The influence of whole body cryotherapy on plasma concentration of melatonin and serotonin in patients with osteoarthrosis of the lumbar spine

Background: ‪Osteoarthrosis (OA) is the most common disease affecting mankind. There are many physiotherapeutic methods of treating OA symptoms. One of them is whole body cryotherapy (WBCT). The aim of this study was to present the impact of WBCT combined with kinesiotherapy on functional efficiency and changes in plasma concentrations of serotonin and melatonin in patients with lumbar spine OA.. Material and methods: ‪60 patients underwent a series of WBCT combined with kinesiotherapy (group A). 60 patients underwent a series of kinesiotherapy alone (group B). Before and after the therapy patients were examined by Rolland Morris Disability Questionnaire (RMDQ), and blood samples were collected for laboratory assessment. Results: ‪Following therapy, the functional efficiency (RMDQ) improved by 33% in both study groups (p < 0.0001). After the therapy, both in the group of patients undergoing WBCT combined with exercises (group A, p = 0.032) and the cryotherapy alone (group B, p < 0.0001), the plasma melatonin concentration significantly increased. The rise of plasma serotonin concentrations was higher in group B as compared to group A, but in both study groups the increase in plasma serotonin was statistically significant (p < 0.0001).. Conclusions: ‪WBCT combined with therapeutic exercises as well as kinesiotherapy used alone resulted in an increase in melatonin and serotonin plasma levels and an improvement in functional efficiency in patients with lumbar spine OA.

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Impact of General Anesthesia Guided by State Entropy (SE) and Response Entropy (RE) on Perioperative Stability in Elective Laparoscopic Cholecystectomy Patients—A Prospective Observational Randomized Monocentric Study

Entropy ◽

10.3390/e22030356 ◽

2020 ◽

Vol 22 (3) ◽

pp. 356 ◽

Cited By ~ 1

Author(s):

Anca Raluca Dinu ◽

Alexandru Florin Rogobete ◽

Sonia Elena Popovici ◽

Ovidiu Horea Bedreag ◽

Marius Papurica ◽

...

Keyword(s):

Study Groups ◽

Depth Of Anesthesia ◽

Hemodynamic Stability ◽

State Entropy ◽

Multimodal Monitoring ◽

Response Entropy ◽

Group A ◽

Group B ◽

The Individual ◽

The Impact

Laparoscopic cholecystectomy is one of the most frequently performed interventions in general surgery departments. Some of the most important aims in achieving perioperative stability in these patients is diminishing the impact of general anesthesia on the hemodynamic stability and the optimization of anesthetic drug doses based on the individual clinical profile of each patient. The objective of this study is the evaluation of the impact, as monitored through entropy (both state entropy (SE) and response entropy (RE)), that the depth of anesthesia has on the hemodynamic stability, as well as the doses of volatile anesthetic. A prospective, observational, randomized, and monocentric study was carried out between January and December 2019 in the Clinic of Anesthesia and Intensive Care of the “Pius Brînzeu” Emergency County Hospital in Timișoara, Romania. The patients included in the study were divided in two study groups: patients in Group A (target group) received multimodal monitoring, which included monitoring of standard parameters and of entropy (SE and RE); while the patients in Group B (control group) only received standard monitoring. The anesthetic dose in group A was optimized to achieve a target entropy of 40–60. A total of 68 patients met the inclusion criteria and were allocated to one of the two study groups: group A (N = 43) or group B (N = 25). There were no statistically significant differences identified between the two groups for both demographical and clinical characteristics (p > 0.05). Statistically significant differences were identified for the number of hypotensive episodes (p = 0.011, 95% CI: [0.1851, 0.7042]) and for the number of episodes of bradycardia (p < 0.0001, 95% CI: [0.3296, 0.7923]). Moreover, there was a significant difference in the Sevoflurane consumption between the two study groups (p = 0.0498, 95% CI: [−0.3942, 0.9047]). The implementation of the multimodal monitoring protocol, including the standard parameters and the measurement of entropy for determining the depth of anesthesia (SE and RE) led to a considerable improvement in perioperative hemodynamic stability. Furthermore, optimizing the doses of anesthetic drugs based on the individual clinical profile of each patient led to a considerable decrease in drug consumption, as well as to a lower incidence of hemodynamic side-effects.

