scholarly journals Association between Grade of Normoalbuminuria and Left Ventricular Diastolic Dysfunction (LVDD) in Hypertensive Population of Gunungsari Village, Pamijahan-Bogor, Indonesia

2019 ◽  
Vol 40 (2) ◽  
Author(s):  
Nur Zamiatun Qomara ◽  
Nani Hersunarti B ◽  
Anwar Santoso
Keyword(s):  
Diastolic Dysfunction ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Vascular Medicine ◽  
Cross Sectional ◽  
Urine Albumin ◽  
Hypertensive Population ◽  
Increased Risk ◽  
Significant Difference ◽  
Ventricular Diastolic Dysfunction

Association between Grade of Normoalbuminuria and Left Ventricular Diastolic Dysfunction (LVDD) in Hypertensive Population of Gunungsari Village, Pamijahan-Bogor, Indonesia Nur Z Qomara MD, Nani Hersunarti MD, Anwar Santoso MDDepartement of Cardiology and Vascular Medicine Faculty of Universitas Indonesia  ABSTRACT  Background: Albuminuria has been considered an important diagnostic marker of decreasing renal function, but lately albuminuria has also been linked to cardiovascular and peripheral vascular disease. Many studies have analyzed the association between micro- or macroalbuminuria and the increased risk of cardiovascular disease, but only few examined the association between normoalbuminuria and cardiovascular disease.Objective: To analyze the association between the degree of normoalbuminuria and the occurrence of left ventricular diastolic dysfunction in hypertensive patients.Method: This is cross-sectional analysis in hypertensive patients. Normoalbuminuric subjects are divided into three tertiles based on the cutoff of Urine-Albumin-Creatinine Ratio (UACR). To evaluate left ventricular function, all subjects undergo echocardiography examination. Left ventricular diastolic dysfunction is positive if more than fifty percent of positive findings are present from the fourth parameters stated in the 2016 American Society of Echocardiography criterias.Results: No significant difference in the occurrence of LVDD was found between the two groups according to age, sex, smoking, dyslipidemia, physical activity, BMI, hypertension therapy and HbA1c, but a significant difference was seen in the UACR tertile of the two group. This study showed that upper-limit normoalbuminuria (third tertile) was associated with the occurrence of LVDD (OR 15.57, 95% CI: 2.88-84.25).Conclusion: This study showed that normoalbuminuria in hypertensive population is associated with left ventricular diastolic dysfunction. Keywords: hypertension, normoalbuminuria, left ventricular diastolic dysfunctio

scholarly journals Characteristics of Cirrhosis Patients With Left Ventricular Diastolic Dysfunction In China: A Single-Center Retrospective Study.

2021 ◽  
Author(s):  
Jingjing Hu ◽  
Zhaobin Cai
Keyword(s):  
Diastolic Dysfunction ◽  
Demographic Data ◽  
Laboratory Data ◽  
Alcoholic Cirrhosis ◽  
Left Ventricular Diastolic Function ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Cross Sectional ◽  
Ventricular Diastolic Dysfunction ◽  
Inner Diameter

Abstract Objective: Mounting evidence links cirrhosis patients with left ventricular diastolic dysfunction（LVDD） has a poor prognosis. However, little is known about these particular individuals. Therefore, we conducted this cross-sectional study to assess the prevalence of LVDD and its associated risk factors.Methods: Consecutive cirrhosis patient who were attending Hangzhou Xixi hospital from January 2018 to December 2019 were included in this study. According to the American Society of Echocardiography 2016 criteria, cirrhosis patients were sorted into two group: the left ventricular diastolic dysfunction(LVDD) group and left ventricular diastolic function normal(LVDDn) group. Patients’ demographic data, clinical characteristics, laboratory data were recorded. Furthermore, we conducted a multi-factor analysis.Results: A total of 398cirrhosis patients were included in the study. The incidence of LVDD in this study was 49.7% (198 cases). In this study, the mean age and BMI of the patients were 52.9±8.2 years and 23.0±3.3kg/m2，respectively. Of 398 patients, 255(64.1%) of them were males. With regard to etiology, there were 296 patients (74.4%) with hepatitis B cirrhosis and 59 patients (14.8%) with alcoholic cirrhosis. The LVDD group had higher age, higher BMI, greater frequency of ascites and esophageal varices, prolonged prothrombin time, increased international normalized ratio, increased bilirubin, increased CK and AST, and longer QT interval than the LVDDn group(p<0.05, both). In terms of echocardiography, the LVDD group had larger aortic inner diameter, left atrial inner diameter and left ventricular wall diastolic thickness than LVDDn group(p<0.05, both). The multivariate analysis showed age>55 years, BMI>24kg/m2, hepatic decompensated, QTcB>440ms were independently associated with risk of LVDD.Conclusion: The prevalence of LVDD among cirrhosis patients was 49.8%. Cirrhosis patients with LVDD had worse liver function. Further, age>55 years, BMI>24kg/m2, hepatic decompensated, QTcB>440ms were independent predictors of LVDD.

