scholarly journals Metformin and Lactic Acidosis in Diabetic Patients

2021 ◽  
Vol 3 (1) ◽  
pp. 21
Author(s):  
Baiyan Zhao ◽  
Zhilu Li ◽  
Zhangyi He ◽  
Xinxin Zhou ◽  
Yiying Yu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Lactic Acidosis ◽  
Clinical Treatment ◽  
Diabetic Patients ◽  
Fatality Rate ◽  
Basic Drug ◽  
Treatment Of Diabetes ◽  
The Relationship

Metformin is the basic drug in the clinical treatment of Diabetes, often used in the treatment of Type 2 Diabetes Mellitus (T2DM).Its effect has been fully verified in the clinical treatment of T2DM. However, in the treatment of T2DM with metformin, there is still a certain probability of related lactic acidosis, and the fatality rate is high. Therefore, is the use of metformin drug treatment a direct risk factor for lactic acidosis in diabetic patients? This paper will review the hypoglycemic mechanism of metformin and related studies on lactic acidosis, so as to further explore the relationship between metformin and lactic acidosis in diabetic patients, and provide help and reference for metformin drugs in the clinical treatment of T2DM.

scholarly journals Sleep Characteristics in Diabetic Patients Depending on the Occurrence of Neuropathic Pain and Related Factors

2020 ◽  
Vol 17 (21) ◽  
pp. 8125
Author(s):  
Cristina Naranjo ◽  
María Dueñas ◽  
Carlos Barrera ◽  
Guillermo Moratalla ◽  
Inmaculada Failde
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Neuropathic Pain ◽  
Sleep Quality ◽  
Depression Scale ◽  
Anxiety And Depression ◽  
Diabetic Patients ◽  
The Relationship

This study aims to compare the sleep characteristics (structure and quality) in patients with type-2 diabetes mellitus with and without diabetic neuropathic pain (DNP), and to investigate the relationship of sensory phenotypes, anxiety, and depression with sleep quality in DNP patients. A cross-sectional study was performed in patients with type-2 diabetes mellitus and neuropathy. Patients were classified into two groups—with or without neuropathic pain—according to the “Douleur Neuropathique-4 (DN4)” scale. Sleep characteristics and quality (Medical Outcomes Study—MOS-sleep), pain phenotype (Neuropathic Pain Symptom Inventory—NPSI), mood status (Hospital Anxiety and Depression scale—HADS), pain intensity (Visual Analogue Scale—VAS), and quality of life (SF-12v2) were measured. The sample included 130 patients (65 with DNP). The mean scores in all the dimensions of the MOS-sleep scale were higher (more disturbances) in the DNP patients. Higher scores in anxiety or depression, greater intensity of pain or a higher score in the paroxysmal pain phenotype were associated with lower sleep quality in DNP patients. A shorter duration of the diabetes and lower levels of glycated hemoglobin were also associated with lower sleep quality. The results show the relationship between DNP and sleep quality, and the importance of assessing sensory phenotypes and mental comorbidities in these patients. Taking these factors into consideration, to adopt a multimodal approach is necessary to achieve better clinical results.

scholarly journals The Relationship between Plasma Taurine Levels and Diabetic Complications in Patients with Type 2 Diabetes Mellitus

Biomolecules ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 96 ◽  
Author(s):  
Duygu Sak ◽  
Fusun Erdenen ◽  
Cuneyt Müderrisoglu ◽  
Esma Altunoglu ◽  
Volkan Sozer ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Complications ◽  
Active Role ◽  
Diabetic Complication ◽  
Diabetic Patients ◽  
Healthy Control ◽  
The Relationship

Background: Taurine has an active role in providing glucose homeostasis and diabetes causes a decline in taurine levels. This paper investigates the relationship between taurine and diabetic complications, patients’ demographic features, and biochemical parameters. Methods: Fifty-nine patients with type 2 diabetes mellitus (T2DM), and 28 healthy control subjects between the ages of 32 and 82 were included in the study. The mean age of subjects was 55.6 ± 10.3 and mean diabetes duration was 10.2 ± 6.0 years. The most commonly accompanying comorbidity was hypertension (HT) (64.5%, n = 38), and the most frequent diabetic complication was neuropathy (50.8%, n = 30). Plasma taurine concentrations were measured by an enzyme-linked immunoassay (ELISA) kit. Results: Plasma taurine concentrations were significantly lower in diabetic patients (0.6 ± 0.1 mmol/L) than controls (0.8 ± 0.2 mmol/L) and in hypertensive (0. 6 ± 0.1 mmol/L) patients (p = 0.000, p = 0.027 respectively). Conclusion: Plasma taurine levels were decreased in patients with T2DM and this was not related to FBG, HbA1c, and microalbuminuria. With regard to complications, we only found a correlation with neuropathy. We suggest that taurine levels may be more important in the development of diabetes; however, it may also have importance for the progression of the disease and the subsequent complications. We further assert that taurine measurement at different times may highlight whether there is a causal relationship in the development of complications.

