scholarly journals METHOTREXATE;

2017 ◽  
Vol 24 (04) ◽  
pp. 607-611
Author(s):  
Muhammad Yasir Qureshi ◽  
Zaheer Hussain Memon ◽  
Ishrat Bibi
Keyword(s):  
Plaque Psoriasis ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Cross Sectional ◽  
Dermatology Department ◽  
Pasi Score ◽  
History Of ◽  
Duration Of Disease ◽  
Study Setting

Objectives: To determine the efficacy of methotrexate as a treatment option forplaque psoriasis. Study Design: Cross sectional study. Setting: Dermatology Department, ofLiaquat University hospital Hyderabad. Period: 6 month duration from January 2016 to June2016. Material & Methods: All the cases more than 20 years of the age having severe-tomoderatechronic plaque psoriasis were selected in the study. All the patients were underwentcomplete medical history and clinical examination. All the patients with history of severecomorbidities were not included. All the patients were underwent oral methotrexate treatment.All the information as: disease duration, involved site and plaque size was recorded. Efficacywas assessed according to PASI score on starting and after 12 weeks. Results: Patients’ meanage was 40.73 years. Male were found in the majority 75.50%, while 24.50 % were female. Inthis study mean duration of disease was 7.38 + 3.46 months and mean duration of plaque sizewas 6.63+ 2.07. Commonest site involved in psoriasis was scalp+elbow seen in 27(55.1%).Psoriasis show significant good outcome after treatment of methotrexate, 9 patients did notcompeted their treatment in remaining 40 cases starting PASI score was 11.97+1.40 and after12 weeks treatment significantly decreased as 6.48+2.45 and mean of clearance time was8.10+2.02 weeks. Conclusion: Methotrexate showed significant satisfactory results in thetherapy required for plaque psoriasis as well as enhanced quality of life.

scholarly journals COMMON BIRTH MARKS

2015 ◽  
Vol 22 (09) ◽  
pp. 1208-1211
Author(s):  
Sadaf Ahmed Asim ◽  
Humaira Maryum ◽  
ShaziaShukar-ud- Din ◽  
Waseem Jamalvi ◽  
Muhammad Aurangzeb
Keyword(s):  
Informed Consent ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Sectional Study ◽  
Exclusion Criteria ◽  
Cross Sectional ◽  
Dermatology Department ◽  
Vascular Birthmarks ◽  
General Physical ◽  
Study Setting

Objectives: To identify the frequency of common birthmarks presenting inoutpatients department of dermatology until and to increase awareness among doctor aboutthe common phenomena. Patients and Study Design: A cross sectional study. Setting: OPDof Dermatology department of Dow University Hospital. Period: January 2014 till October 2014.Methods:During a year, by using non-probability convenient sampling only 100 patients of bothgenders were enrolled in the study after ensuring inclusion, exclusion criteria. Complete historywas recorded and a thorough general physical and cutaneous examination was performed.Information was collected on predesigned questionnaire after taking informed consent. DataAnalysis was carried out on SPSS statistics software. Results: Out of 100 patients, 43% weremales and 57% were females. In 69.6% patients, the birthmarks were noticed around time ofdelivery, 28.3% patients were noticed within 1st year of life and 2.2% later in 5 year. Pigmentedbirthmarks were identified in 65.2% patients while 34.8 % have vascular birthmarks.71.1% hadno changes in color during life span. While 37.8% had 1-3 cms birthmark and 45.7% havereported an increase in birthmark. Conclusions: We found birthmarks benign; they may growwith age but they do not need treatment unless there is concern either cosmetically or they havepain and discharge.

scholarly journals Health-related quality of life in different trimesters during pregnancy

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Huailiang Wu ◽  
Weiwei Sun ◽  
Hanqing Chen ◽  
Yanxin Wu ◽  
Wenjing Ding ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Pregnant Women ◽  
Demographic Data ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Health Related Quality ◽  
Cross Sectional ◽  
Related Quality ◽  
Health Related

