scholarly journals COPING STRESS PADA ORANG TUA ANAK DENGAN LEUKEMIA LIMFOSITIK AKUT(ALL)

Psibernetika ◽  
2017 ◽  
Vol 9 (2) ◽  
Author(s):  
Shanty Sudarji ◽  
Desy Lustiyani Wahono
Keyword(s):  
Lymphoblastic Leukemia ◽  
Lymphocytic Leukemia ◽  
Self Control ◽  
Acute Myelocytic Leukemia ◽  
Coping With Stress ◽  
Myelocytic Leukemia ◽  
Role Of Parents ◽  
Sick Children ◽  
And Coping

<p>Cancer is not a contagious disease but can cause death, especially in children. Cancer that primarily affects children is leukemia with the number of about 25 to 30% of all types of cancer that affects all children in Indonesia. Common type of leukemia in children is acute lymphocytic or lymphoblastic leukemia (ALL) with a percentage of 82% and acute myelocytic leukemia (AML) by 18%. The role of parents in caring for sick children ALL is not easy, a lot of problems that will occur during the care of children who ALL, either of themselves, their families and the environment. Coping with stress is necessary to handle problems that occur during the care for ALL children. Researchers conducted<br />qualitative research with interviews of five parents who have children with acute lymphocytic leukemia. The data obtained showed that the main source of stress experienced came from a family that is the condition of a sick child, then the source of the stress from the environment and self. Symptoms of stress<br />experienced by the whole subject is prolonged fear and sadness. The whole subject S, RS, ME, DM, and NP using problem focused coping that are planful problem solving, seeking social support and coping confrontative. All subjects also use emotion focused coping. The whole subject of S, RS, ME, DM, and NP<br />using self control, accepting responsibility, and positive reappraisal. Only the subject of RS, ME, NP which uses distancing.</p>

scholarly journals Arabinosyl Cytosine: A Useful Agent in the Treatment of Acute Leukemia in Adults

Blood ◽  
1968 ◽  
Vol 32 (4) ◽  
pp. 507-523 ◽  
Author(s):  
ROSE RUTH ELLISON ◽  
JAMES F. HOLLAND ◽  
MARISE WEIL ◽  
CLAUDE JACQUILLAT ◽  
MICHEL BOIRON ◽  
...  
Keyword(s):  
Remission Rate ◽  
Hemoglobin Level ◽  
Lymphocytic Leukemia ◽  
Acute Myelocytic Leukemia ◽  
Pyrimidine Nucleoside ◽  
Myelocytic Leukemia ◽  
Daily Dose ◽  
Significant Superiority ◽  
Infusion Duration ◽  
Arabinosyl Cytosine

Abstract Arabinosyl cytosine (ara-C), a synthetic pyrimidine nucleoside related to the normal metabolites cytidine and deoxycytidine, has been found capable of producing marrow remission at tolerable doses in acute myelocytic and acute lymphocytic leukemia in adults. There were 16 per cent remissions complete in all aspects, 3 per cent complete except for hemoglobin level, and 6 per cent partial remissions among 180 adults with acute myelocytic leukemia treated with any one of 8 variants of infusion duration or daily dose of ara-C. Twenty-four per cent of 37 adults with acute lymphocytic or unclassified leukemia had complete or partial remissions. The comparison of 1, 4, 12 and 24 hours infusion of ara-C (to total dose tolerated) does not show significant superiority for any one group. The complete remission rate with 1 or 12 hour infusions, however, is 25 per cent (superior to that obtained with 6-mercaptopurine) and the recommended schedule of treatment for ara-C based on these data is, therefore, daily infusions of 100 or 50 mg./m.2 in one hour for approximately 3 to 6 weeks followed by maintenance therapy of once weekly subcutaneous injection of 30 mg./m.2 of ara-C. Platelet transfusions should be available when ara-C is used.

scholarly journals Dealing With the Pandemic of COVID-19 in Portugal: On the Important Role of Positivity, Experiential Avoidance, and Coping Strategies

