scholarly journals ACUTE PANCREATITIS;

2019 ◽  
Vol 26 (04) ◽  
Author(s):  
Anwar Hussain Abbasi ◽  
Shahab Abid
Keyword(s):  
Acute Pancreatitis ◽  
University Hospital ◽  
Drug Induced ◽  
Cross Sectional ◽  
Alcohol And Drugs ◽  
Gall Stones ◽  
Number Of Patients ◽  
Causative Agents ◽  
Complications And Mortality ◽  
Study Setting

Objectives: To determine the clinical outcome of acute pancreatitis in relation with major etiologies (Gallstones, Alcohol, and Drugs). Study Design: Cross sectional hospital based study. Setting: Aga Khan University Hospital. Period: 16 years (from 1st January 2001 to 30th June 2016). Methods: All patients with acute pancreatitis admitted. Major risk factors of pancreatitis such as gallstones, alcohol, and drugs were evaluated and outcomes assessed for the development of complications and mortality. Results: We evaluated 3049 patients with acute pancreatitis, the causative agents found, 80.35% (N = 2450), followed by Alcohol 13.05% (N = 398) and drugs 6.59% (N = 201), respectively. Patients with alcohol abuse were relatively older 53.74 years compared to patients with gallstones 39.54 years and drugs induced 43.26 years AP. Among them, the overall complication rate was 5.05% (N = 155). The most common complication was development of sepsis 45.8% (N = 71) and the overall mortality rate observed was 0.91% (N = 28). Conclusions: Gall stones are the leading cause of acute pancreatitis while drugs are the rare cause, however in significant number of patients cause remained obscure. Based on the above results patients with drug induced pancreatitis have good outcome as compared to gall stones and alcohol induced acute pancreatitis, however further studies warranted.

scholarly journals HEPATITIS “C”

2016 ◽  
Vol 23 (09) ◽  
Author(s):  
Muhammad Iqbal ◽  
Adnan Ahmed ◽  
Muhammad Rafique Hingoro
Keyword(s):  
Hepatitis C ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Age Group ◽  
Sectional Study ◽  
Cross Sectional ◽  
Grade 3 ◽  
Chronic Hcv ◽  
Study Setting

Objectives: To determine incidence of steatosis in non-responder casesof chronic HCV. Study Design: Cross-sectional study. Setting: Tertiary Care Sanatorium inMedicine Department of LIAQUAT University Hospital Hyderabad/Jamshoro. Period: 26-9-2011to 25 August 2012. Material & Methods: Total 144 non-responders cases of Hepatitis C wereintegrated. Both gender, age 18 to 50 yrs, chronic HCV non-responder cases as well as cases fitfor hepatic biopsy were integrated in study. Grading of Inflammation was carried out as indicatedby histopathological measures. Results: Mean age was 48.5 + 5.2years. Uppermost prevalenceof chronic HCV disease was 65(45.13%) at 41 to 50 years age interval whereas 42(29.1%) caseswere noticed in 31 to 40 yrs age group and 25(17.3%) cases were observed in 20 to 30 yearsof young age group. In this study hepatic steatosis occurrence was observed in 103 (71.5%)cases and these were categories as: grade 1, grade 2, grade 3, as (<33%) 45/103(43.68%), (33to 66%) 35/103(33.98%), (>66%) 23/103(22.33%) respectively. Conclusion: Hepatic steatosisis a important risk factor the cases of HCV to decreased response to antiviral therapy and forprogression toward fibrosis as observed in cases related to metabolic steatosis.