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Impact of General Anaesthesia - Guided by State Entropy (SE) and Response Entropy (RE) on Perioperative Stability in Elective Laparoscopic Cholecystectomy Patients. A Prospective Observational Randomized Monocentric Study

10.20944/preprints202002.0130.v1 ◽

2020 ◽

Author(s):

Anca Raluca Dinu ◽

Alexandru Florin Rogobete ◽

Sonia Elena Popovici ◽

Ovidiu Horea Bedreag ◽

Marius Papurica ◽

...

Keyword(s):

Study Groups ◽

Depth Of Anesthesia ◽

Hemodynamic Stability ◽

State Entropy ◽

Multimodal Monitoring ◽

Response Entropy ◽

Group A ◽

Group B ◽

The Individual ◽

The Impact

Study background and aims: Laparoscopic cholecystectomy is one of the most frequently performed interventions in departments of general surgery. One of the most important aims in achieving perioperative stability of these patients is diminishing the impact of general anesthesia on the hemodynamic stability and the optimization of anesthetic drug doses based on the individual clinical profile of each patient. The objective of this study is the evaluation of the impact monitoring the depth of anesthesia through Entropy (state entropy – SE and response entropy -RE) has on the hemodynamic stability and on the doses of volatile anesthetic. Material and Methods: This is a prospective, observational, randomized, monocentric study carried out between January 2019 and December 2019 in the Clinic of Anesthesia and Intensive Care from the “Pius Brînzeu” Emergency County Hospital in Timișoara, Romania. The patients included in the study were divided in two study groups; patients in Group A (target group) received multimodal monitoring that included monitoring of standard parameters and of Entropy (SE and RE), while patients in Group B (control group) only received standard monitoring. Anesthetic dose in group A were optimized to achieve a target entropy of 40-60. Results: 68 patients met the inclusion criteria and were allocated to one of the two study groups, Group A (N=43) and Group B (N=25). There were no statistically significant differences identified between the two groups for both demographical and clinical data (p>0.05). Statistically significant differences have been identified for the number of hypotensive episodes (p = 0.011, 95% CI 0.1851 to 0.7042) and for the number of episodes of bradycardia (p < 0.0001, 95% CI 0.3296 to 0.7923). Moreover, there was a significant difference in the Sevoflurane consumption between the two study groups (p = 0.0498, 95% CI -0.3942 to 0.9047). Conclusions: The implementation of the multimodal monitoring protocol that includes the standard parameters and the measurement of Entropy for determining the depth of anesthesia (SE and RE) lead to a considerable improvement in perioperative hemodynamic stability. Optimizing the doses of anesthetic drugs based on the individual clinical profile of each patient leads to a considerable decrease in drug consumption as well as to a lower incidence of hemodynamic side-effects.

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The influence of whole body cryotherapy on the functional efficiency in patients with spondyloarthrosis of the lumbar spine

Baltic Journal of Health and Physical Activity ◽

10.29359/bjhpa.11.4.12 ◽

2019 ◽

pp. 107-114

Author(s):

Marta Barlowska-Trybulec ◽

Jolanta Jaworek

Keyword(s):

Lumbar Spine ◽

Whole Body ◽

Functional Efficiency ◽

Whole Body Cryotherapy

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To assess the impact of various modes of postnatal breastfeeding education in promoting breastfeeding practices

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20171713 ◽

2017 ◽

Vol 4 (3) ◽

pp. 989

Author(s):

Venkatesh Periasami ◽

Vinodh Muthu ◽

Ezhil Vaanija Sakkarai ◽

Aravind Malayappan Ayyavoo ◽

Ganesh Jayachandan

Keyword(s):

Statistical Difference ◽

Study Groups ◽

P Value ◽

Written Information ◽

Breastfeeding Practices ◽

Breastfeeding Education ◽

Visual Aid ◽

Group A ◽

Group B ◽

The Impact

Background: Breast milk is the best nutrient a mother can provide her baby. WHO recommends exclusively breastfeeding up to 6 months of life.The objective of the study was to study the impact of postnatal breastfeeding education in promoting breastfeeding practices and to identify the effective mode of education.Methods: This is a RCT study conducted in Government RSRM lying-in hospital between Dec 2015 and May 2016.300 women who delivered live, term, healthy, AGA babies were divided randomly in to 3 study groups. Participants in group A were counselled about breastfeeding orally. Those in group B received written information and oral counselling. Group C members were shown an educational video apart from oral and written information. They were assessed on 15th day, 45th day, 3.5 months and 6 months using a simple questionnaire.Results: Analysis showed that during the 1st visit, there was no statistical difference between groups. However, during the last visit there was significant statistical difference between groups with a p value of 0.004.Conclusions: Audio-visual aid helps in better breastfeeding practices. Literacy status has no role in promoting breastfeeding practices.

