scholarly journals VITAMIN D;

2019 ◽  
Vol 26 (04) ◽  
Author(s):  
Tanveer Hussain Shah ◽  
Tahir Saeed Siddiqui ◽  
Ahmad Zeb

Background: Present study was designed by keeping in view the importance of vitamin D in adolescents’ age group. Objectives: To explore the cases of low vitamin D status (<50 nmol/l) with respect to age & sex factors in school students. Study Design: Observation cross-sectional study. Setting: Department of Biochemistry faculty of Health Sciences, Hazara University Mansehra, Ayub Medical College and Teaching Hospital Abbottabad. Period: June 2014 to June 2015. Subject & Methods: We recorded daily intake of vitamin D of each individual and  measured serum 25 hydrxoy vitamin D in a school based cross sectional sample of adolescents girls (n=93) and boys (n=96) students. Results: Results of this study reflected that, out of total boys and girls students, 16% and 39% of the sample  respectively showed low serum vitamin D status(<50 nmol/l). Number of cases had low vitamin D level increased with age in girls and decreased with age in boys. Serum vitamin D concentration was decreased with increase in age of girls and found significantly low (p=0.0087) in higher age group (>13-≤16).  No significant difference (p=0.29) was noted regarding daily intake of vitamin D between lower & higher age. Conclusion: It is concluded that, age and sex might be contributory factors in the occurrence of low vitamin D status.

Author(s):  
Julie Christy Amalraj ◽  
Andal . ◽  
Perumal Saraswathi ◽  
Swayam Jothi Dorairaj ◽  
Dr. G. Sumathy

Background:Vitamin D* called the sunshine vitamin is essential throughout life. Pregnancy is an altered physiological state in women, which requires proper nourishment. During gestation, this vitamin also plays an important role in development of the fetus. Objective:To observe the serum vitamin D (25diohydroxycholicalciferol) levels and serum calcium levels in the maternal blood during the three trimesters. Design: Observational Cross sectional study. Study population: Rural Mothers from Kancheepuram District, Tamil Nadu South India. We used 50 antenatal blood samples as experimental group and 15 as control group. The age group included 20-40 years. Blood samples were collected from 50 antenatal mothers between 20 – 40 years age group, from Obstetrics and Gynecology OPD for their routine antenatal check-ups, after getting duly signed informed consent. Control group had 15 women in the same age group not pregnant. Results: The results were tabulated. The mean value of 25dihydroxy vitamin D was observed very low than normal levels in all the three trimesters. The mean value of serum vitamin D in first trimester was 50.87 ng/ml, mean value of serum vitamin D in second trimester was 54.05.ng/ml, and mean third trimester vitamin D was 61.24ng/ml which was well below the optimum level of 100ng/ml. Conclusion: The vitamin D deficiency with normal level maintenance of serum calcium shows the compensatory mechanism that involves the normal calcium level maintence with resorption of bones by the osteoclastic actions to correct the deficit. If the deficiency is left untreated it may lead to faster osteoporosis in the mother. *25 dihydroxycholicalciferol


2021 ◽  
Vol 49 (7) ◽  
pp. 030006052110333
Author(s):  
Jeonghun Lee ◽  
Young Joo Lee ◽  
Youngsun Kim

Objective Many studies have shown that vitamin D deficiency is associated with insulin resistance and metabolic syndrome. However, few studies have shown independent associations between vitamin D deficiency and the metabolic characteristics of prediabetes. We aimed to evaluate the relationship between serum vitamin D concentration and metabolic risk factors in adults with prediabetes. Methods We enrolled 161 patients aged 25 to 75 years in a cross-sectional study and collected clinical and biochemical data, including 25-hydroxyvitamin D (25[OH]D) status and fasting glucose concentration. Vitamin D status was defined as follows: deficiency (25[OH]D <49.9 ng/mL), insufficiency (49.9 to 74.9 nmol/L) or sufficiency (>74.9 nmol/L). Prediabetes was defined using fasting plasma glucose concentrations of 5.55 to 6.49 mmol/L. Results The prevalences of vitamin D deficiency and insufficiency were 49.7% and 24.8%, respectively. Participants with vitamin D deficiency had a higher prevalence of prediabetes than those without (53.8% vs. 32.1%), and there was a significant relationship between female sex and vitamin D status (odds ratio: 1.382; 95% confidence interval: 0.335–5.693). Conclusion Vitamin D deficiency is more closely associated with a high prevalence of prediabetes in women than in men. Further studies are needed to elucidate the explanation for this association.