scholarly journals The Correlation between Periodontal Diseases and Chronological Age among Type 2 Diabetes Mellitus Patients attending at National Healthcare Network (NHN) Mirpur Centre, Dhaka, Bangladesh

2013 ◽  
Vol 3 (2) ◽  
pp. 74-69 ◽  
Author(s):  
Shaikh Zakir Mahmud ◽  
Sheikh Mohammad Alif ◽  
Monowar Ahmad Tarafder ◽  
Sarder Mahmud Hossain
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Periodontal Diseases ◽  
Chronological Age ◽  
Diabetic Patients ◽  
National Healthcare ◽  
Healthcare Network ◽  
The Relationship

Background: The relationship between diabetes and periodontal diseases has been studied extensively during the past 50 years. Type 2 diabetes occurs mainly in people aged over 40, although it is affecting a growing number of young people. Patients with uncontrolled diabetes have poor resistance to infection with effects in mouth cavity and elsewhere in the body and show an unusually high susceptibility to periodontal diseases and increased susceptibility to acute lateral periodontal abscesses. Objective: This descriptive type of cross-sectional study was conducted to find out the relationship between periodontal diseases and chronological age among type 2 diabetes mellitus patients attending at National Healthcare Network (NHN) Mirpur Centre, Dhaka. Materials and Methods: A total 120 type 2 diabetic patients attended at diabetic centre for routine checkup over a period of six months from August 2011 to January 2012 who fulfilled the eligibility criteria were selected consecutively. Pre-tested semi structured interviewer administered questionnaires were used to collect the information. Cross tabulations and associations were determined by using the chi-square test and simple linear regression from Statistical Package for the Social Sciences where applicable. Results: Chronological age of the patients was significantly associated with the manifestation of periodontal diseases (p=0.004). Moreover, age was useful as a predictor of periodontal diseases as the correlation coefficients showed statistically significant result (p=0.008). In addition, for each year increase of age of the patients there was 0.20% increase of occurrence of periodontal diseases. Conclusion: Periodontal diseases can adversely affect the metabolic control of diabetes. Conversely, treatment of periodontal disease and reduction of oral inflammation may have a positive effect on the diabetic condition, although evidence for this remains somewhat equivocal. Birdem Med J 2013; 3(2): 74-79 DOI: http://dx.doi.org/10.3329/birdem.v3i2.17209

scholarly journals Low Carbohydrate Diet and Diabetes Mellitus Treatment

2019 ◽  
Vol 2 (S1) ◽  
pp. 34-37
Author(s):  
Tugrul I
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Carbohydrate Diet ◽  
Low Carbohydrate Diet ◽  
Low Carbohydrate ◽  
Treatment Of Diabetes ◽  
Diabetes Mellitus Treatment ◽  
The Relationship

Diet is one of the main therapies for patients with type 2 diabetes mellitus (T2DM). Many studies have investigated the relationship and risks between diet lifestyle, carbohydrate intake, and diabetes. It is not known exactly how diets, along with medication, affect medication during the treatment of diabetes mellitus. The purpose of this review is to summarize studies investigating the interaction of low-carbohydrate diets (LCD) and diabetes mellitus medication.

scholarly journals Is Uric Acid elevation a random finding or a causative agent of diabetic nephropathy?

2019 ◽  
Vol 65 (9) ◽  
pp. 1155-1160 ◽  
Author(s):  
Mehmet Zahid Kocak ◽  
Gulali Aktas ◽  
Tuba T. Duman ◽  
Burcin M. Atak ◽  
Haluk Savli
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Diabetic Nephropathy ◽  
Study Groups ◽  
Diabetic Patients ◽  
Study Participants ◽  
The Relationship

SUMMARY OBJECTIVE In this study, we aimed to analyze the relationship between serum uric acid (UA) and microalbuminuria as a marker of renal injury in type 2 diabetes mellitus. METHODS A total of 100 patients with type 2 diabetes mellitus were enrolled in the study. Participants were divided into two groups according to the urinary microalbumin/creatinine ratio: diabetic nephropathy and non-nephropathy group. UA and microalbuminuria were compared between the study groups. RESULTS Serum UA levels of diabetic nephropathy patients were significantly higher than those in the non-nephropathy group (UA in patients with diabetic nephropathy groups: 6.3 (1.82) mg/dl, UA in patients of the non-nephropathic group: 4.85 (1.92) mg/dl) (p<0.001). There was a correlation between microalbuminuria and UA (r=0.238). This correlation was statistically significant (p=0.017). CONCLUSION UA levels may be an important predictor of nephropathy in diabetic patients.

scholarly journals Association between Related Purine Metabolites and Diabetic Retinopathy in Type 2 Diabetic Patients