2021 ◽  
Vol 12 ◽  
Author(s):  
Maria José Ferreira ◽  
Rui Sofia ◽  
David F. Carreno ◽  
Nikolett Eisenbeck ◽  
Inês Jongenelen ◽  
...  
Keyword(s):  
Psychological Distress ◽  
Coping Strategies ◽  
Experiential Avoidance ◽  
Online Survey ◽  
Critical Role ◽  
Well Being ◽  
Coping With Stress ◽  
Self Blame ◽  
And Coping

The global COVID-19 pandemic crisis has caused an unprecedented impact on most areas of people’s lives. Thus, framed within the scope of Existential Positive Psychology (PP2.0), this study aimed at assessing the psychological distress of adults living in Portugal during the first national lockdown, how they are coping with stress, as well to contribute to a deeper understanding about the role that positivity, experiential avoidance, and coping strategies have in psychological distress and well-being. For this purpose, 586 Portuguese adults (73% females) ranging between 18 and 78 years old (M = 38.96, SD = 12.20) completed an online survey during the initial phase of the pandemic crisis in Portugal. Findings suggest that experiential avoidance was the strongest predictor of a negative response (depression, anxiety, stress, loneliness, and negative emotions), whereas positivity was a better predictor of psychological well-being and lower levels of depression. Additionally, self-blame, behavioral disengagement, and emotional venting were strong risk factors for psychological distress, whereas positive reframing, planning, and acceptance were associated with more positive outcomes. These findings highlight the critical role of experiential avoidance on individuals’ psychological distress and the essential contribution of positive life orientation in promoting flourishing. By offering a better understanding of the complex navigation through the dialectics between positive and negative life features, this study provides important and useful cues for psychological interventions directed at promoting a more positive and adaptive human functioning even through such potential adverse and painful life events.

Successful marrow transplantation for acute myelocytic leukemia following therapy for Hodgkin's disease.

1988 ◽  
Vol 6 (10) ◽  
pp. 1558-1561 ◽  
Author(s):  
R B Geller ◽  
G B Vogelsang ◽  
J R Wingard ◽  
A M Yeager ◽  
W H Burns ◽  
...  
Keyword(s):  
Hodgkin's Disease ◽  
Marrow Transplantation ◽  
Hematologic Malignancy ◽  
Hodgkin’S Disease ◽  
Combined Modality Therapy ◽  
Intensive Therapy ◽  
Acute Myelocytic Leukemia ◽  
Myelocytic Leukemia ◽  
Histocompatibility Locus

Five patients with acute myelocytic leukemia (AML) after combined modality therapy for Hodgkin's disease (HD) were treated with cyclophosphamide and busulfan followed by bone marrow transplantation (BMT). Four patients received allogeneic transplants from histocompatibility locus antigen (HLA)-compatible siblings and the fifth patient received an autologous marrow treated with 4-hydroperoxycyclophosphamide. Two patients died of complications of acute graft-v-host disease (GVHD) despite prophylaxis with either low-dose cyclophosphamide or cyclosporine. The remaining three patients were alive and disease-free 382, 617, and 620 days after transplant. These initial results are encouraging and more patients with treatment-related AML need to be evaluated with both allogeneic and autologous BMT to fully elucidate the potentially curative role of this intensive therapy in an otherwise fatal hematologic malignancy.

Mutations of the E2F4 gene in hematological malignancies having microsatellite instability

Blood ◽  
2000 ◽  
Vol 95 (4) ◽  
pp. 1509-1510 ◽  
Author(s):  
Naoki Komatsu ◽  
Seisho Takeuchi ◽  
Takayuki Ikezoe ◽  
Taizo Tasaka ◽  
Yoshihiro Hatta ◽  
...  
Keyword(s):  
Microsatellite Instability ◽  
Cell Cycle Progression ◽  
Hematological Malignancies ◽  
Lymphoblastic Leukemia ◽  
Acute Myelocytic Leukemia ◽  
Cycle Progression ◽  
Childhood All ◽  
Adult T Cell Leukemia ◽  
Myelocytic Leukemia ◽  
Repair Genes