2007 ◽  
Vol 77 (6) ◽  
pp. 376-381 ◽  
Author(s):  
de Souza Genaro ◽  
de Paiva Pereira ◽  
de Medeiros Pinheiro ◽  
Szejnfeld ◽  
Araújo Martini

Vitamin D is essential for maintaining calcium homeostasis and optimizing bone health. Its inadequacy is related to many factors including dietary intake. The aim of the present study was to evaluate serum 25(OH)D and its relationship with nutrient intakes in postmenopausal Brazilian women with osteoporosis. This cross-sectional study comprised 45 free-living and assisted elderly at São Paulo Hospital. Three-day dietary records were used to assess dietary intakes. Bone mineral density was measured with a dual-energy X-ray absorptiometer (DXA). Blood and urine sample were collected for analysis of biochemical markers of bone and mineral metabolism. Insufficiency of vitamin D was observed in 24.4% of the women and optimal levels (≥ 50 nmol/L) were observed in 75.6%. Parathyroid hormone was above the reference range in 51% of the participants. The mean calcium (724 mg/day) and vitamin D (4.2 μ g/day) intakes were lower than the value proposed by The Food and Nutrition Board and sodium intake was more than two-fold above the recommendation. Higher levels of serum 25(OH)D were inversely associated with sodium intake. Dietary strategies to improve serum vitamin D must focus on increasing vitamin D intake and should take a reduction of sodium intake into consideration.


Author(s):  
Sanjeeva Kumar Goud T ◽  
Rahul Kunkulol

The present study was aimed to study the effect of Sublingual Vitamin D3 on Serum Vitamin D level in Vitamin D deficiency patients. This was a cross-sectional and interventional study. All the Vitamin D deficiency patients of age 18-60years and either gender, willing to participate in the study were included. Patients who had greater than 20 ng/ml were excluded from the study. The total number of participants in our study was 200, out of these 111 males and 89 females, the mean age in our study was 51.07 ± 7.39Yrs. All volunteers were given sublingual vitamin D3 (60,000IU) in six doses every fifteen days of follow up for 3 months. The subject’s serum 25(OH)D levels were estimated before and after the treatment of sublingual vitamin D3. There was a statistically significant difference in serum vitamin D3 level before 16.61±6.71 ng/ml and after 35.80±7.80 ng/ml after treatment with Sublingual Vitamin D3. Six doses of 60,000IU of Vitamin D3 sublingual route having improved the role of serum 25(OH)D levels in the treatment of Vitamin D3 deficiency patients.Keywords: Vitamin D3; Sublingual route


Diagnostics ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1075
Author(s):  
Masliza Hanuni Mat Ali ◽  
Tuan Salwani Tuan Ismail ◽  
Wan Norlina Wan Azman ◽  
Najib Majdi Yaacob ◽  
Norhayati Yahaya ◽  
...  

Thyroid hormones have a catabolic effect on bone homeostasis. Hence, this study aimed to evaluate serum vitamin D, calcium, and phosphate and bone marker levels and bone mineral density (BMD) among patients with different thyroid diseases. This cross-sectional study included patients with underlying thyroid diseases (n = 64, hyperthyroid; n = 53 euthyroid; n = 18, hypothyroid) and healthy controls (n = 64). BMD was assessed using z-score and left hip and lumbar bone density (g/cm2). The results showed that the mean serum vitamin D Levels of all groups was low (<50 nmol/L). Thyroid patients had higher serum vitamin D levels than healthy controls. All groups had normal serum calcium and phosphate levels. The carboxy terminal collagen crosslink and procollagen type I N-terminal propeptide levels were high in hyperthyroid patients and low in hypothyroid patients. The z-score for hip and spine did not significantly differ between thyroid patients and control groups. The hip bone density was remarkably low in the hyperthyroid group. In conclusion, this study showed no correlation between serum 25(OH)D levels and thyroid diseases. The bone markers showed a difference between thyroid groups with no significant difference in BMD.


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