scholarly journals Evaluation of general anesthesia induced by propofol, ketamine protocol in rabbits premedicated with diazepam

2014 ◽  
Vol 38 (2) ◽  
pp. 100-107
Author(s):  
Areej Ali Atiyah
Keyword(s):  
Heart Rate ◽  
Body Temperature ◽  
General Anesthesia ◽  
Respiratory Rate ◽  
General Anaesthesia ◽  
Intramuscular Injection ◽  
Muscle Relaxation ◽  
Healthy Male ◽  
Male Adult ◽  
Wave Morphology

The present study was designed to evaluate the efficacy of diazepam-propofol-Ketamine protocol for induction of general anaesthesia in rabbits. The experiment was conducted on seventeen healthy male adult local rabbits weighting 0.9-1.5 kg. Rabbits were given protocol, Diazepam 1mg/kg B.W. by intramuscular injection then 15 minutes later propofol 10 mg/kg B.W. as bolus slow intravenous injection and ketamine 25 mg/kg BW by intramuscular injection. Several parameters included respiratory rate, body temperature and heart rate were recorded before injection of drugs and after giving the anesthetic protocol at 0, 5, 10, 15, 20, 30, 45, 60, 75 and 90 minutes. The results showed that the anaesthesia with diazepam, propofol and Ketamine protocol in rabbits was suitable as it produced reliable surgical anaesthesia, good analgesia and muscle relaxation with minimal changes on the wave morphology of the cardiac muscle.

scholarly journals A comparative study between using of Midazolam-Ketamine and Diazepam-Ketamine combinations as anaesthetic program in sheep

2011 ◽  
Vol 10 (1) ◽  
pp. 66
Author(s):  
S. A. A. Al-Redah
Keyword(s):  
Heart Rate ◽  
Respiratory Rate ◽  
Rectal Temperature ◽  
Recovery Time ◽  
Intramuscular Injection ◽  
Healthy Adult ◽  
Muscle Relaxation ◽  
Anaesthetic Drug ◽  
Group D ◽  
Apparently Healthy

The present study was designed to compare the efficacy for using of the two anesthetics combinations (Midazolam-Ketamine and Diazepam-Ketamine). The effect of combinations on the length of surgical anesthesia, degree of flank analgesia, degree of muscle relaxation, respiratory rate, heart rate and rectal temperature were assayed in sheep.The experiment was conducted on ten apparently healthy adult sheep of either sex weighting (24-33kg). Sheep were divided in two equal groups, Diazepam (1mg/kg BW) +Ketamine (10mg/kg BW) group (D+K), Midazolam (1mg/kg BW) +Ketamine 10mg/kg BW group (M+K), was used by intramuscular injection, benzodiazepine derivative (diazepam or midazolam) injected first and then followed by ketamine 10minutes later.The following parameter were recorded at 3minutes before injection of drug and 5, 10, 20, 30, 45, 60 and 75 minutes (min.) respectively after administration of anaesthetic drug (Rectal Temperature , Respiratory Rate , Heart Rate , Degree of Analgesia , Degree of Muscle relaxation), the induction time, surgical anaesthesia and recovery time also were recorded.The experiment showed that the anaesthesia with Midazolam + Ketamine combination in sheep was suitable compared with Diazepam + Ketamine as it produced reliable surgical anaesthesia, good analgesia and muscle relaxation.

scholarly journals Comparative study for three protocols of general anesthesia in bucks

2018 ◽  
Vol 41 (2) ◽  
pp. 15-23
Author(s):  
Raffal A. Omar ◽  
M. J. Eesa
Keyword(s):  
Heart Rate ◽  
Statistical Analysis ◽  
Body Temperature ◽  
General Anesthesia ◽  
Respiratory Rate ◽  
Clinical Signs ◽  
Sharp Decrease ◽  
Significance Level ◽  
Alanine Amino Transferase ◽  
Aspartate Amino Transferase