Mutations of coding repeats within the E2F4, TGF-βRII, BAX, IGFIIR, and hMSH3 are critical targets of microsatellite instability (MSI) in many kinds of cancers. We analyzed 9 childhood acute lymphoblastic leukemia (ALL) samples, 5 acute myelocytic leukemia (AML) samples, and 10 adult T-cell leukemia (ATL) samples having MSI to determine whether they had mutations of the E2F4, TGF-βRII, BAX, IGFIIR, and hMSH3 genes. Frameshift mutations were found at trinucleotide repeats within a coding exon of the E2F4 gene in 2 of 10 (20%) ATL samples and 1 of 9 (11%) childhood ALL samples. No mutations were found in the TGF-βRII, BAX, IGFIIR, andhMSH3 genes. E2F4 is a transcription factor that influences the cell-cycle progression. These results suggest that mutations of the E2F4 gene, presumably caused by an abnormality of one of the DNA repair genes, may play an important role in development of ATL and childhood ALL.

scholarly journals A Comparative Study of Two Regimens of Combination Chemotherapy in Acute Leukemia

Blood ◽  
1958 ◽  
Vol 13 (12) ◽  
pp. 1126-1148 ◽  
Author(s):  
EMIL FREI ◽  
JAMES F. HOLLAND ◽  
MARVIN A. SCHNEIDERMAN ◽  
DONALD PINKEL ◽  
GEORGE SELKIRK ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Survival Time ◽  
Median Survival ◽  
Combination Chemotherapy ◽  
Drug Toxicity ◽  
Acute Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Acute Myelocytic Leukemia ◽  
Myelocytic Leukemia ◽  
Remission Status

Abstract A comparative clinical trial of two regimens of combination chemotherapy has been accomplished in acute leukemia by four separate medical and pediatric services. Sixty-five patients were allocated at random to one of two treatment programs. Daily administration of methotrexate with daily 6-mercaptopurine has been compared to methotrexate every third day in the same total dose with daily 6-mercaptopurine. No difference in frequency of remission, extent of remission or toxicity was observed between the two groups. Among those patients who attained remission status, however, duration of remission (P = .05-.10) and of survival (P = <.05) was longer for the continuous group. All remissions in children occurred in acute lymphocytic leukemia, whereas all remission in adults were observed in acute myelocytic leukemia. The duration of remissions was somewhat shorter for children with acute lymphocytic leukemia than for adults with acute myelocytic leukemia. The frequency of remission, either partial or complete, was higher in children, however (36 per cent), than in adults (19 per cent), although the confidence limits for each figure overlap. The duration of acute leukemia in previously untreated patients did not influence response to therapy from the two antimetabolite regimens in this study. In patients who had had prior antimetabolite therapy, however, complete remissions were attained less often than in previously untreated patients. The toxic manifestations encountered during the administration of these antimetabolites are described. Seventeen deaths occurred during this study, of which 8 occurred in the first 10 days, presumably from leukemia and not drug toxicity. Five patients died with hypoplastic marrows ascribed to drug toxicity. The toxic manifestations were qualitatively and proportionately the same in patients who attained remission status, and in those patients who failed to remit, but who lived long enough to recognize the onset of remission if it were going to occur. No indication was obtained, therefore, that patients who attained remission were subjected to a greater toxic hazard, in order to achieve the therapeutic benefits observed, than those who did not remit. The median survival of patients who achieved remission was longer (p <.05) than for patients who did not remit. Since the survival time of remitters from relapse to death was almost identical with the survival time of nonremitters from onset of treatment to death, this difference can be accounted for by the time spent in remission and getting to remission. The median survival time from symptomatic onset for all children in this study was 12 months, and for adults, 7 months. The median in children is similar to that reported from other clinics. This is evidence that a comparative therapeutic trial in acute leukemia can be accomplished without recognizable compromise of patient welfare.

scholarly journals Human B-lymphocyte antigens expressed by lymphocytic and myelocytic leukemia cells. I. Detection by rabbit antisera.

