scholarly journals Metabolic syndrome: Epidemiology, diagnostic criteria, racial characteristics

2021 ◽  
Vol 6 (4) ◽  
pp. 180-191
Author(s):  
N. I. Vilson ◽  
L. V. Belenkaya ◽  
L. F. Sholokhov ◽  
I. A. Igumnov ◽  
Ya. G. Nadelyaeva ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Risk Factor ◽  
Clinical Practice ◽  
Comparative Analysis ◽  
Diagnostic Criteria ◽  
Indigenous Population ◽  
Pathological Condition ◽  
Scientific Databases ◽  
Different Populations

Metabolic syndrome (MS) is a very serious pathological condition that occurs in the clinical practice of doctors of various specialties. Often, the presence of MS aggravates the course of comorbidities, while various diseases can serve as a risk factor for its development. The significant prevalence of MS determines the need for its early diagnosis for timely correction and prevention of its long-term complications.The aim. To systematize data on the prevalence of metabolic syndrome in various countries and populations and to discuss the most frequently used diagnostic criteria, including racially and ethnically differentiated ones.Materials and method. A literary search was carried out using scientific databases: eLIBRARY, PubMed.NCBI, CyberLeninka, the official website of IDF for the period from 1999 to 2020.Results. It was found that despite different diagnostic criteria used for MS, its prevalence in many countries is comparable (10–30 %) but differs in different populations. Thus, MS occurs more often in Caucasians than among Asians, and its prevalence is significantly higher in the newcomer vs the indigenous population. Nevertheless, a comparative analysis of the frequency of MS is difficult due to the use of research results based on different approaches to its diagnosis in the literature presented in the literature. Although the analysis of literature data indicates the existence of specific features of the prevalence of MS in different populations, the differentiated approaches to detecting MS depending on the race of patients, which are necessary for many countries, have not yet been sufficiently developed.

Characterization of Sepsis and Sepsis-Associated Encephalopathy

2017 ◽  
Vol 34 (11-12) ◽  
pp. 938-945 ◽  
Author(s):  
Qing Feng ◽  
Yu-Hang Ai ◽  
Hua Gong ◽  
Long Wu ◽  
Mei-Lin Ai ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Risk Factors ◽  
Risk Factor ◽  
Diagnostic Criteria ◽  
Mortality Rates ◽  
Apache Ii ◽  
Apache Ii Score ◽  
Long Term Prognosis

Background: Sepsis and sepsis-associated encephalopathy (SAE) are common intensive care unit (ICU) diseases; the morbidity and mortality are high. The present study analyzed the sensitivity of different diagnostic criteria of sepsis 1.0 and 3.0, epidemiological characteristics of sepsis and SAE, and explored its risk factors for death, short-term, and long-term prognosis. Methods: The retrospective study included patients in ICU from January 2015 to June 2016. After excluding 58 patients, 175 were assigned to either an SAE or a non-SAE group (patients with sepsis but no encephalopathy). The sensitivity of the diagnostic criteria was compared between sepsis 1.0 and 3.0, respectively. Between-group differences in baseline data, Acute Physiology and Chronic Health Evaluation II score (APACHE II score), Sequential Organ Failure Assessment score (SOFA score), etiological data, biochemical indicators, and 28-day and 180-day mortality rates were analyzed. Survival outcomes and long-term prognosis were observed, and risk factors for death were analyzed through 180-day follow-up. Results: The sensitivity did not differ significantly between the diagnostic criteria of sepsis 1.0 and 3.0 ( P = .286). The 42.3% incidence of SAE presented a significantly high APACHE II and SOFA scores as well as 28-day mortality and 180-day mortality (all P < .001). The incidence of death was 37.1%. The multivariate stepwise regression analysis demonstrated that the risk of death in SAE group was significantly higher than the non-SAE group ( P < .001). Sepsis-associated encephalopathy is a risk factor for sepsis-related death (relative risk [RR] = 2.868; 95% confidence interval: 1.730-4.754; P < .001). Although males showed a significantly high rate of 28-day and 180-day mortality ( P = .035 and .045), it was not an independent risk factor for sepsis-related death ( P = .072). The long-term prognosis of patients with sepsis was poor with decreased quality of life. No significant difference was observed in prognosis between the SAE and non-SAE groups ( P > .05). Conclusion: Both diagnostic criteria cause misdiagnosis, and the sensitivity did not differ significantly. The incidence of SAE was high, and 28-day and 180-day mortality rates were significantly higher than those without SAE. Sepsis-associated encephalopathy is a risk factor for poor outcome. The overall long-term prognosis of patients with sepsis was poor, and the quality of life decreased.