Abstract Background Pregnant women experience physical, physiological, and mental changes. Health-related quality of life (HRQoL) is a relevant indicator of psychological and physical behaviours, changing over the course of pregnancy. This study aims to assess HRQoL of pregnant women during different stages of pregnancy. Methods This cross-sectional study was performed using the The EuroQoL Group’s five-dimension five-level questionnaire (EQ-5D-5L) to assess the HRQoL of pregnant women, and demographic data were collected. This study was conducted in a regional university hospital in Guangzhou, China. Results A total of 908 pregnant women were included in this study. Pregnant women in the early 2nd trimester had the highest HRQoL. The HRQoL of pregnant women rose from the 1st trimester to the early 2nd trimester, and dropped to the bottom at the late 3rd trimester due to some physical and mental changes. Reports of pain/discomfort problem were the most common (46.0%) while self-care were the least concern. More than 10% of pregnant women in the 1st trimester had health-related problems in at least one dimension of whole five dimensions. In the whole sample, the EuroQoL Group’s visual analog scale (EQ-VAS) was 87.86 ± 9.16. Across the gestational stages, the HRQoL remained stable during the pregnancy but the highest value was observed in the 1st trimester (89.65 ± 10.13) while the lowest was in the late 3rd trimester (87.28 ± 9.13). Conclusions During pregnancy, HRQoL were associated with gestational trimesters in a certain degree. HRQoL was the highest in the early 2nd trimester and then decreased to the lowest in the late 3rd trimester due to a series of physical and psychological changes. Therefore, obstetric doctors and medical institutions should give more attention and care to pregnant women in the late 3rd trimester.

Malaria among migrants in a university hospital in Colombia during 2018: A case series

2020 ◽  
pp. 004947552098130
Author(s):  
Fabián R Carreño-Almánzar ◽  
Adán Coronado-Galán ◽  
Sonia A Cala-Gómez ◽  
Agustín Vega-Vera
Keyword(s):  
Latin American ◽  
Previous History ◽  
Case Series ◽  
Cross Sectional Study ◽  
Imported Malaria ◽  
University Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
History Of ◽  
Clinical Profiles

Imported malaria has increased in Colombia since 2015 and has been attributed to migrants coming from Venezuela. We present a series of malaria cases, nested in a retrospective cross-sectional study between 2017 and 2018, aimed at calculating the prevalence of medical diseases among immigrants in a University Hospital in Colombia. Among 154 immigrants admitted for medical causes between 2017 and 2018, 8 were diagnosed with malaria, all due to Plasmodium vivax. Of these, seven had uncomplicated malaria, five had a previous history of malaria, one was critically ill, but none died. We highlight that, similar to other case series of imported malaria, Latin American migrants were young, with similar clinical profiles, having a low proportion of severe cases, and P. vivax was the most frequent cause.

scholarly journals Quality of life in multiple sclerosis: The differential impact of motor and cognitive fatigue

2021 ◽  
Vol 7 (1) ◽  
pp. 205521732199604
Author(s):  
Sabina David Ruban ◽  
Claudia Christina Hilt ◽  
Thor Petersen
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Short Form ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Cognitive Fatigue ◽  
Cross Sectional ◽  
Impact Scale ◽  
Assessment And Treatment

Background Multiple sclerosis is a chronic disease leading to reduced quality of life. Objectives To investigate whether motor and cognitive fatigue impact differently on aspects of quality of life among patients with multiple sclerosis, independently from bodily disability. Methods 79 patients with multiple sclerosis from Aalborg University Hospital, Denmark were included in an observational, cross-sectional study. Each subject completed two separate questionnaires regarding fatigue (Fatigue Scale for Motor and Cognitive Functions and Modified Fatigue Impact Scale) and one regarding quality of life (Short Form 36). Disability was measured with the Expanded Disability Status Scale (EDSS)-scores obtained from patient records. Results All fatigue scores were significantly correlated to all areas of quality of life (p < 0,05). This remained significant after adjustment for age, disease duration and EDSS-score. When looking at each type of fatigue separately, cognitive fatigue correlated mainly with mental health aspects of quality of life and motor fatigue with physical health areas of quality of life. Conclusion Increased motor and cognitive fatigue lead to a differential reduction in physical and mental quality of life, independently of bodily disability. This underlines the importance of proper assessment and treatment of fatigue among patients with multiple sclerosis.