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Jianfei Xia ◽  
Zonghua Wang ◽  
Feifei Zhang
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Uric Acid ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Purine Metabolites ◽  
The Relationship ◽  
Type 2 Diabetic

Aims. The purpose of the study was to investigate the differences of adenosine, adenine, inosine, xanthine, hypoxanthine, and uric acid concentrations in patients with type 2 diabetes mellitus and diabetic retinopathy and assess the relationship between purine metabolites and disease.Materials and Methods. The study group consisted of 114 subjects which were divided into three groups: control (n=40), type 2 diabetes without retinopathy (n=35), and type 2 diabetes with retinopathy (n=39). Levels of metabolites were measured in plasma of all participants.Results. There is a significant increase of levels of adenosine (0.94±0.17 mg/L versus0.17±0.01 mg/L,P<0.001), inosine (0.297±0.078 mg/L versus0.086±0.010 mg/L,P<0.001), xanthine (1.01±0.21 mg/L versus0.54±0.05 mg/L,P=0.009), and uric acid (70.55±3.97 mg/L versus53.81±2.36 mg/L,P<0.001) with diabetic retinopathy compared to diabetes mellitus. The levels of adenine, hypoxanthine, and xanthine oxidase did not change. Uric acid, xanthine, inosine, and adenosine correlated positively with systolic blood pressure and urea nitrogen.Conclusions. The levels of adenosine, inosine, uric acid, and xanthine may be useful for monitoring the progression of diabetic retinopathy and evaluating the treatment.

Association of Major Dietary Patterns with General and Abdominal Obesity in Iranian Patients with Type 2 Diabetes Mellitus

2015 ◽  
Vol 85 (3-4) ◽  
pp. 145-155 ◽  
Author(s):  
Marjan Ghane Basiri ◽  
Gity Sotoudeh ◽  
Mahmood Djalali ◽  
Mohammad Reza Eshraghian ◽  
Neda Noorshahi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Abdominal Obesity ◽  
Dietary Patterns ◽  
Dietary Pattern ◽  
Diabetic Patients ◽  
General Obesity ◽  
Healthy Dietary Pattern

Abstract. Background: The aim of this study was to identify dietary patterns associated with general and abdominal obesity in type 2 diabetic patients. Methods: We included 728 patients (35 - 65 years) with type 2 diabetes mellitus in this cross-sectional study. The usual dietary intake of individuals over 1 year was collected using a validated semi-quantitative food frequency questionnaire. Weight, height, and waist circumference were measured according to standard protocol. Results: The two major dietary patterns identified by factor analysis were healthy and unhealthy dietary patterns. After adjustment for potential confounders, subjects in the highest quintile of the healthy dietary pattern scores had a lower odds ratio for the general obesity when compared to the lowest quintile (OR = 0.45, 95 % CI = 0.26 - 0.79, P for trend = 0.02), while patients in the highest quintile of the unhealthy dietary pattern scores had greater odds for the general obesity (OR = 3.2, 95 % CI = 1.8 - 5.9, P for trend < 0.001). There were no significant associations between major dietary patterns and abdominal obesity, even after adjusting for confounding factors. Conclusion: This study shows that in patients with type 2 diabetes mellitus, a healthy dietary pattern is inversely associated and an unhealthy dietary pattern is directly associated with general obesity.

ESTIMATION OF SERUM FERRITIN LEVELS IN TYPE 2 DIABETIC PATIENTS AND ITS RELATION WITH HbA1C LEVEL.

2019 ◽  
Vol 3 (8) ◽  
Author(s):  
Shah Namrata Vinubhai ◽  
Pardeep Agarwal ◽  
Bushra Fiza ◽  
Ramkishan Jat
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Sugar ◽  
Serum Ferritin ◽  
Inflammatory Marker ◽  
Control Group ◽  
Diabetic Patients ◽  
Positive Correlation

Background: Serum ferritin is known as an index for body iron stores also as an inflammatory marker and it is influenced by several disease. We were looking for a correlation between HbA1c and S. Ferritin in type 2 DM. Methodology: The present study a total of 150 participants were enrolled of which 100 were confirmed cases of Type 2 Diabetes Mellitus and rest 50 age and sex matched healthy subjects constituted the control group. All were screened for HbA1c, Fasting blood sugar, Post prandial blood sugar and S.Ferritin. Results: A highly significant variation and positive correlation was observed with respect to S.Ferritin and HbA1c levels. Mean S.Ferritin was high in the subgroup with poor glycemic control. Conclusion: The fasting, post prandial sugar levels, HbA1c and S.Ferritin were significantly higher in the diabetic subjects. This study shows a positive correlation between HbA1c and S. Ferritin levels. So we can conclude that in diabetic patients S. Ferritin may serve as an independent marker of poor glycemic and metabolic control. Keywords: Serum ferritin, Type 2 Diabetes Mellitus, HbA1c.

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