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Bilateral Use of Iliac Branch Devices for Aortoiliac Aneurysms Is Safe and Feasible, and Procedural Volume Does Not Seem to Affect Technical or Clinical Effectiveness: Early and Midterm Results From the pELVIS International Multicentric Registry

Journal of Endovascular Therapy ◽

10.1177/15266028211016439 ◽

2021 ◽

pp. 152660282110164

Author(s):

Mario D’Oria ◽

Georgios A. Pitoulias ◽

Giovanni F. Torsello ◽

Apostolos G. Pitoulias ◽

Stefano Fazzini ◽

...

Keyword(s):

Study Groups ◽

Primary Patency ◽

Type I ◽

Mortality And Morbidity ◽

Procedural Volume ◽

Significant Difference ◽

Group A ◽

Group B ◽

The Impact

Objective To evaluate early and follow-up outcomes following bilateral use of iliac branch devices (IBD) for aortoiliac endografting and assess the impact of center volume. We used data from the pELVIS international multicentric registry. Methods For the purpose of this study, only those patients receiving concomitant bilateral IBD implantation were analyzed. To assess the impact that procedural volume of bilateral IBD implantation could have on early and follow-up outcomes, participating institutions were classified as Site(s) A if they had performed >10 and/or >20% concomitant bilateral IBD procedure, otherwise they were classified as Site(s) B. Endpoints of the analysis included early (ie, 30-day) mortality and morbidity, as well as all-cause and aneurysm-related mortality during follow-up. Additional endpoints that were evaluated included IBD-related reinterventions, IBD occlusion or stenosis requiring reintervention (ie, loss of primary patency), and IBD-related type I endoleak. Results Overall, 96 patients received bilateral IBD implantation (out of 910 procedures collected in the whole pELVIS cohort), of whom 65 were treated at Site A (ie, Group A) and 31 were treated at Site(s) B (ie, Group B). In total, only 1 death occurred within 30 days from bilateral IBD implantation, and 9 patients experienced at least 1 major complication without any significant difference between subjects in Group A versus those in Group B (10.8% vs 6.5%, p=0.714). In the overall cohort, the 2-year freedom from IBD-related type I endoleaks and IBD primary patency were 96% and 92%, respectively; no significant differences were seen in those rates between Group A or Group B (95% vs 100%, p=0.335; 93% vs 88%, p=0.470). Freedom from any IBD-related reinterventions was 83% at 2 years, with similar rates between study groups (85% vs 83%, p=0.904). Conclusions Within the pELVIS registry, concomitant bilateral IBD implantation is a safe and feasible technique for management of aortoiliac aneurysms in patients with suitable anatomy. Despite increased technical complexity, effectiveness of the repair is satisfactory with low rates of IBD-related adverse events at mid-term follow-up. Procedural volume does not seem to affect technical or clinical outcomes after bilateral use of IBD, which remains a favorable treatment option in selected patients.

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OR-038 CHANGE of SERUM TESTOSTERONE and ENDOCRINE INDEXS after CRYOTHERAPY in DIFFERENT AGE GROUPS

Exercise Biochemistry Review ◽

10.14428/ebr.v1i2.9683 ◽

2018 ◽

Vol 1 (2) ◽

Author(s):

Zhiguang Zhao ◽

Ke Sun

Keyword(s):