Possible Sulfamethoxazole/Trimethoprim-Induced Pancreatitis in a Complicated Adolescent Patient Posttraumatic Injury

2015 ◽  
Vol 28 (4) ◽  
pp. 419-424 ◽  
Author(s):  
Susan E. Dickey ◽  
William A. Mabry ◽  
Leslie A. Hamilton
Keyword(s):  
Acute Pancreatitis ◽  
Motor Vehicle ◽  
Motor Vehicle Accident ◽  
Pediatric Population ◽  
Pancreatic Enzyme ◽  
Amylase Level ◽  
African American Female ◽  
Adolescent Patient ◽  
Drug Induced ◽  
Causative Agents

Introduction: Multiple medications have been associated with pancreatitis, however, data in the pediatric population are scarce secondary to the nonspecific presentation and infrequent diagnosis. The aim of this report is to characterize drug-induced pancreatitis in an adolescent patient. Case Presentation: A 16-year-old African-American female presented with a surgical site infection 8 weeks after a motor vehicle accident with multiple traumas. Two weeks prior to the admission, the patient was hospitalized for a urinary tract infection (UTI) and was initiated on sulfamethoxazole/trimethoprim (TMP/SMX) daily for UTI prophylaxis. On day 13, the patient was diagnosed with acute pancreatitis with an amylase level of 187 units/L (normal = 30-110) and a lipase level of 987 units/L (normal = 23-208). TMP/SMX was discontinued, and pancreatic enzyme levels decreased but did not reach normal. The patient was asymptomatic at discharge. Discussion: TMP/SMX was identified as the likely etiology of pancreatitis by the medical team. Evaluation with the Naranjo algorithm indicated a “possible” adverse drug reaction. Conclusion: Acute pancreatitis can have significant morbidity and mortality in the pediatric population but can go undiagnosed due to its lower incidence. Pediatric patients presenting with idiopathic abdominal pain should be evaluated for pancreatitis and drug therapy should be reviewed for potential causative agents.

scholarly journals Etiology, presentation and treatment of ocular trauma in paediatric population.

2021 ◽  
Vol 29 (01) ◽  
pp. 67-70
Author(s):  
Noman Ahmed ◽  
Mehatab Alam Khanzada ◽  
Nisar Ahmed Jandan ◽  
Ashok Kumar Narsani
Keyword(s):  
Ocular Trauma ◽  
Pediatric Population ◽  
Financial Burden ◽  
Paediatric Population ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Study Group ◽  
Potential Hazard ◽  
Cross Sectional ◽  
Study Setting

Objective: To determine the etiology, presentation and treatment of ocular trauma in paediatric population. Study Design: Cross Sectional Study. Setting: Institute of Ophthalmology, Liaquat University Hospital Jamshoro. Period: January, 2020 to December 2020. Material & Methods: Data was collected using a questionnaire having age, sex, cause of injury and time at presentation to the emergency. It also focused on which structures were damaged due to injury, investigations being used, and treatment performed. Results: In our study we found 80 cases of ocular trauma in pediatric population visiting the ophthalmology department. Gender distribution of the study group which includes 72.5% (n=58) males and 27.5% (n=22) females. It was found during playing 86.3% of children had ocular trauma followed by injury due to domestic stuff like glass, bleach cleaners in 7.5% of the study group. The most frequently occurring ocular trauma was found to be corneal tear occurring in 25% of the study group. Conclusion: Ocular trauma in children can be prevented by simple measures like supervising children and educating parents and teachers for potential hazard substances. It is important to address like healthcare issue as ocular trauma can lead to lifelong blindness along with psychological and financial burden for the caretaker and children themselves.

scholarly journals TO DETERMINE THE ADVANTAGE OF SNODGRASS REPAIR OF CONGENITAL HYPOSPADIAS AT DIFFERENT LEVEL OF PENILE SHAFT.

2019 ◽  
Vol 26 (07) ◽  
pp. 1027-1031
Author(s):  
Shafaatullah . ◽  
Sadaf Iqbal ◽  
Bilal Suria
Keyword(s):  
Hormonal Therapy ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Common Complication ◽  
Sectional Study ◽  
Penile Shaft ◽  
Cross Sectional ◽  
Good Cosmetic ◽  
Male Patients ◽  
Study Setting