scholarly journals Analysis of quality of life among asthmatic individuals with obesity and its relationship with pulmonary function: cross-sectional study

2017 ◽  
Vol 135 (4) ◽  
pp. 332-338 ◽  
Author(s):  
Letícia Baltieri ◽  
Luiz Claudio Martins ◽  
Everton Cazzo ◽  
Débora Aparecida Oliveira Modena ◽  
Renata Cristina Gobato ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Pulmonary Function ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Morbidly Obese ◽  
Life Questionnaire ◽  
Sectional Study ◽  
Anthropometric Data ◽  
Cross Sectional

ABSTRACT CONTEXT AND OBJECTIVE: The combined effect of obesity and asthma may lead to significant impairment of quality of life (QOL). The aim here was to evaluate the prevalence of asthma among obese individuals, characterize the severity of impairment of quality of life and measure its relationship with pulmonary function. DESIGN AND SETTING: Observational cross-sectional study in public university hospital. METHODS: Morbidly obese individuals (body mass index &gt; 40 kg/m2) seen in a bariatric surgery outpatient clinic and diagnosed with asthma, were included. Anthropometric data were collected, the Standardized Asthma Quality of Life Questionnaire (AQLQ(S)) was applied and spirometry was performed. The subjects were divided into two groups based on the median of the score in the questionnaire (worse &lt; 4 and better &gt; 4) and were compared regarding anthropometric data and pulmonary function. RESULTS: Among the 4791 individuals evaluated, 219 were asthmatic; the prevalence of asthma was 4.57%. Of these, 91 individuals were called to start multidisciplinary follow-up during the study period, of whom 82 answered the questionnaire. The median score in the AQLQ(S) was 3.96 points and, thus, the individuals were classified as having moderate impairment of their overall QOL. When divided according to better or worse QOL, there was a statistically difference in forced expiratory flow (FEF) 25-75%, with higher values in the better QOL group. CONCLUSION: The prevalence of asthma was 4.57% and QOL was impaired among the asthmatic obese individuals. The worst QOL domain related to environmental stimuli and the best QOL domain to limitations of the activities. Worse QOL was correlated with poorer values for FEF 25-75%.

scholarly journals Recurrent Miscarriage and Consanguinity among Omani Women– A Cross Sectional Study

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Fatma Al Hoqani ◽  
Wadha Al Ghafri ◽  
Saneya El tayeb ◽  
Yahya Al Farsi ◽  
Vaidyanathan Gowri
Keyword(s):  
Recurrent Miscarriage ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Control Group ◽  
P Value ◽  
Cross Sectional ◽  
Recurrent Miscarriages ◽  
Sultan Qaboos University ◽  
Chi Squared ◽  
History Of

Objective: to determine the prevalence of explained and unexplained recurrent miscarriages (RM) and to find out if there is a significant relationship between recurrent miscarriages and consanguinity. Methods: A cross sectional in which the cases group included all women with RM attending the outpatient clinic at Sultan Qaboos University Hospital from July 2006 to April 2012 and the controls group included women with no history of RM after matching them with cases for age (case to control ratio was 1:1). The main outcome measures were the prevalence of consanguinity in women with or without recurrent miscarriages. Results: During study period a total of 290 women with RM were seen. Of which, 150 (51.7%) women had unexplained RM. Control group with no history of RM were 300 women. Consanguinity rate among cases (49.5%) %) was less than the controls (52.7 %%). Both first cousin and second cousin marriages were more common in the controls than the cases and it was not statistically significant (p value 0.476, chi squared test). Conclusion: In this study we found that more than half of RM cases were unexplained and there was no significant association between RM and consanguinity.

