◽  
Vol 17 (3) ◽  
pp. 222-226
Author(s):  
Anum Malik ◽  
Arshad Shahani ◽  
Jawad Zahir ◽  
Hassam Zulfiqar ◽  
Tabassum Aziz
Keyword(s):  
Postoperative Nausea ◽  
Postoperative Nausea And Vomiting ◽  
Nausea And Vomiting ◽  
P Value ◽  
Inclusion Criteria ◽  
Significant Difference ◽  
Quasi Experimental ◽  
Group A ◽  
The Mean ◽  
Group B

Objective: To compare the efficacy of dexamethasone 8mg versus ondansetron 4mg in preventing postoperative nausea and vomiting (PONV) in patients undergoing laparoscopic cholecystectomy Methodology: This quasi-experimental study was conducted at the Department of Anaesthesia and Intensive Care, Holy Family Hospital from 29th July 2018 to 28th January 2019.  Anesthesia was induced with propofol (2mg/kg IV) and Atracurium (0.5 mg/kg IV) was given to facilitate tracheal intubation. Nalbuphine (0.2mg/kg) was used as analgesic.Patients were randomly divided into two groups. Patients in Group A received 4mg ondansetron at end of surgery and Group B received 8mg dexamethasone at induction. Results: A total of 90 patients were included according to the inclusion criteria of the study. The mean age (years) in the study was 37.11+10.60 years. Frequency and percentage of nausea (up to 24 hours) among both the groups was 28 (62.2) and 28 (62.2) respectively (p-value = 1.0) while the frequency and percentage of vomiting (within 24 hours after extubation) was 28 (62.2) and 27 (60.0) respectively (p-value = 0.829) Conclusion: The study concluded that there was no significant difference dexamethasone and ondansetron in preventing postoperative nausea and vomiting.

Comparison of Mean Efficacy of Gluma and Ultraez Desensitizer to Decrease Hypersensitivity of Vital Abutment Teeth Prepared for Full Coverage Restoration

2020 ◽  
Vol 10 (3) ◽  
pp. 192-196
Author(s):  
Hamid Bashir ◽  
Shoaib Rahim ◽  
Jawad Shah ◽  
Zarah Afreen ◽  
Ammarah Afreen ◽  
...  
Keyword(s):  
Potassium Nitrate ◽  
Inclusion Criteria ◽  
Full Coverage ◽  
Fixed Dental Prosthesis ◽  
Group A ◽  
Abutment Teeth ◽  
The Mean ◽  
Tooth Preparation ◽  
Group B ◽  
Study Inclusion

OBJECTIVE: To compare the mean change in hypersensitivity between Gluma and Potassium Nitrate (UltraEz) desensitizers, on vital abutment teeth prepared for full coverage restorations. Study Design and Setting: Randomized experimental study conducted at Watim Dental College, Rawalpindi, from February to August 2019. Methodology: Total 100 patients were included in this study. Inclusion criteria consisted of both male and female patients with age ranging from 20-40 years, consisting of vital teeth and no active carious lesion. Two hours after tooth preparation, vital abutment tooth was stimulated with a blast of air and hypersensitivity of the vital abutment was measured using Visual Analog Scale (VAS). Then Gluma Desensitizer was applied on vital abutment for one minute, air dried and then rinsed. After Gluma Desensitizer application, the abutment tooth was again stimulated with a blast of air and hypersensitivity of the vital abutment was measured using VAS. All the data was entered and analysed using SPSS version 20.0. P values of less than or equal to 0.05 was considered significant. RESULTS; All the teeth before tooth preparation had zero hypersensitivity. After preparation, Mean+ SD of hypersensitivity on VAS were 8.92 + 0.77 and 8.96 + 0.75 in Group A (Gluma) and Group B (UltraEz) respectively. After desensitizers application, Mean+ SD of hypersensitivity on VAS were 4.00 + 0.75 and 2.00 + 0.72 in Group A (Gluma) and Group B (UltraEz) respectively. CONCLUSION: It was concluded that both desensitizers reduce Hypersensitivity but UltraEz Desensitizer (containing Potassium Nitrate) relieves Hypersensitivity to a greater extent than Gluma Desensitizer when used on vital teeth prepared for providing conventional Fixed Dental Prosthesis

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