scholarly journals Evaluation of the anesthetic effects of xylazine-ketamine, xylazine-tiletamine-zolazepam and tiletamine-zolazepam using clinical and laboratory parameters in rabbits

2018 ◽  
Vol 74 (10) ◽  
pp. 646-652 ◽  
Author(s):  
ABDULLAH KARASU ◽  
NURI ALTUG ◽  
LOGMAN ASLAN ◽  
BAHTIYAR BAKIR ◽  
NAZMI YUKSEK
Keyword(s):  
Heart Rate ◽  
Body Temperature ◽  
Respiratory Rate ◽  
Hematological Parameters ◽  
The Other ◽  
Equal Treatment ◽  
Anesthesia Induction ◽  
Treatment Groups ◽  
Reference Limits ◽  
Hematological And Biochemical Parameters

The aim of this study was to evaluate the anesthetic effects of xylazine-ketamine (XK), xylazine-tiletamine-zolazepam (XTZ) and tiletamine-zolazepam (TZ) using hematological and biochemical parameters in rabbits. A total of 18 rabbits were divided into three equal treatment groups (n = 6). The rabbits in the XK, XTZ, and TZ groups were administered xylazine (5 mg/kg) and ketamine (50 mg/kg), xylazine (5 mg/kg) and TZ (15 mg/kg), and TZ (15 mg/kg), respectively, via the intramuscular route. Following the injection, their reflexes were tested every 5 minutes. Heart rate, respiratory rate, and body temperature were determined before the injection (0 min) and at 5, 15, 30, 45, 60, 75, 90, and 120 min after injecting the anesthetic combinations. Furthermore, hematological and biochemical (alanine transaminase [ALT], aspartate transaminase [AST], alkaline phosphatase [ALP], bilirubin, blood urea nitrogen [BUN], and urea) analyses were also performed before, during, and after anesthesia administration. The duration of anesthesia and loss of reflexes were significantly longer in the XTZ group than in the other groups. However, in the TZ group, reflexes were remained. Respiratory rate and body temperature decreased in all the groups. Moreover, heart rate reduced only in the XK and XTZ groups, and the hematological parameters of all groups were comparable. Serum AST and ALP levels increased in the XTZ group compared to that in the XK and TZ groups, respectively. However, these increases were within the reference limits. The post-anesthesia serum BUN and urea levels significantly increased in the XTZ group (p < 0.05) compared to that in the other groups. Thus, although the XTZ combination provided satisfactory anesthetic effect in rabbits, it may be nephrotoxic. Therefore, its use for anesthesia induction in invasive renal procedures and experimental nephrotoxicity studies is not advisable..

scholarly journals Distribution of Pediatric Vital Signs in the Emergency Department: A Nationwide Study

Children ◽  
2020 ◽  
Vol 7 (8) ◽  
pp. 89
Author(s):  
Woori Bae ◽  
Kyunghoon Kim ◽  
Bongjin Lee
Keyword(s):  
Emergency Department ◽  
Heart Rate ◽  
Body Temperature ◽  
Respiratory Rate ◽  
Life Support ◽  
Vital Signs ◽  
Reference Ranges ◽  
Normal Body Temperature ◽  
Heart Rates ◽  
Normal Body

To effectively use vital signs as indicators in children, the magnitude of deviation from expected vital sign distribution should be determined. The purpose of this study is to derive age-specific centile charts for the heart rate and respiratory rate of the children who visited the emergency department. This study used the Korea’s National Emergency Department Information System dataset. Patients aged <16 years visiting the emergency department between 1 January 2016 and 31 December 2017 were included. Heart rate and respiratory rate centile charts were derived from the population with normal body temperature (36 to <38 °C). Of 1,901,816 data points retrieved from the database, 1,454,372 sets of heart rates and 1,458,791 sets of respiratory rates were used to derive centile charts. Age-specific centile charts and curves of heart rates and respiratory rates showed a decline in heart rate and respiratory rate from birth to early adolescence. There were substantial discrepancies in the reference ranges of Advanced Paediatric Life Support and Pediatric Advanced Life Support guidelines. Age-based heart rate and respiratory rate centile charts at normal body temperature, derived from children visiting emergency departments, serve as new evidence-based data and can be used in follow-up studies to improve clinical care for children.

scholarly journals Effect of Silver Nanoparticle Administration on Productive Performance, Blood Parameters, Antioxidative Status, and Silver Residues in Growing Rabbits under Hot Climate

Animals ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 845 ◽  
Author(s):  
Magdy Abdelsalam ◽  
Ibrahim Al-Homidan ◽  
Tarek Ebeid ◽  
Osama Abou-Emera ◽  
Mohamed Mostafa ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Average Daily Gain ◽  
Blood Parameters ◽  
Equal Treatment ◽  
Feed Conversion ◽  
Antioxidative Status ◽  
Treatment Groups ◽  
Hot Climate ◽  
Total Antioxidant ◽  
Hematological And Biochemical Parameters