Introduction: Hypospadias is a congenital defect with various presentations. It is diagnosed clinically. Hormonal therapy can be used but is not curative. The Snodgrass intervention is the better one to get result oriented outcomes. Objectives: To find out the advantages of Snodgrass repair in distal as well as proximal types of hypospadias. Study Design: Cross sectional study. Setting: Baqai university hospital Karachi. Period: January 2015 to December 2017. Material and Method: Total 40 male patients were included in this study. They were admitted through OPD. Age of patients was from 4 years to 22 years. Patients were prepared and Snodgrass repair was done to all patients. Results: In our study, of 40, 19 (47.5%) patients presented between age 04 to 10 years. Most common Subcoronal type was found in 16 (40%). Catheter blockage was in 4 (10%) patients that was a common complication in our study. Conclusion: To sum up, Snodgrass method is the good one with good cosmetic results and least complication rate. 

scholarly journals A multinational e-survey on the delivery of cardiology services in Africa during the COVID-19 pandemic: what should we expect after this pandemic?

2020 ◽  
Author(s):  
Chris Nadege Nganou-Gnindjio ◽  
Mazou Ngou Temgoua ◽  
Liliane Mfeukeu Kuate ◽  
Clovis Nkoke ◽  
Joel Noutakdie Tochie ◽  
...  
Keyword(s):  
Care Delivery ◽  
Cardiovascular Complications ◽  
Survey Study ◽  
African Countries ◽  
Cross Sectional ◽  
Outcomes Measures ◽  
Number Of Patients ◽  
Secondary Outcomes ◽  
The Impact ◽  
Study Setting

Abstract Objective: To evaluate the impact of the COVID-19 pandemic on the delivery of cardiology services in Africa. Design: Cross-sectional e-survey study. Setting: African countries Participants: Cardiologists Primary and Secondary outcomes measures: The primary outcome was the change in service delivery in African cardiology units during the on-going COVID-19 pandemic. The secondary outcomes were the satisfaction of cardiologists with regards to the workload and factors associated with this satisfaction. Results: There was a significant reduction in working time and the number of patients consulted by week during this pandemic (p<0.001). In general, there was a decrease in the overall activities in cardiovascular care delivery. The majority of cardiology services (76.5%) and consulting programs (85%) were adjusted to the pandemic. Only half of the participants were satisfied with their workload. Reconfiguration of the consultation schedule was associated with a reduced satisfaction of participants (p=0.02). Conclusions: COVID-19 is associated with an overall reduction in cardiology services rendered in Africa. Since the cardiovascular burdens continue to increase in this part of the World and the risk of cardiovascular complications linked to SARS COV2 remains unchanged cardiology, departments in Africa should anticipate a significant surge of cardiology services demanded by patients after the COVID-19 pandemic.

The presentation of older people with vertebral fragility fractures to a university hospital: a cross-sectional analysis

2020 ◽  
Vol 16 ◽  
Author(s):  
Terence Ong ◽  
Syed Ajmal bin Syed Ali ◽  
Opinder Sahota
Keyword(s):  
Fragility Fracture ◽  
Geriatric Medicine ◽  
Health Assessment ◽  
Fragility Fractures ◽  
University Hospital ◽  
Hospital Services ◽  
Cross Sectional ◽  
Number Of Patients ◽  
Thoracolumbar Region ◽  
Vertebral Fragility Fracture

Introduction: There is a lack of robust data on hospitalised acute vertebral fragility fractures. This analysis aimed to report on the number of hospitalised vertebral fragility fractures treated in a large UK teaching hospital. This information would support better design of hospital services and resource allocation to manage this group of patients. Method: Patients aged 50 years and over hospitalised with a vertebral fragility fracture from 1/2/2016 to 31/1/2017 were identified from radiology and hospital records. Patients sustaining vertebral fractures due to either major trauma or malignancy were excluded. Data was collected on patient demographics, fracture details, hospitalisation details and health outcomes. Results: 208 patients with acute vertebral fragility fractures were hospitalised over a 12 month period. The mean(SD) age was 80.5(11) years, of which 68% were female. 94% presented to the Emergency Department (ED) as their first point of contact of which 70% were subsequently hospitalised. Two-thirds presented with a single level vertebral fracture predominantly around the thoracolumbar region. The majority (87%) were non-operatively managed by general physicians of which most were under Geriatric Medicine. The median length of stay was 12 (IQR 6-20) days and in-patient mortality was 3%. 52% of patients went on to have a bone health assessment. Conclusion: We have reported on the number of patients presenting to hospital with an acute vertebral fragility fracture over 12 months. This helps identify resources needed to design hospital services to manage them adequately.