Assessment and clinical relevance of the dynamic parameters of ventricular repolarization in patients with grade I left ventricular diastolic dysfunction

2019 ◽  
Vol 97 (6) ◽  
pp. 577-580
Author(s):  
Antoinette Oliveira Blackman ◽  
José Sobral Neto ◽  
Melchior Luiz Lima ◽  
Tânia Maria Andrade Rodrigues ◽  
Otoni Moreira Gomes
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Diastolic Dysfunction ◽  
Qt Dispersion ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Ventricular Repolarization ◽  
Premature Ventricular Complex ◽  
Increased Risk ◽  
Ventricular Diastolic Dysfunction

Imbalance in ventricular repolarization parameters are related to increased risk of severe arrhythmia and sudden cardiac death. There is limited research regarding markers to detect patients at risk in this early stage. We aimed to assess the influence of grade I left ventricular diastolic dysfunction on repolarization parameters in asymptomatic patients. Ambulatory patients with grade I left ventricular diastolic dysfunction were studied and compared with a control group. We assessed the QT dispersion circadian variation, heart rate variability in the time and frequency domains, and dynamics of QT using a 12-lead Holter. In the diastolic dysfunction group, 8 (30%) patients had QT dispersion > 80 ms. One (3.8%) patient presented premature ventricular complex > 10/h. The comparison between the 2 groups showed that the difference between the standard deviation of normal-to-normal intervals and low frequency power in both groups was statistically significant. We therefore conclude that increased parameters of ventricular repolarization and depressed heart rate variability reflect an imbalance in autonomic responses in patients with grade I left ventricular diastolic dysfunction without cardiovascular symptoms, enabling the identification of patients that are at a higher risk for cardiovascular events.

scholarly journals Correlation between P-Wave Terminal Force V1 (PTFV1) from 12-Lead ECG and Left Ventricular Diastolic Dysfunction in Patients Diagnosed With Hypertension

2020 ◽  
Vol 6 (2) ◽  
pp. 97-103
Author(s):  
Bambang Arie Hidayat Dalimunthe ◽  
Nizam Akbar ◽  
Refli Hasan ◽  
Harris Hasan ◽  
Andika Sitepu ◽  
...  
Keyword(s):  
Diastolic Dysfunction ◽  
Systolic Dysfunction ◽  
Hypertensive Heart Disease ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
P Wave ◽  
P Value ◽  
Cross Sectional ◽  
Ventricular Diastolic Dysfunction ◽  
Grade Iii

Background: Patients diagnosed with hypertension will deteriorate into hypertensive heart disease which is characterized by diastolic dysfunction first followed by systolic dysfunction later in the course of the disease. Diastolic dysfunction of the left ventricle causes an increase in LVEDP as well as in the dimension of the left atrium. P-Wave Terminal Force V1 (PTFV1) which is derived from 12 lead ECG could help diagnose diastolic dysfunction in centers where echocardiography is not available. The purpose of this study was to determine the correlation of PTFV1 on the 12-lead Electrocardiography with diastolic dysfunction in patients diagnosed with hypertension in the outpatient clinic of Cardiac Center Adam Malik General Hospital in Medan. Methods: This is a cross-sectional study conducted from March 2019 until August 2019. Patients with hypertension who met the inclusion criteria were examined electrocardiographically to obtain PTFV1 value. Then echocardiography examination was then performed to assess the grades of diastolic dysfunction and other parameters. Analysis of correlation between PTFV1 values and diastolic dysfunction was then conducted. Results: From the clinical characteristics, there is no difference regarding age, sex , and risk factorsbetween the three diastolic dysfunction groups, while echocardiography characteristic shows more reduced EF in grade III diastolic dysfunction (36.5±7.7). Significant differences in PTFV1 are found among diastolic dysfunction groups. Grade I diastolic dysfunction has PTFV1 value of 23.8 mm.ms, grade II diastolic dysfunction has PTFV1 value of 34.1 mm.ms, and grade III diastolic dysfunction has PTFV1 value of 52.1 mm.ms, Significance of  p value is <0.001. There is a strong correlation between PTFV1 and diastolic dysfunction grade (r = 0.63 (P <0.001)). Cut off point of PTFV1 > 29.8 mm.ms can discriminate patients who have increased LAP with a sensitivity of 84% and specificity of 71%. Conclusions: PTFV1 is a simple screening tool which is widely available and correlate well with left ventricular diastolic dysfunction in patients with hypertension, which makes it a good alternative tool especially in areas where echocardiography is not readily available.