Low Temperature ◽

Cold Treatment ◽

Whole Body ◽

Control Group ◽

Testosterone Secretion ◽

Cold Therapy ◽

Significant Difference ◽

Group A ◽

Group B ◽

Whole Body Cryotherapy

Objective Ultra-low Temperature Whole-Body Cryotherapy can relieve pain, inhibit inflammation, improve sleep quality, promote immune regulation, reduce excessive muscle tone, and improve damaged joints and muscle function. Currently, it is widely used in competitive sports. There have been few studies on the effects of Ultra-low Temperature Whole-Body Cryotherapy on some endocrine indexes such as testosterone. In the previous study, it was found that the 25-year-old soldier had a good effect on the changes of hormones and other indicators after the cold treatment the next morning and after a week of cold treatment. However, the impact of Ultra-low Temperature Whole-Body Cryotherapy on large age groups with a marked decline in testosterone secretion has not yet begun. Therefore, this study intends to pass a rigorous controlled experiment, taking ordinary healthy men aged 20 and 40 as research subjects, to observe the changes of testosterone and other endocrine indicators before and two hours after cryotherapy for 2 different age groups. Investigate deeply of the changes in testosterone and other endocrine indicators after ultra-low cryotherapy in the general population of different ages, to provide more reference for the application of ultra-low temperature cold therapy in a wider population. Methods Eight male students with age of 22.0±0.8 yrs in the physical fitness class of Beijing sport university as group A. Eight healthy men with age of 42.2±4.5yrs as group B. The cold therapy parameters used in the experiment were -130 ° C ,for 150 s. The blood samples collected in group A were from 8:00 to 9:00 in the morning，immediately after cold therapy，30 minutes after cold therapy,，and 2 hours after cold therapy. In group B were collected before cold treatment and 2 hours after cold treatment. In order to avoid the influence of the time rhythm of testosterone secretion, the time points of blood sample collection during cold therapy and non-cold therapy were strictly consistent. Group A and group B were compared before and after cold treatment at the same time at room temperature. No statistical comparison was made between groups A and B. The test indicators were testosterone (T), follicular stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E2). The data obtained from the experiment were expressed by mean and standard deviation, and the relevant indicators collected were statistically analyzed. Results (1) Compared with the test value of before cryotherapy, Testosterone(T) in group A had a decrease of -7.8%, -13.4%, and -3.6% at the point of the cryotherapy finished immediately, 30 minutes after cryotherapy, and 2 hours after cryotherapy, respectively. There has been a continuous decline in the Control group with a decrease of -5.7%, -11.3%, and -12.0%, respectively. Compared with the test value of before cryotherapy, there was a significant difference at each time between the cryotherapy group and the control group; there was also a significant difference between the two groups at 2 hours after the cryotherapy. (2) Compared with the test value of before cryotherapy, FSH in group A increased 8.6% after cryotherapy immediately, increased 2.3% at the time of 2 hours after cryotherapy, However, the control group showed different degrees of decline, with a decrease of -4.09%, -6.9%, and -6.4%, respectively. And there were significant differences in FSH between the time point of after cryotherapy immediately and 30 minutes after cryotherapy compared with before cryotherapy. (3) Compared with the test value of before cryotherapy, group A had an increase of 7.9% in LH immediately after Cryotherapy and 1.0% in 2 hours after cryotherapy, while the control group showed different degrees of decline, with a decrease of -13.4%， -13.5% and -8.0%.（4）Compared with the test value of before Cryotherapy, group A showed different degrees of decline in E2 as immediately after cryotherapy, 30 minutes after cryotherapy and 2 hours after cryotherapy with the decrease ranges of -8.6%, -21.9% and -35.2% respectively. The changes of the control group were 8.7%, -18.7% and -22.6%, respectively. There were significant differences between the cryotherapy group and the control group at 30 minutes and 2 hours after the cryotherapy compared with before the intervention.(5) Before cryotherapy and 2 hours after cryotherapy, FSH and LH in group B decreased in cryotherapy and control, but the decrease in cryotherapy group was higher than control group; The change of T was different from FSH and LH. After the cryotherapy, the cryotherapy group showed a significant increase, which was 27% higher than before the cryotherapy, while the control group decreased by -7.5%,and there was a significant difference in T between the cryotherapy group and the control group before and after cryotherapy. Conclusions (1)Ultra-low Temperature Whole-Body Cryotherapy has a certain degree of influence on the hypothalamic-pituitary-gonadal (H-P-G) axis. Testosterone will increase 2 hours after cryotherapy, and Ultra-low Temperature Whole-Body Cryotherapy can promote testosterone secretion.(2) Ultra-low Temperature Whole-Body Cryotherapy can reduce the decomposition of testosterone and improve serum testosterone to some extent. (3) Ultra-low Temperature Whole-Body Cryotherapy is more effective in promoting testosterone secretion in people with relatively high age and testosterone secretion relative to the downhill stage (35-40 years old and older).