The influence of subcutaneous injections of silver nanoparticles (AgNPs) on rabbit performance, hematological and biochemical parameters of blood, antioxidant status, and the residues of silver in meat and blood in two breeds (New Zealand White (NZW) and Jabali) of rabbits growing under high ambient temperature was evaluated. A total of 90 six-week-old rabbits (45 NZW and 45 Jabali) were randomly distributed into three equal treatment groups (control, 0.5 mg, and 1.0 mg AgNPs/kg body weight). The treated rabbits were injected twice a week for four consecutive weeks. The results revealed that AgNPs administration had no significant effect on average daily gain (ADG), feed intake, and feed conversion ratio (FCR). The NZW breed surpassed the Jabali breed in growth performance traits, carcass weight, dressing percentage, and cuts of mid parts and hind cuts. Administration of AgNPs had a significant effect on hematocrit (HCT) and platelet (PLT) values. Rabbits injected with AgNPs at a dose of 0.5 mg showed a lower plasma concentration of total cholesterol and triglycerides than that of control rabbits. The NZW breed had significantly low platelet, total cholesterol, and triglyceride values. Rabbits injected with 0.5 mg/kg BW had the lowest total antioxidant capacity and highest malondialdehyde (MDA) and glutathione peroxidase. The Ag residues were higher in blood than those in meat in treated rabbits. The local breed (Jabali) had significantly lower residues than the imported one (NZW) either in meat or in blood. However, the amount of accumulated silver in blood plasma and meat increased with increasing dose.

Acclimatization of calves to a hot humid environment

1959 ◽  
Vol 52 (3) ◽  
pp. 305-312 ◽  
Author(s):  
W. Bianca
Keyword(s):  
Heart Rate ◽  
Body Temperature ◽  
Respiratory Rate ◽  
Skin Temperature ◽  
Rectal Temperature ◽  
Heat Production ◽  
Metabolic Heat ◽  
Hot Environment ◽  
Humid Environment ◽  
Physiological Reactions

1. Three calves were exposed in a climatic room to an environment of 40° C. dry-bulb and 38° C. wet-bulb temperature for up to 110 min. each day for 1-2 weeks.2. These exposures produced progressive changes in the physiological reactions of the animals to heat:(a) Rectal temperature and skin temperature (for a given time of exposure) declined. In consequence there was a marked increase in the tolerance time, i.e. in the time for which the animals could withstand the hot environment before reaching a rectal temperature of 42° C.(b) Respiratory rate rose earlier and assumed higher levels (for given levels of body temperature).(c) Heart rate decreased markedly.3. These changes are discussed in relation to heat loss and heat production and have been interpreted as reflecting chiefly a reduction in the metabolic heat production of the animals.

scholarly journals Comparative study for three protocols of general anesthesia in bucks

2018 ◽  
Vol 41 (2) ◽  
pp. 15-23
Author(s):  
Raffal A. Omar ◽  
M. J. Eesa
Keyword(s):  
Heart Rate ◽  
Statistical Analysis ◽  
Body Temperature ◽  
General Anesthesia ◽  
Respiratory Rate ◽  
Clinical Signs ◽  
Sharp Decrease ◽  
Significance Level ◽  
Alanine Amino Transferase ◽  
Aspartate Amino Transferase

     The aim of this study was to evaluate three regimens in induction and maintenance of general anesthesia in local breed bucks and the investigation of the best protocol of them based on different parameters. Eighteen healthy adult bucks weighing (27.50 ± 0.682 kg), aged (1.989 ± 0.135 years) were used. Animals were divided randomly into three equal groups to undergo pre-experiment preparation. All groups were premedicated intravenously with (0.5 mg/ kg) Diazepam, ten min. Later, the induction for first group was done by Propofol (3 mg/kg B.W), second group was done by Ketamine Hcl (2 mg/kg B.W), while in the third group was done by Thiopental sodium (3mg/kg B.W). After intubation with suitable endotracheal tube, maintenance of the three groups was done by (1.3-1.5%) isoflurane and nitrous oxide with oxygen at ratio 2:1. All the three groups underwent the measurement of the following parameters; (Induction, recovery and duration times) Clinical parameters (heart rate, respiratory rate and body temperature); Clinical signs, analgesia, muscle relaxation; Liver enzyme (Aspartate Amino Transferase and Alanine Amino Transferase). The complete randomized design within statistical analysis system (SAS) program were used for statistical analysis as relevant with a significance level set at P<0.05. The results of this study showed that the induction of the anesthesia was smooth and uneventful in all the three groups and recovery time was shorter in 3rd group in comparison with 2nd and 1st groups. The three regimens showed no significant differences in heart rate. The 2nd group recorded a sharp decrease in respiratory rate and body temperature in comparison with 1st and 3rd groups. Analgesia was very suitable in all the three groups. There were significant changes among groups concerning Alanine Amino Transferase and, Aspartate Amino Transferase. It was concluded that all the three protocols were safe and caused no hazard effect on the animals.