scholarly journals Association of Body Mass Index with Left Ventricular Diastolic Dysfunction Among Ambulatory Patients with Diabetes Mellitus in Rural Uganda: A Cross Sectional Study.

2021 ◽  
Author(s):  
Boniface Amanee Elias Lumori ◽  
Edwin Nuwagira ◽  
Fardous Charles Abeya ◽  
Abdirahman Ali Araye ◽  
Godfrey Masete ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Body Mass Index ◽  
Diastolic Dysfunction ◽  
Body Mass ◽  
Cross Sectional Study ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Sectional Study ◽  
Cross Sectional ◽  
Ventricular Diastolic Dysfunction

Abstract Background: Left ventricular diastolic dysfunction (LVDD) is a recognized complication of diabetes mellitus which precedes and is a risk factor for heart failure. We aimed to determine the prevalence of LVDD and its association with body mass index (BMI) in ambulatory adults with diabetes mellitus. Methods: We conducted a cross-sectional study of 195 ambulatory Ugandan adults living with diabetes mellitus for at least five years from the time of diagnosis at Mbarara Regional Referral Hospital (MRRH). We collected demographic, clinical data and measured body mass index. Laboratory tests included glycated hemoglobin (HbA1c), low-density lipoprotein (LDL), and urine microalbumin. Echocardiography was done to determine LVDD by assessing the mitral inflow E/A ratio, E/è ratio, TR jet peak velocity, and left atrium maximum volume index. Logistic regression was used to establish associations of body mass index and other covariates with LVDD. Results: Overall, 195 participants were enrolled and 141(72.3%) were females. The mean age was 62 [standard deviation (SD), 11.5] years and median duration of diabetes diagnosis was 10 [Interquartile range (IQR), 7,15] years. LVDD was prevalent at 86% and majority, 127(65.13%) had grade-1 diastolic dysfunction. BMI ≥25kg/m2 [adjusted Odds Ratio (aOR)=2.8, (95% confidence interval (CI)=1-7.6), p=0.038], age 50 year or more [aOR= 4.9, (95%CI=1.5-16.2), p=0.010], and history of hypertension [aOR= 3.0, (95% CI= 1.1-8.1), p=0.031] were associated with LVDD.Conclusion: The prevalence of LVDD was high during the study period. We recommend early and periodic echocardiographic screening for diabetes patients with high body mass index.

CORRELATION AND CLINICAL SIGNIFICANCE OF CAROTID INTIMA MEDIA THICKNESS, HSCRP IN CEREBROVASCULAR STROKE

2021 ◽  
pp. 34-35
Author(s):  
Manoj Kumar Mathur ◽  
Ajeet Kumar Chaurasia ◽  
Poonam Gupta ◽  
Manish Yadav
Keyword(s):  
Diastolic Dysfunction ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Blood Parameter ◽  
Media Thickness ◽  
Increased Risk ◽  
Ventricular Diastolic Dysfunction ◽  
Cerebrovascular Stroke