scholarly journals OVARIAN MALIGNANCY

2018 ◽  
Vol 25 (02) ◽  
pp. 237-241
Author(s):  
Shabana Rafiq ◽  
Razia Bibi ◽  
Samina Ashraf
Keyword(s):  
Cross Sectional Study ◽  
Reproductive Age ◽  
Ovarian Malignancy ◽  
Ovarian Mass ◽  
Sectional Study ◽  
Women Of Reproductive Age ◽  
Cross Sectional ◽  
Increased Risk ◽  
History Of ◽  
Study Setting

Objectives: To determine the frequency of ovarian malignancy in women ofreproductive age presenting with ovarian mass and to determine frequency of factors leadingto ovarian malignancy. Study Design: Cross sectional study. Setting: Department of Obstetrics& Gynaecology, Lady Wallington Hospital, Lahore. Period with Dates: From 05.11.11 to26.06.12. Results: The result of our study reveals majority of the patients between 21-30 yearsi.e. 45.88%(n=39), common age was 24.21+3.76 years, 43.53%(n=37) were nulliparous (inmajority), while frequency of ovarian malignancy in women of reproductive age presenting withovarian mass was recorded in 14.11%(n=12) while frequency of factors leading to ovarianmalignancy was 91.67%(n=11) patients were nulliparous while family history of ovarianmalignancy was in 8.33%(n=1) patients. Conclusions: The frequency of ovarian malignancy ishigher among reproductive age females with increased risk of nulliparity.

scholarly journals Hepatitis C in pregnancy: an observational study highlighting its association with maternal parameters

2019 ◽  
Vol 8 (1) ◽  
pp. 344
Author(s):  
Bushra . ◽  
Ambreen Ghori ◽  
Azra Ahmed ◽  
Najma Dalwani ◽  
Mushtaque Ali Shah ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Previous History ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Prior History ◽  
Singleton Pregnancy ◽  
Cross Sectional ◽  
History Of

Background: Pregnancy is a very crucial time in a woman’s life. In this period of time, not only multiple physiological alterations effect the usual health status but also makes women more vulnerable to contract infection and face negative sequalae. Hepatitis C, a blood borne viral infection serve the similar fate when encountered by pregnant ladies. This study is based on exploring the prevalence of the Hepatitis C virus seropositivity among pregnant population. Moreover, we also evaluated the major risk factors leading to the infection in these mothers. Besides this, infected mothers were studied for their pregnancy outcomes.Methods: In this study 114 pregnant females were observed for this cross-sectional study. It was conducted in Gynecology Unit- 1, Liaquat University Hospital Hyderabad, for the period of January 2017 to July 2017. Chi square test was applied for statistical analysis on SPSS version 16. The criteria for enrollment in the study was set to be a pregnant lady belonging to age group 20-35 years; having singleton pregnancy; was a booked case at the hospital with compliant to antenatal follow ups; admitted to the labor room for delivery. All the non-pregnant ladies, whom had co morbid conditions such as hypertension or diabetes or had infected with hepatitis B or D were excluded from the study. Furthermore, pregnant ladies with multiple gestion or those who were either diagnosed of hepatitis C prior to conceive or had a previous history of hepatitis C were also excluded.Results: Present study revealed that out of 114, 10(8.8%) pregnant ladies were found seropositive for Hepatitis C virus. Prior history for transfusion of blood was the Foremost risk factor discovered, with 60.5% women reported this. History of surgery was the 2nd commonest factor and 43.9% had this in their medical records. On the other hand, only 8.8% women gave the history for previous evacuation. While observing pregnancy outcomes, we found 48.2% neonates had low birth weight, 41.2% were born preterm and 21.1% had low APGAR score.Conclusions: In a nutshell hepatitis c is prevalent in the pregnant population of this region and showing its effects in the form of compromised pregnancies. History of blood transfusion and previous surgery were found to be chief risk factors in the study.