     The aim of this study was to evaluate three regimens in induction and maintenance of general anesthesia in local breed bucks and the investigation of the best protocol of them based on different parameters. Eighteen healthy adult bucks weighing (27.50 ± 0.682 kg), aged (1.989 ± 0.135 years) were used. Animals were divided randomly into three equal groups to undergo pre-experiment preparation. All groups were premedicated intravenously with (0.5 mg/ kg) Diazepam, ten min. Later, the induction for first group was done by Propofol (3 mg/kg B.W), second group was done by Ketamine Hcl (2 mg/kg B.W), while in the third group was done by Thiopental sodium (3mg/kg B.W). After intubation with suitable endotracheal tube, maintenance of the three groups was done by (1.3-1.5%) isoflurane and nitrous oxide with oxygen at ratio 2:1. All the three groups underwent the measurement of the following parameters; (Induction, recovery and duration times) Clinical parameters (heart rate, respiratory rate and body temperature); Clinical signs, analgesia, muscle relaxation; Liver enzyme (Aspartate Amino Transferase and Alanine Amino Transferase). The complete randomized design within statistical analysis system (SAS) program were used for statistical analysis as relevant with a significance level set at P<0.05. The results of this study showed that the induction of the anesthesia was smooth and uneventful in all the three groups and recovery time was shorter in 3rd group in comparison with 2nd and 1st groups. The three regimens showed no significant differences in heart rate. The 2nd group recorded a sharp decrease in respiratory rate and body temperature in comparison with 1st and 3rd groups. Analgesia was very suitable in all the three groups. There were significant changes among groups concerning Alanine Amino Transferase and, Aspartate Amino Transferase. It was concluded that all the three protocols were safe and caused no hazard effect on the animals.

scholarly journals Distribution of Pediatric Vital Signs in the Emergency Department: A Nationwide Study

Children ◽  
2020 ◽  
Vol 7 (8) ◽  
pp. 89
Author(s):  
Woori Bae ◽  
Kyunghoon Kim ◽  
Bongjin Lee
Keyword(s):  
Emergency Department ◽  
Heart Rate ◽  
Body Temperature ◽  
Respiratory Rate ◽  
Life Support ◽  
Vital Signs ◽  
Reference Ranges ◽  
Normal Body Temperature ◽  
Heart Rates ◽  
Normal Body

To effectively use vital signs as indicators in children, the magnitude of deviation from expected vital sign distribution should be determined. The purpose of this study is to derive age-specific centile charts for the heart rate and respiratory rate of the children who visited the emergency department. This study used the Korea’s National Emergency Department Information System dataset. Patients aged <16 years visiting the emergency department between 1 January 2016 and 31 December 2017 were included. Heart rate and respiratory rate centile charts were derived from the population with normal body temperature (36 to <38 °C). Of 1,901,816 data points retrieved from the database, 1,454,372 sets of heart rates and 1,458,791 sets of respiratory rates were used to derive centile charts. Age-specific centile charts and curves of heart rates and respiratory rates showed a decline in heart rate and respiratory rate from birth to early adolescence. There were substantial discrepancies in the reference ranges of Advanced Paediatric Life Support and Pediatric Advanced Life Support guidelines. Age-based heart rate and respiratory rate centile charts at normal body temperature, derived from children visiting emergency departments, serve as new evidence-based data and can be used in follow-up studies to improve clinical care for children.

Acclimatization of calves to a hot humid environment

1959 ◽  
Vol 52 (3) ◽  
pp. 305-312 ◽  
Author(s):  
W. Bianca
Keyword(s):  
Heart Rate ◽  
Body Temperature ◽  
Respiratory Rate ◽  
Skin Temperature ◽  
Rectal Temperature ◽  
Heat Production ◽  
Metabolic Heat ◽  
Hot Environment ◽  
Humid Environment ◽  
Physiological Reactions

1. Three calves were exposed in a climatic room to an environment of 40° C. dry-bulb and 38° C. wet-bulb temperature for up to 110 min. each day for 1-2 weeks.2. These exposures produced progressive changes in the physiological reactions of the animals to heat:(a) Rectal temperature and skin temperature (for a given time of exposure) declined. In consequence there was a marked increase in the tolerance time, i.e. in the time for which the animals could withstand the hot environment before reaching a rectal temperature of 42° C.(b) Respiratory rate rose earlier and assumed higher levels (for given levels of body temperature).(c) Heart rate decreased markedly.3. These changes are discussed in relation to heat loss and heat production and have been interpreted as reflecting chiefly a reduction in the metabolic heat production of the animals.

scholarly journals Evaluation of the anesthetic effects of xylazine-ketamine, xylazine-tiletamine-zolazepam and tiletamine-zolazepam using clinical and laboratory parameters in rabbits