OBJECTIVE: CIMT and hsCRP are strongly related with cerebrovascular stroke.This study was done to evaluate patients with cerebrovascular stroke, correlation of hsCRP, carotid intima media thickness with outcome. METHOD:This study was an observational cross-sectional study. The study was conducted in the Department of Medicine, MLN Medical College and SRN Hospital, Allahabad .All individuals aged ≥18 years . Ethical Committee approval was taken from Institutional Ethics Committee. Patient of CVA with symptoms lasting for more than 24 hours and admitted within 72 hours after the onset of stroke were included in the study. Routine blood parameter including CBC, LFT, KFT, electrolyte, lipid prole was done. HbA1c, hsCRP, CT Head/ MRI brain, Carotid Doppler to assess intima media thickness. RESULT: Total number of CVAcases selected for study was 100,out of which 77patients (77%) had ischaemia and 23 (23%)patients had haemorrhage.Mean age of ischaemic patient was (60.69±13.05) and mean age of haemorrhagic group was 67.74±13.79.In haemorrhagic group CIMT>0.5 mm was present in 21 % cases and CIMT <0.5mm was seen in only 2 cases.This was statistically signicant.In ischaemic group CIMT>0.5mm was present in 73 % cases and CIMT<0.5mm was 4% cases. This was also statistically signicant .CIMT was signicantly higher in haemorrhagic group. In haemorrhagic group hsCRP>3 was present in 20 cases (20%) as compared to only 3 patients with hsCRP <3. This was statistically signicant. Mean hsCRP level was higher in haemorrhagic group as compared to ischaemic group this correlate with increased risk of stroke in cases with hsCRPIn ischaemic group GCS<8 had higher hsCRPlevel as compared to cases of ischaemic stroke with GCS >8.In haemorrhagic group GCS<8 had lower hsCRPlevel as compared to cases of haemorrhagic stroke with GCS >8. CONCLUSION: Carotid intima media thickness was higher in haemorrhagic group as compared to ischaemic group. Haemorrhagic group (82.6%) had low GCS compare to ischaemic group (35.05%) while cases with haemorrhage have more left ventricular diastolic dysfunction in comparison to ischaemic cases. Carotid intima media thickness, triglyceride and more left ventricular diastolic dysfunction was higher in haemorrhagic group

Left Ventricular Diastolic Dysfunction — Early Cardiac Impairment in Patients with Polymyositis/Dermatomyositis: A Tissue Doppler Imaging Study

2013 ◽  
Vol 40 (9) ◽  
pp. 1572-1577 ◽  
Author(s):  
Zhang Lu ◽  
Qiao Wei ◽  
Zu Ning ◽  
Zhao Qian-Zi ◽  
Shu Xiao-Ming ◽  
...  
Keyword(s):  
Risk Factors ◽  
Diastolic Dysfunction ◽  
Late Onset ◽  
Mitral Annulus ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Doppler Imaging ◽  
Mitral Annulus Velocity ◽  
Significant Difference ◽  
Ventricular Diastolic Dysfunction

Objective.To investigate early cardiac involvement in patients with polymyositis/dermatomyositis (PM/DM), and to evaluate the risk factors for early cardiac impairment.Methods.The study population included 46 patients with PM/DM who did not have overt cardiovascular manifestations and 21 age- and sex-matched healthy controls. Traditional echocardiography and tissue Doppler imaging (TDI) were used to evaluate cardiac function in both groups. Clinical characteristics were recorded. Multivariate logistics regression analysis was applied to investigate risk factors for early cardiac impairment in patients with PM/DM.Results.No significant difference was found between patients and controls by traditional echocardiography. However, compared to controls, PM/DM patients had a significantly lower ratio of early diastolic mitral annulus velocity to late diastolic mitral annulus velocity (Em/Am; 1.23 ± 0.52, 1.79 ± 0.37, respectively; t = −4.485, p < 0.001) and a higher ratio of peak early diastolic transmitral flow velocity to Em (E/Em; 8.26 ± 2.57, 6.76 ± 1.17; t = 3.287, p < 0.05) as found by TDI measurements. There was no significant difference between the TDI variables of patients with PM and DM. The multivariate regression analysis showed that female sex (OR 11.044, 95% CI 1.066–114.357, p = 0.044), late onset (OR 1.157, 95% CI 1.047–1.278, p = 0.004), and duration of disease (OR 1.060, 95% CI 1.008–1.115, p = 0.023) were risk factors for abnormal left ventricular filling pressures.Conclusion.TDI is useful for detecting early cardiac impairment in patients with PM/DM. Left ventricular diastolic dysfunction is an early feature of cardiac involvement. Female sex, late onset, and long course of disease are 3 independent risk factors for predicting left ventricular diastolic dysfunction in patients with PM/DM.

Sign in / Sign up

Export Citation Format

Share Document