scholarly journals Risk factors of metabolic syndrome among food suppliers

2017 ◽  
Vol 145 (5-6) ◽  
pp. 289-293 ◽  
Author(s):  
Yahya Pasdar ◽  
Mitra Darbandi ◽  
Parisa Niazi ◽  
Behrooz Hamzeh ◽  
Mostafa Nachvak ◽  
...  
Keyword(s):  
Physical Activity ◽  
Metabolic Syndrome ◽  
Risk Factor ◽  
Liver Enzymes ◽  
Dietary Consumption ◽  
Low Hdl ◽  
Kolmogorov Smirnov ◽  
Different Populations ◽  
The City ◽  
High Triglyceride

Introduction/Objective. As a risk factor for chronic diseases, metabolic syndrome (MS) is increasing at an alarming rate. The prevalence of MS varies according to lifestyle and occupation in different populations. The present study aimed to determine the prevalence of MS and its components in food suppliers. Methods. A total of 112 food suppliers were randomly selected from all around the city. Data collection tools included demographic, physical activity, and food frequency questionnaires. Body composition was measured using Bio-Electrical Body Analyzer. A sample of 5 ml of fasting blood was taken from participants to assess lipid profile, blood sugar, insulin, and liver enzymes. The data were analyzed using ?2, Kolmogorov?Smirnov and ANOVA tests. Results. Participants? mean BMI was 27.1 ? 3.9 kg/m2, 43.6% were overweight, and 26.4% were obese. Consumption of vegetables was less and of meats more than recommended amounts. The prevalence of MS was 45.5% (51 people), which increased with aging (p = 0.02). Among factors causing MS, the most common one was waist-to-hip ratio (WHR) > 0.09 (72.7%), followed by high triglyceride and low HDL. Conclusion. In this study, the prevalence of MS among food suppliers was higher than the world average and than prevalence in other countries. WHR (or obesity) was found to be the most important risk factor for MS. To reduce the risk of MS, changing dietary consumption habits and increased physical activity are recommended to persons with high risk and sedentary occupations.

scholarly journals A Comparative Analysis of the Influence of Gender, Pathway Delays, and Risk Factor Exposures on the Long-term Outcomes of Bladder Cancer

2015 ◽  
Vol 1 (1) ◽  
pp. 82-89 ◽  
Author(s):  
Richard T. Bryan ◽  
Tim Evans ◽  
Janet A. Dunn ◽  
Gulnaz Iqbal ◽  
Sarah Bathers ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Risk Factor ◽  
Comparative Analysis ◽  
Long Term Outcomes

scholarly journals Efficacy, Safety and Long-term Outcomes of Nicorandil Use in Patients with Stable Ischemic Heart Disease According to the Results of Randomized and Observational Studies

2019 ◽  
Vol 15 (5) ◽  
pp. 641-648
Author(s):  
Yu. V. Lukina ◽  
N. P. Kutishenko ◽  
S. Yu. Martsevich
Keyword(s):  
Heart Disease ◽  
Clinical Practice ◽  
Comparative Analysis ◽  
Ischemic Heart Disease ◽  
Ischemic Heart ◽  
Long Term Outcomes ◽  
Stable Ischemic Heart Disease ◽  
The Impact ◽  
Real Clinical Practice