Self-reported burden in patients with localized prostate cancer treated with stereotactic body radiation therapy (SBRT).

2018 ◽  
Vol 36 (6_suppl) ◽  
pp. 51-51
Author(s):  
Abigail Pepin ◽  
Nima Aghdam ◽  
Colin Johnson ◽  
Malika Danner ◽  
Marilyn Ayoob ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Localized Prostate Cancer ◽  
Cross Sectional ◽  
Validated Questionnaire ◽  
Number Of Patients ◽  
Over Time

51 Background: Retaining quality of life in patients treated with SBRT for prostate cancer remains paramount. As such, balancing the benefits of treatment against the effects of therapy on patients is essential. The quality of life is influenced by the disease and treatment related burden. The EORTC QLQ-ELD14 (ELD14) is a validated questionnaire that can assess burden. This study reports burden trends in patients with prostate cancer treated with SBRT. Methods: All patients with localized prostate cancer treated with SBRT at Georgetown University Hospital from 2007 to 2016 were eligible for inclusion in this cross-sectional cohort. The ELD14 questionnaire was used to assess self-reported patient quality of life at time points before and following treatment. Initially, 267 patients (Median age of 70) responded to the ELD14 questionnaire. Approximately 30% received ADT. The specific questions reviewed for this study were focused on burden of disease and treatment. The responses to these questions were grouped into three clinically relevant categories (not at all, a little and quite a bit to very much). Results: Number of patients reporting quite a bit or very much burden from prostate cancer declined over time from 13% prior to treatment to 8% at 36 months post-SBRT. This was highest at one month post-SBRT (15%) and resolved to baseline by 6 months. Treatment burden similarly decreased over time from 10% to 3%. Patients treated with androgen deprivation therapy (ADT) experienced greater burden than others. At initial consult, 19% of patients on ADT reported quite a bit or very much burden from their illness. At one month post-SBRT, this had increased to 27% and subsequently decreased to 16% at 36 months. Of those not receiving ADT, 12% reported having quite a bit or very much burden from illness initially, 9% at one month and 6% at 36 months. Conclusions: This cross-sectional study suggests that the burden of clinically localized prostate and its treatment with SBRT improves over time. Increased burden was noted in patients receiving ADT. These findings can inform decision making in improving quality of life for patients with prostate cancer treated with SBRT.

scholarly journals PREGNANCY

2015 ◽  
Vol 22 (06) ◽  
pp. 776-781
Author(s):  
Shazia Shukar-ud- Din ◽  
Sadaf Ahmed Asim
Keyword(s):  
Informed Consent ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Outpatient Department ◽  
Physiological Changes ◽  
Sectional Study ◽  
Third Trimester ◽  
Cross Sectional ◽  
Skin Changes ◽  
Study Setting

Objective: To determine frequency and pattern of skin changes duringpregnancy. Study Design: Cross sectional study. Setting: Outpatient department ofDermatology and Gynaecology at Dow University Hospital, Ojha campus in Karachi. Period:May 10, 2013 and January 10, 2014. (8 months). Patients & Methods: It comprises 80consecutive pregnant women with skin problem, who presented in outpatient department ofDermatology with referral cases from Obs&Gynae outpatient department.Information wascollected on predesigned questionnaire after taking informed consent. Results: Total 80pregnant women were included in study with different skin problems. The results indicatethatmost of women 72.5% presented during third trimester and 43.8% women were primigravida.Striagravidarum and lneanigra was commonest physiological changes, reported in 54%, 52%women consecutively. Eczema,utricaria and candidiasis were reported in 16.3% and 15% and15% women consecutively. Prurigo of pregnancy was reported in 17.5% followed by pruriticfolliculitis of pregnancy in 6.3% women. Conclusions: This study concluded that skin changesduring pregnancy are frequent in Pakistani women. These changes could be physiological orpathological.