scholarly journals HEPATITIS “C”

2016 ◽  
Vol 23 (09) ◽  
Author(s):  
Muhammad Iqbal ◽  
Adnan Ahmed ◽  
Muhammad Rafique Hingoro
Keyword(s):  
Hepatitis C ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Age Group ◽  
Sectional Study ◽  
Cross Sectional ◽  
Grade 3 ◽  
Chronic Hcv ◽  
Study Setting

Objectives: To determine incidence of steatosis in non-responder casesof chronic HCV. Study Design: Cross-sectional study. Setting: Tertiary Care Sanatorium inMedicine Department of LIAQUAT University Hospital Hyderabad/Jamshoro. Period: 26-9-2011to 25 August 2012. Material & Methods: Total 144 non-responders cases of Hepatitis C wereintegrated. Both gender, age 18 to 50 yrs, chronic HCV non-responder cases as well as cases fitfor hepatic biopsy were integrated in study. Grading of Inflammation was carried out as indicatedby histopathological measures. Results: Mean age was 48.5 + 5.2years. Uppermost prevalenceof chronic HCV disease was 65(45.13%) at 41 to 50 years age interval whereas 42(29.1%) caseswere noticed in 31 to 40 yrs age group and 25(17.3%) cases were observed in 20 to 30 yearsof young age group. In this study hepatic steatosis occurrence was observed in 103 (71.5%)cases and these were categories as: grade 1, grade 2, grade 3, as (<33%) 45/103(43.68%), (33to 66%) 35/103(33.98%), (>66%) 23/103(22.33%) respectively. Conclusion: Hepatic steatosisis a important risk factor the cases of HCV to decreased response to antiviral therapy and forprogression toward fibrosis as observed in cases related to metabolic steatosis.

scholarly journals Prevalence and reasons of use of different psychoactive substances among prisoners at Malir Prison, Karachi.

2020 ◽  
Vol 27 (07) ◽  
pp. 1488-1492
Author(s):  
Muhammad Ilyas Jat ◽  
Muhammad Tarique Arain ◽  
Saima Qureshi ◽  
Kheenpal Das ◽  
Anum Haider
Keyword(s):  
Substance Use ◽  
Peer Pressure ◽  
Cross Sectional Study ◽  
Psychoactive Substance ◽  
Psychoactive Substances ◽  
Ethical Considerations ◽  
Cross Sectional ◽  
History Of ◽  
Male Prisoners ◽  
Study Setting

The use psychoactive substances are on the rise in general population and even seen more among those who are involved in criminal activities. There are many reasons for such irrational use of psychoactive substances. Objectives: To determine the prevalence and reasons of use of different psychoactive substances among prisoners at Malir prison, Karachi. Study Design: Descriptive Cross-Sectional study. Setting: Malir prison, Karachi. Period: 22nd April 2019 to 26th May 2019. Material & Methods: This study was conducted at district Malir prison, Karachi. All the cases who were imprisoned due to any reason and had history of psychoactive substance use were enrolled. Thorough history and examination was carried out. Ethical considerations were taken as per international guidelines. Results: Among all 490 male prisoners who used to take different type of psychoactive substance, majority were of age ranges of 21 to 35 years and 55% were married while 44% were single and 1% were divorced or separated. Out of 490 cases 453 (92%) were using different substances thorough routes other than injections while 37 (8%) were injection users. Majority of prisoners 252 (52%) were using Heroin while 86 (17%) were using Crystals, 74 (15%) Cannabis, 37 (8%) Synthetic substances, 24 (5%) Ice, 6 (1%) Opioid and 11 (2%) were using some other type of substance. The most common reason of substance use was peer pressure followed by fun and frustration. Conclusion: Substance use prevalence is high in prison. Existing services for the management of drug dependence are not meeting the global standard of evidence based comprehensive drug treatment and rehabilitation.

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