Working Group of the NIKEA Study. Yekaterinburg: Akulina E.N., Reznik I.I.; Izhevsk: Grebnev S.A., Yezhov A., Shinkareva S.E.; Krasnodar: Kudryashov E.A., Skibitsky A.V., Skibitsky V.V., Fendrikova A.V.; Krasnoyarsk: Altayev V.D., Matyushin G.V., Nemik D.B., Pitaev R.R., Samokhvalov E.V., Stolbikov Yu.Yu.; Moscow: Balashov I.S., Voronina V.P., Gaisenok O.V., Dmitrieva N.A., Zagrebelny A.V., Zakharova A.V., Zelenova T.I., Kolganova E.V., Leonov A.S., Lerman O.V., Maximova M.A., Sladkova T.A., Shestakova G.N.; Novosibirsk: Kuimov A.D., Shurkevich A.A.; Omsk: Goodilin V.A., Loginova E.N., Nechaeva G.I.; Orel: Zhuravleva L.L., Lobanova G.N., Luneva M.M., Mitroshina T.N.; Orenburg: Kondratenko V.Yu., Libis R.A.; Rostov-on-Don: Dubishcheva N.F., Kalacheva N.M., Kolomatskaya O.E., Romadina G., Skarzhinskaya N.S., Chesnikova A.I., Chugunova I.B.; Ryazan: Dobrynina N.V., Nikolaev A.S., Trofimova Ya.M., Yakushin S.S.; Tula: Berberfish L.D., Gomova T.A., Gorina G.I., Dabizha V.G., Zubareva L.A., Nadezhkina K.N., Nikitina V.F., Renko I.E., Soin I.A., Yunusova K.N.Background. Nicorandil is an antianginal drug for which, the ability to positively influence the prognosis of patients (pts) with stable ischemic heart disease (IHD) was confirmed in a randomized controlled trial (RCT) of IONA (the Impact Of Nicorandil in Angina). To study whether the results of RCTs are reproduced in real clinical practice seems to be an actual scientific and practical task.Aim. To compare the data on the effectiveness and safety of nicorandil in pts with stable IHD obtained in the NIKEA observational study (OS) and in the IONA randomized study.Material and methods. 590 pts with IHD and stable angina pectoris were included in the OS NIKEA. All pts were recommended to take nicorandil in addition to the standard antiischemic therapy. 21 months after being included in the study, 524 pts received a phone call. During the telephone contact with pts or their relatives, the life status of pts was determined. According to these results of the survey data were obtained, that 15 people died and 509 pts were alive. The events included in the primary combined endpoint (PCEP) were also determined: death from all causes, new cases of acute myocardial infarction and acute cerebrovascular accident, unscheduled operations of myocardial revascularization, hospitalization for decompensation of chronic heart failure, atrial fibrillation, unstable angina, information on taking nicorandil and other drug therapy, adverse events of drug treatment have been reported. A comparative analysis of the results of the OS NIKEA and RCT IONA was carried out. The results of the IONA study were taken according to the publication in the Lancet 2002. A comparative analysis of the results of the effectiveness of nicorandil in real practice (according to the OS results) was performed with the data obtained in the RCT: the nicorandil/placebo groups in the RCT were compared with the adherent/non-adherent nicorandil groups in the OS.Results. The follow-up duration in both studies was similar and averaged 1.6±0.5 years at RCT IONA and 1.8±0.4 years at NIKEA study. The average age of pts was 67,0±8,0 years in RCT and 65.1±9.6 years in OS. In pts of OS more pronounced comorbidity was noted (cardiovascular diseases, diabetes mellitus). Drugs that favorably affect the prognosis in pts with IHD were more often prescribed to NIKEA study pts (p<0.05). In both RCTs and OS, the antianginal effectiveness of nicorandil was confirmed. According to the OS results, a reduction in the number of angina attacks and a decrease in the need for short-acting nitrates were demonstrated. The frequency of PCEP components was higher in RCT.Conclusion. Long-term outcomes according to the NIKEA observational program for various components of the PCEP turned out to be similar to the results of RCT IONA. It is demonstrated the efficacy of nicorandil in real clinical practice. 