scholarly journals Comparison of different sets of immunological tests to identify treatable immunodeficiencies in adult bronchiectasis patients

2021 ◽  
pp. 00388-2021
Author(s):  
Stefano Aliberti ◽  
Francesco Amati ◽  
Andrea Gramegna ◽  
Barbara Vigone ◽  
Martina Oriano ◽  
...  
Keyword(s):  
Lymphocyte Subsets ◽  
Complete Blood Count ◽  
Fold Increase ◽  
Primary Objective ◽  
Igg Subclasses ◽  
University Hospital ◽  
Cross Sectional ◽  
Immunological Tests ◽  
Number Of Patients ◽  
Immunological Screening

BackgroundReported prevalence of immunodeficiencies in bronchiectasis patients is variable depending on the frequency and extent of immunological tests performed. ERS Guidelines recommend a minimum bundle of tests. Broadening the spectrum of immunological tests could increase the number of patients diagnosed with an immunodeficiency and those who could receive specific therapy. The primary objective of the present study was to assess the performance of different sets of immunological tests in diagnosing any, primary, secondary, or treatable immunodeficiencies in adults with bronchiectasis.MethodsAn observational, cross-sectional study was conducted at the Bronchiectasis Program of the Policlinico University Hospital in Milan, Italy, from September 2016 to June 2019. Adult outpatients with a clinical and radiological diagnosis of bronchiectasis underwent the same immunological screening during the first visit when clinically stable consisting of: complete blood count, IgA, IgG, IgM, IgG subclasses, total IgE, lymphocyte subsets, and HIV antibodies. The primary endpoint was the prevalence of patients with any immunodeficiencies using five different sets of immunological tests.ResultsA total of 401 bronchiectasis patients underwent the immunological screening. A significantly different prevalence of bronchiectasis patients diagnosed with any, primary, or secondary immunodeficiencies was found across different bundles. 44.6% bronchiectasis patients had a diagnosis of immunodeficiency using when IgG subclasses and lymphocyte subset are added to the minimum bundle suggested by the guidelines.ConclusionA 4-fold increase in the diagnosis of immunodeficiencies can be found in adults with bronchiectasis when IgG subclasses and lymphocyte subsets are added to the bundle of tests recommended by guidelines.

scholarly journals METHOTREXATE;

2017 ◽  
Vol 24 (04) ◽  
pp. 607-611
Author(s):  
Muhammad Yasir Qureshi ◽  
Zaheer Hussain Memon ◽  
Ishrat Bibi
Keyword(s):  
Plaque Psoriasis ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Cross Sectional ◽  
Dermatology Department ◽  
Pasi Score ◽  
History Of ◽  
Duration Of Disease ◽  
Study Setting

Objectives: To determine the efficacy of methotrexate as a treatment option forplaque psoriasis. Study Design: Cross sectional study. Setting: Dermatology Department, ofLiaquat University hospital Hyderabad. Period: 6 month duration from January 2016 to June2016. Material & Methods: All the cases more than 20 years of the age having severe-tomoderatechronic plaque psoriasis were selected in the study. All the patients were underwentcomplete medical history and clinical examination. All the patients with history of severecomorbidities were not included. All the patients were underwent oral methotrexate treatment.All the information as: disease duration, involved site and plaque size was recorded. Efficacywas assessed according to PASI score on starting and after 12 weeks. Results: Patients’ meanage was 40.73 years. Male were found in the majority 75.50%, while 24.50 % were female. Inthis study mean duration of disease was 7.38 + 3.46 months and mean duration of plaque sizewas 6.63+ 2.07. Commonest site involved in psoriasis was scalp+elbow seen in 27(55.1%).Psoriasis show significant good outcome after treatment of methotrexate, 9 patients did notcompeted their treatment in remaining 40 cases starting PASI score was 11.97+1.40 and after12 weeks treatment significantly decreased as 6.48+2.45 and mean of clearance time was8.10+2.02 weeks. Conclusion: Methotrexate showed significant satisfactory results in thetherapy required for plaque psoriasis as well as enhanced quality of life.

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