2018 ◽  
Vol 74 (10) ◽  
pp. 646-652 ◽  
Author(s):  
ABDULLAH KARASU ◽  
NURI ALTUG ◽  
LOGMAN ASLAN ◽  
BAHTIYAR BAKIR ◽  
NAZMI YUKSEK
Keyword(s):  
Heart Rate ◽  
Body Temperature ◽  
Respiratory Rate ◽  
Hematological Parameters ◽  
The Other ◽  
Equal Treatment ◽  
Anesthesia Induction ◽  
Treatment Groups ◽  
Reference Limits ◽  
Hematological And Biochemical Parameters

The aim of this study was to evaluate the anesthetic effects of xylazine-ketamine (XK), xylazine-tiletamine-zolazepam (XTZ) and tiletamine-zolazepam (TZ) using hematological and biochemical parameters in rabbits. A total of 18 rabbits were divided into three equal treatment groups (n = 6). The rabbits in the XK, XTZ, and TZ groups were administered xylazine (5 mg/kg) and ketamine (50 mg/kg), xylazine (5 mg/kg) and TZ (15 mg/kg), and TZ (15 mg/kg), respectively, via the intramuscular route. Following the injection, their reflexes were tested every 5 minutes. Heart rate, respiratory rate, and body temperature were determined before the injection (0 min) and at 5, 15, 30, 45, 60, 75, 90, and 120 min after injecting the anesthetic combinations. Furthermore, hematological and biochemical (alanine transaminase [ALT], aspartate transaminase [AST], alkaline phosphatase [ALP], bilirubin, blood urea nitrogen [BUN], and urea) analyses were also performed before, during, and after anesthesia administration. The duration of anesthesia and loss of reflexes were significantly longer in the XTZ group than in the other groups. However, in the TZ group, reflexes were remained. Respiratory rate and body temperature decreased in all the groups. Moreover, heart rate reduced only in the XK and XTZ groups, and the hematological parameters of all groups were comparable. Serum AST and ALP levels increased in the XTZ group compared to that in the XK and TZ groups, respectively. However, these increases were within the reference limits. The post-anesthesia serum BUN and urea levels significantly increased in the XTZ group (p &lt; 0.05) compared to that in the other groups. Thus, although the XTZ combination provided satisfactory anesthetic effect in rabbits, it may be nephrotoxic. Therefore, its use for anesthesia induction in invasive renal procedures and experimental nephrotoxicity studies is not advisable..

A Randomized Comparative Trial to Study the effect of Preoperative single shot Epidural with Ropivacaine in Lumbar Laminectomy

2021 ◽  
pp. 2945-2949
Author(s):  
Karuna Taksande ◽  
G. Swathi Reddy
Keyword(s):  
Heart Rate ◽  
Blood Loss ◽  
General Anesthesia ◽  
General Anaesthesia ◽  
Anesthetic Management ◽  
Comparative Trial ◽  
Single Shot ◽  
General Anesthetics ◽  
Rescue Analgesia ◽  
Randomised Study

Background: laminectomy surgeries are usually performed in cases of spinal canal stenosis, disc prolapse etc. It has been reported that the use of regional anesthesia techniques in combination to general anaesthesia has shown better heamodynamic stability intraoperatively, better pain scores and reduced intraoperative blood loss. The present study was conducted to evaluate the efficacy of fusion technique of combining epidural and general anaesthesia in patients undergoing lumbar laminectomies. Aim: To evaluate the efficacy of combined epidural general anesthesia for lumbar laminectomy surgeries with epidural ropivacaine. Materials and Methods: A prospective randomised study was conducted in 100 patients who are scheduled for lumbar laminectomy surgeries belonging to ASA Class I and II age between 40-60 years were randomly allocated into two groups (Group E and Group F) of 50 each. Group E: 12ml of 0.5% Ropivacaine and 50µg fentanyl epidurally. Group F:12ml of Normal Saline and 50µg fentanyl epidurally. The parameters recorded were intraoperative analgesia by heart rate and blood pressure, Rescue analgesia, Blood loss. Results: Intraoperatively requirement of general anesthetics, Heart rate, MBP, Blood loss, is lesser in Group E when compared with Group F. It was observed that longer time to rescue analgesia in group E than in group F. Conclusion: combined epidural general anesthesia with local anesthetic (ropivacaine) with narcotic (fentanyl) is a better technique for anesthetic management of patients posted for lumbar laminectomy. Thus from our study we conclude that combined epidural general anesthesia technique with epidural ropivacaine is a better alternative to general anesthesia providing stable hemodynamics, reducing dose of general anesthetics, less blood loss.

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