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The effects of programmed therapeutic exercises on fall risk factors in elderly

Journal of Health Sciences ◽

10.17532/jhsci.2018.621 ◽

2018 ◽

Vol 8 (3) ◽

pp. 140-147

Author(s):

Bakir Katana ◽

Samir Bojičić ◽

Muris Pecar ◽

Eldad Kaljić ◽

Namik Trtak ◽

...

Keyword(s):

Risk Factors ◽

Fall Risk ◽

Moderate Intensity ◽

Control Group ◽

Fast Evaluation ◽

Fall Risk Factors ◽

Therapeutic Exercises ◽

Group A ◽

Group B ◽

The Impact

Introduction: Identification of the risk factors that can be modified is an essential aspect in the development of the effective strategy for therapeutic intervention with the purpose to improve mobility and injury prevention and post-fall consequences. This research aimed to analyze the impact of programmed therapeutic exercises on the fall risk factors in the elderly. Methods: We included 260 patients older than 65 years, and assigned them randomly into three groups. Group A: 65 patients subjected to therapeutic exercises for moderate-intensity muscle strengthening with Theraband stretch straps (corresponding to 11-14 on the Borg rating of perceived exertion scale). Group B: 65 patients subjected to therapeutic anti-gravity exercises. Control group: 130 patients not participating in programmed therapeutic exercises. Presence of fall risk factors was assessed in all three groups with standardized Fast Evaluation of Mobility, Balance, and Fear test (FEMBAF) before the initiation of therapy, after three and after six months of treatment. Results: At the end of the study, the subjects of the group A had significantly fewer limitations in performing basic life activities at home compared to the patients of the control and Group B, p = 0.037. The control group subjects were statistically significantly more likely to complain of vertigo than subjects of the experimental groups, p = 0.021. The subjects of the experimental groups had more than two falls than the control group subjects, p = 0.003 statistically. In the control group, the number of fractures after the fall at the end of the study increased significantly, statistically higher than in the subjects of the experimental groups, P = 0.037. Conclusion: Programmed therapeutic exercise significantly reduces the risk of falling factors, and significant effects have been achieved among subjects who have exercised with elastic strips.

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THE ROLE OF MANUAL THERAPY IN THE TREATMENT OF CHRONIC CERVICAL PAINS

SPORT AND SOCIETY ◽

10.36836/2020/1/6 ◽

2020 ◽

pp. 1-4

Author(s):

George-Sebastian Iacob ◽

Constantin Munteanu

Keyword(s):

Manual Therapy ◽

Therapy Group ◽

Neck Disability Index ◽

Initial Assessment ◽

Visual Analogue Pain Scale ◽

Rehabilitation Protocol ◽

Visual Analogue Pain ◽

Therapeutic Exercises ◽

Group A ◽

Group B

Cervical back pain is one of the most important and common musculoskeletal disorders in medical recovery clinics and clinics. The main objective of the study was to highlight the effectiveness of an individualized therapeutic program adapted to the particularities of 22 subjects, which combines physical exercise with manual therapy. Subjects were randomly assigned to two equal groups. Group A - rehabilitation protocol consisting of therapeutic exercises (specific to the head, neck and upper limbs). Group B - rehabilitation protocol that included both therapeutic exercises and manual therapy (specific maneuvers of vertebral mobilization, massage, myofascial techniques, stretching and manipulations). The Visual Analogue Pain Scale (VAS) and the Neck Disability Index (NDI) were used to monitor the evolution of the research subjects, both of which have a specific applicability character to chronic pain. According to VAS (p <0.001), Group B showed mean values reduced to 2.2 ± 0.9 at week 12, compared to 7.3 ± 0.92, following the initial assessment. NDI values indicate better functional status after 12 weeks of treatment for both groups of subjects. NDI showed a beneficial decrease for Group B (13.2 ± 2.2 after 12 weeks, compared to 25.8 ± 2.3 in the first week). The mean results of VAS and NDI indicated a better evolution of symptoms in the case of the protocol that combined exercise and manual therapy (group B), but there were no statistically significant differences (compared to group A).

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The Role of Obesity in Predicting the Clinical Outcomes of COVID-19

Obesity Facts ◽

10.1159/000517180 ◽

2021 ◽

pp. 1-9

Author(s):

Serdar Sahin ◽

Havva Sezer ◽

Ebru Cicek ◽

Yeliz Yagız Ozogul ◽

Murat Yildirim ◽

...