Effect of air temperature and humidity in a stable on basic physiological parameters in horses

2020 ◽  
Vol 16 (3) ◽  
pp. 55-65
Author(s):  
Iwona Janczarek ◽  
Izabela Wilk ◽  
Anna Wiśniewska ◽  
Roland Kusy ◽  
Katarzyna Cikacz ◽  
...  
Keyword(s):  
Heart Rate ◽  
Body Temperature ◽  
Relative Humidity ◽  
Respiratory Rate ◽  
Marked Effect ◽  
Physiological Parameters ◽  
Research Material ◽  
Different Seasons ◽  
One Year ◽  
Internal Body

The aim of the study was to analyse selected air parameters in a stable (microclimate) and the basic physiological parameters of horses housed in the stable in different seasons of the year. The research material was 12 adult hot-blooded horses kept in a brick stable with stalls. Air parameters in the stable (temperature in the passageway, temperature in the stall at two points, relative humidity in the passageway, and relative humidity in the stall at two points) were determined four times in one year, in summer, autumn, winter and spring. Measurements were made with a Bluetooth BLE-LOGGER LB-518 battery-operated cordless thermo-hygrometer at 12 noon at five points in the stable located 300 cm apart. Physiological parameters of the horses, i.e. internal body temperature (Veterinär SC 12 veterinary thermometer), heart rate (Polar ELECTRO OY RS800CX with PolarProTrainer 5.0. software), and respiratory rate (with a manual stopwatch) were measured at 6 a.m. and 6 p.m. on each day of the study. The season of the year was found to have a significant influence on the microclimate of the stable. To ensure optimal air humidity, airing of the stable should be limited only in winter and periodically in autumn. It is also worth emphasizing that the stable microclimate has a marked effect on the basic physiological parameters of horses. High temperature and relative humidity in the stable can cause unfavourable changes in the form of an increase in evening body temperature in the summer and a decrease in the winter. The remaining parameters, i.e. heart rate and respiratory rate, can also unfavourably increase, mainly in the summer. Horses should have fewer problems maintaining normal physiological parameters in winter, even fewer in autumn, and the fewest in spring.

Pulse oximetry and clinical changes during electrosurgery in dogs anaesthetized with Xylazine-Thiopentone and Xylazine-Ketamine combinations

2020 ◽  
Vol 7 (1) ◽  
pp. 97-105
Author(s):  
Mohammad Raguib Munif ◽  
Md Mahmudul Alam ◽  
Md Rafiqul Alam
Keyword(s):  
Heart Rate ◽  
Body Temperature ◽  
Respiratory Rate ◽  
Experimental Period ◽  
Complete Recovery ◽  
Blood Oxygen Saturation ◽  
Group A ◽  
Group B ◽  
Clinical Changes

This study was performed to explore the pulse oximetric evaluation of cardio-respiratory systems along with the determination of body temperature in dogs anaesthetized with xylazine-thiopentone (X-T) and xylazine-ketamine (X-K) combinations during electrosurgery. Six apparently healthy dogs weighed 20 to 25 kg undergoing electrosurgery (bipolar), were divided into two groups: group A (X-T) and group B (X-K). In group A (n=3), dogs were anaesthetized with xylazine @ 1.1 mg/kg body weight (BW) as intramuscular (IM) and thiopentone @ 20 mg/kg BW as intravenous (IV) injections, and in group B (n=3), dogs were anaesthetized with xylazine @ 1.1mg/kg BW IM and ketamine @ 5.5 mg/kg BW IM after premedication with atropine sulphate @ 0.05 mg/kg BW IM. Bipolar electrosurgery for gastrotomy or castration was performed in the dogs. Pulse oximetric monitoring and the evaluation of clinical changes: heart rate, respiratory rate and peripheral blood oxygen saturation (SpO2) were done along with the determination of body temperature before the induction of anaesthesia (control) and thereafter on 10, 20, 30, 40 and 50 minutes postinduction in both groups during electrosurgery. Temperature, heart rate and respiratory rate were altered significantly (P<0.05) during the experimental period in both groups as compared to the control values. SpO2 was decreased significantly (P<0.05) throughout the experiment and returned to the level of initial control value after complete recovery in both groups. These findings revealed that during electrosurgery in dogs the anaesthetic combinations of X-T and X-K exert certain clinical changes in the vital signs (body temperature, heart rate, respiratory rate) and SpO2 which should be carefully considered to take necessary steps for perioperative patient’s safety and recovery. Res. Agric., Livest. Fish.7(1): 97-105, April 2020

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