1976 ◽  
Vol 144 (1) ◽  
pp. 167-178 ◽  
Author(s):  
R Billing ◽  
B Rafizadeh ◽  
I Drew ◽  
G Hartman ◽  
R Gale ◽  
...  
Keyword(s):  
B Cell ◽  
B Lymphocytes ◽  
Cell Lines ◽  
B Lymphocyte ◽  
Lymphocytic Leukemia ◽  
Immunofluorescent Staining ◽  
Leukemia Cells ◽  
Acute Myelocytic Leukemia ◽  
Normal Peripheral Blood ◽  
Myelocytic Leukemia

A previously uncharacterized human B-lymphocyte antigen has been detected by rabbit antisera raised to papain digests of spleen cell membranes. The unabsorbed sera reacted in both cytotoxicity and immunofluorescent tests with normal B lymphocytes and cultured B-cell lines but not with normal T lymphocytes or cultured T-cell lines. The cytotoxicity titers against B cells were as high as 1:32,000, whereas the same sera undiluted were negative against T cells. By immunofluorescent staining 6-14% of unfractionated normal lymphocytes and 48-85% of B-rich lymphocyte preparations were positive. Normal peripheral blood granulocytes, platelets, erythrocytes, and phytohemagglutinin blasts were negative. The antisera reacted with the same high titers against leukemia cells from approximately 70% of the patients with acute lymphocytic leukemia, acute myelocytic leukemia, chronic myelocytic leukemia, and seven of eight cases of chronic lymphocytic leukemia. From absorption studies it appeared that the same antigen was being expressed by leukemia cells and normal B lymphocytes. Using immunofluorescent staining the anti-B-cell antisera were able to detect positive leukemia cells in the bone marrow of patients with advanced leukemia and to monitor the elimination of these cells after chemotherapy. Soluble B-cell antigen was found in the serum of some leukemia and lymphoma patients do but not in normal serum.

scholarly journals PERAN ORANG TUA DALAM PENYESUAIAN DIRI ANAK TUNAGRAHITA DI SEKOLAH LUAR BIASA PGRI GENTENG BANYUWANGI

2019 ◽  
Vol 17 (2) ◽  
pp. 255
Author(s):  
Eka Ramiati ◽  
Yuli Tri Andini
Keyword(s):  
Married Couples ◽  
Self Control ◽  
Mental Disability ◽  
Disabled Children ◽  
Mentally Disabled ◽  
Know How ◽  
Normal People ◽  
The Subject ◽  
Role Of Parents

Being a parent is a very meaningful gift to every couple, especially with the presence of a child who is the epitome of love for both of her parents. If a child is born in a state of mental disability or a tunagrahita, then the parent will begin to think about how they should raise the child who is mentally disabled. The fact that is happening in the community about the parenting of disabled is the number of parents who let even hide the children of disabled because of shame, but there are also parents who give good parenting to them. The purpose of this study is to explain and give an overview of the form of self-adjustment and the cause of the children's causes, the factors that cause self-adjustment in children, the factors that influence self-adjustment Children and to know how the role of parents in assisting the self-adjustment of the child is a disabled. The study used a qualitative approach in the form of case studies. The characteristics of the subject in this study were 15-year-old disabled children and male genders, while the characteristics of respondents in this study were married couples who had a 30-50-year-old child of disabled . Based on the results of the research known that the form of self-adjustment of children such as those who want to be independent, have the same desire with normal people, social interaction, have self control, and confident. The cause of child disabled is due to high fever pain (convulsions) and the economic difficulties of the subject family, so that their child is too late to get treatment that eventually leads to disabled. Factors that are the cause of self-adjustment in the child are physical and psychological factors and environmental factors, namely the attention of the environment, such as family members and neighbors around the place of residence. In an effort to adjust itself, the child needs a good role of parents, which provides proper support and parenting. Parenting roles include material support, attention support, parental acceptance, advice and parenting.

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