Keyword(s):

Clinical Outcomes ◽

Health Care Providers ◽

Study Groups ◽

Normal Weight ◽

Overweight And Obesity ◽

Care Providers ◽

Significant Difference ◽

Group A ◽

Group B ◽

Group D

Introduction: The aim of this was to describe the predictors of mortality related to COVID-19 infection and to evaluate the association between overweight, obesity, and clinical outcomes of COVID-19. Methods: We included the patients >18 years of age, with at least one positive SARS-CoV-2 reverse transcriptase-polymerase chain reaction. Patients were grouped according to body mass index values as normal weight <25 kg/m2 (Group A), overweight from 25 to <30 kg/m2 (Group B), Class I obesity 30 to <35 kg/m2 (Group C), and ≥35 kg/m2 (Group D). Mortality, clinical outcomes, laboratory parameters, and comorbidities were compared among 4 groups. Results: There was no significant difference among study groups in terms of mortality. Noninvasive mechanical ventilation requirement was higher in group B and D than group A, while it was higher in Group D than Group C (Group B vs. Group A [p = 0.017], Group D vs. Group A [p = 0.001], and Group D vs. Group C [p = 0.016]). Lung involvement was less common in Group A, and presence of hypoxia was more common in Group D (Group B vs. Group A [p = 0.025], Group D vs. Group A [p < 0.001], Group D vs. Group B [p = 0.006], and Group D vs. Group C [p = 0.014]). The hospitalization rate was lower in Group A than in the other groups; in addition, patients in Group D have the highest rate of hospitalization (Group B vs. Group A [p < 0.001], Group C vs. Group A [p < 0.001], Group D vs. Group A [p < 0.001], Group D vs. Group B [p < 0.001], and Group D vs. Group C [p = 0.010]). Conclusion: COVID-19 patients with overweight and obesity presented with more severe clinical findings. Health-care providers should take into account that people living with overweight and obesity are at higher risk for COVID-19 and its complications.

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The Effect of Repeated Whole-Body Cryotherapy on Sirt1 and Sirt3 Concentrations and Oxidative Status in Older and Young Men Performing Different Levels of Physical Activity

Antioxidants ◽

10.3390/antiox10010037 ◽

2020 ◽

Vol 10 (1) ◽

pp. 37

Author(s):

Gabriela Wojciak ◽

Jadwiga Szymura ◽

Zbigniew Szygula ◽

Joanna Gradek ◽

Magdalena Wiecek

Keyword(s):

Physical Activity ◽

Young Men ◽

Oxidative Status ◽

Whole Body ◽

Stress Index ◽

Blood Levels ◽

Long Distance ◽

Antioxidant Defence ◽

Whole Body Cryotherapy ◽

The Impact

Background: The activity of antioxidant enzymes and sirtuins (Sirt) decreases along with age, which is counteracted by aerobic training. Sirtuins increase antioxidant defence. Whole-body cryotherapy (WBC) increases total antioxidant capacity (TAC) in young men. The aim of our study was to assess the impact of 24 WBC treatments on the blood concentration of selected sirtuins and the level of antioxidant defence as well as oxidative stress index of training and non-training men depending on age. Methods: The study involved 40 males. In each group, there were 10 non-training older and young men (60 NTR and 20 NTR), and 10 older and young long-distance runners (60 TR, 20 TR). During an 8-week period, participants underwent 24 WBC treatments (3 min −130 °C), which were performed three times a week (Monday, Wednesday, Friday). The concentrations of Sirt1, Sirt3, TAC, total oxidative status and the activity of superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx) in the blood were determined before 1 WBC and after 1 WBC, 12 WBC and 24 WBC. Results: After 1 WBC, the activity of GPx and the concentration of Sirt1 and TAC in 60 TR and TAC in 60 NTR increased. After 12 WBC, the level of Sirt1 in 20 NTR and SOD in 20 TR increased. After 24 WBC, the level of Sirt1 increased in 60 TR and in 20 NTR, Sirt3 in 60 TR and SOD in 20 TR. Conclusions: Cryogenic temperatures increase blood levels of Sirt1 and Sirt3 and systemic antioxidant defence in men, but the effect is dependent on age, level of performed physical activity and the number of applied treatments.

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