Diagnostic criteria for metabolic syndrome: a comparative analysis in an unselected sample of adult male population

Metabolism ◽  
2008 ◽  
Vol 57 (3) ◽  
pp. 355-361 ◽  
Author(s):  
Pasquale Strazzullo ◽  
Antonio Barbato ◽  
Alfonso Siani ◽  
Francesco P. Cappuccio ◽  
Marco Versiero ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Comparative Analysis ◽  
Diagnostic Criteria ◽  
Adult Male ◽  
Male Population ◽  
Unselected Sample

Thrombocytopenia in a real clinical practice of cardiologist: the results of the long-term observational study

2020 ◽  
Author(s):  
Л.И. Малинова ◽  
Н.Ф. Пучиньян ◽  
Н.В. Фурман ◽  
П.В. Долотовская ◽  
Т.П. Денисова ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Observational Study ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Pathological Condition ◽  
Clinical Severity ◽  
Clinical State ◽  
Cardiovascular Disorders ◽  
Real Clinical Practice

Цель исследования: оценить частоту встречаемости тромбоцитопении (ТП) в реальной практике врача-кардиолога и характеризовать ее в зависимости от тяжести состояния пациента (варианта оказания специализированной кардиологической помощи). Материалы и методы: Проведено многолетнее ретроспективное обсервационное исследование на базе крупного кардиологического центра, оказывающего специализированную кардиологическую помощь как в плановом, так и в экстренном порядке, а также в условиях консультационно-поликлинического отделения. Анализировались данные 31430 пациентов. Под ТП понималось патологическое состояние, характеризующееся снижением количества тромбоцитов, циркулирующих в периферической крови, < 150×109/л. Результаты: У 2,69% пациентов кардиологического профиля был выявлен уровень тромбоцитов в периферической крови < 150×109/л. Среди пациентов, госпитализированных по неотложным и экстренным показаниям, частота ТП составила 9,41%. У пациентов, нуждающихся в экстренной и неотложной кардиологической помощи, ТП была более тяжелая (LQ 7×103/мм3; p = 0,012), сопровождалась анемией (гемоглобин LQ 13 г/л; р = 0,003) и лейкоцитозом (лейкоциты UQ 16,3×103/мм3; р = 0,000). Нарастание степени тяжести ТП у больных, госпитализированных в экстренном порядке, было ассоциировано со значимым снижением степени тромбоцитарного анизоцитоза — PDW = 8,7 [6,6; 12,4]% (p = 0,001) и минимальными изменениями размера тромбоцитов (MPV). Заключение: В реальной клинической практике тромбоцитопения выявляется у 2,7% пациентов кардиологического профиля, частота ее встречаемости увеличивается с нарастанием тяжести клинического состояния больных. Установлены цитоморфологические различия тромбоцитопении у пациентов кардиологического профиля в зависимости от тяжести состояния. Полученные данные свидетельствуют об угнетении тромбоцитопоэза в качестве ведущего механизма снижения количества тромбоцитов у кардиологических пациентов с тромбоцитопенией, госпитализированных в ургентном порядке. Objectives: to evaluate the frequency of thrombocytopenia in the real cardiological clinical practice, and to characterize it according to the severity of the patient’s condition. Patients/Methods: A long-term retrospective observational study was performed in the large cardiological center providing specialized cardiological care: planned and emergency hospitalizations as well as outpatient consultation. We analyzed data from 31,430 patients. Thrombocytopenia (TP) was considered as a pathological condition characterized by abnormally low levels of platelets < 150×109/L. Results: Platelets levels < 150×109/L were detected in 2.69% of patients with cardiovascular disorders. Among critically ill patients the incidence of TP was 9.41%. In patients requiring urgent admission to intensive cardiovascular care unit (ICU), TP was more severe (LQ 7×103/mm3; p = 0.012) and accompanied by anemia (hemoglobin LQ 13 g/L; p = 0.003) and leukocytosis (leukocytes UQ 16.3×103/mm3; p = 0.000). An increase in the severity of TP in patients admitted to ICU was associated with a significant decrease of platelet anisocytosis — PDW = 8.7 [6.6; 12.4]% (p = 0.001) and minimal changes in platelet volume (MPV). Conclusions: In real clinical practice, thrombocytopenia was detected in 2.7% of patients with cardiovascular disorders; and its frequency increased with worsening of the patients’ clinical state. Thrombocytopenia characterized by cytomorphological differences according to the clinical severity in cardiovascular patients. Received data suggest an inhibition of platelet production as a leading mechanism for platelet count reducing in critically ill patients with cardiovascular disorders.

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